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公开(公告)号：JP2004002467A
公开(公告)日：2004-01-08
申请号：JP2003287230
申请日：2003-08-05
Inventor： BIANCO JAMES A , WOODSON PAUL , PORUBEK DAVID , SINGER JACK
IPC: C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10
CPC classification number: A61K31/522 , A61K31/519 , A61K31/52 , C07D473/10 , Y02P20/582 , Y10S514/814 , Y10S514/866 , Y10S514/921
Abstract: PROBLEM TO BE SOLVED: To provide a treatment compound which is safely and effectively administered to human beings or animals, maintains a homeostasis for various inflammatory irritations, and is pure and effective as an enantiomer wherein an activity in a single isomer is kept. SOLUTION: A medicament composition is composed of a substituted xanthine compound, shown by formula 1, treated for oral administration, parenteral administration, ex vivo administration or local administration to patients, and an adjuvant recipient in pharmaceutics. In formula 1, R 1 shows independently a separated enantiomer which has no other enantiomer excepting an alkyl(5-8C) substituted with a (ω-1) secondary alcohol, and R 2 and R 3 are independently an alkyl(1-12C) which may contain one or two non-adjacent oxygen atoms instead of a carbon atom as required. COPYRIGHT: (C)2004,JPO
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公开(公告)号：JP2753395B2
公开(公告)日：1998-05-20
申请号：JP51603693
申请日：1993-03-01
Applicant: CELL THERAPEUTICS INC
Inventor： BIANCO JAMES A , WOODSON PAUL , PORUBEK DAVID , SINGER JACK
IPC: C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10
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公开(公告)号：JPH06509584A
公开(公告)日：1994-10-27
申请号：JP51603693
申请日：1993-03-01
Applicant: CELL THERAPEUTICS INC
Inventor： BIANCO JAMES A , WOODSON PAUL , PORUBEK DAVID , SINGER JACK
IPC: C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10
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公开(公告)号：JPH08259565A
公开(公告)日：1996-10-08
申请号：JP4362596
申请日：1996-02-29
Applicant: CELL THERAPEUTICS INC
Inventor： BIANCO JAMES A , WOODSON PAUL , PORUBEK DAVID , SINGER JACK
IPC: C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10
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公开(公告)号：JP2002087961A
公开(公告)日：2002-03-27
申请号：JP2001238414
申请日：2001-08-06
Applicant: CELL THERAPEUTICS INC
Inventor： BIANCO JAMES A , WOODSON PAUL , PORUBEK DAVID , SINGER JACK
IPC: C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10
Abstract: PROBLEM TO BE SOLVED: To provide a compound and a pharmaceutical composition containing the compound each usable for maintaining a homeostasis in highly diversified cells subjected to various kinds of inflammatory or proliferative excitation. SOLUTION: This compound is the isolated R- or S-enantiomer (preferably R-enantiomer) of an ω-1 alcohol of a straight-chain 5-8C alkyl substituted on the 1-position of a 3,7-disubstituted xanthine. This compound is effective for the regulation of cellular response to an external or in situ excitation and to a specific type of administration of such an excitation. The other objective pharmaceutical composition containing the compound is also provided.
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Patent Agency Ranking
公开(公告)号：DK0584347T3
公开(公告)日：2003-02-24
申请号：DK93908327
申请日：1993-03-01
Applicant: CELL THERAPEUTICS INC
Inventor： BIANCO JAMES A , WOODSON PAUL , PORUBEK DAVID , SINGER JACK
IPC: C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10 , A61P37/00 , C07D473/08
Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
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公开(公告)号：AU669702B2
公开(公告)日：1996-06-20
申请号：AU3919093
申请日：1993-03-01
Applicant: CELL THERAPEUTICS INC
Inventor： BIANCO JAMES A , WOODSON PAUL , PORUBEK DAVID , SINGER JACK
IPC: C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10
Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
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公开(公告)号：WO9317684A3
公开(公告)日：1993-11-25
申请号：PCT/US9302304
申请日：1993-03-01
Applicant: CELL THERAPEUTICS INC
Inventor： BIANCO JAMES A , WOODSON PAUL , PORUBEK DAVID , SINGER JACK
IPC: C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10
CPC classification number: A61K31/522 , A61K31/519 , A61K31/52 , C07D473/10 , Y02P20/582 , Y10S514/814 , Y10S514/866 , Y10S514/921
Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an w-1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such.
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公开(公告)号：DE69332634T2
公开(公告)日：2003-05-08
申请号：DE69332634
申请日：1993-03-01
Applicant: CELL THERAPEUTICS INC
Inventor： BIANCO JAMES A , WOODSON PAUL , PORUBEK DAVID , SINGER JACK
IPC: C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10 , C07D473/08 , G01N33/536
Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
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公开(公告)号：NO943263L
公开(公告)日：1994-11-02
申请号：NO943263
申请日：1994-09-02
Applicant: CELL THERAPEUTICS INC
Inventor： BIANCO JAMES A , WOODSON PAUL , PORUBEK DAVID , SINGER JACK
IPC: C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10
Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
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