公开(公告)号：BR0106682A

公开(公告)日：2002-05-14

申请号：BR0106682

申请日：2001-06-05

Applicant: CELLTECH R&D LTD

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C07K16/24 ,  C07K16/46 ,  C12N1/21 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  C07K19/00 ,  C12N15/62 ,  C12N15/70

Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF± There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±

公开(公告)号：ES2230975A1

公开(公告)日：2005-05-01

申请号：ES200250012

申请日：2001-06-05

Applicant: CELLTECH R&D LTD

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C07K16/24 ,  C07K16/46 ,  C12N1/21 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08

Abstract: Se describen moléculas de anticuerpo que contienen al menos una CDR procedente de un anticuerpo monoclonal de ratón que tiene especificidad por el TNFa humano. También se describe un anticuerpo de CDR injertadas en el que al menos una de las CDR es una CDR híbrida. También se describen secuencias de ADN que codifican las cadenas de las moléculas de anticuerpo, vectores, células huésped transformadas y usos de las moléculas de anticuerpo en el tratamiento de enfermedades mediadas por TNFap.

公开(公告)号：DE10192353T1

公开(公告)日：2003-05-22

申请号：DE10192353

申请日：2001-06-05

Applicant: CELLTECH R&D LTD

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C07K16/24 ,  C07K16/46 ,  C12N1/21 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  C07K19/00 ,  C12N15/62 ,  C12N15/70

Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF± There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±

公开(公告)号：CZ20020837A3

公开(公告)日：2002-05-15

申请号：CZ20020837

申请日：2001-06-05

Applicant: CELLTECH R&D LTD

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C07K16/24 ,  C07K16/46 ,  C12N1/21 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  C07K19/00 ,  C12N15/62 ,  C12N15/70

CPC classification number: C07K16/241 ,  A61K47/6845 ,  A61K47/6875 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565

公开(公告)号：IS6217A

公开(公告)日：2002-01-03

申请号：IS6217

申请日：2002-01-03

Applicant: CELLTECH R&D LTD

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: A61K39/395 ,  A61K47/48 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C07K16/24 ,  C07K16/46 ,  C12N1/21 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  C12N15/09 ,  C07K19/00 ,  C12N15/62 ,  C12N15/70

公开(公告)号：AU6051101A

公开(公告)日：2001-12-17

申请号：AU6051101

申请日：2001-06-05

Applicant: CELLTECH R&D LTD

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C07K16/24 ,  C07K16/46 ,  C12N1/21 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  C07K19/00 ,  C12N15/62 ,  C12N15/70

Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF± There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±