公开(公告)号：JPH11311569A

公开(公告)日：1999-11-09

申请号：JP11859898

申请日：1998-04-28

Applicant: HAMAMATSU PHOTONICS KK

Inventor： UEDA YUKIO ,  TSUCHIYA YUTAKA

IPC: G01N21/17 ,  G01J1/00

Abstract: PROBLEM TO BE SOLVED: To obtain a method and an apparatus in which the distribution regarding the absolute value of the internal characteristic of a scattering and absorbing body can be measured with high accuracy, by computing the change amount of the internal characteristic on the basis of the measured value and the reference value of the parameter of measuring light, while a constraint expressed by (sum total of change amounts of internal characteristic) = constant is being added. SOLUTION: Optical fiber holders 1 to 12 are arranged at equal intervals around one section of a scattering and absorbing body SM. Beams of measuring light are made incident on the absorbing body SM at set time intervals sequentially from light incident fibers 1a to 12a by a control part 50. Detection signals are output from a photodetector 40 on the basis of respective beams of measuring light detected by light detecting fibers 1b to 12b. The detected signals are converted into measured values which are proportional to the quantities of detected measuring light by a computing and processing part 60. While a restraint express by (sum total of change amounts of internal characteristic) = constant is being added, the absolute value μa of an absorption coefficient is computed by μa =μa0 +Δμa , while the change amount Δμa of the absorption coefficient and the reference value μa0 of the absorption coefficient in every region are used, and an image which displays a distribution is displayed on a display part 80.

公开(公告)号：JP2013019696A

公开(公告)日：2013-01-31

申请号：JP2011151086

申请日：2011-07-07

Applicant: Univ Of Tsukuba ,  国立大学法人 筑波大学 ,  Hamamatsu Photonics Kk ,  浜松ホトニクス株式会社

Inventor： KUDO HIROYUKI ,  SAITO NAOYA ,  UEDA YUKIO ,  YOSHIMOTO KENJI ,  YAMASHITA YUTAKA

IPC: G01N21/17 ,  A61B6/03 ,  A61B8/00 ,  G01N22/02 ,  G01N29/00 ,  G01N29/44

CPC classification number: A61B5/7203 ,  A61B5/0073 ,  A61B5/0082 ,  A61B6/5247 ,  A61B8/15 ,  A61B8/5207 ,  A61B10/0041 ,  G01N21/4795 ,  G06T11/006

Abstract: PROBLEM TO BE SOLVED: To provide a biological measurement apparatus and an image formation method that can form an image which is as uniform as possible by suppressing differences in spatial resolution and noise characteristic with positions in a region to be measured.SOLUTION: A biological measurement apparatus 10 includes a light irradiation part which irradiates a region B to be measured with light, an optical detection part which detects diffused light from the region to be measured, and an arithmetic part 14 which forms a reconstructed image associated with the interior of the region to be measured. The operation part 14 forms the reconstructed image by calculating J coefficients w(J is the number of pixels of the reconstructed image) which are set by the pixels of the reconstructed image, and larger than 0 and equal to or less than 1, and performing a sequential approximation operation using an iterative expression (where (k) is an integer of 1 to N, N is the number of times of iterative operation, xis a pixel value in a (k)th iterative operation of a (j)th pixel, and dis an update quantity in the (k)th iterative operation of the (j)th pixel).

Abstract translation: 解决的问题：提供一种可以通过抑制在待测区域中的位置的空间分辨率和噪声特性的差异来形成尽可能均匀的图像的生物测量装置和图像形成方法。 解决方案：生物测量装置10包括用光照射待测区域B的光照射部分，检测来自待测区域的漫射光的光检测部分和形成重建的运算部分14的运算部分14。 与要测量的区域的内部相关联的图像。 操作部分14通过计算由重构图像的像素设置的J个系数，从而形成重构图像，并且 大于0且等于或小于1，并且使用迭代表达式（其中（k）是1到N的整数）执行顺序近似运算，N是迭代操作的次数，x 是第（j）个像素的（k）次迭代运算中的像素值，d 是第（j）个像素的（k）次迭代运算中的更新量。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JPH08136448A

公开(公告)日：1996-05-31

申请号：JP27250894

申请日：1994-11-07

Applicant: HAMAMATSU PHOTONICS KK

Inventor： MIWA MITSUHARU ,  TSUCHIYA YUTAKA ,  UEDA YUKIO

IPC: G01N21/27 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B10/00 ,  G01N21/49 ,  A61B5/14

Abstract: PURPOSE: To reduce errors in measurement, and thereby enhance accuracy in measurement by computing a scattering factor and an absorption factor within a scatter absorbing body based on the simultaneous relation-ship composed of a computed value and a theoritical formula for an average light path length. CONSTITUTION: A light source 30 emits measuring light P0 of wave lengths λ1 through λN-1 for the number N of the kinds of absorbing constituents contained in a scatter absorbing body 10. Light P0 which is injected from a light guide 70, and diffused and propagated within the absorbing body 10, is emitted to light detectors 41 and 42 taken by light guides 71 and 72. In this case, distances between a light incident position and a light detected position over the surface of the absorbing body 10 are set to be ρ1 and ρ2 respectively. Light P0 is processed by photoelectric conversion, measured by time resolution, and detection signals M1 and M2 are thereby outputted. An operation processing unit 50 computes the average light path lengths L (ρ1 ) and L (ρ2 ) of the light P0 in response to the respective wave lengths of the light P0 and the distances ρ1 and ρ2 based on the signals M1 and M2 . Besides, based on a plurality of simultaneous relationships composed of these average light path lengths and respective theoritical formulas, transport scattering factors μrs (λ1 ) through μrs (λN-1 ) and absorption factors μA (λ1 ) through μA (λN-1 ) are computed 52.

公开(公告)号：JP2005245624A

公开(公告)日：2005-09-15

申请号：JP2004058054

申请日：2004-03-02

Applicant: Hamamatsu Photonics Kk ,  浜松ホトニクス株式会社

Inventor： KOBAYASHI YUKIO ,  SUZUKI TOSHIHIKO ,  UEDA YUKIO ,  HIRUMA HIDEO

IPC: G01N21/17 ,  A61B10/00 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/359

Abstract: PROBLEM TO BE SOLVED: To provide a probe holder capable of easily holding a probe brought into contact with a living body in a short time, and an optical living body measuring apparatus. SOLUTION: The probe holder 5 is provided with a holder substrate 21 mounted on a subject and a socket 22 for attaching the probes 2 and 3 to the holder substrate 21. The socket 22 has: a socket body 28 provided with a male thread part 34 on an outer peripheral surface, into which the probe head 7 of the probes 2 and 3 is inserted; a fixing nut 29 fitted onto the male thread part 34 for fixing the socket body 28 to the holder substrate 21; a holding member 39 mounted on the socket body 28 and provided with a plurality of clamping pawls 36 for clamping the probe head 7; and a cap 31 provided with a female thread part 39 screw-fitted with the male thread part 34 on an inner peripheral surface for tightening the holding member 30 to the socket body 28 so that the respective clamping pawls 36 hold the probe head 7. COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种能够在短时间内容易地保持与生物体接触的探针的探针保持器和光生物体测量装置。 解决方案：探针保持器5设置有安装在被检体上的保持器基板21和用于将探针2和3附接到保持器基板21的插座22。插座22具有：插座体28，其设置有阳极 探针2和3的探针头7插入其外周表面上的螺纹部分34; 安装在阳螺纹部34上的固定螺母29，用于将插座主体28固定到保持器基板21; 保持构件39，其安装在插座主体28上并设置有用于夹紧探针头7的多个夹紧爪36; 以及盖31，其具有在内周面上与外螺纹部34螺纹配合的阴螺纹部39，用于将保持构件30紧固到插座主体28，使得各夹持爪36保持探头7。 P>版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JPH1026585A

公开(公告)日：1998-01-27

申请号：JP33467496

申请日：1996-11-29

Applicant: HAMAMATSU PHOTONICS KK

Inventor： UEDA YUKIO ,  TSUCHIYA YUTAKA ,  OTA KAZUYOSHI

IPC: G01B11/00 ,  A61B10/00 ,  G01J1/00 ,  G01N21/17 ,  G01N21/49

Abstract: PROBLEM TO BE SOLVED: To measure the distribution of an internal characteristic with high reliability and with high accuracy by a method wherein a mean measured value which is found on the basis of a combination of a light incident position and a light detection position which are relatively in the same relationship with reference to one point inside an object to be measured is used as a reference value. SOLUTION: Detection signals which are issued from a photodetector 40 on the basis of respective beams of measuring light detected by light detecting fibers 1b to 12b are processed by a computing and processsing part 60, and measured values are retained temporarily in a storafe part 70. Then, in the computing and processing part 60, a plurality of measured values which are found on the basis of a plurality of combinations of light incident fibers 1a to 12a and the light detecting fibers 1b to 12b whose positional relationship is relatively identical are extracted, and a reference value as their mean value is computed. On the basis of the reference value in every positional relationship, an average absorption coefficient and an average equivalent scattering coefficient at the inside of a scattering absorber SM are found so as to be retained in the storage part 70. Then, by using one reference value, the change amount of a prescribed internal characteristic in every region divided into a plurality of regions is computed, and the distribution of the change amount of the internal characteristic of an object is found.

公开(公告)号：JP2014027960A

公开(公告)日：2014-02-13

申请号：JP2012150793

申请日：2012-07-04

Applicant: Univ Of Tsukuba ,  国立大学法人 筑波大学 ,  Hamamatsu Photonics Kk ,  浜松ホトニクス株式会社

Inventor： KUDO HIROYUKI ,  SAITO NAOYA ,  UEDA YUKIO ,  YOSHIMOTO KENJI ,  YAMASHITA YUTAKA

IPC: A61B10/00

CPC classification number: G06K9/0014 ,  A61B5/0073 ,  A61B2576/00 ,  G06T7/70 ,  G06T2207/10101

Abstract: PROBLEM TO BE SOLVED: To shorten the creation time for image data by decreasing the number of measurement data required fro creating the image data.SOLUTION: In this measurement data selection method, when measurement data obtained for every combination of a plurality of light emission positions, a plurality of photo detecting positions and a plurality of resolution times in the time resolution waveform is taken as y, a vector, the component of which is a pixel value of learning image data previously provided as an example of internal image data is taken as an x, and a system matrix for calculating the internal image data from the measurement data y is taken as A, the following conditional expression is satisfied, or a vector y satisfying the following conditional expression is obtained by inverse operation, and in measuring a subject, internal image data is created using only measurement data corresponding to the component of the vector y that is not zero.

Abstract translation: 要解决的问题：通过减少创建图像数据所需的测量数据的数量来缩短图像数据的创建时间。解决方案：在该测量数据选择方法中，当对于多个发光位置的每个组合获得的测量数据 将时间分辨率波形中的多个光检测位置和多个分辨率时间取为y，将其分量作为内部图像数据的示例的先前提供的学习图像数据的像素值的矢量作为 将x和用于从测量数据y计算内部图像数据的系统矩阵作为A，满足以下条件表达式，或者通过反向操作获得满足以下条件表达式的向量y，并且在测量对象 ，仅使用对应于不为零的矢量y的分量的测量数据来创建内部图像数据。

公开(公告)号：JP2013116214A

公开(公告)日：2013-06-13

申请号：JP2011264891

申请日：2011-12-02

Applicant: Hamamatsu Photonics Kk ,  浜松ホトニクス株式会社 ,  Hamamatsu Univ School Of Medicine ,  国立大学法人浜松医科大学

Inventor： SUZUKI TOSHIHIKO ,  YAMASHITA YUTAKA ,  UEDA YUKIO ,  YAMAKI ETSUKO ,  YAMASHITA DAISUKE ,  YOSHIMOTO KENJI ,  SAKAHARA HARUMI ,  OGURA HIROYUKI ,  NASU HATSUKO

IPC: A61B10/00 ,  A61B8/00

CPC classification number: A61B5/0091 ,  A61B5/0035 ,  A61B5/708 ,  A61B8/0825 ,  A61B8/4416 ,  A61B2562/046 ,  A61B2562/146 ,  A61B2562/168 ,  G01N21/4795 ,  G01N2021/4797 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: PROBLEM TO BE SOLVED: To provide a mammography apparatus capable of lessening an impact on the accuracy of interior information due to differences in shapes or sizes of a breast.SOLUTION: A mammography apparatus 1 for illuminating the breast B of a subject A with light, and acquires information of the interior of the breast B by detecting diffuse light, includes a container 3 surrounding the breast B, and a plurality of optical fibers 11 attached toward the inner side of the container 3 and carrying out illumination and detection of the light. The container 3 includes a base member 30 having an opening 30a, a plurality of ring-shaped members 40 communicating with the opening 30a and positioned in series, and a bottom part member 50 positioned on the inner side of the ring-shaped member 40 the furthest from the base member 30. Each ring-shaped member 40 and the bottom part member 50 are configured to be relatively displaceable in the communication direction of either the ring-shaped member 40 adjacent to the base member 30 side or the base member 30. At least part of the plurality of the optical fibers 11 are attached to the plurality of the ring-shaped members 40.

Abstract translation: 要解决的问题：提供一种能够减轻由于乳房的形状或尺寸的差异对内部信息的精度的影响的乳房X线照相设备。 解决方案：用于通过光照射被检体A的乳房B并通过检测漫射光获取乳房B的内部的信息的乳房照相术设备1包括围绕乳房B的容器3和多个光学 光纤11朝向容器3的内侧安装并进行照明和光的检测。 容器3包括具有开口30a的底座构件30，与开口30a连通并且串联连接的多个环形构件40和位于环形构件40的内侧的底部构件50 每个环形构件40和底部构件50被构造成可以在与基部构件30侧或基底构件30相邻的环形构件40的连通方向上相对移动。 多个光纤11的至少一部分被安装在多个环状部件40上。（C）2013，JPO＆INPIT

公开(公告)号：JP2012085965A

公开(公告)日：2012-05-10

申请号：JP2010237726

申请日：2010-10-22

Applicant: Hamamatsu Photonics Kk ,  Hamamatsu Univ School Of Medicine ,  国立大学法人浜松医科大学 ,  浜松ホトニクス株式会社

Inventor： SUZUKI TOSHIHIKO ,  YAMASHITA YUTAKA ,  UEDA YUKIO ,  YAMAKI ETSUKO ,  YAMASHITA DAISUKE ,  YOSHIMOTO KENJI ,  SAKAHARA HARUMI ,  OGURA HIROYUKI ,  NASU HATSUKO

IPC: A61B10/00 ,  A61B8/08

CPC classification number: A61B8/5261 ,  A61B5/0035 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  A61B5/6835 ,  A61B5/708 ,  A61B5/72 ,  A61B5/7425 ,  A61B8/0825 ,  A61B8/14 ,  A61B8/406 ,  A61B8/4227 ,  A61B8/4281 ,  A61B8/4416 ,  A61B8/4444 ,  A61B8/4455 ,  A61B8/4477 ,  A61B8/5207 ,  A61B10/0041 ,  A61B2562/146

Abstract: PROBLEM TO BE SOLVED: To provide a mammographic measuring apparatus which is capable of acquiring an ultrasonic image and an optical CT image under the same measurement condition.SOLUTION: The mammographic measuring apparatus 1 includes: a vessel 3 surrounded a breast B; a plurality of optical fibers 11 disposed toward the inside of the vessel 3 while irradiating the examination light to the breast B in order to detect a transmission scattered light from the breast B; an image generating part 53 for generating the optical CT image related to the breast B based on a detection signal of the transmission scattered light; an ultrasonic probe 21 disposed toward the inside of the vessel 3 while scanning an ultrasonic wave to the breast B to receive a reflected wave from the breast B; an image generating part 24 for generating the ultrasonic image related to the breast B based on the reflected wave; and a mechanism of injecting and discharging a liquid-like interface agent I toward the inside of the vessel 3.

Abstract translation: 要解决的问题：提供一种在相同测量条件下能够获取超声波图像和光学CT图像的乳房X射线测量装置。 解决方案：乳房X线摄影测量装置1包括：包围乳房B的容器3; 多个光纤11，同时向胸部B照射检查光，朝向容器3的内部设置，以检测来自乳房B的透射散射光; 图像生成部53，用于根据透射散射光的检测信号生成与乳房B相关的光学CT图像; 超声波探头21朝向容器3的内侧设置，同时向乳房B扫描超声波以接收来自乳房B的反射波; 用于基于反射波产生与乳房B相关的超声波图像的图像生成部24; 以及将液体状界面剂I注入和排出到容器3内部的机构。版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2009103619A

公开(公告)日：2009-05-14

申请号：JP2007276770

申请日：2007-10-24

Applicant: Hamamatsu Photonics Kk ,  浜松ホトニクス株式会社

Inventor： UEDA YUKIO ,  YAMASHITA YUTAKA

IPC: G01N21/17 ,  A61B10/00

CPC classification number: G01N21/4795 ,  A61B5/0091 ,  A61B5/4312 ,  G01N2201/0846

Abstract: PROBLEM TO BE SOLVED: To provide a biological measurement apparatus for measuring a location at which a light adsorber such as a tumor exists in the entire to-be-measured region. SOLUTION: The biological measurement apparatus 10 includes: a vessel 12 for holding an optical interface material 20; a light irradiation means for irradiating the to-be-measured region immersed in the optical interface material 20 with first and second lights having different wavelengths; a light detection means for detecting a diffusion light from the to-be-measured region; and a calculation/control section 14 for calculating internal information from an output signal of the light detection means. The wavelength λ1 of the first light is a wavelength at which an absorption coefficient of the to-be-measured region is substantially equal to an absorption coefficient of a medium. The wavelength λ2 of the second light is a wavelength at which the absorption coefficient of the to-be-measured region is larger than the absorption coefficient of the medium. The calculation/control section 14 calculates the internal information from the output signal related to the diffusion light of the first light, and calculates a boundary between the to-be-measured region and the optical interface material 20 from the output signal related to the diffusion light of the second light. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供一种用于测量在整个被测量区域中存在肿瘤等光吸收剂的位置的生物测定装置。 生物测定装置10包括：保持光学界面材料20的容器12; 光照射装置，用于用浸没在光学界面材料20中的待测量区域照射具有不同波长的第一和第二光; 光检测装置，用于检测来自待测区域的漫射光; 以及用于根据光检测装置的输出信号计算内部信息的计算/控制部分14。 第一光的波长λ1是待测量区域的吸收系数基本上等于介质的吸收系数的波长。 第二光的波长λ2是待测量区域的吸收系数大于介质的吸收系数的波长。 计算/控制部分14根据与第一光的扩散光相关的输出信号计算内部信息，并根据与扩散相关的输出信号计算被测量区域和光学界面材料20之间的边界 第二个光的光。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2005049238A

公开(公告)日：2005-02-24

申请号：JP2003282067

申请日：2003-07-29

Applicant: Hamamatsu Photonics Kk ,  浜松ホトニクス株式会社

Inventor： YAMANAKA TAKESHI ,  UEDA YUKIO ,  YAMASHITA YUTAKA

IPC: G01N21/35 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/359 ,  G01N21/49

CPC classification number: G01N21/4795 ,  A61B5/14553 ,  A61B2562/0233 ,  A61B2562/046 ,  G01N21/49

Abstract: PROBLEM TO BE SOLVED: To provide a scattering absorber measuring device and a measuring method for suppressing crosstalk between channels without spacial restriction. SOLUTION: This scattering absorber measuring device is constituted of a measuring module 1 having an irradiation probe 11 and detection probes 61, 71, and a measuring module 2 having an irradiation probe 21 and detection probes 81, 91. A light delaying unit 22 is provided between a light source 30 and the irradiation probe 21 relative to the pulse light source 30 which is a common light source to the irradiation probes 11, 21, and thereby pulsed light is irradiated successively from the irradiation probes 11, 21. A trigger circuit 50 indicates irradiation timing of the pulsed light to the light source 30, and indicates each light detection timing synchronized with the irradiation timing to signal processing circuits 62-92. COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种散射吸收器测量装置和用于抑制通道之间的串扰的测量方法，而不受空间限制。 解决方案：该散射吸收器测量装置由具有照射探针11和检测探针61,71的测量模块1和具有照射探针21和检测探针81,91的测量模块2构成。光延迟单元 22相对于作为照射探头11,21的共同光源的脉冲光源30在光源30和照射探测器21之间设置，从而从照射探测器11,21依次照射脉冲光。 触发电路50表示对光源30的脉冲光的照射定时，并且将与照射定时同步的每个光检测定时指示给信号处理电路62-92。 版权所有（C）2005，JPO＆NCIPI