公开(公告)号：WO2007127286A3

公开(公告)日：2007-11-08

申请号：PCT/US2007/010100

申请日：2007-04-24

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: B65D83/06

Abstract: A device and related method are provided for lyophiliziπg a substance within the device and storing the lyophilized substance. The device is penetrable by a needle for filling the device with the substance to be lyophilized, and a resulting needle hole in the device is laser resealable by transmitting thereon laser radiation from a laser source. The device defines a chamber for receiving therein the substance to be lyophilized. A needle penetrable and laser resealable portion of the device is pierceable with a needle to form a needle aperture therethrough to fill the chamber with the substance to be lyophilized through the needle, and is laser resealable to hermetically seal the needle aperture by applying laser radiation thereto.

公开(公告)号：WO2007120719A3

公开(公告)日：2007-10-25

申请号：PCT/US2007/008961

申请日：2007-04-10

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: B65B1/04

Abstract: A container is provided for storing a product, such as a fat containing liquid product, and includes a body defining a chamber for receiving the product; and a container closure including a sealing portion for sealing the product within the chamber. The container closure includes a member forming a substantially fluid-tight seal between the container closure and the body; a nipple in fluid communication with the chamber that seals the chamber with respect to the ambient atmosphere during storage of the product in the chamber and that can be opened to dispense product from the chamber therethrough; and a needle penetrable and laser resealable portion that is penetrable by the needle for aseptically filling the chamber with the product, and that is thermally resealable by the application of laser radiation thereto to seal the product within the chamber.

公开(公告)号：WO2005072427A3

公开(公告)日：2005-08-11

申请号：PCT/US2005/003035

申请日：2005-01-27

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: B67D5/40

Abstract: A dispenser has a housing, and a variable-volume storage chamber formed within the housing and defining a substantially fluid-tight seal between the chamber and exterior of the housing for storing a substance to be dispensed. A piston is mounted within the housing, and a one-way valve is mounted within the housing and coupled in fluid communication with the variable-volume storage chamber. A compression chamber is coupled in fluid communication between the piston and one-way valve, and at least one of the piston and valve is manually depressible relative to the other between (i) a first position in which the piston is located at least partially outside of the compression chamber for permitting substance to flow from the variable-volume storage chamber into the compression chamber, and (ii) a second position in which the piston is located at least partially within the compression chamber for pressurizing substance within the compression chamber aboye a valve opening pressuring and, in turn, dispensing substance through the one-way valve and out of the dispenser.

公开(公告)号：WO2004096113A2

公开(公告)日：2004-11-11

申请号：PCT/US2004/012985

申请日：2004-04-28

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: A61J

CPC classification number: B65B55/08 ,  A61J1/1425 ,  A61J1/1431 ,  A61J1/1468 ,  A61J1/1481 ,  A61J1/1487 ,  A61J1/18 ,  A61J1/2037 ,  A61J1/2041 ,  A61J1/2055 ,  A61J1/2096 ,  A61M2207/00 ,  B65B3/003 ,  B65D47/248

Abstract: A vial has a body defining a chamber for receiving a substance therein; and a valve assembly coupled in fluid communication with the chamber and defining (i) an open position permitting at least one of (a) passage of the substance through the valve assembly and into the chamber for storing the substance in the chamber, and (b) passage of the substance out of the chamber for dispensing the substance therefrom; and (ii) a closed position forming a fluid-tight seal between the chamber and exterior of the container. A filling member engages a flexible valve member of the valve assembly to move the valve member between the closed and open positions to fill and seal the vial, respectively. A syringe is connectable to the vial. The valve assembly opens upon connecting the syringe to the vial to allow the substance within the vial to be withdrawn from the vial and into the syringe by actuating a plunger of the syringe, and the valve assembly closes upon disconnecting the vial and syringe to hermetically seal and store the substance remaining in the syringe for later use.

Abstract translation: 小瓶具有限定用于在其中接收物质的室的主体; 以及阀组件，其与所述腔室流体连通地联接并且限定（i）允许所述物质通过所述阀组件并进入所述腔室中的至少一个的打开位置，以将所述物质存储在所述腔室中，并且（b ）物质从室中通过以从其中分配物质; 和（ii）在容器和容器的外部之间形成流体密封的封闭位置。 填充构件接合阀组件的柔性阀构件以在闭合位置和打开位置之间移动阀构件以分别填充和密封小瓶。 注射器可连接到小瓶。 在将注射器连接到小瓶上时，阀组件打开，以通过致动注射器的柱塞来使小瓶内的物质从小瓶中取出并进入注射器，并且在断开小瓶和注射器之后阀组件关闭以气密密封 并将剩余的物质储存在注射器中以备后用。

公开(公告)号：WO2004037708A3

公开(公告)日：2004-05-06

申请号：PCT/US2003/033503

申请日：2003-10-21

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel ,  ASSION, Norbert, M. ,  CHAN, Julian, V. ,  TING, Joseph, M.

Inventor： PY, Daniel ,  ASSION, Norbert, M. ,  CHAN, Julian, V. ,  TING, Joseph, M.

IPC: B65D35/56

Abstract: An ophthalmic dispenser has a rigid housing defining a fluid-receiving chamber, a flexible bladder receivable within the fluid-receiving chamber, a pump coupled in fluid communication with the fluid-receiving chamber, and a nozzle having a valve defining an annular, axially­ extending valve seat, an outlet aperture coupled in fluid communication between the valve seat and the pump, and a flexible valve cover extending about the valve seat and forming an annular, axially-extending interface therebetween. The valve interface is connectable in fluid communication with the outlet aperture, and at least part of the valve cover is movable between (i) a normally closed position with the valve cover engaging the valve seat to close the interface and form a fluid-tight seal therebetween, and (ii) an open position with at least part of the valve cover spaced away from the valve seat in response to pumped fluid flowing through the outlet aperture at a pressure greater than a valve opening pressure to allow the passage of pressurized fluid therebetween. A spring is drivingly connected to the housing and moves at least one of the pump and housing relative to the other to actuate the pump. The rigid housing is mountable within a cartridge which, in turn, is mountable within a dispenser housing including an eyelid depressor and a trigger for simultaneously actuating the eyelid depressor and pump.

公开(公告)号：WO2003033363A1

公开(公告)日：2003-04-24

申请号：PCT/US2002/032935

申请日：2002-10-16

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel ,  ASSION, Norbert ,  CHAN, Julian, V.

Inventor： PY, Daniel ,  ASSION, Norbert ,  CHAN, Julian, V.

IPC: B65D5/22

CPC classification number: B65D47/2031 ,  A45D40/26 ,  A61M5/31586 ,  A61M5/31595 ,  A61M5/50 ,  A61M5/502 ,  B65D35/06 ,  B65D35/08 ,  B65D35/38 ,  B65D35/44 ,  G01F11/027

Abstract: A syringe (10) is provided for the delivery of controlled, metered amounts of any of numerous different substances to humans or animals, such as medicaments, pharmaceuticals, cosmetics, and food products, or to deliver materials which may react upon exposure to air, such as glue. The syringe (10) includes a body (12) and a plunger (14). Means (34, 48) are provided in the syringe body (12) and the plunger (14) to effect controlled movement of the plunger (14) into the syringe (10) to permit delivery of a pre-detemined amount of the substance contained in the syringe (10) . A one-way valve (54) is provided at the dispensing tip (16) of the syringe (10) to hermetically seal the portion of the syringe (10) containing the subtance to be dispensed.

Abstract translation: 提供注射器（10），用于向人或动物（例如药物，药物，化妆品和食品）递送受控量的计量量的许多不同物质，或者输送在暴露于空气中可能反应的材料， 如胶水。 注射器（10）包括主体（12）和柱塞（14）。 装置（34,48）设置在注射器主体（12）和柱塞（14）中以实现柱塞（14）进入注射器（10）的受控运动，以允许递送预定量的所含物质 在注射器（10）中。 单向阀（54）设置在注射器（10）的分配尖端（16）处，以密封包含要分配的突出物的注射器（10）的部分。

公开(公告)号：WO2003028785A2

公开(公告)日：2003-04-10

申请号：PCT/US2002/031834

申请日：2002-10-03

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: A61M

CPC classification number: A61M5/3129 ,  A61J1/2041 ,  A61J1/2044 ,  A61J1/2055 ,  A61J1/2093 ,  A61M5/1782 ,  A61M5/284 ,  A61M2005/3123

Abstract: A syringe and a reconstitution syringe are provided for the delivery of controlled doses of any of numerous different sterile substances, such as vaccines, medicaments, pharmaceutical preparations, cosmetics, and food products. A plunger of the syringe defines a resealable stopper frictionally and slidably received within a hollow syringe body for dispensing the medicament or other substance through a dispensing tip of the syringe upon movement of the plunger. The resealable stopper defines a heat-sealable portion to allow the stopper to be penetrated by a needle or other filling device to fill the syringe with a medicament or other substance, and in turn allow the hole remaining upon withdrawal of the needle to be heat sealed by transmission of laser energy thereon. The plunger assembly further defines a plurality of cam-like members that each engage and cooperate with a respective helical path of steps formed on the inner wall of the syringe body to provide stepwise movement of the plunger and, in turn, precise metering of the substance dispensed therefrom. A reconstitution syringe defines within a syringe body plural compartments, wherein each compartment stores a respective component of a multi-component medicament or other preparation. An elastomeric plug is coupled to the plunger and connected between the two compartments to prevent intermixing of the components. Upon moving the plunger, the plug is released to thereby place the compartments in fluid communication with each other, and to facilitate intermixing of the components upon shaking the syringe.

Abstract translation: 提供注射器和重组注射器用于递送受控剂量的许多不同的无菌物质，例如疫苗，药物，药物制剂，化妆品和食品中的任何一种。 注射器的柱塞限定了摩擦并可滑动地容纳在中空注射器主体内的可再密封塞子，用于在柱塞移动时通过注射器的分配尖端分配药物或其它物质。 可重新密封的止动件限定了可热封部分，以允许止动器被针或其他填充装置穿透，以用药物或其它物质填充注射器，并且进而允许在针头被热封时提供剩余的孔 通过在其上传送激光能量。 柱塞组件还限定多个凸轮状构件，每个凸轮状构件与形成在注射器本体的内壁上的步骤的相应的螺旋路径接合并配合，以提供柱塞的逐步运动，并且进而精确地计量物质 从中分配。 重建注射器在注射器主体内限定多个隔室，其中每个隔室存储多组分药物或其它制剂的相应组分。 弹性塞连接到柱塞并连接在两个隔室之间以防止部件的混合。 在移动柱塞时，释放塞子，从而将隔间彼此流体连通，并且有助于在振动注射器时组件的混合。

公开(公告)号：WO2002088780A3

公开(公告)日：2002-11-07

申请号：PCT/US2002/014116

申请日：2002-05-02

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: A61F9/00

Abstract: A contact lens applicator (10) has an elongated housing (12) defining an interior chamber (34) for storing contact lenses (CL), first and second triggers (16, 18) mounted on the housing (12), a depressor (20) for depressing each eyelid where the roller (20) is drivingly coupled to the triggers (16, 18), a pair of opposing wing-shaped members (26) projecting outwardly from opposite sides of the roller (20) for providing a support surface (28) for facilitating locating the apparatus (10) over the eye, and a pusher (40) assembly slidably mounted within the interior chamber (34) for engaging a contact lens holder (75) and applying a contact lens (CL) thereon to the eye when the triggers (16, 18) are actuated. The contact lens (CL) is stored in a cartridge (36) within the housing (12). The lens holder (75) is movable within the cartridge (36) upon actuating the pusher (40), and includes a predetermined amount of saline or other solution for defining appropriate conditions for storing the contact lens (CL).

公开(公告)号：WO2017127589A1

公开(公告)日：2017-07-27

申请号：PCT/US2017/014204

申请日：2017-01-19

Applicant: PY, Daniel

Inventor： PY, Daniel

IPC: A61M5/162 ,  A61M5/24 ,  A61M39/10 ,  F16L37/252 ,  F16L37/30

CPC classification number: A61J1/201 ,  A61J1/2055 ,  A61M5/162 ,  A61M5/1626 ,  A61M39/10 ,  A61M39/1011 ,  A61M39/18 ,  A61M2039/267

Abstract: Connector assembly including a piercing member having a flow port therein attached to a first piece, with the piercing member slidingly receivable within a second piece, wherein the piercing member and the second pierce are movable relative to each other between a first position where the second pieces closes the flow port and a second position where the flow port is open. The first piece contains a locking mechanism that lockingly engages with a device when connected thereto, preventing subsequent disconnection of first piece and the device. Upon initial connection of the first piece to the device, the second piece is moved from the first position to the second position.

Abstract translation: 连接器组件包括其中具有流动端口的刺穿构件，所述刺穿构件附接到第一件，所述刺穿件可滑动地容纳在第二件内，其中刺穿件和第二刺穿件可相对于彼此移动 在第二部件关闭流动端口的第一位置和流动端口打开的第二位置之间。 第一件包含锁定机构，当与设备连接时锁定机构与设备锁定接合，防止第一件与设备的随后断开。 在第一块连接到设备上时，第二块从第一位置移动到第二位置。

公开(公告)号：WO2013109794A1

公开(公告)日：2013-07-25

申请号：PCT/US2013/021998

申请日：2013-01-17

Applicant: PY, Daniel

Inventor： PY, Daniel

IPC: A61M5/178

CPC classification number: A61J1/2096 ,  A61J1/10 ,  A61J1/1406 ,  A61J1/1475 ,  A61J1/22 ,  A61M39/24

Abstract: A vial for storing multiple doses of a substance to be dispensed into one or more syringes or other delivery devices. The vial has a body, a variable- volume storage chamber within the body for storing multiple doses of the substance therein, and a one-way valve connectable in fluid communication with a syringe or other delivery device. The one-way valve is moveable relative to the body between first and second positions (i) one of which permits the valve to open so that substance from the variable-volume storage chamber can flow therethrough and into the syringe or other delivery device connected in fluid communication therewith, and (ii) one of which prevents the valve from opening.

Abstract translation: 用于储存多剂量待分配到一个或多个注射器或其他递送装置中的物质的小瓶。 该小瓶具有主体，体内可变容积的储存室，用于在其中储存多个剂量的物质，以及可与注射器或其它输送装置流体连通的单向阀。 单向阀可在第一和第二位置（i）之间相对于主体移动（i），其中一个允许阀打开，使得来自可变容积的储存室的物质可以流过其中并进入连接在其中的注射器或其他输送装置 与其流体连通，和（ii）其中之一防止阀打开。