公开(公告)号：WO2015084314A1

公开(公告)日：2015-06-11

申请号：PCT/US2013/072671

申请日：2013-12-02

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： YANG, Ying ,  TRIVEDI, Harsh M. ,  XU, Guofeng

IPC: A61K8/27 ,  A61Q11/00 ,  A61P1/02

CPC classification number: A61K8/27 ,  A61K8/365 ,  A61Q11/00

Abstract: A composition comprising a zinc ion source for use in inhibiting the adherence to or invasion of oral soft tissue, such as gingival epithelial cells, by a periodontal pathogen is provided.

Abstract translation: 提供了包含用于通过牙周病原体抑制口腔软组织如牙龈上皮细胞的粘附或侵入的锌离子源的组合物。

公开(公告)号：WO2013081626A1

公开(公告)日：2013-06-06

申请号：PCT/US2011/063028

申请日：2011-12-02

Applicant: COLGATE-PALMOLIVE COMPANY ,  FEI, Lin ,  JARACZ, Stanislav ,  YANG, Ying ,  XU, Guofeng

Inventor： FEI, Lin ,  JARACZ, Stanislav ,  YANG, Ying ,  XU, Guofeng

IPC: A61K8/34 ,  A61K8/37 ,  A61Q11/00 ,  A61Q17/00

CPC classification number: A61K8/345 ,  A61K8/21 ,  A61K8/25 ,  A61K8/347 ,  A61K8/37 ,  A61K8/463 ,  A61K8/49 ,  A61K8/8111 ,  A61K2800/49 ,  A61Q11/00 ,  A61Q17/005

Abstract: The invention provides oral care compositions comprising isobutyl magnolol and propylene glycol monolaurate, together with methods of making and using the same. Also described is a method of enhancing the solubility of isobutyl magnolol in an oral care composition comprising effective amount of propylene glycol monolaurate. The composition is for use in the treatment of caries, gingivitis, periodontitis, tooth yellowing and halitosis.

Abstract translation: 本发明提供了包含异丁基木洛酚和丙二醇单月桂酸酯的口腔护理组合物及其制备和使用方法。 还描述了提高异丁基硼酸在含有效量的丙二醇单月桂酸酯的口腔护理组合物中的溶解度的方法。 该组合物用于治疗龋齿，牙龈炎，牙周炎，牙齿变黄和口臭。

公开(公告)号：WO2013070184A1

公开(公告)日：2013-05-16

申请号：PCT/US2011/059544

申请日：2011-11-07

Applicant: COLGATE-PALMOLIVE COMPANY ,  PILLAI, Shyamala ,  XU, Guofeng

Inventor： PILLAI, Shyamala ,  XU, Guofeng

IPC: A61K8/73 ,  A61K8/81 ,  A61Q11/00

CPC classification number: A61K8/8158 ,  A61K8/21 ,  A61K8/29 ,  A61K8/731 ,  A61K2800/594 ,  A61Q11/00 ,  A61Q17/00

Abstract: The invention provides novel dental film-forming compositions, comprising i. an acrylate / octylacrylamide copolymer, ii. one or more alkyl cellulose ethers, and iii. a solvent, and optionally further comprising whitening materials and/or active agents, together with method for using the same.

Abstract translation: 本发明提供了新的牙膜成形组合物，其包括i。 丙烯酸酯/辛基丙烯酰胺共聚物，ii。 一种或多种烷基纤维素醚，和iii。 溶剂，以及任选地进一步包含增白材料和/或活性剂，以及使用它们的方法。

公开(公告)号：WO2013036229A1

公开(公告)日：2013-03-14

申请号：PCT/US2011/050795

申请日：2011-09-08

Applicant: COLGATE-PALMOLIVE COMPANY ,  SUBRAMANYAM, Ravi ,  UTGIKAR, Neelima ,  XU, Guofeng ,  YANG, Ying ,  FEI, Lin

Inventor： SUBRAMANYAM, Ravi ,  UTGIKAR, Neelima ,  XU, Guofeng ,  YANG, Ying ,  FEI, Lin

IPC: A61K8/34 ,  A61Q11/00 ,  A61Q15/00 ,  A61Q19/06 ,  A61Q17/00 ,  A61Q90/00

CPC classification number: A61K31/05 ,  A61K8/347 ,  A61K2800/5922 ,  A61Q11/00 ,  A61Q15/00 ,  A61Q17/005 ,  A61Q19/10

Abstract: Described herein are compositions comprising antibacterially effective amounts of a compound of Formula (I): or a salt thereof in which R1 and R2 are each independently(C1-C6) alkyl or (C2 C6) alkenyl, and a carrier. Suitable carriers include orally acceptable carriers and dermatologically acceptable carriers. The disclosed compositions include oral care and personal care compositions useful for treating or preventing oral and skin conditions, respectively.

Abstract translation: 本文描述的是包含抗菌有效量的式（I）化合物或其盐，其中R 1和R 2各自独立地为（C 1 -C 6）烷基或（C 2 -C 6）烯基和载体的组合物。 合适的载体包括口服可接受的载体和皮肤病学可接受的载体。 所公开的组合物包括分别用于治疗或预防口腔和皮肤病症的口腔护理和个人护理组合物。

公开(公告)号：WO2012087289A1

公开(公告)日：2012-06-28

申请号：PCT/US2010/061428

申请日：2010-12-21

Applicant: COLGATE-PALMOLIVE COMPANY ,  SUBRAMANYAM, Ravi ,  XU, Guofeng ,  GRONLUND, Jennifer ,  ANSARI, Shamim

Inventor： SUBRAMANYAM, Ravi ,  XU, Guofeng ,  GRONLUND, Jennifer ,  ANSARI, Shamim

IPC: C07C39/373 ,  A61K31/055 ,  A61P17/10 ,  A61P1/02 ,  A61K8/34 ,  A61Q11/00

CPC classification number: C07C39/373 ,  A61K8/347 ,  A61Q11/00 ,  A61Q19/06

Abstract: Described herein are compounds of Formula (I): or a salt thereof; wherein: R1 and R5 are independently selected from H, OH and alkoxy; R 2 -R 4 and R 6 -R 8 are independently selected from H, OH, F, Cl, Br, and I; R 9 and R 10 are independently selected from H, alkyl, alkenyl, alkynyl, and aryl; with the proviso that: at least one of R 1 and R 5 is OH or alkoxy; and at least one of R 2 -R 4 and R 6 -R 8 is F, Cl, Br or I; compositions comprising said compounds; and methods of making and using the same.

Abstract translation: 本文描述的是式（I）的化合物或其盐; 其中：R 1和R 5独立地选自H，OH和烷氧基; R2-R4和R6-R8独立地选自H，OH，F，Cl，Br和I; R 9和R 10独立地选自H，烷基，烯基，炔基和芳基; 条件是：R 1和R 5中的至少一个是OH或烷氧基; 并且R 2 -R 4和R 6 -R 8中的至少一个是F，Cl，Br或I; 包含所述化合物的组合物; 以及制作和使用它们的方法。

公开(公告)号：WO2011106493A2

公开(公告)日：2011-09-01

申请号：PCT/US2011/026019

申请日：2011-02-24

Applicant: COLGATE-PALMOLIVE COMPANY ,  YANG, Ying ,  PILLAI, Shyamala ,  FEI, Lin ,  SUBRAMANYAM, Ravi ,  XU, Guofeng

Inventor： YANG, Ying ,  PILLAI, Shyamala ,  FEI, Lin ,  SUBRAMANYAM, Ravi ,  XU, Guofeng

IPC: A61Q11/00

CPC classification number: A61Q11/00 ,  A61K8/347 ,  A61K8/39 ,  A61K8/86 ,  A61K2800/49

Abstract: Disclosed herein are methods of enhancing the solubility and delivery of one or more active ingredients found in magnolia extract, or a synthetic analogue thereof, in an oral composition.

Abstract translation: 本文公开了在口腔组合物中增强在木兰提取物或其合成类似物中发现的一种或多种活性成分的溶解度和递送的方法。

公开(公告)号：WO2011094613A1

公开(公告)日：2011-08-04

申请号：PCT/US2011/023023

申请日：2011-01-28

Applicant: COLGATE-PALMOLIVE COMPANY ,  XU, Guofeng ,  VISCIO, David B. ,  GAFFAR, Abdul

Inventor： XU, Guofeng ,  VISCIO, David B. ,  GAFFAR, Abdul

IPC: A61C19/06 ,  A61K9/00 ,  A61K9/70

CPC classification number: A61C19/063 ,  A61C15/041 ,  A61K9/006 ,  A61K9/7007

Abstract: Described herein, are dental strips comprising a film backing, and an adhesive layer, the adhesive layer comprising a water-swellable polymer and at least one active agent; and uses thereof.

Abstract translation: 本文描述的是包括膜背衬和粘合剂层的牙科带，所述粘合剂层包含水溶胀性聚合物和至少一种活性剂; 及其用途。

公开(公告)号：WO2005058265A1

公开(公告)日：2005-06-30

申请号：PCT/US2004/042442

申请日：2004-12-16

Applicant: COLGATE-PALMOLIVE COMPANY ,  BOYD, Thomas, J. ,  XU, Guofeng ,  CARALE, M., Teresa, R. ,  BOFF, Beth, Ann

Inventor： BOYD, Thomas, J. ,  XU, Guofeng ,  CARALE, M., Teresa, R. ,  BOFF, Beth, Ann

IPC: A61K7/16

CPC classification number: A61Q15/00 ,  A61K8/0208 ,  A61Q5/065 ,  A61Q5/12

Abstract: A composition comprising a film or a plurality of film fragments entrained in a carrier is disclosed. The film or plurality of film fragments can comprise a functional material. The film or plurality of film fragments can comprise repeated shapes. Also disclosed is a composition comprising a plurality of discernable lamellar fragments entrained in a carrier. Also disclosed is a method for administering a functional material to a human or animal subject in need thereof, the method comprising applying to the subject a composition comprising a film or a plurality of film fragments entrained in a carrier, wherein the film comprises the functional material. The composition is preferably a dentifrice, containing shaped and/or coloured filmfragments, which may also comprise an oral agent.

Abstract translation: 公开了一种包含夹带在载体中的膜或多个膜片段的组合物。 膜或多个膜片段可以包括功能材料。 膜或多个薄膜碎片可以包括重复的形状。 还公开了包含夹带在载体中的多个可辨别的层状碎片的组合物。 还公开了向有需要的人或动物受试者施用功能材料的方法，所述方法包括向受试者施用包含夹带在载体中的膜或多个膜片段的组合物，其中所述膜包含功能材料 。 该组合物优选为洁齿剂，其含有成型和/或着色的薄片片段，其也可包含口服剂。

公开(公告)号：WO2002072050A1

公开(公告)日：2002-09-19

申请号：PCT/US2002/007105

申请日：2002-03-11

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： XU, Guofeng ,  VISCIO, David, B.

IPC: A61K7/16

CPC classification number: A61K8/0208 ,  A61K8/19 ,  A61K8/22 ,  A61K8/86 ,  A61K2800/31 ,  A61Q11/00

Abstract: A thin, flexible film which when applied to stained teeth is hydrated by saliva and is effective in such form to whiten teeth, the film comprising an anhydrous water hydratable ethylene oxide polymer matrix containing a solid peroxide whitening agent whereby upon application to stained tooth surfaces, the peroxide whitening agent is solublilized by saliva present in the oral cavity into active whitening activity when the film is positioned and placed on the teeth.

Abstract translation: 一种薄而柔软的膜，当应用于染色的牙齿时，通过唾液进行水合，并且以这种形式有效地使牙齿变白，该膜包含含有固体过氧化物增白剂的无水可水合环氧乙烷聚合物基质，由此当应用于染色的牙齿表面时， 当将膜定位并放置在牙齿上时，过氧化物增白剂可通过口腔中的唾液溶解而成活性增白活性。

公开(公告)号：WO2022188083A1

公开(公告)日：2022-09-15

申请号：PCT/CN2021/080127

申请日：2021-03-11

Applicant: COLGATE-PALMOLIVE COMPANY ,  XU, Shaopeng

Inventor： YANG, Ying ,  XU, Guofeng ,  TRIVEDI, Harsh Mahendra ,  MASTERS, James ,  CHEN, Dandan ,  WON, Betty

IPC: A61K8/27 ,  A61K8/44 ,  A61K8/365 ,  A61P1/02 ,  A61Q11/00 ,  A61K8/21

Abstract: Methods of increasing sIgA levels in an individual's oral cavity are disclosed. The methods comprise applying effective amounts of zinc oxide, zinc citrate, and arginine. Methods of increasing the concentration of sIgA in the individual's mucosa pellicle in the oral cavity are disclosed. Methods of increasing phagocytotic activity of phagocytotic cells in the individual's oral cavity are also disclosed. In addition, methods of increasing levels of β-Defensin 1 in the individual's oral cavity are disclosed.