公开(公告)号：CZ291271B6

公开(公告)日：2003-01-15

申请号：CZ43696

申请日：1996-02-14

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C311/59 ,  C07C327/40 ,  C07C335/42

Abstract: In the present invention there are disclosed benzenesulfonyl ureas and thioureas of the general formula I, in which R(1) represents hydrogen, methyl or trifluoromethyl, R(2) denotes alkoxy having 4 to 10 carbon atoms, where 1 to 6 carbon atoms are replaced by oxygen, sulfur or NH hetero atoms, E represents oxygen or sulfur, Y denotes -[CR(3)i2 ]i(1-4), R(3) represents hydrogen or alkyl having 1 or 2 carbon atoms, X denotes hydrogen, halogen or alkyl having 1 to 6 carbon atoms, Z represents a nitro group, a halogen, an alkoxy group having 1 to 4 carbon atoms or an alkyl group having 1 to 4 carbon atoms, as well as their pharmaceutically acceptable salts. These compounds exhibit effects on the cardiovascular system. In the invention there is further described a process for preparing these compounds as well as a medicament in which they are comprised.

公开(公告)号：ES2127875T3

公开(公告)日：1999-05-01

申请号：ES94118931

申请日：1994-12-01

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  MANIA DIETER DR ,  HARTUNG JENS DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/64 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  C07C303/36 ,  C07C311/57 ,  C07C311/58 ,  C07C335/42 ,  C07D295/135

Abstract: Amino-substituted benzenesulphonylureas and -thioureas of the formula I are described. The compounds I are used for treating cardiac dysrhythmias and for preventing sudden heart death due to arrhythmias and can therefore be used as antiarrhythmics. They are particularly suitable for cases in which arrhythmias are the consequence of a constriction of a coronary vessel, such as in angina pectoris or acute myocardial infarct.

公开(公告)号：CZ149497A3

公开(公告)日：1997-12-17

申请号：CZ149497

申请日：1997-05-14

Applicant: HOECHST AG

Inventor： LANG HANS JOCHEN DR ,  GERLACH UWE DR ,  BRENDEL JOACHIM DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  GOGELEIN HEINZ DR ,  HROPOT MAX DR ,  BOHN HELMUT DR ,  HERLING ANDREAS DR ,  BUSCH ANDREAS PROF DR ,  GREGER RAINER PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/44 ,  A61K31/443 ,  A61P1/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/06 ,  C07D311/68 ,  C07D311/70 ,  C07D311/72 ,  C07D311/96 ,  C07D405/12

公开(公告)号：AU4556096A

公开(公告)日：1996-08-29

申请号：AU4556096

申请日：1996-02-15

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C311/59 ,  C07C327/40 ,  C07C335/42 ,  A61K31/17

Abstract: Substd. benzene sulphonyl urea and thiourea derivs. of formula (I) and their salts are new. R1 = H, Me or CF3; R2 = 4-10C alkoxy with 1-6C replaced by O, S or NH; Q = O or S; Y = ÄC(R3)2Üm; R3 = H, Me or Et; R' = H, halo or 1-6C alkyl; R" = halo, 1-4C alkoxy or 1-4C alkyl; and m = 1-4.

公开(公告)号：AU4442996A

公开(公告)日：1996-08-22

申请号：AU4442996

申请日：1996-02-08

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  GERLACH UWE DR ,  CRAUSE PETER DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: C07D333/20 ,  A61K31/18 ,  A61K31/34 ,  A61K31/35 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/40 ,  A61K31/425 ,  A61K31/426 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C327/40 ,  C07C335/42 ,  C07D207/32 ,  C07D207/335 ,  C07D213/40 ,  C07D277/28 ,  C07D307/52 ,  C07C311/59 ,  A61K31/17

Abstract: Substd. benzenesulphonylurea or -thiourea cpds. of formula (I) are new: R1 = H, 1-6C alkyl, or 3-6C cycloalkyl; R2 = 1-6C alkyl, 1-6C alkoxy, 1-6C mercaptoalkyl, 3-6C cycloalkyl, or a 1-8C chain in which 1-3C may be replaced by O, NH or S; R3, R4 = H or 1-6C alkyl; or R3 + R4 = (CH2)p; p = 2-5; E, X = O or S; Y = ÄC(R5)2Üm; R5 = H, Me or Et; m = 1 or 2; Ar = phenyl, thienyl, furyl, pyrrolyl, thiazolyl, naphthyl or pyridyl (all opt. substd. by 1-3 Me, Et, MeO, EtO, Cl, Br or F).

公开(公告)号：CZ9600382A3

公开(公告)日：1996-08-14

申请号：CZ38296

申请日：1996-02-08

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  GERLACH UWE DR ,  CRAUSE PETER DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: C07D333/20 ,  A61K31/18 ,  A61K31/34 ,  A61K31/35 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/40 ,  A61K31/425 ,  A61K31/426 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C327/40 ,  C07C335/42 ,  C07D207/32 ,  C07D207/335 ,  C07D213/40 ,  C07D277/28 ,  C07D307/52 ,  C07C303/36 ,  C07C311/57 ,  C07C327/42

CPC classification number: C07C335/42 ,  C07C311/58

公开(公告)号：ES2206525T3

公开(公告)日：2004-05-16

申请号：ES96101096

申请日：1996-01-26

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  HARTUNG JENS DR ,  CRAUSE PETER DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/38 ,  A61K31/381 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  A61P43/00 ,  C07C335/00 ,  C07D333/34

Abstract: N-((2-Benzamidoethyl)- thiophene-sulphonyl)-urea or-thiourea derivs. of formula (I) are new. R1 = H, halogen, Me, Et, OMe, OEt, SMe, SEt, 1-2C fluoroalkyl or 1-2C fluoroalkoxy; X = O or S; R2 = H, Me or CF3; Y, Z = H, F, Cl, Br, I, Me, Et, OMe or OEt.

公开(公告)号：CZ291219B6

公开(公告)日：2003-01-15

申请号：CZ48696

申请日：1996-02-19

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: C07D331/02 ,  A61K31/18 ,  A61K31/38 ,  A61K31/64 ,  A61P9/00 ,  A61P9/02 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C327/46 ,  C07C335/42 ,  C07D203/08 ,  C07D295/00 ,  C07D303/48

Abstract: In the present invention there are disclosed benzenesulfonyl ureas and benzenesulfonyl thioureas of the general formula I, in which R(l) represents alkyl containing 1 to 6 carbon atoms, R(2) represents an alkoxy group containing 1 to 6 carbon atoms, R(3) denotes hydrogen, R(4), R(5) and R(6) represent independently on each other hydrogen, an aryl group, being represents by phenyl, thienyl, furyl, pyrrolyl, thiazolyl, naphthyl or pyridyl group, whereby any of the above groups can be optionally substituted with one to three substituents being selected from the group comprising alkyl groups containing 1 to 2 carbon atoms, alkoxy groups containing 1 to 2 carbon atoms, chlorine, bromine and fluorine, or alkyl containing 1 to 6 carbon atoms, E denotes oxygen or sulfur, X represents oxygen, and Y denotes [CHi2]i1-4, and their pharmaceutically acceptable salts. These compounds exhibit excellent effect on cardiovascular system. There is further described a process for preparing these compounds for preparing medicaments as well as the medicaments in which the compounds are comprised.

公开(公告)号：CZ291094B6

公开(公告)日：2002-12-11

申请号：CZ365896

申请日：1996-12-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  LINZ WOLFGANG DR ,  GOGELEIN HEINZ DR ,  KLAUS ERIK DR ,  CRAUSE PETER DR

IPC: C07D311/58 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  C07D311/64 ,  C07D311/70 ,  C07D405/12

Abstract: In the present invention there are described substituted chromanylsulfonyl(thio)ureas of the general formula I, in which Re1 represents hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, a halogen, trifluoromethyl, an amino group, NH-alkyl having 1 to 4 carbon atoms, N(alkyl)2 having 1 to 4 carbon atoms in the identical or different alkyl radicals, or S-alkyl having 1 to 4 carbon atoms; Re2a represents hydrogen or alkyl having 1 or 2 carbon atoms; Re2b and Re2d are each hydrogen, alkyl having 1 or 2 carbon atoms, an optionally substituted phenyl, or optionally substituted benzyl, Re2c and Re2e are each hydrogen or alkyl having 1 or 2 carbon atoms; Re3 represents hydrogen, alkyl having 1 to 4 carbon atoms, cycloalkyl having 3 to 6 ring carbon atoms, CHi2-cycloalkyl having 3 to 6 ring carbon atoms, or trifluoromethyl; Q denotes (CHi2)n, wherein n is 1 or 2; Z represents sulfur or oxygen; and A denotes an optionally substituted phenyl or a is radical of a saturated or unsaturated lactam a radical of a heterocyclic bicyclic system, and their pharmaceutically acceptable salts. These compounds are valuable pharmaceuticals for the treatment of cardiac arrhythmias and for the prevention of sudden heart death due to arrhythmia. They can be used as antiarrhythmics and are suitable for the prevention of sudden heart death, for the treatment of cardiac insufficiency and also heart failure as a result of the effects of shock. Described are also processes for preparing the indicated compounds as well as their use for the preparation of medicaments.

公开(公告)号：ES2151614T3

公开(公告)日：2001-01-01

申请号：ES96102255

申请日：1996-02-15

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: C07D331/02 ,  A61K31/18 ,  A61K31/38 ,  A61K31/64 ,  A61P9/00 ,  A61P9/02 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C327/46 ,  C07C335/42 ,  C07D203/08 ,  C07D295/00 ,  C07D303/48

Abstract: N-(3-substd. benzensulphonyl)-urea or -thiourea derivs. of formula (I) and their salts are new. R1 = H, 1-7C alkyl or 3-7C cycloalkyl; R2 = H, F, Cl, 1-6C alkyl, 1-6C alkoxy, 1-6C mercaptoalkyl, 3-6C cycloalkyl or CbH2b+1, in which one or more C can be replaced by Het; Het = heteroatoms, e.g. O, NH or S; b = 1-8; 1-8C alkyl in which 1-4C may be replaced by O, N or S; R3 = H, 1-12C alkyl, 3-10C cycloalkyl, 1-6C fluoroalkyl, 3-6C fluorocycloalkyl or CaH2a+1 in which 1-4C are replaced by Het; a = 1-10; R4 = aryl or as R3; or R3+R4 = CbH2b, in which one or more CH2 can be replaced by Het; R5 = as R4; R6 = as R4 but not 3-10C cycloalkyl; Q, X = O or S; Y = -(C(R7)2)c, O, S or NH; c = 1-4; R7 = H, 1-4C alkyl, F, Cl or Br.