Abstract:
PROBLEM TO BE SOLVED: To acquire the clear image of small-diameter projection part and to improve an analysis accuracy without using a complicated dyeing method. SOLUTION: The apparatus 1 for automatic cell analysis is equipped with an imaging device 4 for imaging fluorescence emitted from cells S and acquiring cell images, an exposure change means 5 for changing exposure conditions in the acquisition of cell images by the imaging device 4 and a treatment means 5 for analyzing the cells S on the basis of each of a plurality of acquired cell images under the changed exposure conditions. COPYRIGHT: (C)2008,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide a method for analyzing cells by which the throughput of the analysis is improved by shortening an imaging time, and a management cost of data can be reduced by reducing the amount of the data. SOLUTION: The method for analyzing the cells by taking the image of a cell group, recognizing each of the cells by recognizing a first component in each cell by using the taken image, and evaluating characteristic amounts of components except the first component by the cell includes the step of labeling the first component with a first dye, the step of labeling the components except the first component with a second dye, the step of simultaneously taking the image of the first component and the components except the first component by changing the brightness level of the light from a first dye from the brightness level of the light from the second dye in a degree of enabling a threshold value to be set, the step of recognizing the first component and the components except the first component from the obtained image via the brightness threshold value, and the evaluation step of evaluating by the cell the characteristic amounts of the components except the first component by evaluating the characteristics of the light from the second dye in the region of the components except the first component in the obtained image. COPYRIGHT: (C)2011,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide an image pickup device for certainly extracting a target signal from all of imaging target regions at a high speed to perform detailed analysis, not becoming large-scale and for being reduced in cost, and a cell image analyzing system equipped with the same. SOLUTION: The electron multiplying gain of a cooling CCD camera 4 is made high, the resolving power of the cooling CCD camera is made low and the exposure time of a light source 3 is made short with respect to all of the imaging target regions in a container 1 to perform imaging in a high throughput mode and the target signal is extracted from an image group picked up in the high throughput mode on the basis of a predetermined extraction condition. Subsequently, the electron multiplying gain of the cooling CCD camera is made low, the resolving power of the cooling CCD camera is made high and the exposure time of the light source is made long only with respect to the imaging target regions corresponding to the region where the target signal in the image, wherein the target signal is extracted in the container, to perform imaging in a highly detailed mode. COPYRIGHT: (C)2010,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide a box type microscopic apparatus capable of easily placing a sample container at an optimum position without adjusting the position of the sample container on a stage when changing the sample container with inexpensive and simple constitution, and easily and rapidly changing the sample container. SOLUTION: The box type microscopic apparatus which includes the stage 12, a microscope and a housing 20, and where the housing 20 is equipped with a fixed housing 21 and a movable housing 22 capable of moving to be openable/closable relative to the fixed housing 21 includes: a sample container positioning means 50 fixing the sample container 40 placed on the stage 12 at the fixed position on the stage 12; and a positioning release means 60 for actuating the sample container positioning means 50 when the movable housing 22 moves in a closing direction, and releases the positioning of the sample container 40 relative to the stage 12 by the sample container positioning means 50 when the movable housing 22 is opened. COPYRIGHT: (C)2009,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide an automatic focusing device where, in the acquisition of the image of a cell, a focal position is correctly set to a cell having high activity without adjusting the focus on a dead cell. SOLUTION: The automatic focusing device 8 used for a microscope 1 where fluorescence emitted from a cell is imaged to acquire a cell image, is provided with: a setting means 5 for setting a luminance range showing the presence region of a living cell on the basis of the luminance distribution of the acquired cell image; and a focusing detection means 5 for detecting the focal position on the basis of luminance of the image of the nuclei of the cell in the luminance range set by the setting means 5. COPYRIGHT: (C)2008,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To carry out the screening of medicines in high accuracy by using a proper morphological character. SOLUTION: The screening method comprises the analysis of cell images photographed by a microscope, the evaluation of the parameterized value of the deviation of the contour of the cell from circles C I and C O as a morphological character representing the morphological character of each cell in the cell images and the screening of medicines based on the evaluation. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation:要解决的问题:通过适当的形态特征,高精度地进行药物筛选。 解决方案:筛选方法包括通过显微镜拍摄的细胞图像的分析,细胞轮廓偏离参数值的评估圆圈C I SB>和C O SB>作为代表细胞图像中的每个细胞的形态特征和基于评估的药物筛选的形态特征。 版权所有(C)2007,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide a cell image analyzer capable of precisely extracting the total number of cells or the characteristic quantity of an individual cell. SOLUTION: The cell image analyzer is equipped with a cell image acquiring means 55 for imaging a plurality of cells developed in color by different dyes under different conditions to acquire a plurality of images and an image analyzing means 80 for extracting predetermined element contained in the respective cells in a plurality of images. COPYRIGHT: (C)2005,JPO&NCIPI
Abstract:
PROBLEM TO BE SOLVED: To reduce the size and production costs of an optical microscope blocking light or maintaining the specimen environment. SOLUTION: The provided optical microscope apparatus 1 includes: a microscope 2 that has a stage 4 for mounting a specimen A, a transmission-illumination optical system 6, and an image-forming optical system 7; and a housing 3 that surrounds the microscope 2, wherein the housing 3 includes a fixed housing 24, and a movable housing 25. Among optical parts constituting the transmission-illumination optical system 6 and the image-forming optical system 7, at least some optical parts disposed above the stage 4 are movable, and a switching mechanism is provided which is configured to retract the optical parts away from above the stage 4 when the movable housing 25 is disposed in an open position relative to the fixed housing 24, and to substantially align the optical axes of both optical systems when the movable housing 25 is disposed in a closed position relative to the fixed housing 24. COPYRIGHT: (C)2011,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide an optical microscope that prevents entry of excitation light, harmful to the eyes of an operator, by an optical attenuation member, that allows the operator to confirm the position of a dispensing burette and to perform safe manual dispensing, and allows the operator, regardless of whether he or she is right- or left-handed, to carry out manual dispensing by area provided on the side of the optical attenuation member, thereby facilitating dispensing. SOLUTION: The optical microscope includes: a housing for shielding light or maintaining environment for a specimen; and a door 4 that is provided in the housing 1 and can be opened and closed for allowing the operator to perform manual dispensing on a specimen container enclosing a living-organism sample, which is an observation subject. In the optical microscope, a part of an aperture 2 defined when the door is opened is covered by the optical attenuation member 4 that shields light of a specific wavelength. COPYRIGHT: (C)2010,JPO&INPIT