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    HYDROGEL POROGENS FOR FABRICATING BIODEGRADABLE SCAFFOLDS
    22.
    发明专利
    HYDROGEL POROGENS FOR FABRICATING BIODEGRADABLE SCAFFOLDS 未知

    公开(公告)号：CA2535857A1

    公开(公告)日：2005-03-10

    申请号：CA2535857

    申请日：2004-08-27

    Applicant: MAYO FOUNDATION

    Inventor： YASZEMSKI MICHAEL J ,  LU LICHUN ,  CURRIER BRADFORD L ,  JABBARI ESMAIEL

    IPC: C08J9/00 ,  A61F20060101 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  C08K5/00

    Abstract: Hydrogel microparticles with entrapped liquid are used as the porogen to reproducibly form interconnected pore networks in a porous scaffold. In one embodiment, a biodegradable unsaturated polymer, a crosslinking agent, and a porogen comprising biodegradable hydrogel microparticles are mixed together and allowed to form a porous scaffold in an mold or in a body cavity. Exampl e biodegradable unsaturated polymers include poly(propylene fumarate) and poly(.epsilon.-caprolactone-fumarate). The crosslinking agent may be a free radical initiator, or may include a free radical initiator and a monomer capable of addition polymerization. Example hydrogel microparticles include uncrosslinked or crosslinked collagen , an uncrosslinked or crosslinked collagen derivative, and an uncrosslinked or crosslinked synthetic biodegradable polymer such as oligo(poly(ethylene glycol) fumarate).

    Hydroxyapatite grafted fumarate based macromers for biodegradable composites
    23.
    发明专利
    Hydroxyapatite grafted fumarate based macromers for biodegradable composites 未知

    公开(公告)号：AU2004267349A1

    公开(公告)日：2005-03-03

    申请号：AU2004267349

    申请日：2004-06-29

    Applicant: MAYO FOUNDATION

    Inventor： CURRIER BRADFORF L ,  LU LICHUN ,  YASZEMSKI MICHAEL J ,  JABBARI ESMAIEL

    IPC: C08J5/12 ,  A61F2/00 ,  A61F2/02 ,  A61F2/28 ,  A61L27/42

    Abstract: A composition is disclosed which comprises (i) a macromer prepared by reacting an unsaturated diacid having a carbon-carbon double bond and a saturated diacid, and (ii) a bioactive ceramic grafted to the macromer. In one embodiment, the unsaturated diacid having a carbon-carbon double bond is fumaric acid, the saturated diacid is compatible with fumaric acid and poly(propylene fumarate) such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid and mixtures thereof, and the bioactive ceramic is hydroxyapatite. In another embodiment, hydroxyapatite is grafted with a biodegradable and crosslinkable macromer comprising silane units alternating with furnarate and adipate units.

    PHOTOCROSSLINKABLE POLY(CAPROLACTONE FUMARATE)
    25.
    发明申请
    PHOTOCROSSLINKABLE POLY(CAPROLACTONE FUMARATE) 审中-公开
    光触媒聚合物（CAPROLACTONE FUMARATE）

    公开(公告)号：WO2006053031A2

    公开(公告)日：2006-05-18

    申请号：PCT/US2005040571

    申请日：2005-11-10

    Applicant: MAYO FOUNDATION ,  WANG SHANGFENG ,  LU LICHUN ,  YASZEMSKI MICHAEL J

    Inventor： WANG SHANGFENG ,  LU LICHUN ,  YASZEMSKI MICHAEL J

    IPC: C08G65/42

    CPC classification number: C08G63/912 ,  A61L27/18 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  C08G63/08 ,  C08L67/06 ,  C08L67/04

    Abstract: Fumaric acid or a salt thereof, such as a fumaryl halide (e.g. fumaryl chloride), which contains unsaturated carbon-carbon double bonds that can be used for in situ crosslinking, is copolymerized with poly(caprolactone) diol in the presence of an alkali metal salt. The resulting photocrosslinkable biocompatible and bioresorbable poly(caprolactone fumarate) biomaterial is useful in the fabrication of injectable an in-situ hardening scaffolds for application in skeletal reconstruction.

    Abstract translation: 含有可用于原位交联的不饱和碳 - 碳双键的富马酸或其盐，例如富马酰卤（例如富马酰氯）与聚（己内酯）二醇在碱金属存在下共聚 盐。 所得到的可光交联的生物相容性和生物可吸收性聚（己内酯富马酸酯）生物材料可用于制造用于骨骼重建的可注射的原位硬化支架。

    HYDROGEL POROGENS FOR FABRICATING BIODEGRADABLE SCAFFOLDS
    26.
    发明申请
    HYDROGEL POROGENS FOR FABRICATING BIODEGRADABLE SCAFFOLDS 审中-公开
    用于制作生物可降解胶囊的HYDROGEL POROGENS

    公开(公告)号：WO2005020849A3

    公开(公告)日：2005-07-14

    申请号：PCT/US2004027926

    申请日：2004-08-27

    Applicant: MAYO FOUNDATION ,  JABBARI ESMAIEL ,  YASZEMSKI MICHAEL J ,  CURRIER BRADFORD L ,  LU LICHUN

    Inventor： JABBARI ESMAIEL ,  YASZEMSKI MICHAEL J ,  CURRIER BRADFORD L ,  LU LICHUN

    IPC: A61F20060101 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  C08J9/00 ,  C08K5/00

    CPC classification number: A61L27/56 ,  A61L27/48 ,  A61L27/58

    Abstract: Hydrogel microparticles with entrapped liquid are used as the porogen to reproducibly form interconnected pore networks in a porous scaffold. In one embodiment, a biodegradable unsaturated polymer, a crosslinking agent, and a porogen comprising biodegradable hydrogel microparticles are mixed together and allowed to form a porous scaffold in an mold or in a body cavity. Example biodegradable unsaturated polymers include poly(propylene fumarate) and poly(ϵ-caprolactone-fumarate). The crosslinking agent may be a free radical initiator, or may include a free radical initiator and a monomer capable of addition polymerization. Example hydrogel microparticles include uncrosslinked or crosslinked collagen , an uncrosslinked or crosslinked collagen derivative, and an uncrosslinked or crosslinked synthetic biodegradable polymer such as oligo(poly(ethylene glycol) fumarate).

    Abstract translation: 使用具有捕获液体的水凝胶微粒作为致孔剂，以在多孔支架中可再现形成互连的孔网络。 在一个实施方案中，将可生物降解的不饱和聚合物，交联剂和包含可生物降解的水凝胶微粒的致孔剂混合在一起并允许在模具或体腔中形成多孔支架。 可生物降解的不饱和聚合物的实例包括聚（丙烯酸富马酸酯）和聚（ε-己内酯 - 富马酸酯）。 交联剂可以是自由基引发剂，或者可以包括自由基引发剂和能够进行加成聚合的单体。 示例性水凝胶微粒包括未交联或交联的胶原蛋白，未交联或交联的胶原衍生物，以及未交联或交联的合成生物可降解聚合物，例如寡（聚（乙二醇）富马酸酯）。

    CHARGED OLIGO(POLY(ETHYLENE GLYCOL) FUMARATE) HYDROGELS FOR NERVE GROWTH
    29.
    发明申请
    CHARGED OLIGO(POLY(ETHYLENE GLYCOL) FUMARATE) HYDROGELS FOR NERVE GROWTH 审中-公开
    充气OLIGO（聚（乙二醇）FUMARATE）氢化物生长增强

    公开(公告)号：WO2008008288A3

    公开(公告)日：2008-11-20

    申请号：PCT/US2007015612

    申请日：2007-07-06

    Applicant: MAYO FOUNDATION ,  DADSENTAN MAHROKH ,  YASZEMSKI MICHAEL J ,  LU LICHUN

    Inventor： DADSENTAN MAHROKH ,  YASZEMSKI MICHAEL J ,  LU LICHUN

    IPC: A61F13/00

    CPC classification number: A61K35/30 ,  A61L27/18 ,  A61L27/52 ,  A61L27/56 ,  A61L2430/32 ,  C08L71/02

    Abstract: A biodegradable material for improving the regeneration of nerve cells is disclosed. The material includes a copolymer formed by reacting a first reactant selected from monomers, oligomers and polymers and a second charged reactant selected from charged monomers, charged oligomers and charged polymers. Nerve cells are contained within or attracted to the copolymer. The first reactant can be oligo(poly( ethylene glycol) fumarate). The charged reactant can be selected from unsaturated quaternary ammonium compounds. The material can include a photoinitiator such that the material is photocrosslinkable. The material can include a bioactive agent such as a nerve growth factor. In one form, the material is a hydrogel that can be injected as a fluid into a patient's body via minimally invasive arthroscopic techniques to form a scaffold for nerve tissue regeneration.

    Abstract translation: 公开了一种用于改善神经细胞再生的可生物降解材料。 该材料包括通过使选自单体，低聚物和聚合物的第一反应物和选自带电单体，带电荷的低聚物和带电聚合物的第二带电反应物反应形成的共聚物。 神经细胞被包含在共聚物内或被吸引到共聚物中。 第一反应物可以是寡（聚（乙二醇）富马酸盐）。 带电荷的反应物可以选自不饱和季铵化合物。 该材料可以包括光引发剂，使得该材料是光致交联的。 该材料可包括生物活性剂如神经生长因子。 在一种形式中，该材料是可以通过微创关节镜技术作为流体注入患者体内的水凝胶，以形成用于神经组织再生的支架。

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