公开(公告)号：DE69730345T2

公开(公告)日：2005-09-22

申请号：DE69730345

申请日：1997-12-03

Applicant: CELLTECH R&D LTD

Inventor： WARRELLOW GRAHAM JOHN ,  BROWN JULIEN ALISTAIR

IPC: A61K31/4409 ,  A61P1/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P17/06 ,  A61P37/08 ,  A61P43/00 ,  C07D213/38 ,  C07D213/53 ,  C07D213/89 ,  A61K31/44

公开(公告)号：ZA200305372B

公开(公告)日：2004-07-12

申请号：ZA200305372

申请日：2003-07-11

Applicant: CELLTECH R&D LTD

Inventor： BAILEY STUART ,  BROWN JULIEN ALISTAIR ,  BRAND STEPHEN ,  JOHNSON JAMES ANDREW ,  PORTER JOHN ROBERT ,  HEAD JOHN CLIFFORD

IPC: A61P20060101 ,  C07C20060101 ,  C07D20060101 ,  C07D ,  A61P ,  C07C

公开(公告)号：SK10322003A3

公开(公告)日：2004-02-03

申请号：SK10322003

申请日：2002-01-18

Applicant: CELLTECH R&D LTD

Inventor： BAILEY STUART ,  BROWN JULIEN ALISTAIR ,  BRAND STEPHEN ,  JOHNSON JAMES ANDREW ,  PORTER JOHN ROBERT ,  HEAD JOHN CLIFFORD

IPC: A61K31/198 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/497 ,  A61P3/10 ,  A61P9/00 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P37/00 ,  A61P37/06 ,  A61P43/00 ,  C07C229/34 ,  C07C229/46 ,  C07C233/82 ,  C07C321/22 ,  C07C323/30 ,  C07D213/81 ,  C07D213/89 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04 ,  C07C229/36

Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.

公开(公告)号：DE60315032D1

公开(公告)日：2007-08-30

申请号：DE60315032

申请日：2003-07-16

Applicant: CELLTECH R&D LTD

Inventor： BROWN JULIEN ALISTAIR ,  BAILEY STUART ,  BRAND STEPHEN

IPC: C07D471/04 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/5377 ,  A61P1/04 ,  A61P3/10 ,  A61P9/00 ,  A61P11/06 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P37/06 ,  A61P43/00 ,  C07D221/00

Abstract: Phenylalanine enamide derivatives of formula (1) are described:wherein R is a -CH(CH3)2, -(CH2)2CH3, -CH2C(CH3)3, -CH2CH2OH, -CH2CH2OCH3, -CH2CH2OCH2CH2OH, -CH2CH2OCH2CH2OCH3,group; and the salts, solvates and N-oxides thereof.Compounds according to the invention are potent and selective inhibitors of alpha4 integrins. The compounds are of use in modulating cell adhesion and in particular are of use in the prophylaxis and treatment of diseases or disorders including inflammation in which the extravasation of leukocytes plays a role and the invention extends to such a use and to the use of the compounds for the manufacture of a medicament for treating such diseases or disorders.

公开(公告)号：PT1370531E

公开(公告)日：2007-04-30

申请号：PT02715515

申请日：2002-01-18

Applicant: CELLTECH R&D LTD

Inventor： BAILEY STUART ,  BROWN JULIEN ALISTAIR ,  BRAND STEPHEN ,  JOHNSON JAMES ANDREW ,  PORTER JOHN ROBERT ,  HEAD JOHN CLIFFORD

IPC: C07D213/81 ,  A61K31/198 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/497 ,  A61P3/10 ,  A61P9/00 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P37/00 ,  A61P37/06 ,  A61P43/00 ,  C07C229/34 ,  C07C229/36 ,  C07C229/46 ,  C07C233/82 ,  C07C321/22 ,  C07C323/30 ,  C07D213/89 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04

公开(公告)号：PL364142A1

公开(公告)日：2004-12-13

申请号：PL36414202

申请日：2002-01-18

Applicant: CELLTECH R&D LTD

Inventor： BAILEY STUART ,  BROWN JULIEN ALISTAIR ,  BRAND STEPHEN ,  JOHNSON JAMES ANDREW ,  PORTER JOHN ROBERT ,  HEAD JOHN CLIFFORD

IPC: A61K31/198 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/497 ,  A61P3/10 ,  A61P9/00 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P37/00 ,  A61P37/06 ,  A61P43/00 ,  C07C229/34 ,  C07C229/46 ,  C07C233/82 ,  C07C321/22 ,  C07C323/30 ,  C07D213/81 ,  C07D213/89 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04

Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.

公开(公告)号：AT273955T

公开(公告)日：2004-09-15

申请号：AT97947166

申请日：1997-12-03

Applicant: CELLTECH R&D LTD

Inventor： WARRELLOW GRAHAM JOHN ,  BROWN JULIEN ALISTAIR

IPC: A61K31/4409 ,  A61P1/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P17/06 ,  A61P37/08 ,  A61P43/00 ,  C07D213/38 ,  C07D213/53 ,  C07D213/89 ,  A61K31/44

公开(公告)号：AU2003281162A1

公开(公告)日：2004-02-02

申请号：AU2003281162

申请日：2003-07-16

Applicant: CELLTECH R&D LTD

Inventor： BROWN JULIEN ALISTAIR ,  BAILEY STUART ,  BRAND STEPHEN

IPC: A61K31/4409 ,  A61P1/04 ,  A61P3/10 ,  A61P7/00 ,  A61P9/00 ,  A61P11/06 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P37/06 ,  C07D213/81 ,  A61K31/44

Abstract: Phenylalanine enamide derivatives of formula (1) are described:wherein R is a -CH3, -(CH2)3CH3, -CH2CH2OH, -CH2CH2OCH3, -CH2CH2OCH2CH2OH, -CH2CH2OCH2CH2OCH3,group;and the salts, solvates and N-oxides thereof.Compounds according to the invention are potent and selective inhibitors of alpha4 integrins. The compounds are of use in modulating cell adhesion and in particular are of use in the prophylaxis and treatment of diseases or disorders including inflammation in which the extravasation of leukocytes plays a role and the invention extends to such a use and to the use of the compounds for the manufacture of a medicament for treating such diseases or disorders.

公开(公告)号：CZ20032259A3

公开(公告)日：2004-01-14

申请号：CZ20032259

申请日：2002-01-18

Applicant: CELLTECH R&D LTD

Inventor： BAILEY STUART ,  BROWN JULIEN ALISTAIR ,  BRAND STEPHEN ,  JOHNSON JAMES ANDREW ,  PORTER JOHN ROBERT ,  HEAD JOHN CLIFFORD

IPC: A61K31/198 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/497 ,  A61P3/10 ,  A61P9/00 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P37/00 ,  A61P37/06 ,  A61P43/00 ,  C07C229/34 ,  C07C229/46 ,  C07C233/82 ,  C07C321/22 ,  C07C323/30 ,  C07D213/81 ,  C07D213/89 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04 ,  C07C229/36 ,  A61K31/435

Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.

公开(公告)号：GB2387845A

公开(公告)日：2003-10-29

申请号：GB0318429

申请日：2002-01-18

Applicant: CELLTECH R&D LTD

Inventor： BAILEY STUART ,  BROWN JULIEN ALISTAIR ,  BRAND STEPHEN ,  JOHNSON JAMES ANDREW ,  PORTER JOHN ROBERT ,  HEAD JOHN CLIFFORD

IPC: A61K31/198 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/497 ,  A61P3/10 ,  A61P9/00 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P37/00 ,  A61P37/06 ,  A61P43/00 ,  C07C229/34 ,  C07C229/46 ,  C07C233/82 ,  C07C321/22 ,  C07C323/30 ,  C07D213/81 ,  C07D213/89 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04 ,  C07C229/36

Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R , R , R , R , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.