公开(公告)号：ES2143675T3

公开(公告)日：2000-05-16

申请号：ES96101976

申请日：1996-02-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C311/59 ,  C07C327/40 ,  C07C335/42

Abstract: Substd. benzene sulphonyl urea and thiourea derivs. of formula (I) and their salts are new. R1 = H, Me or CF3; R2 = 4-10C alkoxy with 1-6C replaced by O, S or NH; Q = O or S; Y = ÄC(R3)2Üm; R3 = H, Me or Et; R' = H, halo or 1-6C alkyl; R" = halo, 1-4C alkoxy or 1-4C alkyl; and m = 1-4.

公开(公告)号：DK0657423T3

公开(公告)日：1999-07-19

申请号：DK94118931

申请日：1994-12-01

Applicant: HOECHST AG

Inventor： GOEGELEIN HEINZ DR ,  KAISER JOACHIM DR ,  ENGLERT HEINRICH DR ,  MANIA DIETER DR ,  HARTUNG JENS DR

IPC: A61K31/64 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  C07C303/36 ,  C07C311/57 ,  C07C311/58 ,  C07C335/42 ,  C07D295/135

Abstract: Amino-substituted benzenesulphonylureas and -thioureas of the formula I are described. The compounds I are used for treating cardiac dysrhythmias and for preventing sudden heart death due to arrhythmias and can therefore be used as antiarrhythmics. They are particularly suitable for cases in which arrhythmias are the consequence of a constriction of a coronary vessel, such as in angina pectoris or acute myocardial infarct.

公开(公告)号：AU701278B2

公开(公告)日：1999-01-21

申请号：AU4560096

申请日：1996-02-19

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: C07D331/02 ,  A61K31/18 ,  A61K31/38 ,  A61K31/64 ,  A61P9/00 ,  A61P9/02 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C327/46 ,  C07C335/42 ,  C07D203/08 ,  C07D295/00 ,  C07D303/48 ,  A61K31/17

Abstract: N-(3-substd. benzensulphonyl)-urea or -thiourea derivs. of formula (I) and their salts are new. R1 = H, 1-7C alkyl or 3-7C cycloalkyl; R2 = H, F, Cl, 1-6C alkyl, 1-6C alkoxy, 1-6C mercaptoalkyl, 3-6C cycloalkyl or CbH2b+1, in which one or more C can be replaced by Het; Het = heteroatoms, e.g. O, NH or S; b = 1-8; 1-8C alkyl in which 1-4C may be replaced by O, N or S; R3 = H, 1-12C alkyl, 3-10C cycloalkyl, 1-6C fluoroalkyl, 3-6C fluorocycloalkyl or CaH2a+1 in which 1-4C are replaced by Het; a = 1-10; R4 = aryl or as R3; or R3+R4 = CbH2b, in which one or more CH2 can be replaced by Het; R5 = as R4; R6 = as R4 but not 3-10C cycloalkyl; Q, X = O or S; Y = -(C(R7)2)c, O, S or NH; c = 1-4; R7 = H, 1-4C alkyl, F, Cl or Br.

公开(公告)号：CZ28096A3

公开(公告)日：1998-04-15

申请号：CZ28096

申请日：1996-01-30

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  HARTUNG JENS DR ,  CRAUSE PETER DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/38 ,  A61K31/381 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  A61P43/00 ,  C07C335/00 ,  C07D333/34

Abstract: N-((2-Benzamidoethyl)- thiophene-sulphonyl)-urea or-thiourea derivs. of formula (I) are new. R1 = H, halogen, Me, Et, OMe, OEt, SMe, SEt, 1-2C fluoroalkyl or 1-2C fluoroalkoxy; X = O or S; R2 = H, Me or CF3; Y, Z = H, F, Cl, Br, I, Me, Et, OMe or OEt.

公开(公告)号：CZ48696A3

公开(公告)日：1996-09-11

申请号：CZ48696

申请日：1996-02-19

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: C07D331/02 ,  A61K31/18 ,  A61K31/38 ,  A61K31/64 ,  A61P9/00 ,  A61P9/02 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C327/46 ,  C07C335/42 ,  C07D203/08 ,  C07D295/00 ,  C07D303/48 ,  C07C311/57 ,  C07C303/36 ,  C07D203/12 ,  C07D295/08 ,  A61K31/495 ,  A61K31/535 ,  A61K31/445

Abstract: N-(3-substd. benzensulphonyl)-urea or -thiourea derivs. of formula (I) and their salts are new. R1 = H, 1-7C alkyl or 3-7C cycloalkyl; R2 = H, F, Cl, 1-6C alkyl, 1-6C alkoxy, 1-6C mercaptoalkyl, 3-6C cycloalkyl or CbH2b+1, in which one or more C can be replaced by Het; Het = heteroatoms, e.g. O, NH or S; b = 1-8; 1-8C alkyl in which 1-4C may be replaced by O, N or S; R3 = H, 1-12C alkyl, 3-10C cycloalkyl, 1-6C fluoroalkyl, 3-6C fluorocycloalkyl or CaH2a+1 in which 1-4C are replaced by Het; a = 1-10; R4 = aryl or as R3; or R3+R4 = CbH2b, in which one or more CH2 can be replaced by Het; R5 = as R4; R6 = as R4 but not 3-10C cycloalkyl; Q, X = O or S; Y = -(C(R7)2)c, O, S or NH; c = 1-4; R7 = H, 1-4C alkyl, F, Cl or Br.

公开(公告)号：AU4560096A

公开(公告)日：1996-08-29

申请号：AU4560096

申请日：1996-02-19

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: C07D331/02 ,  A61K31/18 ,  A61K31/38 ,  A61K31/64 ,  A61P9/00 ,  A61P9/02 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C327/46 ,  C07C335/42 ,  C07D203/08 ,  C07D295/00 ,  C07D303/48 ,  A61K31/17

Abstract: N-(3-substd. benzensulphonyl)-urea or -thiourea derivs. of formula (I) and their salts are new. R1 = H, 1-7C alkyl or 3-7C cycloalkyl; R2 = H, F, Cl, 1-6C alkyl, 1-6C alkoxy, 1-6C mercaptoalkyl, 3-6C cycloalkyl or CbH2b+1, in which one or more C can be replaced by Het; Het = heteroatoms, e.g. O, NH or S; b = 1-8; 1-8C alkyl in which 1-4C may be replaced by O, N or S; R3 = H, 1-12C alkyl, 3-10C cycloalkyl, 1-6C fluoroalkyl, 3-6C fluorocycloalkyl or CaH2a+1 in which 1-4C are replaced by Het; a = 1-10; R4 = aryl or as R3; or R3+R4 = CbH2b, in which one or more CH2 can be replaced by Het; R5 = as R4; R6 = as R4 but not 3-10C cycloalkyl; Q, X = O or S; Y = -(C(R7)2)c, O, S or NH; c = 1-4; R7 = H, 1-4C alkyl, F, Cl or Br.

公开(公告)号：DE19505397A1

公开(公告)日：1996-08-22

申请号：DE19505397

申请日：1995-02-17

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  GOEGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C311/59 ,  C07C327/40 ,  C07C335/42 ,  C07C311/54 ,  C07C303/36 ,  A61K31/17

Abstract: Substd. benzene sulphonyl urea and thiourea derivs. of formula (I) and their salts are new. R1 = H, Me or CF3; R2 = 4-10C alkoxy with 1-6C replaced by O, S or NH; Q = O or S; Y = ÄC(R3)2Üm; R3 = H, Me or Et; R' = H, halo or 1-6C alkyl; R" = halo, 1-4C alkoxy or 1-4C alkyl; and m = 1-4.

公开(公告)号：DE19504379A1

公开(公告)日：1996-08-14

申请号：DE19504379

申请日：1995-02-10

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  GERLACH UWE DR ,  CRAUSE PETER DR ,  MANIA DIETER DR ,  GOEGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: C07D333/20 ,  A61K31/18 ,  A61K31/34 ,  A61K31/35 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/40 ,  A61K31/425 ,  A61K31/426 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C327/40 ,  C07C335/42 ,  C07D207/32 ,  C07D207/335 ,  C07D213/40 ,  C07D277/28 ,  C07D307/52 ,  C07C311/57 ,  C07C303/36 ,  C07C327/42

Abstract: Substd. benzenesulphonylurea or -thiourea cpds. of formula (I) are new: R1 = H, 1-6C alkyl, or 3-6C cycloalkyl; R2 = 1-6C alkyl, 1-6C alkoxy, 1-6C mercaptoalkyl, 3-6C cycloalkyl, or a 1-8C chain in which 1-3C may be replaced by O, NH or S; R3, R4 = H or 1-6C alkyl; or R3 + R4 = (CH2)p; p = 2-5; E, X = O or S; Y = ÄC(R5)2Üm; R5 = H, Me or Et; m = 1 or 2; Ar = phenyl, thienyl, furyl, pyrrolyl, thiazolyl, naphthyl or pyridyl (all opt. substd. by 1-3 Me, Et, MeO, EtO, Cl, Br or F).

公开(公告)号：DE4344957A1

公开(公告)日：1995-07-06

申请号：DE4344957

申请日：1993-12-30

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  MANIA DIETER DR ,  HARTUNG JENS DR ,  GOEGELEIN HEINZ DR DR ,  KAISER JOACHIM DR ,  GERLACH UWE DR

IPC: C07D217/24 ,  A61K31/40 ,  A61K31/64 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P43/00 ,  C07C303/36 ,  C07C311/58 ,  C07C335/42 ,  C07D207/38 ,  C07D521/00 ,  C07C311/57 ,  C07C303/40 ,  A01N1/02

Abstract: There are described substituted benzenesulphonylureas and -thioureas of the formula I where R(1) is H, (cyclo)(CH2)a(fluoro)alk(en)yl, R(2) is H, Hal, (fluoro)(mercapto)(CH2)e(cyclo)alk(oxy)(yl), NR(4)R(5) where R(4) and R(5) together are a (CH2)2-7 chain, or R(4), R(5), R(6) are H, (alkyl)(cyclo)(fluoro)alk(en)yl, E is O, S; Y is -[CR(7)2]n-R(3) B is (C3-C6)-alkenyl, or R(3) is X is H, Hal, alkyl; Z is Hal, (cyclo)alk(yl)(oxy). Compounds I are used for the treatment of cardiac arrhythmias and for the prevention of sudden heart death caused by arrhythmia and can therefore be used as antiarrhythmics. They are particularly suitable in those cases in which arrhythmias are the result of constriction of a coronary vessel, such as in angina pectoris or in acute cardiac infarct.

公开(公告)号：DE4341655A1

公开(公告)日：1995-06-08

申请号：DE4341655

申请日：1993-12-07

Applicant: HOECHST AG

Inventor： ENLERT HEINRICH DR ,  MANIA DIETER DR ,  HARTUNG JENS DR ,  GOEGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/64 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  C07C303/36 ,  C07C311/57 ,  C07C311/58 ,  C07C335/42 ,  C07D295/135 ,  C07C273/18

Abstract: Amino-substituted benzenesulphonylureas and -thioureas of the formula I are described. The compounds I are used for treating cardiac dysrhythmias and for preventing sudden heart death due to arrhythmias and can therefore be used as antiarrhythmics. They are particularly suitable for cases in which arrhythmias are the consequence of a constriction of a coronary vessel, such as in angina pectoris or acute myocardial infarct.