公开(公告)号：WO1991015490A1

公开(公告)日：1991-10-17

申请号：PCT/US1991002355

申请日：1991-04-04

Applicant: GLAXO INC. ,  VINCE, Robert ,  PETERSON, Mark, Lee ,  LACKEY, John, William ,  MOOK, Robert, Anthony, Jr. ,  PARTRIDGE, John, Joseph

Inventor： GLAXO INC.

IPC: C07D473/18

CPC classification number: C07D473/40 ,  C07C69/96 ,  C07D473/18

Abstract: This invention relates to new process for preparing certain optically active purine substituted cyclopentene derivatives and novel intermediates used in this process. In particular, the invention concerns the synthesis of the 1R-cis isomer of carbovir, (1R-cis)-amino-1,9-dihydro-9-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-purin-6-one, an antiviral agent, and certain intermediates.

公开(公告)号：WO1991015489A1

公开(公告)日：1991-10-17

申请号：PCT/US1991002345

申请日：1991-04-04

Applicant: GLAXO INC. ,  JOHNSON, M., Ross ,  PEEL, Michael, R. ,  STERNBACH, Daniel, D.

Inventor： GLAXO INC.

IPC: C07D473/18

CPC classification number: C07D473/00 ,  C07F7/081

Abstract: This invention relates to a new process for preparing certain optically active cyclopentene derivatives and novel intermediates used in this process. In particular, the invention concerns the synthesis of the 1'R-cis isomer of carbovir, (1'R-cis)-2-amino-1,9-dihydro-9[4-(hydroxymethyl)-2-cyclopenten-1-yl]- 6H-purin-6-one, an antiviral agent.