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    FLUORESCENT PHOTOMETRIC APPARATUS
    6.
    发明公开
    FLUORESCENT PHOTOMETRIC APPARATUS 审中-公开
    光电子荧光灯

    公开(公告)号：EP1760454A4

    公开(公告)日：2008-09-03

    申请号：EP05750917

    申请日：2005-06-20

    Applicant: OLYMPUS CORP

    Inventor： SHIMADA YOSHIHIRO

    IPC: G01N21/64

    CPC classification number: G01N21/6456 ,  G01N2021/6419 ,  G01N2021/6421

    Abstract: A fluorescent photometric device at least having light sources (301, 302, 303), light irradiation means for collecting and irradiating light from the light sources on to a sample (1) through an objective lens (103), and photodetectors (306a, 306b) for detecting fluorescence emitted from the sample. The fluorescent photometric device further has illumination means (104, 105) for obtaining an image of the sample, position adjustment means (102) for adjusting relative positions of the sample and a light spot position at which light is collected by the light irradiation means, and imaging means (400, 800) for simultaneously imaging, as two-dimensional and three-dimensional images, the image of the sample and a light spot image coming from the light irradiation means and collected on the sample.

    Microscope
    7.
    发明专利
    Microscope 有权
    显微镜

    公开(公告)号：JP2012118553A

    公开(公告)日：2012-06-21

    申请号：JP2012006789

    申请日：2012-01-17

    Applicant: Olympus Corp ,  オリンパス株式会社

    Inventor： SHIMADA MASAKAZU ,  SHIMADA YOSHIHIRO ,  KITAGAWA HISAO

    IPC: G02B21/00 ,  G02B7/28 ,  G02B7/36

    Abstract: PROBLEM TO BE SOLVED: To provide a microscope capable of keeping a focal point even when corrected aberration in an objective lens.SOLUTION: A microscope comprises: a stage 502 to mount a sample thereon; an objective lens 506 with an aberration correction function, having an aberration correction lens to correct a thickness error of a sample holding member 503A and opposing to the stage 502; electrically-driven traveling means 509 to travel the aberration correction lens; light detection means 535 to detect light entered into a light receiving surface; a detection optical system 534 to guide light passed through the objective lens 506 with an aberration correction function to the light receiving surface of the light detection means 535; electrically-driven focusing means 501 to vary a distance between the stage 502 and the objective lens 506 with an aberration correction function; an observation optical system 533 to transmit light from the sample passed through the objective lens 506 with an aberration correction function and convert the light into an observation image of the sample; and processing means 540 to obtain contrast of the image of the sample at the light receiving surface, repeatedly control the electrically-driven traveling means 509 and the electrically-driven focusing means 501, focus the observation image, and correct the aberration of the observation image.

    Abstract translation: 要解决的问题：提供即使在物镜中的校正像差时也能够保持焦点的显微镜。 解决方案：显微镜包括：在其上安装样品的载物台502; 具有像差校正功能的物镜506，具有用于校正样品保持部件503A的厚度误差并与台架502相对的像差校正透镜; 驱动像差校正透镜的电驱动行进装置509; 光检测装置535，用于检测进入光接收表面的光; 检测光学系统534，其将具有像差校正功能的光通过物镜506引导到光检测装置535的光接收表面; 电驱动聚焦装置501，用像差校正功能来改变舞台502与物镜506之间的距离; 观察光学系统533，其通过像差校正功能透过来自物镜506的样品的光，并将光转换成样品的观察图像; 以及处理装置540，以获得在光接收表面处的样品的图像的对比度，重复地控制电驱动行进装置509和电驱动聚焦装置501，聚焦观察图像，并校正观察图像的像差 。 版权所有（C）2012，JPO＆INPIT

    Total reflection type microscope
    8.
    发明专利
    Total reflection type microscope 有权
    总反射型微型显微镜

    公开(公告)号：JP2012003284A

    公开(公告)日：2012-01-05

    申请号：JP2011203731

    申请日：2011-09-16

    Applicant: Olympus Corp ,  オリンパス株式会社

    Inventor： SHIMADA YOSHIHIRO

    IPC: G02B21/00 ,  G01N21/64

    Abstract: PROBLEM TO BE SOLVED: To provide a laser microscope which permits selective use of both functions of a scanning type and a total reflection type.SOLUTION: A scanning type laser microscope 2 has irradiation means which irradiates the top of a sample 38 with a beam emitted from a light source 4 through an objective lens 34 and generates fluorescence from the sample 38. Furthermore, the microscope as a total reflection type microscope includes, in addition to the above-described constitution, a lens 10 which condenses the beam to a position conjugate with a pupil position of the objective lens 34, and a parallel flat plate 12, which makes the beam incident on a position offset at a predetermined distance parallel to the beam and offset from the center of the objective lens 34, makes the beam be refracted by the objective lens 34 to make the beam incident obliquely on the sample 38, and makes the beam total reflect at a boundary between a cover glass 36 and the sample 38, and has an inserting/removing device 8 which inserts each of the condenser lens 10 and the parallel flat plate 12 into the irradiation means by the device capable of inserting/removing the same, and holding means which holds a laser scanning device 16 at a predetermined angle.

    Abstract translation: 要解决的问题：提供一种激光显微镜，其允许选择性地使用扫描型和全反射型的两种功能。 解决方案：扫描型激光显微镜2具有照射装置，其通过物镜34从光源4发射的光束照射样品38的顶部，并从样品38产生荧光。此外，显微镜作为 全反射型显微镜除了上述结构之外还包括将光束聚光到与物镜34的光瞳位置共轭的位置的透镜10和平行的平板12，其使光束入射到 在平行于光束并且偏离物镜34的中心的预定距离处的位置偏移使得光束被物镜34折射以使光束倾斜地入射到样品38上，并使光束全反射到 盖玻璃36和样品38之间的边界，并且具有插入/移除装置8，其通过装置盖将每个聚光透镜10和平行平板12插入到照射装置中 以及将激光扫描装置16保持在规定角度的保持机构。 版权所有（C）2012，JPO＆INPIT

    Image analyzing method for fish cell, image analyzing system for fish cell and image analyzing apparatus for fish cell
    9.
    发明专利
    Image analyzing method for fish cell, image analyzing system for fish cell and image analyzing apparatus for fish cell 有权
    FISH细胞的图像分析方法，FISH细胞的图像分析系统和FISH细胞的图像分析装置

    公开(公告)号：JP2011030492A

    公开(公告)日：2011-02-17

    申请号：JP2009179592

    申请日：2009-07-31

    Applicant: Olympus Corp ,  オリンパス株式会社

    Inventor： MATSUO YUICHIRO ,  TAKAGI KOSUKE ,  AMAKAWA GENTA ,  SHIMADA YOSHIHIRO

    IPC: C12Q1/68 ,  C12M1/34 ,  G01N21/78

    Abstract: PROBLEM TO BE SOLVED: To provide an image analyzing method for FISH cell, system and apparatus to accurately detect target fluorescent spots unaffected by three-dimensional configuration of fluorescent spots in a cell nucleus, light emission by foreign matter, etc., out of the cell, confusion of fluorescent wavelength, etc.
    SOLUTION: The image analyzing apparatus includes an image-pickup device 1 to pick up a plurality of cell images including a first fluorescent reporter molecule to report a cell segment and second and third fluorescent reporter molecules reporting first and second gene sequences, and an image analyzing device 2 having a computer. The image-pickup device takes a plurality of images of a plurality of cells by varying a Z direction, and the image analyzing device has a software to function the computer as a means 2a to construct a three-dimensional cell segment from the images, a means 2b to discriminate inside and outside of the three-dimensional cell segment, a means 2c to recognize a fluorescent signal from the second and third fluorescent reporter molecules in the three-dimensional cell segment, and a means 2d to determine the characteristic value of the recognized fluorescent signal.
    COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：为了提供一种FISH细胞，系统和装置的图像分析方法，用于准确地检测不受细胞核中的荧光斑点的三维构型，异物发光等的影响的目标荧光斑点， 出现细胞，荧光波长混淆等。解决方案：图像分析装置包括摄像装置1，用于拾取包括第一荧光报告分子的多个细胞图像以报告细胞片段和第二和 报告第一和第二基因序列的第三荧光报道分子，以及具有计算机的图像分析装置2。 图像拾取装置通过改变Z方向来获取多个单元的多个图像，并且图像分析装置具有使计算机功能化的软件作为从图像构建三维单元格段的装置2a， 用于区分三维细胞片段的内部和外部的装置2b，用于识别来自三维细胞片段中的第二和第三荧光报道分子的荧光信号的装置2c和用于确定三维细胞片段的特征值的装置 识别荧光信号。 版权所有（C）2011，JPO＆INPIT

    Optical microscope
    10.
    发明专利
    Optical microscope 审中-公开
    光学显微镜

    公开(公告)号：JP2011008188A

    公开(公告)日：2011-01-13

    申请号：JP2009154024

    申请日：2009-06-29

    Applicant: Olympus Corp ,  オリンパス株式会社

    Inventor： TSUTSUI AKIRA ,  SHIMADA YOSHIHIRO

    IPC: G02B21/06

    Abstract: PROBLEM TO BE SOLVED: To provide an optical microscope capable of performing observation by proper focal illumination by relatively rotating a sample and focal illumination with respect to the vertical axis of the sample, while being made to correspond to the shape of the sample, thereby performing irradiation, without intercepting the focal illumination by the sample.SOLUTION: The optical microscope includes a stage 2 holding the sample 3 and a transmission illumination optical system 4 illuminating the sample 3. The transmission illumination optical system 4 includes a light shielding means 43 asymmetrically intercepting a luminous flux from a light source 1, to perform illumination and the light shielding means 43 is configured so as to relatively rotate around an optical axis with respect to the stage 2.

    Abstract translation: 要解决的问题：提供一种光学显微镜，其能够通过相对于样品的垂直轴相对旋转样品和聚焦照明而通过适当的聚焦照明进行观察，同时使其对应于样品的形状，由此执行 照射，而不会拦截样品的焦点照明。解决方案：光学显微镜包括保持样品3的载物台2和照射样品3的透射照明光学系统4.透射照明光学系统4包括遮光装置43，其不对称地截断 来自光源1的光束，以进行照明，并且遮光装置43被构造为相对于舞台2围绕光轴相对旋转。

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