公开(公告)号：US20240182954A1

公开(公告)日：2024-06-06

申请号：US18352080

申请日：2023-07-13

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Emil P. KARTALOV ,  Aditya RAJAGOPAL ,  Axel SCHERER

IPC: C12Q1/6825 ,  C12Q1/68 ,  C12Q1/6851 ,  G01N21/64 ,  G16B5/00 ,  G16B25/00 ,  G16B25/20 ,  G16B40/10

CPC classification number: C12Q1/6825 ,  C12Q1/68 ,  C12Q1/6851 ,  G01N21/6486 ,  G16B5/00 ,  G16B25/00 ,  G16B25/20 ,  G16B40/10 ,  G06F17/10

Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.

公开(公告)号：US20230363672A1

公开(公告)日：2023-11-16

申请号：US18319085

申请日：2023-05-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson CHEN ,  Axel SCHERER ,  Dvin I. ADALIAN ,  Peter PETILLO ,  Muhammad Musab JILANI ,  Xiomara L. MADERO ,  Deepan KISHORE KUMAR

IPC: A61B5/1486 ,  C12N11/14 ,  A61B5/145 ,  A61B5/1459 ,  G01N27/327 ,  C12N9/02 ,  C12N11/02

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1459 ,  C12N9/0004 ,  C12N11/02 ,  C12N11/14 ,  G01N27/3272 ,  C12Y101/01001 ,  C12Y101/03003 ,  C12Y101/03005 ,  C12Y101/03007 ,  C12Y101/03008 ,  C12Y101/0301 ,  C12Y101/03011 ,  C12Y101/03012 ,  C12Y101/03015 ,  C12Y101/03016 ,  C12Y101/03018 ,  C12Y101/03019 ,  C12Y101/0302 ,  C12Y101/03023 ,  C12Y101/03027 ,  C12Y101/03029 ,  C12Y101/0303 ,  C12Y101/03037 ,  C12Y101/03038 ,  C12Y101/0304 ,  C12Y101/03041

Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.

公开(公告)号：US20220155276A1

公开(公告)日：2022-05-19

申请号：US17486660

申请日：2021-09-27

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel SCHERER

IPC: G01N33/483 ,  A61B5/00 ,  G01N27/414 ,  A61F13/00 ,  A61B5/0531 ,  A61B5/1486 ,  A61B5/145

Abstract: A sensing chip attached to a bandage monitors the healing process of a wound by detecting growth factors, thrombin and fibrinogen. The complementary metal-oxide semiconductor includes a functionalized working electrode, functionalized counter electrode and functionalized reference electrode. The healing progress is stimulated by generating oxygen in the wound.

公开(公告)号：US20210373013A1

公开(公告)日：2021-12-02

申请号：US17344870

申请日：2021-06-10

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel SCHERER ,  Samuel NJOROGE ,  Jingqing HUANG

IPC: G01N33/566 ,  A61B5/1459 ,  G01N33/543 ,  G01N21/41 ,  G01N33/552

Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

公开(公告)号：US20190320903A1

公开(公告)日：2019-10-24

申请号：US16457642

申请日：2019-06-28

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Muhammad MUJEEB-U-RAHMAN ,  Axel SCHERER

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1473

Abstract: An implantable device having a communication system, a sensor, and a monolithic substrate is described. The monolithic substrate has an integrated sensor circuit configured to process input from the sensor into a form conveyable by the communication system.

公开(公告)号：US20190195872A1

公开(公告)日：2019-06-27

申请号：US16206294

申请日：2018-11-30

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel SCHERER ,  Samuel NJOROGE ,  Jingqing HUANG

IPC: G01N33/566 ,  G01N33/543 ,  A61B5/1459 ,  G01N21/41 ,  G01N33/552

CPC classification number: G01N33/566 ,  A61B5/1459 ,  A61B5/1491 ,  A61B2562/0233 ,  A61B2562/043 ,  G01N21/41 ,  G01N33/54373 ,  G01N33/552 ,  G01N2201/068 ,  G01N2201/08

Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

公开(公告)号：US20190060218A1

公开(公告)日：2019-02-28

申请号：US16044124

申请日：2018-07-24

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson CHEN ,  Axel SCHERER ,  Richard Daniel SMITH, JR.

IPC: A61K9/00 ,  A61J1/14 ,  A61B5/145

Abstract: An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.

公开(公告)号：US20170055835A1

公开(公告)日：2017-03-02

申请号：US15222866

申请日：2016-07-28

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel SCHERER ,  Muhammad Mujeeb-U-Rahman ,  Meisam Honavar Nazari ,  Muhammad Musab Jilani

IPC: A61B5/00 ,  A61B5/1459 ,  A61M37/00 ,  A61B5/145 ,  A61B5/1473

CPC classification number: A61B5/0022 ,  A61B5/14521 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/6832 ,  A61B5/685 ,  A61B2560/0214 ,  A61B2562/12 ,  G06F19/00 ,  G16H40/67

Abstract: A sensing device allows detection of biological quantities in ways that are minimally invasive. Micrometer or nanometer sized needles allow sensing of bodily fluids in a minimally invasive method. The device comprises electronics and power harvesting. Antennas or coils allow communication and power harvesting from an external device, which can be attached to smartphones to allow operation of a camera and camera light for biosensing.

Abstract translation: 感测装置允许以微创方式检测生物量。 千分尺或纳米尺寸的针允许以微创方法感测体液。 该设备包括电子和电力收集。 天线或线圈允许从外部设备进行通信和电力采集，该外部设备可以连接到智能手机，以允许相机和相机灯的操作进行生物感测。

公开(公告)号：US20170020416A1

公开(公告)日：2017-01-26

申请号：US15216675

申请日：2016-07-21

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Axel SCHERER ,  Meisam Honarvar NAZARI ,  Muhammad MUJEEB-U-RAHMAN ,  Mehmet SENCAN ,  Arti GAUR

IPC: A61B5/1473 ,  A61M5/142 ,  A61B17/34 ,  A61M5/172 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/1473 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14735 ,  A61B5/14865 ,  A61B5/4839 ,  A61B17/3468 ,  A61B2560/0219 ,  A61B2562/0209 ,  A61B2562/028 ,  A61B2562/04 ,  A61B2562/125 ,  A61M5/14276 ,  A61M5/172 ,  A61M5/1723 ,  A61M2205/3523 ,  A61M2205/8237 ,  A61M2207/00

Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.

Abstract translation: 描述了完全集成的小尺寸植入式感测装置，其可以包括传感器和电子电路以与传感器接口并与外部设备通信。 描述了用于感测装置的各种制造方法，包括提供使用与电子电路相同的制造技术产生的孔，以容纳传感器的电极和相应的功能化学品。 这种植入式感测装置可以用于生物体内的各种电化学测量应用，以及通过将电流注入生物体来启动。

公开(公告)号：US20150299757A1

公开(公告)日：2015-10-22

申请号：US14753741

申请日：2015-06-29

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Aditya RAJAGOPAL ,  Axel SCHERER ,  Michael D. HENRY ,  Sameer WALAVALKAR ,  Thomas A. TOMBRELLO ,  Andrew P. HOMYK

IPC: C12Q1/02

CPC classification number: C12Q1/02 ,  A61B5/04001 ,  G01N27/3275 ,  G01N27/4146 ,  G01R1/06711 ,  G01R1/07342 ,  H01L29/413 ,  H01L29/42376 ,  H01L29/4966 ,  H01L29/66477 ,  H01L29/78 ,  H01L29/7831

Abstract: The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest.

Abstract translation: 本文公开的探针的基本结构和功能允许灵活地并入到探针中，用于各种感测应用的各种感测元件。 这些各种感测应用中的两个示例应用包括生物感测和化学感测应用。 对于生物感测应用，制造在硅衬底上的探针包括诸如纳米柱晶体管的生物感测元件，并且对于化学感测应用，探针包括具有功能化接触区域的感测元件， 当暴露于感兴趣的一种或多种化学品时，感测元件产生电压。