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    BENZODIAZEPINE FORMULATION IN A POLYORTHOESTER CARRIER
    21.
    发明申请
    BENZODIAZEPINE FORMULATION IN A POLYORTHOESTER CARRIER 审中-公开
    多氯联苯载体中的苯二酚配方

    公开(公告)号：WO2009129519A2

    公开(公告)日：2009-10-22

    申请号：PCT/US2009041068

    申请日：2009-04-20

    Applicant: MEDTRONIC INC ,  HOBOT CHRISTOPHER M ,  BENZ MICHAEL E ,  HILDEBRAND KEITH R ,  PUDIL BRYANT J

    Inventor： HOBOT CHRISTOPHER M ,  BENZ MICHAEL E ,  HILDEBRAND KEITH R ,  PUDIL BRYANT J

    IPC: A61K47/34 ,  A61K31/197

    CPC classification number: A61K31/197 ,  A61K9/0024 ,  A61K47/34

    Abstract: Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of a benzodiazepine, such as midazolam, formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.

    Abstract translation: 提供长时间有效的疼痛治疗。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的苯二氮卓类，如咪达唑仑。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。

    POLYMERIZATION OF MULTIFUNCTIONAL AZIDES, AND POLYMERS THEREFROM
    23.
    发明申请
    POLYMERIZATION OF MULTIFUNCTIONAL AZIDES, AND POLYMERS THEREFROM 审中-公开
    多功能颗粒的聚合及其聚合物

    公开(公告)号：WO2008115694A3

    公开(公告)日：2010-06-03

    申请号：PCT/US2008055905

    申请日：2008-03-05

    Applicant: MEDTRONIC INC ,  BENZ MICHAEL E ,  MUNIE METASEBIA T ,  LUO LIAN L

    Inventor： BENZ MICHAEL E ,  MUNIE METASEBIA T ,  LUO LIAN L

    IPC: A61L27/14 ,  A61K31/4192

    CPC classification number: A61L27/14 ,  C07C247/04

    Abstract: Methods for preparing polymers from multifunctional azides and multifunctional azide-reactants are described in the present disclosure. Exemplary multifunctional azide-reactants include multifunctional alkynes and/or multifunctional a-phosphine esters. In certain embodiments, such polymers can be prepared in vivo. Such polymers can be useful in a wide variety of biomedical applications.

    Abstract translation: 在本公开中描述了从多官能叠氮化物和多官能叠氮化物 - 反应物制备聚合物的方法。 示例性的多官能叠氮化物反应物包括多官能炔和/或多官能α-膦酯。 在某些实施方案中，可以在体内制备这些聚合物。 这些聚合物可用于各种各样的生物医学应用。

    BUPIVACAINE FORMULATION IN A POLYORTHOESTER CARRIER
    26.
    发明申请
    BUPIVACAINE FORMULATION IN A POLYORTHOESTER CARRIER 审中-公开
    多聚体载体中的布洛沙因配方

    公开(公告)号：WO2009129531A3

    公开(公告)日：2009-12-10

    申请号：PCT/US2009041107

    申请日：2009-04-20

    Applicant: MEDTRONIC INC ,  HOBOT CHRISTOPHER M ,  BENZ MICHAEL E ,  HILDEBRAND KEITH R ,  PUDIL BRYANT J

    Inventor： HOBOT CHRISTOPHER M ,  BENZ MICHAEL E ,  HILDEBRAND KEITH R ,  PUDIL BRYANT J

    IPC: A61K9/16 ,  A61K31/445

    CPC classification number: A61K31/445 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/1641 ,  A61K9/1694 ,  A61K9/5031 ,  A61L31/16 ,  A61L2300/402 ,  A61L2300/602

    Abstract: Effective treatments of pain, such as chronic pelvic pain, for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of bupivacaine formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least thirty days, at least sixty days, at least one hundred days or at least one hundred and thirty-five days.

    Abstract translation: 提供有效的治疗疼痛，如慢性盆腔疼痛，延长时间。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的布比卡因。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施例中，浮雕可以是至少三十天，至少六十天，至少一百天或至少一百三十五天。

    BACLOFEN FORMULATION IN A POLYORTHOESTER CARRIER
    27.
    发明申请
    BACLOFEN FORMULATION IN A POLYORTHOESTER CARRIER 审中-公开
    口服制剂中多巴酚丁胺载体的制备

    公开(公告)号：WO2009129527A3

    公开(公告)日：2009-12-10

    申请号：PCT/US2009041098

    申请日：2009-04-20

    Applicant: MEDTRONIC INC ,  HOBOT CHRISTOPHER M ,  BENZ MICHAEL E ,  HILDEBRAND KEITH R ,  PUDIL BRYANT J

    Inventor： HOBOT CHRISTOPHER M ,  BENZ MICHAEL E ,  HILDEBRAND KEITH R ,  PUDIL BRYANT J

    IPC: A61K9/16 ,  A61K31/197

    CPC classification number: A61K31/197 ,  A61K9/0024 ,  A61K47/34

    Abstract: Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of baclofen formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least thirty days, at least sixty days, at least one hundred days or at least one hundred and thirty-five days.

    Abstract translation: 提供长时间有效的疼痛治疗。 治疗包括脊髓内施用一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的巴氯芬。 通过施用一个或多个药物贮存库，可以缓解由各种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，脊椎间盘突出症（即坐骨神经痛），导丝术，狭窄，背痛和关节疼痛，以及 与手术有关的疼痛。 在一些实施方案中，缓解剂可以是至少三十天，至少六十天，至少一百天或至少一百三十五天。

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