公开(公告)号：NZ247038A

公开(公告)日：1995-02-24

申请号：NZ24703893

申请日：1993-03-02

Applicant: CELL THERAPEUTICS INC

Inventor： BIANCO JAMES A ,  PORUBEK DAVID ,  SINGER JACK ,  WOODSON PAUL

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/44 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61P1/00 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/06 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P19/10 ,  A61P25/20 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/06 ,  A61P39/02 ,  A61P43/00 ,  C07D473/04 ,  C07D473/10

Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.

公开(公告)号：NO943263D0

公开(公告)日：1994-09-02

申请号：NO943263

申请日：1994-09-02

Applicant: CELL THERAPEUTICS INC

Inventor： BIANCO JAMES A ,  WOODSON PAUL ,  PORUBEK DAVID ,  SINGER JACK

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/44 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61P1/00 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/06 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P19/10 ,  A61P25/20 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/06 ,  A61P39/02 ,  A61P43/00 ,  C07D473/04 ,  C07D473/10 ,  A61K

Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.

公开(公告)号：AU3919093A

公开(公告)日：1993-10-05

申请号：AU3919093

申请日：1993-03-01

Applicant: CELL THERAPEUTICS INC

Inventor： BIANCO JAMES A ,  WOODSON PAUL ,  PORUBEK DAVID ,  SINGER JACK

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/44 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61P1/00 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/06 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P19/10 ,  A61P25/20 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/06 ,  A61P39/02 ,  A61P43/00 ,  C07D473/04 ,  C07D473/10

Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.

公开(公告)号：ZA931542B

公开(公告)日：1993-09-27

申请号：ZA931542

申请日：1993-03-04

Applicant: CELL THERAPEUTICS INC

Inventor： BIANCO JAMES A ,  WOODSON PAUL ,  PORUBEK DAVID ,  SINGER JACK

IPC: A61K20060101 ,  C07D20060101 ,  A61K ,  C07D

公开(公告)号：ZA9301542B

公开(公告)日：1993-09-27

申请号：ZA9301542

申请日：1993-03-04

Applicant: CELL THERAPEUTICS INC

Inventor： BIANCO JAMES A ,  WOODSON PAUL ,  PORUBEK DAVID ,  SINGER JACK

IPC: A61K20060101 ,  C07D20060101 ,  A61K ,  C07D