公开(公告)号：BRPI0613693A2

公开(公告)日：2011-01-25

申请号：BRPI0613693

申请日：2006-06-16

Applicant: HOFFMANN LA ROCHE

Inventor： ALANINE ALEXANDER ,  GOBBI LUCA CLAUDIO ,  KOLCZEWSKI SABINE ,  LUEBBERS THOMAS ,  PETERS JENS-UWE ,  STEWARD LUCINDA

IPC: C07D239/84 ,  A61K31/517

Abstract: The present invention relates to compounds of formula wherein R1, R2, R3, and n are as described in the specification and pharmaceutically acceptable acid addition salts thereof. The compounds of formula I can be used for the treatment of 5-HT5A receptor antagonists related diseases, which include depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, disorders of eating behaviors, sexual dysfunction, sleep disorders, withdrawal from abuse of drugs, motor disorders such as Parkinson's disease, dementia in Parkinson's disease, neuroleptic-induced Parkinsonism and tardive dyskinesias, as well as other psychiatric disorders and gastrointestinal disorders such as irritable bowel syndrome.

公开(公告)号：ES2345724T3

公开(公告)日：2010-09-30

申请号：ES06777337

申请日：2006-06-16

Applicant: HOFFMANN LA ROCHE

Inventor： ALANINE ALEXANDER ,  GOBBI LUCA CLAUDIO ,  KOLCZEWSKI SABINE ,  LUEBBERS THOMAS ,  PETERS JENS-UWE ,  STEWARD LUCINDA

IPC: C07D239/84 ,  A61K31/517

Abstract: Compuestos de fórmula general **(Ver fórmula)** en los que R1 es hidrógeno, halógeno o alquilo inferior; R2 es alquilo inferior o cicloalquilo C3-C7; R3 es hidrógeno, alquilo inferior, alquilo inferior substituido con halógeno, cicloalquilo C3-C7 o es bencilo, opcionalmente substituido con halógeno; n es 0, 1 o 2; y sales por adición de ácidos farmacéuticamente aceptables de los mismos, siendo el alquilo inferior un alquilo C1-C7.

公开(公告)号：DE602006015193D1

公开(公告)日：2010-08-12

申请号：DE602006015193

申请日：2006-06-16

Applicant: HOFFMANN LA ROCHE

Inventor： ALANINE ALEXANDER ,  GOBBI LUCA CLAUDIO ,  KOLCZEWSKI SABINE ,  LUEBBERS THOMAS ,  PETERS JENS-UWE ,  STEWARD LUCINDA

IPC: C07D239/84 ,  A61K31/517

公开(公告)号：AT472538T

公开(公告)日：2010-07-15

申请号：AT06777337

申请日：2006-06-16

Applicant: HOFFMANN LA ROCHE

Inventor： ALANINE ALEXANDER ,  GOBBI LUCA CLAUDIO ,  KOLCZEWSKI SABINE ,  LUEBBERS THOMAS ,  PETERS JENS-UWE ,  STEWARD LUCINDA

IPC: C07D239/84 ,  A61K31/517

Abstract: The present invention relates to compounds of formula wherein R1, R2, R3, and n are as described in the specification and pharmaceutically acceptable acid addition salts thereof. The compounds of formula I can be used for the treatment of 5-HT5A receptor antagonists related diseases, which include depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, disorders of eating behaviors, sexual dysfunction, sleep disorders, withdrawal from abuse of drugs, motor disorders such as Parkinson's disease, dementia in Parkinson's disease, neuroleptic-induced Parkinsonism and tardive dyskinesias, as well as other psychiatric disorders and gastrointestinal disorders such as irritable bowel syndrome.

公开(公告)号：BRPI0608729A2

公开(公告)日：2010-01-26

申请号：BRPI0608729

申请日：2006-02-08

Applicant: HOFFMANN LA ROCHE

Inventor： ALANINE ALEXANDER ,  GOBBI LUCA CLAUDIO ,  KOLCZEWSKI SABINE ,  LUEBBERS THOMAS ,  PETERS JENS-UWE ,  STEWARD LUCINDA

IPC: A61K31/517 ,  C07D239/94

Abstract: The present invention relates to methods for treating 5-HT 5A receptor related diseases which comprises administering compounds of formula I wherein R 1 , R 2 , aryl, and n are defined in the specification and pharmaceutically acceptable acid addition salts thereof.

公开(公告)号：PL204215B1

公开(公告)日：2009-12-31

申请号：PL36138701

申请日：2001-08-20

Applicant: HOFFMANN LA ROCHE

Inventor： ALANINE ALEXANDER ,  BUETTELMANN BERND ,  FISCHER HOLGER ,  HEITZ NEIDHART MARIE-PAULE ,  HUWYLER JOERG ,  JAESCHKE GEORG ,  PINARD EMMANUEL ,  WYLER RENE

IPC: C07D211/42 ,  A61K31/445 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/675 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07F9/09 ,  C07F9/59

公开(公告)号：CA2434813C

公开(公告)日：2009-12-22

申请号：CA2434813

申请日：2002-01-21

Applicant: HOFFMANN LA ROCHE

Inventor： HEITZ NEIDHART MARIE-PAULE ,  JAESCHKE GEORG ,  BUETTELMANN BERND ,  WYLER RENE ,  PINARD EMMANUEL ,  ALANINE ALEXANDER

IPC: C07D233/54 ,  C07D233/64 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4725 ,  A61P25/00 ,  A61P25/04 ,  A61P25/14 ,  A61P25/16 ,  A61P25/24 ,  A61P25/28 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P43/00 ,  C07D233/61 ,  C07D233/84 ,  C07D233/88 ,  C07D249/08 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D521/00

Abstract: The invention related to compounds of the general formula (I), wherein the substituents are defined in claim 1. These compounds have a good affinity to the NMDA (N-methyl-D-aspartate)-receptor subtype selective blockers, which have a key function in modulating neuronal activity and plasticity which mak es them key players in mediating processes underlying development of CNS as wel l as learning and memory formation. These compounds are therefore suitable in the control or treatment of diseases, related to this receptor.

公开(公告)号：AT449082T

公开(公告)日：2009-12-15

申请号：AT06754806

申请日：2006-04-24

Applicant: HOFFMANN LA ROCHE

Inventor： ALANINE ALEXANDER ,  GOBBI LUCA CLAUDIO ,  KOLCZEWSKI SABINE ,  LUEBBERS THOMAS ,  PETERS JENS-UWE ,  STEWARD LUCINDA

IPC: C07D239/84 ,  A61K31/517 ,  A61P25/18 ,  A61P25/24 ,  C07D409/04 ,  C07D413/04

Abstract: The present invention relates to compounds of formula I wherein R, R1, R2, R3, R4, aryl, n, and m are as defined in the specification and pharmaceutically acceptable acid addition salts and tautomeric forms thereof. Such compounds have good activity on the 5-HT5A receptor. Therefore, the invention provides methods for the treatment of certain CNS disorders with such compounds.

公开(公告)号：DE60231477D1

公开(公告)日：2009-04-23

申请号：DE60231477

申请日：2002-01-21

Applicant: HOFFMANN LA ROCHE

Inventor： ALANINE ALEXANDER ,  BUETTELMANN BERND ,  HEITZ NEIDHART MARIE-PAULE ,  JAESCHKE GEORG ,  PINARD EMMANUEL ,  WYLER RENE

IPC: C07D233/54 ,  C07D233/64 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4725 ,  A61P25/00 ,  A61P25/04 ,  A61P25/14 ,  A61P25/16 ,  A61P25/24 ,  A61P25/28 ,  A61P31/04 ,  A61P31/12 ,  A61P43/00 ,  C07D233/61 ,  C07D233/84 ,  C07D233/88 ,  C07D249/08 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D521/00

Abstract: Novel imidazole derivatives are disclosed. These compounds have a good affinity to the NMDA (N-methyl-D-aspartate)-receptor subtype selective blockers, which have a key function in modulating neuronal activity and plasticity which makes them key players in mediating processes underlying development of CNS as well as learning and memory formation. These compounds are useful in the control or treatment of diseases mediated by this receptor.

公开(公告)号：PT1358165E

公开(公告)日：2009-04-22

申请号：PT02714095

申请日：2002-01-21

Applicant: HOFFMANN LA ROCHE

Inventor： ALANINE ALEXANDER ,  PINARD EMMANUEL ,  NEIDHART MARIE-PAULE HEITZ ,  BUETTELMANN BERND ,  WYLER RENE ,  JAESCHKE GEORG

IPC: C07D233/54 ,  C07D233/64 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4725 ,  A61P25/00 ,  A61P25/04 ,  A61P25/14 ,  A61P25/16 ,  A61P25/24 ,  A61P25/28 ,  A61P31/04 ,  A61P31/12 ,  A61P43/00 ,  C07D233/61 ,  C07D233/84 ,  C07D233/88 ,  C07D249/08 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D521/00