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公开(公告)号：US20240043443A1
公开(公告)日：2024-02-08
申请号：US18228452
申请日：2023-07-31
Applicant: CASE WESTERN RESERVE UNIVERSITY , BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
Inventor： Sanford Markowitz , James K.V. Willson , Bruce Posner , Joseph Ready , Yongyou Zhang , Hsin-Hsiung Tai , Monica Antczak , Stanton Gerson , KiBeom Bae , Sung Yeun Yang , Amar Desai
IPC: C07D495/04 , C07C311/21 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D405/12 , C07D239/42 , C07D241/20 , C07D261/14 , C07D207/263 , C07D275/03 , C07D209/08 , C07D277/46 , C07D295/185 , A61K31/4365 , A61K31/519
CPC classification number: C07D495/04 , C07C311/21 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D405/12 , C07D239/42 , C07D241/20 , C07D261/14 , C07D207/263 , C07D275/03 , C07D209/08 , C07D277/46 , C07D295/185 , A61K31/4365 , A61K31/519 , C07C2601/14
Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
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2.发明公开公开(公告)号：US20230355636A1
公开(公告)日：2023-11-09
申请号：US18144065
申请日：2023-05-05
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Sanford Markowitz , Won Jin Ho , Stephen P. Fink , Vinay Varadan
IPC: A61K31/5377 , A61P1/00 , A61K31/421 , A61K31/426 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/4985 , A61K31/519 , A61K31/573 , A61K31/56
CPC classification number: A61K31/5377 , A61P1/00 , A61K31/421 , A61K31/426 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/4985 , A61K31/519 , A61K31/573 , A61K31/56
Abstract: A method of treating intestinal, gastrointestinal, or bowel disorders in a subject in need thereof includes administering to the subject a therapeutically effective amount of 15-PGDH inhibitor alone or in combination with a corticosteroid and/or TNF alpha antagonist.
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公开(公告)号：US20230322684A1
公开(公告)日：2023-10-12
申请号：US18207777
申请日：2023-06-09
Inventor： Sanford Markowitz , Yiyuan Yuan , Yongyou Zhang , Joseph Ready , Bin Hu
IPC: C07D235/18 , C07D239/74 , C07D241/42 , C12N9/04
CPC classification number: C07D235/18 , C07D239/74 , C07D241/42 , C12N9/0006 , A61K45/06
Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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公开(公告)号：US20200095206A1
公开(公告)日：2020-03-26
申请号：US16484045
申请日：2018-02-06
Inventor： Sanford Markowitz , Yiyuan Yuan , Yongyou Zhang , Joseph Ready , Bin Hu
IPC: C07D235/18 , C07D239/74 , C07D241/42 , C12N9/04
Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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公开(公告)号：US20190261962A1
公开(公告)日：2019-08-29
申请号：US16405634
申请日：2019-05-07
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Sanford Markowitz , Amitabh Chak , Joseph Willis , Jeffrey Silver Taggart , Rebecca Blice , Dean Secrest , Dennis Seidlak
IPC: A61B10/02
Abstract: A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20180125829A1
公开(公告)日：2018-05-10
申请号：US15799307
申请日：2017-10-31
Inventor： Sanford Markowitz , Amar Desai , Joseph Ready
IPC: A61K31/4365 , A61K31/495 , A61K38/19
Abstract: A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
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公开(公告)号：US20170165241A1
公开(公告)日：2017-06-15
申请号：US15359330
申请日：2016-11-22
Applicant: CASE WESTERN RESERVE UNIVERSITY , Board of Regents of the University of Texas System , University of Kentucky Research Foundation
Inventor： Sanford Markowitz , James K.V. Willson , Bruce Posner , Joseph Ready , Youngyou Zhang , Hsin-Hsiung Tai , Melissa Moss , Monika Antczak , Stanton Gerson , KiBeom Bae , Sung Yeun Yang , Amar Desai
IPC: A61K31/4365 , A61K31/519
CPC classification number: C07D495/04 , A61K31/4365 , A61K31/519 , C07C311/21 , C07C2601/14 , C07D207/263 , C07D209/08 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07D277/46 , C07D295/185 , C07D405/12
Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
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公开(公告)号：US12262879B2
公开(公告)日：2025-04-01
申请号：US16902579
申请日：2020-06-16
Applicant: Case Western Reserve University
Inventor： Amitabh Chak , Sanford Markowitz , Dennis Siedlak , Joseph Willis , Lishan Aklog , Michael Boutillette , Richard Yazbeck
Abstract: A device for collecting a biological sample in a subject, the device including an inflatable portion attached to a tubular member, and designed to expand from within the tubular member when inflated and to retract within the tubular member, a surface on the inflatable portion provided with varied thickness to facilitate movement of the inflatable portion between an expanded state and a retracted state, and a plurality of projections on the surface to allow collection of the biological sample when the inflatable portion is in the expanded state.
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公开(公告)号：US11718589B2
公开(公告)日：2023-08-08
申请号：US16484045
申请日：2018-02-06
Inventor： Sanford Markowitz , Yiyuan Yuan , Yongyou Zhang , Joseph Ready , Bin Hu
IPC: C07D235/18 , C07D239/74 , C07D241/42 , C12N9/04 , A61K45/06 , A61K31/4164
CPC classification number: C07D235/18 , C07D239/74 , C07D241/42 , C12N9/0006 , A61K31/4164 , A61K45/06
Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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10.发明授权公开(公告)号：US11690847B2
公开(公告)日：2023-07-04
申请号：US16465500
申请日：2017-11-30
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Sanford Markowitz , Won Jin Ho , Stephen P. Fink , Vinay Varadan
IPC: A61K31/5377 , A61P1/00 , A61K31/421 , A61K31/426 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/4985 , A61K31/519 , A61K31/573 , A61K31/56
CPC classification number: A61K31/5377 , A61K31/421 , A61K31/426 , A61K31/437 , A61K31/4365 , A61K31/4439 , A61K31/4985 , A61K31/519 , A61K31/56 , A61K31/573 , A61P1/00
Abstract: A method of treating intestinal gastrointestinal, or bowel disorders in a subject in need thereof includes administering to the subject a therapeutically effective amount of 15-PGDH inhibitor alone or in combination with a corticosteroid and/or TNF alpha antagonist.
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