公开(公告)号：EP3924723A1

公开(公告)日：2021-12-22

申请号：EP20716610.9

申请日：2020-03-03

Applicant: Quantum-Si Incorporated

Inventor： BELLOS, Michael ,  AHMAD, Faisal R. ,  BEACH, James ,  COUMANS, Michael ,  HOSALI, Sharath ,  KABIRI, Ali ,  PRESTON, Kyle ,  SCHMID, Gerard ,  SHEN, Bing ,  ROTHBERG, Jonathan M.

IPC: G01N21/64 ,  G02B5/20 ,  G02B5/22

公开(公告)号：EP3709003A1

公开(公告)日：2020-09-16

申请号：EP20150534.4

申请日：2014-11-17

Applicant: Quantum-Si Incorporated

Inventor： ROTHBERG, Jonathan M. ,  KABIRI, Ali ,  SICKLER, Jason W. ,  GYARFAS, Brett J. ,  LACKEY, Jeremy ,  SCHMID, Gerard ,  CIPRIANY, Benjamin ,  JEWELL, Jack ,  WEST, Lawrence ,  FERRIGNO, Michael ,  GLENN, Paul E. ,  COHEN, Adam E. ,  BELLOFIORE, Anthony

IPC: G01N21/64 ,  G01N21/77 ,  B01L3/00

Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.

公开(公告)号：EP3658682A1

公开(公告)日：2020-06-03

申请号：EP18837972.1

申请日：2018-07-24

Applicant: Quantum-Si Incorporated

Inventor： ROTHBERG, Jonathan M. ,  LACKEY, Jeremy ,  REED, Brian ,  SHI, Xinghua ,  HUANG, Haidong ,  DODD, David

IPC: C12Q1/68 ,  G01N21/64 ,  G01N21/76

公开(公告)号：EP3074531B1

公开(公告)日：2020-01-08

申请号：EP14812050.4

申请日：2014-11-17

Applicant: Quantum-Si Incorporated

Inventor： ROTHBERG, Jonathan M. ,  KABIRI, Ali ,  SICKLER, Jason W. ,  GYARFAS, Brett J. ,  LACKEY, Jeremy ,  SCHMID, Gerard ,  CIPRIANY, Benjamin ,  JEWELL, Jack ,  WEST, Lawrence ,  FERRIGNO, Michael ,  GLENN, Paul E. ,  COHEN, Adam E. ,  BELLOFIORE, Anthony

IPC: C12Q1/6874 ,  G01N21/64 ,  G01N21/77 ,  B01L3/00 ,  C12Q1/6869

公开(公告)号：EP4421188A3

公开(公告)日：2024-10-23

申请号：EP24161226.6

申请日：2015-08-07

Applicant: Quantum-Si Incorporated

Inventor： ROTHBERG, Jonathan M. ,  KABIRI, Ali ,  SICKLER, Jason W. ,  GYARFAS, Brett J. ,  LACKEY, Jeremy ,  SCHMID, Gerard ,  WEST, Lawrence C. ,  CIPRIANY, Benjamin ,  FIFE, Keith G. ,  GHASEMI, Farshid

IPC: G01N21/64 ,  C12Q1/6874 ,  C12Q1/6869

Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device. One of multiple markers distinguishable by temporal parameters of the emission energy may label the sample and configuration of the sensor within a pixel may allow for detection of a temporal parameter associated with the marker labeling the sample.

公开(公告)号：EP4224530A1

公开(公告)日：2023-08-09

申请号：EP23162952.8

申请日：2017-12-22

Applicant: Quantum-Si Incorporated

Inventor： ROTHBERG, Jonathan M. ,  FIFE, Keith G ,  BOISVERT, David

IPC: H01L27/146 ,  H01L27/148 ,  G01N21/64

Abstract: An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit includes at least one charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers directly into the at least one charge carrier storage region based upon times at which the charge carriers are produced.

公开(公告)号：EP4141416A3

公开(公告)日：2023-06-07

申请号：EP22183103.5

申请日：2017-12-15

Applicant: Quantum-Si Incorporated

Inventor： ROTHBERG, Jonathan M. ,  KABIRI, Ali ,  SCHMID, Gerard ,  SICKLER, Jason W. ,  GLENN, Paul E. ,  WEST, Lawrence C. ,  PRESTON, Kyle ,  GONDARENKO, Alexander ,  CIPRIANY, Benjamin ,  BEACH, James ,  FIFE, Keith G. ,  GHASEMI, Farshid

IPC: G01N21/25 ,  G01N21/64 ,  G01N21/77

Abstract: An integrated device (1-102) comprising:
a plurality of sample wells (1-108);
a first optical waveguide (1-312) configured to couple excitation energy to a first portion of the plurality of sample wells;
a second optical waveguide (1-312) configured to couple the excitation energy to a second portion of the plurality of sample wells; and
a grating coupler (1-216) configured to receive the excitation energy from an optical source positioned outside the integrated device, and to couple the excitation energy to the first optical waveguide and to the second optical waveguide.

公开(公告)号：EP4141416A2

公开(公告)日：2023-03-01

申请号：EP22183103.5

申请日：2017-12-15

Applicant: Quantum-Si Incorporated

Inventor： ROTHBERG, Jonathan M. ,  KABIRI, Ali ,  SCHMID, Gerard ,  SICKLER, Jason W. ,  GLENN, Paul E. ,  WEST, Lawrence C. ,  PRESTON, Kyle ,  GONDARENKO, Alexander ,  CIPRIANY, Benjamin ,  BEACH, James ,  FIFE, Keith G. ,  GHASEMI, Farshid

IPC: G01N21/25 ,  G01N21/64 ,  G01N21/77

Abstract: An integrated device (1-102) comprising:
a plurality of sample wells (1-108);
a first optical waveguide (1-312) configured to couple excitation energy to a first portion of the plurality of sample wells;
a second optical waveguide (1-312) configured to couple the excitation energy to a second portion of the plurality of sample wells; and
a grating coupler (1-216) configured to receive the excitation energy from an optical source positioned outside the integrated device, and to couple the excitation energy to the first optical waveguide and to the second optical waveguide.

公开(公告)号：EP4050886A1

公开(公告)日：2022-08-31

申请号：EP21217400.7

申请日：2016-05-20

Applicant: Quantum-Si Incorporated

Inventor： ROTHBERG, Jonathan M. ,  SICKLER, Jason W. ,  WEST, Lawrence C. ,  AHMAD, Faisal ,  HUANG, Brendan ,  GLENN, Paul E. ,  SCHULTZ, Jonathan C. ,  CAMARA, Jose

IPC: H04N5/374 ,  H04N5/335

Abstract: Compact optical sources and methods for producing short and ultrashort optical pulses are described. A semiconductor laser or LED may be driven with a bipolar waveform to generate optical pulses with FWHM durations as short as approximately 85 ps having suppressed tail emission. The pulsed optical sources may be used for fluorescent lifetime analysis of biological samples and time-of-flight imaging, among other applications.

公开(公告)号：EP3658900A1

公开(公告)日：2020-06-03

申请号：EP18839142.9

申请日：2018-07-23

Applicant: Quantum-Si Incorporated

Inventor： ROTHBERG, Jonathan M. ,  SCHMID, Gerard ,  GONDARENKO, Alexander ,  BEACH, James ,  PRESTON, Kyle ,  GHASEMI, Farshid ,  LACKEY, Jeremy ,  JEWELL, Jack ,  FIFE, Keith G. ,  KABIRI, Ali

IPC: G01N21/64 ,  C12Q1/68