公开(公告)号：CZ290809B6

公开(公告)日：2002-10-16

申请号：CZ38296

申请日：1996-02-08

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  GERLACH UWE DR ,  CRAUSE PETER DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: C07D333/20 ,  A61K31/18 ,  A61K31/34 ,  A61K31/35 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/40 ,  A61K31/425 ,  A61K31/426 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C327/40 ,  C07C335/42 ,  C07D207/32 ,  C07D207/335 ,  C07D213/40 ,  C07D277/28 ,  C07D307/52

Abstract: In the present invention, there are disclosed substituted benzenesulfonyl ureas and benzenesulfonyl thioureas of the general formula I. These compounds as well as their pharmaceutically acceptable salts are valuable medicaments that are suitable not only as antiarrhythmic but also as compounds used for prophylaxis of cardiovascular system disorders, heart insufficiency, heart transplantations or cerebral vascular diseases in humans or animals.

公开(公告)号：AT189213T

公开(公告)日：2000-02-15

申请号：AT96101976

申请日：1996-02-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  GOEGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C311/59 ,  C07C327/40 ,  C07C335/42

Abstract: Substd. benzene sulphonyl urea and thiourea derivs. of formula (I) and their salts are new. R1 = H, Me or CF3; R2 = 4-10C alkoxy with 1-6C replaced by O, S or NH; Q = O or S; Y = ÄC(R3)2Üm; R3 = H, Me or Et; R' = H, halo or 1-6C alkyl; R" = halo, 1-4C alkoxy or 1-4C alkyl; and m = 1-4.

公开(公告)号：GR3029768T3

公开(公告)日：1999-06-30

申请号：GR990400855

申请日：1999-03-23

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  MANIA DIETER DR ,  HARTUNG JENS DR ,  GOEGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/64 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  C07C303/36 ,  C07C311/57 ,  C07C311/58 ,  C07C335/42 ,  C07D295/135

Abstract: Amino-substituted benzenesulphonylureas and -thioureas of the formula I are described. The compounds I are used for treating cardiac dysrhythmias and for preventing sudden heart death due to arrhythmias and can therefore be used as antiarrhythmics. They are particularly suitable for cases in which arrhythmias are the consequence of a constriction of a coronary vessel, such as in angina pectoris or acute myocardial infarct.

公开(公告)号：CZ9600280A3

公开(公告)日：1998-04-15

申请号：CZ28096

申请日：1996-01-30

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  HARTUNG JENS DR ,  CRAUSE PETER DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/38 ,  A61K31/381 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  A61P43/00 ,  C07C335/00 ,  C07D333/34

CPC classification number: C07D333/34

公开(公告)号：DK0556672T3

公开(公告)日：1998-03-02

申请号：DK93101840

申请日：1993-02-05

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG DR ,  SCHOLZ WOLFGANG DR ,  LANG HANS-JOCHEN DR ,  ENGLERT HEINRICH DR ,  ALBUS UDO DR ,  MANIA DIETER DR

IPC: A61K31/155 ,  A61K31/165 ,  A61K31/445 ,  A61P1/16 ,  A61P3/08 ,  A61P3/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  C07C279/22 ,  C07D213/65 ,  C07D295/14 ,  C07D295/155

Abstract: There are described benzoylguanidines of the formula I in which R(1) or R(2) is an amino group -NR(3)R(4), where R(3) and R(4) are equal to H, (cyclo)alkyl or R(3) is equal to phenyl-(CH2)p- where p = 0, 1, 2, 3 or 4, or phenyl, or R(3) and R(4) together can also be a methylene chain, and in which the other substituent R(1) or R(2) in each case is H, F, Cl, alkyl, alkoxy, CF3, CmF2m+1-CH2-, benzyl or phenoxy, and their pharmaceutically tolerable salts. The compounds according to the invention have very good antiarrhythmic properties, such as they show, for example, in the case of oxygen deficiency symptoms. The compounds are used as antiarrhythmic medicaments having a cardioprotective component for infarct prophylaxis and infarct treatment and also for the treatment of angina pectoris, where they preventively inhibit or strongly decrease the pathophysiological processes during the formation of ischaemically induced damage, in particular during the induction of ischaemically induced cardiac arrhythmias.

公开(公告)号：CZ43696A3

公开(公告)日：1996-09-11

申请号：CZ43696

申请日：1996-02-14

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C311/59 ,  C07C327/40 ,  C07C335/42 ,  C07C311/54 ,  C07C303/36 ,  A61K31/17

Abstract: Substd. benzene sulphonyl urea and thiourea derivs. of formula (I) and their salts are new. R1 = H, Me or CF3; R2 = 4-10C alkoxy with 1-6C replaced by O, S or NH; Q = O or S; Y = ÄC(R3)2Üm; R3 = H, Me or Et; R' = H, halo or 1-6C alkyl; R" = halo, 1-4C alkoxy or 1-4C alkyl; and m = 1-4.

公开(公告)号：DE19505910A1

公开(公告)日：1996-08-22

申请号：DE19505910

申请日：1995-02-21

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  GOEGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: C07D331/02 ,  A61K31/18 ,  A61K31/38 ,  A61K31/64 ,  A61P9/00 ,  A61P9/02 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C327/46 ,  C07C335/42 ,  C07D203/08 ,  C07D295/00 ,  C07D303/48 ,  C07C311/57 ,  C07C303/36 ,  C07D303/46 ,  C07D203/12 ,  C07D295/08 ,  A61K31/495 ,  A61K31/535 ,  A61K31/445

Abstract: N-(3-substd. benzensulphonyl)-urea or -thiourea derivs. of formula (I) and their salts are new. R1 = H, 1-7C alkyl or 3-7C cycloalkyl; R2 = H, F, Cl, 1-6C alkyl, 1-6C alkoxy, 1-6C mercaptoalkyl, 3-6C cycloalkyl or CbH2b+1, in which one or more C can be replaced by Het; Het = heteroatoms, e.g. O, NH or S; b = 1-8; 1-8C alkyl in which 1-4C may be replaced by O, N or S; R3 = H, 1-12C alkyl, 3-10C cycloalkyl, 1-6C fluoroalkyl, 3-6C fluorocycloalkyl or CaH2a+1 in which 1-4C are replaced by Het; a = 1-10; R4 = aryl or as R3; or R3+R4 = CbH2b, in which one or more CH2 can be replaced by Het; R5 = as R4; R6 = as R4 but not 3-10C cycloalkyl; Q, X = O or S; Y = -(C(R7)2)c, O, S or NH; c = 1-4; R7 = H, 1-4C alkyl, F, Cl or Br.

公开(公告)号：DE19503136A1

公开(公告)日：1996-08-08

申请号：DE19503136

申请日：1995-02-01

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  HARTUNG JENS DR ,  CRAUSE PETER DR ,  MANIA DIETER DR ,  GOEGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/38 ,  A61K31/381 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  A61P43/00 ,  C07C335/00 ,  C07D333/34

Abstract: N-((2-Benzamidoethyl)- thiophene-sulphonyl)-urea or-thiourea derivs. of formula (I) are new. R1 = H, halogen, Me, Et, OMe, OEt, SMe, SEt, 1-2C fluoroalkyl or 1-2C fluoroalkoxy; X = O or S; R2 = H, Me or CF3; Y, Z = H, F, Cl, Br, I, Me, Et, OMe or OEt.

公开(公告)号：DE59202242D1

公开(公告)日：1995-06-22

申请号：DE59202242

申请日：1992-12-11

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  MANIA DIETER DR ,  KIBAT PAUL-GERHARD DR ,  GEHRING DORIS ,  PAULUS ERICH DR

IPC: A61K31/35 ,  A61K9/12 ,  A61K31/352 ,  A61K31/353 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/445 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08 ,  C07D207/12 ,  C07D311/68 ,  C07D311/74 ,  C07D405/04

Abstract: The invention relates to ethanol adducts of the compounds of the formula I I to a process for their preparation and to their use as inhalants in diseases, in particular in asthma.

公开(公告)号：DE58908228D1

公开(公告)日：1994-09-29

申请号：DE58908228

申请日：1989-07-14

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  KLAUS ERIK DR ,  MANIA DIETER DR ,  SCHOELKENS BERNWARD DR

IPC: C07D311/22 ,  A61K31/40 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61P11/00 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  C07D405/04 ,  C07D409/12 ,  C07D413/04 ,  C07D417/04

Abstract: The use of 3,4-dihydro-2H-benzo[b]pyrans of the formula I in which R is H, OH, (C1-C2)-alkoxy, (C1-C2)-alkyl or NR R , where R and R are identical or different and are H, (C1-C2)-alkyl or (C1-C3)-alkylcarbonyl, R and R are identical or different and are alkyl with 1-4 C atoms, Ar is an aromatic or heteroaromatic system which is unsubstituted or substituted by 1 to 3 identical or different radicals (C1-C2)-alkyl, (C1-C2)-alkoxy, halogen, trifluoromethyl, CN, NO2, CO-(C1-C2)-alkyl or SOm-(C1-C2)-alkyl with m = 1 or 2, n is 1 or 2, X is a chain (CH2)r which can be interrupted by a heteroatom O, S or NR where R is H or (C1-C4)-alkyl and r is the numbers 2, 3, 4 or 5, for the production of a medicament for urinary tract disorders.