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公开(公告)号：US20190290171A1
公开(公告)日：2019-09-26
申请号：US16437890
申请日：2019-06-11
Inventor： Axel SCHERER , Meisam Honarvar NAZARI , Muhammad MUJEEB-U-RAHMAN , Mehmet SENCAN , Arti GAUR
IPC: A61B5/1473 , A61B5/07 , A61B5/1459 , A61M5/172 , A61B17/34 , A61B5/1486 , A61B5/145 , A61M5/142 , A61B5/00
Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.
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公开(公告)号：US20190127799A1
公开(公告)日：2019-05-02
申请号：US16102583
申请日：2018-08-13
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Emil P. KARTALOV , Aditya RAJAGOPAL , Axel SCHERER , Mark D. GOLDBERG
IPC: C12Q1/6883 , C12Q1/70 , C12Q1/68 , C12Q1/6851
Abstract: FRET-based analytes detection and related methods and systems are described where a pair of FRET labeled primers and/or oligonucleotides are used that are specific for target sequences located at a distance up to four time the Förster distance of the FRET chromophores presented on the FRET labeled primers and/or oligonucleotides one with respect to the other in one or more polynucleotide analyte; in particular the pair of FRET labeled primers and/or oligonucleotides is combined with a sample and subjected to one or more polynucleotide amplification reactions before measuring FRET signals from at least one FRET chromophore.
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公开(公告)号：US20190090796A1
公开(公告)日：2019-03-28
申请号：US16144079
申请日：2018-09-27
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson CHEN , Axel SCHERER
IPC: A61B5/1486 , C12N9/02 , C12N11/02
Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
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公开(公告)号：US20180338681A1
公开(公告)日：2018-11-29
申请号：US15987843
申请日：2018-05-23
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Axel SCHERER , Peter A. PETILLO , Samson CHEN , Azita EMAMI
IPC: A61B5/00 , A61B5/145 , A61B5/11 , A61B5/01 , A61B5/1486 , H04B5/00 , A01K1/03 , A01K29/00 , A01K11/00
Abstract: A smart cage includes radiofrequency transceivers and tags attached to laboratory animals. The tags include sensors to detect monitorable conditions of the laboratory animals. The sensors include working electrodes, counter electrodes, reference electrodes, and potentiostats. The top surface of the electrodes is coated with ionophores or enzymes which detect the monitorable conditions of the laboratory animals.
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公开(公告)号：US20180277329A1
公开(公告)日：2018-09-27
申请号：US15987645
申请日：2018-05-23
Applicant: California Institute of Technology
Inventor： Axel SCHERER , William M. JONES , Danil M. LUKIN , Sameer WALAVALKAR , Chieh-feng CHANG
CPC classification number: H01J19/24 , H01J9/025 , H01J21/02 , H01J21/105 , H01J2209/0223
Abstract: Nanoscale field-emission devices are presented, wherein the devices include at least a pair of electrodes separated by a gap through which field emission of electrons from one electrode to the other occurs. The gap is dimensioned such that only a low voltage is required to induce field emission. As a result, the emitted electrons energy that is below the ionization potential of the gas or gasses that reside within the gap. In some embodiments, the gap is small enough that the distance between the electrodes is shorter than the mean-free path of electrons in air at atmospheric pressure. As a result, the field-emission devices do not require a vacuum environment for operation.
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Patent Agency Ranking
公开(公告)号：US20180230524A1
公开(公告)日：2018-08-16
申请号：US15887828
申请日：2018-02-02
Applicant: California Institute of Technology
Inventor： Meisam HONARVAR NAZARI , Muhammad MUJEEB-U-RAHMAN , Axel SCHERER
IPC: C12Q1/6837 , G01N27/327
CPC classification number: C12Q1/6837 , A61B5/14503 , G01N27/3276 , G01N27/3278
Abstract: A sensor incorporates one or more working electrodes, a counter electrode and a reference electrode. The sensor is inserted in a needle and connected to control electronics to detect the concentration of target molecules. The electrodes are arrays of nanostructures increasing the detection surface area. The nanostructures are functionalized with nucleic acids which bind to select target molecules.
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公开(公告)号：US20170336340A1
公开(公告)日：2017-11-23
申请号：US15601503
申请日：2017-05-22
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson CHEN , Axel SCHERER , Muhammad M. JILANI
IPC: G01N27/327
CPC classification number: G01N27/3274
Abstract: A cycle of positive and negative voltage pulses applied to an electrode sensor removes passivation of an electrode surface. The conditioned sensors have improved sensitivity to concentrations for analytes of interest. The electrode surfaces can also be passivated on purpose to reduce sensitivity. The voltages applied are varied according to the solution present.
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28.发明申请公开(公告)号：US20170020415A1
公开(公告)日：2017-01-26
申请号：US15216662
申请日：2016-07-21
Inventor： Axel SCHERER , Arti GAUR
IPC: A61B5/1473 , A61B5/07 , A61B5/1459 , A61B5/145 , A61B5/00
Abstract: Wireless electrochemical measurements methods using minimally invasive micro-sensors that monitor response of cells to specific analytes are described. Micro-actuators integrated on a same chip as the micro-sensors are used to provide closed loop in-vivo local therapy on demand. An in-vivo bio-electronic system that can monitor the health of cell colonies and accordingly dispense corresponding therapeutic drugs is also described.
Abstract translation: 描述使用监测细胞对特定分析物的反应的微创微传感器的无线电化学测量方法。 集成在与微传感器相同的芯片上的微执行器用于根据需要提供闭环体内局部治疗。 还描述了可以监测细胞集落的健康并因此分配相应的治疗药物的体内生物电子系统。
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29.发明申请公开(公告)号：US20150279949A1
公开(公告)日：2015-10-01
申请号：US14720473
申请日：2015-05-22
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , SANOFI
Inventor： Aditya RAJAGOPAL , Chieh-feng CHANG , Oliver PLETTENBURG , Stefan PETRY , Axel SCHERER , Charles L. TSCHIRHART
IPC: H01L29/41 , H01L29/735 , H01L29/78 , H01L29/49 , H01L29/45
CPC classification number: H01L29/413 , B82Y15/00 , G01N27/4145 , G01N27/4146 , H01L29/0676 , H01L29/45 , H01L29/49 , H01L29/73 , H01L29/732 , H01L29/735 , H01L29/78
Abstract: Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a functionalized layer contacted to either the base or the gate electrode. The functional layer can bind molecules, which causes an electrical signal in the sensor.
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公开(公告)号：US20150268191A1
公开(公告)日：2015-09-24
申请号：US14673700
申请日：2015-03-30
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Andrew P. HOMYK , Michael D. HENRY , Axel SCHERER , Sameer WALAVALKAR
IPC: G01N27/414 , H01L29/06 , H01L29/66
CPC classification number: G01N27/4146 , B82Y10/00 , B82Y15/00 , H01L29/0676 , H01L29/66666 , H01L29/775
Abstract: Methods for fabricating silicon nanowire chemical sensing devices, devices thus obtained, and methods for utilizing devices for sensing and measuring chemical concentration of selected species in a fluid are described. Devices may comprise a metal-oxide-semiconductor field-effect transistor (MOSFET) structure.
Abstract translation: 描述了制造硅纳米线化学感测装置的方法，如此获得的装置，以及利用用于感测和测量流体中选定物种的化学浓度的装置的方法。 器件可以包括金属氧化物半导体场效应晶体管（MOSFET）结构。
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