公开(公告)号：EP1996643B1

公开(公告)日：2010-02-24

申请号：EP07711258.9

申请日：2007-03-07

Applicant: Coloplast A/S

Inventor： VANGE, Jakob ,  SCHWACH-ABDELLAOUI, Khadija ,  EVERLAND, Hanne ,  NIELSEN, Peter, Sylvest ,  NIELSEN, Brian ,  JESPERSEN, Lene, Karin ,  NIELSEN, Lene, Feldskov

IPC: C08G63/664 ,  C08G81/00 ,  C08J9/00 ,  C08J9/28 ,  A61L27/18 ,  A61L15/26 ,  A61L27/56

CPC classification number: C08G63/664 ,  A61L15/26 ,  A61L15/425 ,  A61L27/18 ,  A61L27/56 ,  C08G2261/126 ,  C08J9/28 ,  C08J2201/0482 ,  C08J2201/0484 ,  C08J2367/04 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2533/40 ,  Y10T428/249958 ,  C08L67/04

Abstract: The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A-O-(CHR1CHR2O)n-B wherein A is a poly(lactide-co-glycolide) residue, the molar ratio of (i) lactide units [-CH(CH3)-COO-] and (ii) glycolide units [-CH2-COO-] in the poly(lactide-co-glycolide) residue being in the range of 80:20 to 10:90, B is either a poly(lactide-co-glycolide) residue or hydrogen, C1-6-alkyl or hydroxy protecting groups, one of R1 and R2 is hydrogen or methyl, and the other is hydrogen, n is 10-1000, the molar ratio of (iii) polyalkylene glycol units [-(CHR1CHR2O)-] to the combined amount of (i) lactide units and (ii) glycolide units in the poly(lactide-co-glycolide) residue(s) is at the most 14:86, and the molecular weight of the copolymer is at least 20,000 g/mol.

Abstract translation: 本申请公开了可生物降解的聚合物，包含这种聚合物的多孔材料和其他材料，以及这些材料的各种医学用途，包括用作支持细胞粘附或组织再生的向内生长的支架。 （i）丙交酯单元[-CH（CH 3）-COO-]和（ii）乙交酯的摩尔比为1:1，聚合物具有式AO-（CHR 1 CHR 2 O）n B，其中A为丙交酯 - 乙交酯共聚物残基。 （丙交酯 - 共 - 乙交酯）残基中的单元[-CH 2 -COO-]为80:20至10:90，B为聚（丙交酯 - 共 - 乙交酯）残基或氢， 6-烷基或羟基保护基，R 1和R 2之一是氢或甲基，另一个是氢，n是10-1000，（iii）聚亚烷基二醇单元[ - （CHR 1 CHR 2 O） - ]与组合 （丙交酯 - 共 - 乙交酯）残基中的（i）丙交酯单元和（ii）乙交酯单元的量最多为14:86，并且共聚物的分子量为至少20,000g / mol。