公开(公告)号：AU2012283775A8

公开(公告)日：2014-02-20

申请号：AU2012283775

申请日：2012-07-13

Applicant: PHARMACYCLICS INC ,  WANG LONGCHENG

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  WANG LONGCHENG

IPC: C07D473/32 ,  A61K31/433 ,  A61K31/52 ,  A61P17/00 ,  A61P29/00 ,  C07D473/34

Abstract: Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase.

公开(公告)号：CA2863140A1

公开(公告)日：2013-08-08

申请号：CA2863140

申请日：2013-01-30

Applicant: PHARMACYCLICS INC

Inventor： YAN SHUNQI ,  WANG LONGCHENG ,  FRYE LEAH LYNN ,  CHEN WEI ,  LOURY DAVID J

IPC: C07D473/32 ,  A61K31/52 ,  A61P35/00 ,  A61P37/00

Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.