公开(公告)号：US20240068033A1

公开(公告)日：2024-02-29

申请号：US18261366

申请日：2022-01-14

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  THE JOHNS HOPKINS UNIVERSITY

Inventor： Sanford Markowitz ,  Amitabh Chak ,  Helen Moinova ,  Joseph Willis ,  Bert Vogelstein ,  Kenneth Kinzler ,  Nickolas Papadopoulos ,  Chetan Bettewgowda ,  Christopher Douville

IPC: C12Q1/6883

CPC classification number: C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/156

Abstract: A method of detecting Barrett's esophagus with low grade dysplasia, or Barrett's esophagus with high grade dysplasia, or adenocarcinoma of the esophagus, applying a Repetitive Element Aneuploidy Sequencing System (RealSeqS) methodology to a biological sample from the esophagus of the subject to detect Barrett's esophagus with low grade dysplasia, or Barrett's esophagus with high grade dysplasia, or adenocarcinoma of the esophagus.

公开(公告)号：US20210386410A1

公开(公告)日：2021-12-16

申请号：US16902579

申请日：2020-06-16

Applicant: Case Western Reserve University

Inventor： Amitabh Chak ,  Sanford Markowitz ,  Dennis Siedlak ,  Joseph Willis ,  Lishan Aklog ,  Michael Boutillette ,  Richard Yazbeck

IPC: A61B10/02 ,  A61M25/10

Abstract: A device for collecting a biological sample in a subject, the device including an inflatable portion attached to a tubular member, and designed to expand from within the tubular member when inflated and to retract within the tubular member, a surface on the inflatable portion provided with varied thickness to facilitate movement of the inflatable portion between an expanded state and a retracted state, and a plurality of projections on the surface to allow collection of the biological sample when the inflatable portion is in the expanded state.

公开(公告)号：US20210369256A1

公开(公告)日：2021-12-02

申请号：US17331375

申请日：2021-05-26

Applicant: Case Western Reserve University

Inventor： Sanford Markowitz ,  Amitabh Chak ,  Joseph Willis ,  Lishan Aklog ,  Richard Yazbeck ,  Michael Boutillette ,  Brian deGuzman ,  David Wurtman

IPC: A61B10/04

Abstract: A method for collecting a cell sample, including eosinophil white blood cells in a patient is provided. The method includes advancing to a location in an esophagus associated with eosinophilic esophagitis (EoE), a device provided with a collection portion having a first axial end portion and an inflatable second axial end portion. Thereafter, axially moving the second axial end portion, relative to the first axial end portion, from a collapsed position within the first axial end portion into an expanded position out from the first axial end portion. Once the second axial end portion is in the expanded position, allowing it to engage the location associated with EoE to collect a sample of cells.

公开(公告)号：US10660621B2

公开(公告)日：2020-05-26

申请号：US15103638

申请日：2014-12-12

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Sanford Markowitz ,  Amitabh Chak ,  Joseph Willis ,  Jeffrey Silver Taggart ,  Rebecca Blice ,  Dean Secrest ,  Dennis Siedlak

IPC: A61B5/00 ,  A61B10/02

Abstract: A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.

公开(公告)号：US20200077992A1

公开(公告)日：2020-03-12

申请号：US16610115

申请日：2018-05-03

Applicant: Case Western Reserve University

Inventor： Sanford Markowitz ,  Dean Secrest ,  Amitabh Chak ,  Joseph Willis ,  Dennis Siedlak

IPC: A61B10/04

Abstract: A device for collecting a biological sample in an esophagus of a patient includes a swallowable collection portion for collecting a sample at a collection site in the esophagus. A stylet is connected with the collection portion for placing the collection portion into the back of a throat of a patient for swallowing. The device may have a collection portion having a first axial end portion and a second axial end portion. A sleeve is in the first axial end portion. The device may have at least one tissue collecting projection extending from an outer surface of the collection portion; a first side wall of the tissue collecting; a second wall of the tissue collecting projection. A method for collecting a biological sample includes moving the swallowable collection portion with the stylet into the back of a throat of a patient for swallowing.

公开(公告)号：US20190390285A1

公开(公告)日：2019-12-26

申请号：US16564392

申请日：2019-09-09

Applicant: Case Western Reserve University

Inventor： Sanford D. Markowitz ,  Joseph Willis ,  Amitabh Chak ,  Rom Leidner

IPC: C12Q1/6886 ,  C07H21/04

Abstract: This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as neoplasia of the upper or lower gastrointestinal tract, pancreas, and/or bladder.

公开(公告)号：US20190241973A1

公开(公告)日：2019-08-08

申请号：US16388029

申请日：2019-04-18

Applicant: Case Western Reserve University

Inventor： Sanford D. Markowitz ,  Joseph Willis ,  Amitabh Chak ,  Rom Leidner

IPC: C12Q1/6886 ,  C07H21/04

Abstract: This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as neoplasia of the upper or lower gastrointestinal tract, pancreas, and/or bladder.