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公开(公告)号：AU2005208748A1
公开(公告)日：2005-08-11
申请号：AU2005208748
申请日：2005-01-21
Inventor： NOWATZKI PAUL J , TIRRELL DAVID A , SCHWARTZ DANIEL M , GRUBBS ROBERT H
Abstract: The present invention provides engineered proteins and biomedical products made from the engineered proteins. The biomedical products include lenses useful for ophthalmic purposes.
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公开(公告)号：CA2491128A1
公开(公告)日：2004-01-15
申请号：CA2491128
申请日：2003-07-01
Applicant: UNIV CALIFORNIA , CALIFORNIA INST OF TECHN
Inventor： FRASER SCOTT , GALLIVAN JUSTIN P , YU CHANGJUN , SCHWARTZ DANIEL M , GRUBBS ROBERT H
IPC: G01N21/64 , A61B3/12 , A61F9/007 , A61K9/127 , A61K38/46 , A61K38/48 , A61K41/00 , A61K45/00 , A61K47/48 , A61K49/00 , A61P27/02 , A61P27/06 , G01N21/17 , A61K38/43
Abstract: The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment of any eye disorder, although in particular embodiments the individual has a thickened Bruch's membrane. An activating energy source is utilized to effect a controlled diffusion enhancement and/or degradation of Bruch's membrane that enables improved diffusional transport between the choroid and retina. The individual is administered an inactivated diffusion-enhancing molecule that becomes associated with the membrane, which is then precisely exposed to an activati ng energy source, such as light or ultrasound.
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公开(公告)号：SG175568A1
公开(公告)日：2011-11-28
申请号：SG2011070554
申请日：2007-10-24
Applicant: CALIFORNIA INST OF TECHN , UNIV CALIFORNIA
Inventor： SCHWARTZ DANIEL M , MATTSON MATTHEW S , KORNFIELD JULIA A , MALONEY ROBERT K , GRUBBS ROBERT H
Abstract: The disclosure concerns altering the mechanical and/or chemical property of a body tissue, particularly an ocular tissue. In specific cases, it concerns altering or stabilizing the shape of the cornea, such as in a subject suffering or at risk for ectasia or keratoconus. In other specific cases, it concerns strengthening the sclera in a subject suffering or at risk for myopia. The invention employs light irradiation of a photoactivatable compound, such as one that applies crosslinking to the tissue, for example.No Suitable Figure.
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公开(公告)号：DE69935449D1
公开(公告)日：2007-04-19
申请号：DE69935449
申请日：1999-10-13
Applicant: UNIV CALIFORNIA , CALIFORNIA INST OF TECHN
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Patent Agency Ranking
公开(公告)号：AT355800T
公开(公告)日：2007-03-15
申请号：AT99951937
申请日：1999-10-13
Applicant: CALIFORNIA INST OF TECHN , UNIV CALIFORNIA
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公开(公告)号：AT331233T
公开(公告)日：2006-07-15
申请号：AT01918931
申请日：2001-03-20
Applicant: CALIFORNIA INST OF TECHN , CALHOUN VISION INC , UNIV CALIFORNIA
Inventor： SANDSTEDT CHRISTIAN A , JETHMALANI JAGDISH M , GRUBBS ROBERT H , KORNFIELD JULIA A , SCHWARTZ DANIEL M , MALONEY ROBERT
Abstract: A system for correcting aberrations in an optical system comprising: an optical element and a wavefront sensor, characterised in that the optical element comprises a first polymer matrix and arefraction modulating composition dispersed and freely diffusable within the first polymer matrix, wherein the refraction modulating composition is capable of stimulus-induced polymerization to produce desired changes in the optical element, the first polymer matrix having been polymerised in the presence of the refraction modulating composition.
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27.发明专利
公开(公告)号：AU2001245948B2
公开(公告)日：2004-05-13
申请号：AU2001245948
申请日：2001-03-20
Applicant: CALHOUN VISION INC , CALIFORNIA INST OF TECHN , UNIV CALIFORNIA
Inventor： MALONEY ROBERT , SCHWARTZ DANIEL M , KORNFIELD JULIA A , GRUBBS ROBERT H , JETHMALANI JAGDISH M , SANDSTEDT CHRISTIAN A
IPC: G01M11/02 , A61B3/10 , A61F2/16 , G02B1/04 , G02B26/06 , G02B27/00 , G02B027/00 , G02B001/04 , A61F002/16 , A61B003/103
Abstract: A system for correcting aberrations in an optical system comprising: an optical element and a wavefront sensor, characterised in that the optical element comprises a first polymer matrix and arefraction modulating composition dispersed and freely diffusable within the first polymer matrix, wherein the refraction modulating composition is capable of stimulus-induced polymerization to produce desired changes in the optical element, the first polymer matrix having been polymerised in the presence of the refraction modulating composition.
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公开(公告)号：BR9916895A
公开(公告)日：2002-03-19
申请号：BR9916895
申请日：1999-10-13
Applicant: CALIFORNIA INST OF TECHN , UNIV CALIFORNIA SAN FRANCISCO
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29.发明专利
公开(公告)号：AU4594801A
公开(公告)日：2001-10-03
申请号：AU4594801
申请日：2001-03-20
Applicant: CALIFORNIA INST OF TECHN
Inventor： SANDSTEDT CHRISTIAN A , JETHMALANI JAGDISH M , GRUBBS ROBERT H , KORNFIELD JULIA A , SCHWARTZ DANIEL M , MALONEY ROBERT
Abstract: A system for correcting aberrations in an optical system comprising: an optical element and a wavefront sensor, characterised in that the optical element comprises a first polymer matrix and arefraction modulating composition dispersed and freely diffusable within the first polymer matrix, wherein the refraction modulating composition is capable of stimulus-induced polymerization to produce desired changes in the optical element, the first polymer matrix having been polymerised in the presence of the refraction modulating composition.
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