公开(公告)号：WO2010088333A3

公开(公告)日：2011-04-14

申请号：PCT/US2010022329

申请日：2010-01-28

Applicant: CALIFORNIA INST OF TECHN ,  LC VISION LLC ,  KORNFIELD JULIA A ,  WAND MICHAEL ,  KURJI ZULEIKHA

Inventor： KORNFIELD JULIA A ,  WAND MICHAEL ,  KURJI ZULEIKHA

IPC: C09K19/02 ,  C09K19/12 ,  C09K19/38 ,  G02F1/141

CPC classification number: C09K19/0225 ,  C09K19/3842 ,  C09K19/406 ,  G02F1/13725 ,  G02F1/141 ,  Y10T428/10 ,  Y10T428/1036

Abstract: A system having a ferroelectric liquid host material and a small amount of polymer additive is provided. In an embodiment, the polymer additive improves the physical characteristics of the system. In an embodiment, the system can be used in FLC applications.

Abstract translation: 提供具有铁电液体主体材料和少量聚合物添加剂的体系。 在一个实施方案中，聚合物添加剂改善了体系的物理特性。 在一个实施例中，该系统可用于FLC应用。

公开(公告)号：EP2970672A4

公开(公告)日：2016-08-24

申请号：EP14764716

申请日：2014-03-17

Applicant: CALIFORNIA INST OF TECHN

Inventor： KORNFIELD JULIA A ,  WEI MING-HSIN ,  JONES SIMON ,  SAROHIA VIRENDRA

IPC: C08L101/02 ,  C08F265/00 ,  C08F290/00 ,  C08G83/00 ,  C08L51/00 ,  C10L1/198

CPC classification number: C08K11/00 ,  C08G83/008 ,  C08L101/02 ,  C10L1/1973 ,  C10L1/1976 ,  C10L1/198 ,  C10L1/2366 ,  C10L1/2368 ,  C10L10/00 ,  C10L10/02 ,  C10L10/08

Abstract: Described herein are associative polymers capable of controlling one or more physical and/or chemical properties of non-polar compositions and related compositions, methods and systems.

Abstract translation: 本文描述了能够控制非极性组合物和相关组合物，方法和系统的一种或多种物理和/或化学性质的缔合聚合物。

公开(公告)号：EP1755584A4

公开(公告)日：2007-10-31

申请号：EP05746596

申请日：2005-05-09

Applicant: UNIV CALIFORNIA ,  CALIFORNIA INST OF TECHN

Inventor： SCHWARTZ DANIEL M ,  YU CHANG JUN ,  GRUBBS ROBERT H ,  KORNFIELD JULIA A ,  FRASER SCOTT E ,  MATTSON MATTHEW S

IPC: A61K31/135 ,  A61K31/295 ,  A61K31/325 ,  A61K31/37 ,  A61K31/382 ,  A61K31/47 ,  A61K31/495 ,  A61K31/765 ,  A61K33/04 ,  A61K41/00 ,  A61K49/00 ,  A61P27/10

CPC classification number: A61K31/135 ,  A61K31/295 ,  A61K31/325 ,  A61K31/37 ,  A61K31/382 ,  A61K31/47 ,  A61K31/495 ,  A61K41/0042 ,  A61K49/0002

Abstract: The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment and/or prevention of myopia. An activating energy source is utilized to photopolymerize or crosslink molecules in the sclera, thereby increasing the strength of the tissue. The individual is administered a crosslinking reagent or photopolymerizable molecule that becomes associated with the membrane, which is then precisely exposed to an energy source, such as light or ultrasound.

公开(公告)号：EP1173517A4

公开(公告)日：2006-06-28

申请号：EP00931980

申请日：2000-04-26

Applicant: CALIFORNIA INST OF TECHN

Inventor： HUBBELL JEFFREY A ,  KORNFIELD JULIA A ,  TAE GIYOONG

IPC: A61K9/00 ,  A61K31/77 ,  A61K47/32 ,  A61K47/34 ,  C08G65/08 ,  C08G65/323 ,  C08J3/075 ,  C08L5/16 ,  C08L71/02

CPC classification number: C08J3/075 ,  A61K31/77 ,  C08L5/16 ,  C08L2666/02

Abstract: The invention features materials and methods for the liquid to solid transition of an injectable pre-hydrogel composition to a hydrogel. These methods can be carried out in situ.

公开(公告)号：WO2012054541A3

公开(公告)日：2012-07-12

申请号：PCT/US2011056788

申请日：2011-10-18

Applicant: CALIFORNIA INST OF TECHN ,  UNIV LOUGHBOROUGH ,  KORNFIELD JULIA A ,  AILIANOU ARTEMIS ,  RONCA SARA ,  RASTOGI SANJAY ,  FORTE GIUSEPPE

Inventor： KORNFIELD JULIA A ,  AILIANOU ARTEMIS ,  RONCA SARA ,  RASTOGI SANJAY ,  FORTE GIUSEPPE

IPC: C08F2/00 ,  C08F2/44 ,  C08F10/02 ,  C08J3/02

CPC classification number: C08L25/14 ,  C08F10/02 ,  C08F110/02 ,  C08F210/16 ,  C08G69/02 ,  C08L23/02 ,  C08L25/06 ,  C08L75/04 ,  C08F2/14 ,  C08F2500/01 ,  C08F2500/22 ,  C08F2500/24 ,  C08F210/08 ,  C08F2500/08 ,  C08F2500/10 ,  C08F2500/12

Abstract: A method for controlling the physical state of an ultra-high molecular weight polymer to make the ultra-high molecular weight polymer suitable for further processing, and related polymers compositions methods and systems, wherein the method comprises combining a catalyst, monomers, and an additive, for a time and under condition to allow synthesis of a nascent polymer and co-crystallization of the nascent polymer with the additive.

Abstract translation: 一种控制超高分子量聚合物的物理状态以制备适用于进一步加工的超高分子量聚合物的方法，以及相关聚合物组合物的方法和系统，其中所述方法包括将催化剂，单体和添加剂 一段时间并处于允许合成新生聚合物和新生聚合物与添加剂共结晶的条件下。

公开(公告)号：WO2010117947A2

公开(公告)日：2010-10-14

申请号：PCT/US2010029966

申请日：2010-04-05

Applicant: CALIFORNIA INST OF TECHN ,  WANG MUZHOU ,  MATTSON MATTHEW S ,  TIRRELL DAVID A ,  KORNFIELD JULIA A

Inventor： WANG MUZHOU ,  MATTSON MATTHEW S ,  TIRRELL DAVID A ,  KORNFIELD JULIA A

IPC: A61L24/10 ,  A61F9/007 ,  A61L24/04

CPC classification number: A61L24/108 ,  A61F9/007 ,  A61L2430/16

Abstract: There is provided in one embodiment of the disclosure a tissue adhesive composition comprising an engineered protein having repeated blocks of an elastin domain and at least one cell-binding domain and further comprising a polymer crosslinker. When the engineered protein and the polymer crosslinker are introduced onto a tissue, the engineered protein and the polymer crosslinker initiate an in situ crosslinking reaction to form an adhesive bond that is mechanically strong, transparent, biocompatible, and stimulates regrowth of one or more tissue layers over the adhesive bond. In another embodiment of the disclosure there is provided a molded corneal onlay and method of making the same.

Abstract translation: 在本公开的一个实施方案中提供了组织粘合剂组合物，其包含具有弹性蛋白结构域和至少一个细胞结合结构域的重复嵌段的工程改造的蛋白质，并且还包含聚合物交联剂。 当将工程蛋白质和聚合物交联剂引入到组织上时，工程改造的蛋白质和聚合物交联剂引发原位交联反应以形成机械强度，透明度，生物相容性和刺激一个或多个组织层的再生长的粘合剂粘合 超过粘合剂粘合。 在本公开的另一个实施方案中，提供了一种模制的角膜嵌体及其制备方法。

公开(公告)号：WO2008052081A2

公开(公告)日：2008-05-02

申请号：PCT/US2007082435

申请日：2007-10-24

Applicant: CALIFORNIA INST OF TECHN ,  UNIV CALIFORNIA

Inventor： SCHWARTZ DANIEL M ,  MATISON MATTHEW S ,  KORNFIELD JULIA A ,  MALONEY ROBERT K ,  GRUBBS ROBERT H

IPC: A61M5/00

CPC classification number: A61K9/0048 ,  A61F9/0079 ,  A61F9/008 ,  A61F2009/00865 ,  A61F2009/00872 ,  A61F2009/00893 ,  A61K9/0051 ,  A61K9/19 ,  A61K31/00

Abstract: The disclosure concerns altering the mechanical and/or chemical property of a body tissue, particularly an ocular tissue. In specific cases, it concerns altering or stabilizing the shape of the cornea, such as in a subject suffering or at risk for ectasia or keratoconus. In other specific cases, it concerns strengthening the sclera in a subject suffering or at risk for myopia. The invention employs light irradiation of a photoactivatable compound, such as one that applies crosslinking to the tissue, for example.

Abstract translation: 本公开涉及改变身体组织，特别是眼组织的机械和/或化学性质。 在具体情况下，它涉及改变或稳定角膜的形状，例如患有或具有扩张或圆锥角膜风险的受试者。 在其他具体情况下，它涉及加强遭受或面临近视眼的受试者的巩膜。 本发明使用例如对组织进行交联的可光活化化合物的光照射。

公开(公告)号：WO2008052081A8

公开(公告)日：2008-08-14

申请号：PCT/US2007082435

申请日：2007-10-24

Applicant: CALIFORNIA INST OF TECHN ,  UNIV CALIFORNIA

Inventor： SCHWARTZ DANIEL M ,  MATTSON MATTHEW S ,  KORNFIELD JULIA A ,  MALONEY ROBERT K ,  GRUBBS ROBERT H

IPC: A61M35/00 ,  A61M31/00

CPC classification number: A61K9/0048 ,  A61F9/0079 ,  A61F9/008 ,  A61F2009/00865 ,  A61F2009/00872 ,  A61F2009/00893 ,  A61K9/0051 ,  A61K9/19 ,  A61K31/00

Abstract: The disclosure concerns altering the mechanical and/or chemical property of a body tissue, particularly an ocular tissue. In specific cases, it concerns altering or stabilizing the shape of the cornea, such as in a subject suffering or at risk for ectasia or keratoconus. In other specific cases, it concerns strengthening the sclera in a subject suffering or at risk for myopia. The invention employs light irradiation of a photoactivatable compound, such as one that applies crosslinking to the tissue, for example.

Abstract translation: 本公开涉及改变身体组织，特别是眼组织的机械和/或化学性质。 在特定情况下，它涉及改变或稳定角膜的形状，例如在患有或可能患有扩张或圆锥角膜的受试者中。 在其他特定情况下，它涉及加强患有或有近视风险的受试者的巩膜。 例如，本发明采用可光活化化合物的光照射，例如对组织施加交联的化合物。

公开(公告)号：WO0171411A3

公开(公告)日：2002-03-07

申请号：PCT/US0109276

申请日：2001-03-20

Applicant: CALIFORNIA INST OF TECHN

Inventor： SANDSTEDT CHRISTIAN A ,  JETHMALANI JAGDISH M ,  GRUBBS ROBERT H ,  KORNFIELD JULIA A ,  SCHWARTZ DANIEL M ,  MALONEY ROBERT

IPC: G01M11/02 ,  A61B3/10 ,  A61F2/16 ,  G02B1/04 ,  G02B26/06 ,  G02B27/00 ,  A61B3/103

CPC classification number: G02B27/0025 ,  A61B3/1015 ,  A61F2/1627 ,  A61F2/1635 ,  B29D11/00461 ,  G02B1/04 ,  G02B1/043 ,  G02B26/06 ,  G02C2202/14

Abstract: The present invention relates to methods of implementing an optical element having a refraction modulating composition. The methods include using a wavefront sensor to provide an optical measurement of the optical element. The present invention also relates to systems comprising an optical element having a refraction modulating composition and a wavefront sensor. An embodiment is described in which the optical element is an intraocular lens. Optical aberrations of the lens measured by the wavefront sensor are corrected by photo-polymerization of the refraction modulating composition which alters the refractive properties of the lens. Correction of lens refractive errors can be carried out after the lens has been implanted in the eye.

Abstract translation: 本发明涉及实现具有折射调制组合物的光学元件的方法。 这些方法包括使用波前传感器来提供光学元件的光学测量。 本发明还涉及包括具有折射调制组合物和波前传感器的光学元件的系统。 描述了一种实施例，其中光学元件是眼内透镜。 由波前传感器测量的透镜的光学像差通过改变透镜的折射特性的折射调制组合物的光聚合来校正。 镜片屈光不正的矫正可以在镜片植入眼睛后进行。

公开(公告)号：WO0041650B1

公开(公告)日：2000-10-19

申请号：PCT/US9923728

申请日：1999-10-13

Applicant: CALIFORNIA INST OF TECHN ,  UNIV CALIFORNIA SAN FRANCISCO ,  JETHMALANI JAGDISH M ,  GRUBBS ROBERT H ,  SANDSTEDT CHRISTIAN A ,  KORNFIELD JULIA A ,  SCHWARTZ DANIEL M

Inventor： JETHMALANI JAGDISH M ,  GRUBBS ROBERT H ,  SANDSTEDT CHRISTIAN A ,  KORNFIELD JULIA A ,  SCHWARTZ DANIEL M

IPC: G02C7/04 ,  A61F2/16 ,  A61L27/00 ,  A61L27/18 ,  G02B1/04 ,  G02B3/14 ,  G02C7/06

CPC classification number: G02B3/00 ,  A61F2/16 ,  A61F2/1627 ,  A61F2/1635 ,  A61L27/18 ,  A61L2430/16 ,  G02B1/043 ,  G02C7/04 ,  G02C2202/14 ,  C08L83/04

Abstract: The present invention relates to lenses that are capable of post-fabrication power modifications. In general, the inventive lenses comprise (i) a first polymer matrix and (ii) a refraction modulating composition that is capable of stimulus-induced polymerization dispersed therein. When at least a portion of the lens is exposed to an appropriate stimulus, the refraction modulating composition forms a second polymer matrix. The amount and location of the second polymer matrix may modify a lens characteristic such as lens power by changing its refractive index and/or by altering its shape. The inventive lenses have a number of applications in the electronics and medical fields as data storage means and as medical lenses, particularly intraocular lenses, respectively.

Abstract translation: 本发明涉及能够进行制造后功率修改的透镜。 通常，本发明的镜片包含（i）第一聚合物基质和（ii）能够刺激分散于其中的刺激聚合的折射调节组合物。 当透镜的至少一部分暴露于适当的刺激时，折射调制组合物形成第二聚合物基质。 第二聚合物基质的量和位置可以通过改变其折射率和/或通过改变其形状来改变透镜特性，例如透镜光焦度。 本发明的透镜在电子和医疗领域中作为数据存储装置和作为医用透镜，尤其是眼内透镜分别具有许多应用。