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公开(公告)号：WO2004020668A3
公开(公告)日：2004-06-17
申请号：PCT/JP0310591
申请日：2003-08-21
Applicant: ONCOTHERAPY SCIENCE INC , JAPAN GOVERNMENT , NAKAMURA YUSUKE , KATAGIRI TOYOMASA
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA
IPC: C07K16/30 , C12Q1/68 , A61K31/7088 , A61K39/395 , C07K16/28 , C12N15/11
CPC classification number: C07K16/30 , C07K2317/34 , C07K2317/732 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136
Abstract: Methods of detecting synovial sarcoma using differentially expressed genes are disclosed. Also disclosed are methods of identifying agents for treating synovial sarcoma. Further, a method for treating or preventing a disease that is associated with Frizzled homologue 10 (FZD10) in a subject, comprising administering to the subject an effective amount of an antibody against FZD10 protein or a fragment thereof is provided.
Abstract translation: 公开了使用差异表达基因检测滑膜肉瘤的方法。 还公开了鉴定用于治疗滑膜肉瘤的药剂的方法。 此外，提供了用于治疗或预防受试者中与卷曲蛋白同系物10（FZD10）相关的疾病的方法，其包括向受试者施用有效量的抗FZD10蛋白或其片段的抗体。
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公开(公告)号：SG11202000424VA
公开(公告)日：2020-02-27
申请号：SG11202000424V
申请日：2018-07-18
Applicant: UNIV TOKUSHIMA , ONCOTHERAPY SCIENCE INC
Inventor： KATAGIRI TOYOMASA , YOSHIMARU TETSURO , MIYAMOTO TAKASHI , OKAMOTO YASUHIDE
Abstract: The present invention provides peptides having a structure in which portions of a dominant-negative peptide of BIG3 which inhibits the interaction between BIG3 and PHB2 are replaced by at least two stapling structures. The peptides of the present invention have excellent cell growth inhibiting activity. The cell growth inhibiting activity lasts longer, compared to a single-stapled peptide. Therefore, the peptides of the present invention have a feature suitable for clinical applications in cancer therapy.
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公开(公告)号：AU2018302855A1
公开(公告)日：2020-02-06
申请号：AU2018302855
申请日：2018-07-18
Applicant: ONCOTHERAPY SCIENCE INC , UNIV TOKUSHIMA
Inventor： KATAGIRI TOYOMASA , YOSHIMARU TETSURO , MIYAMOTO TAKASHI , OKAMOTO YASUHIDE
Abstract: The present invention provides a peptide having a structure in which a portion of a dominant-negative peptide of BIG3 which inhibits interaction between BIG3 and PHB2, is replaced by at least two stapling structures. The peptide according to the present invention has excellent cell growth inhibiting activity. The cell growth inhibiting activity is sustained for a long period of time, compared to a single-stapled peptide. Therefore, the peptide according to the present invention has a feature suitable for clinical applications in cancer therapy.
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公开(公告)号：BRPI0716498A2
公开(公告)日：2015-01-27
申请号：BRPI0716498
申请日：2007-08-10
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
Abstract: The present application provides novel human genes A7322, whose expression is markedly elevated in breast cancer. The present application also provides human genes F3374 whose expression is markedly elevated in breast cancer. These genes and polypeptides encoded thereby can be used, for example, in the diagnosis of breast cancer, and as targets molecules for developing drugs against breast cancer. The invention features methods of screening for modulators of the kinase activity of PBK/TOPK. The invention further provides methods of screening for agents to prevent or treat cancer, such as breast cancer.
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公开(公告)号：ES2405618T3
公开(公告)日：2013-05-31
申请号：ES06783136
申请日：2006-08-24
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI , ENDO KEIGO , KUHARA MOTOKI , YAGI KASUMI
IPC: C07K16/30 , A61K39/395
Abstract: Un anticuerpo quimérico o humanizado o fragmento del mismo que se une a la proteína FZD10 y en el quelas regiones determinantes de complementariedad (CDR) y las CDR del anticuerpo monoclonal de ratón 92-13(FERM BP-10628).
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Patent Agency Ranking
公开(公告)号：AT557277T
公开(公告)日：2012-05-15
申请号：AT04773337
申请日：2004-09-14
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA
IPC: G01N33/68 , G01N33/574
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公开(公告)号：BRPI0621800A2
公开(公告)日：2011-12-20
申请号：BRPI0621800
申请日：2006-08-24
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI , ENDO KEIGO
IPC: C07K16/30 , A61K39/395
Abstract: The present invention relates to an antibody or a fragment thereof which is capable of binding to a Frizzled homologue 10 (FZD10) protein, such as a mouse monoclonal antibody, a chimeric antibody and a humanized antibody. Also, the present invention relates to a method for treating and/or preventing FZD10-associated disease; a method for diagnosis or prognosis of FZD10-associated disease; and a method for in vivo imaging of FZD10 in a subject.
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公开(公告)号：ES2365732T3
公开(公告)日：2011-10-10
申请号：ES04773526
申请日：2004-09-24
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
IPC: C12Q1/68 , C07K14/47 , C12N9/10 , G01N33/574
Abstract: Un procedimiento in vivo de diagnóstico de carcinoma ductal invasivo (IDC) o una predisposición para desarrollar IDC en un sujeto, que comprende determinar un nivel de expresión de un gen asociado al cáncer de mama en una muestra biológica derivada de un paciente, en el que un aumento en dicho nivel de expresión de la muestra en comparación con un nivel de control normal de dicho gen indica que dicho sujeto padece o está en riesgo de desarrollar IDC, en el que dicho gen asociado al cáncer de mama es BRC nº 456.
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公开(公告)号：DE602006021315D1
公开(公告)日：2011-05-26
申请号：DE602006021315
申请日：2006-07-26
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
IPC: C12N15/113 , C12Q1/68
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公开(公告)号：DE60321356D1
公开(公告)日：2008-07-10
申请号：DE60321356
申请日：2003-08-12
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA
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