-
公开(公告)号：WO2019023146A1
公开(公告)日：2019-01-31
申请号：PCT/US2018/043333
申请日：2018-07-23
Applicant: QUANTUM-SI INCORPORATED
Inventor： ROTHBERG, Jonathan M. , SCHMID, Gerard , GONDARENKO, Alexander , BEACH, James , PRESTON, Kyle , GHASEMI, Farshid , LACKEY, Jeremy , JEWELL, Jack , FIFE, Keith G. , KABIRI, Ali
Abstract: An integrated device and related instruments and systems for analyzing samples in parallel are described. The integrated device may include sample wells arranged on a surface of where individual sample wells are configured to receive a sample labeled with at least one fluorescent marker configured to emit emission light in response to excitation light. The integrated device may further include photodetectors positioned in a layer of the integrated device, where one or more photodetectors are positioned to receive a photon of emission light emitted from a sample well. The integrated device further includes one or more photonic structures positioned between the sample wells and the photodetectors, where the one or more photonic structures are configured to attenuate the excitation light relative to the emission light such that a signal generated by the one or more photodetectors indicates detection of photons of emission light.
-
公开(公告)号：WO2021086954A1
公开(公告)日：2021-05-06
申请号：PCT/US2020/057722
申请日：2020-10-28
Applicant: QUANTUM-SI INCORPORATED
Inventor： ROTHBERG, Jonathan M. , LEAMON, John H. , SCHULTZ, Jonathan C. , MILLHAM, Michele , LV, Caixia , MA, Xiaxiao
Abstract: Methods and devices for enriching and analyzing target molecules from a sample are provided herein. In some embodiments, methods and devices using cartridges involve enrichment of target molecules (e.g., using SCODA) and detection and analysis using sequencing. The method may employ lysing of cells, fragmentation of target in the sample preparation module and enriching the target in the module and moving the target to the sequencing module.
-
公开(公告)号：WO2019023257A1
公开(公告)日：2019-01-31
申请号：PCT/US2018/043526
申请日：2018-07-24
Applicant: QUANTUM-SI INCORPORATED
Inventor： ROTHBERG, Jonathan M. , LACKEY, Jeremy , REED, Brian , SHI, Xinghua , HUANG, Haidong , DODD, David
Abstract: Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleic acid connected to a nucleotide and two or more luminescent labels. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.
-
4.发明申请
公开(公告)号：WO2018204810A1
公开(公告)日：2018-11-08
申请号：PCT/US2018/031125
申请日：2018-05-04
Applicant: QUANTUM-SI INCORPORATED
Inventor： ROTHBERG, Jonathan M. , LACKEY, Jeremy , CHEN, Guojun
Abstract: Methods of preparing surfaces of sample wells are provided. In some aspects, methods of preparing a sample well surface involve contacting the sample well with a block copolymer to form an antifouling overlay over a metal oxide surface of the sample well. In some aspects, methods of passivating and/or selectively functionalizing a sample well surface are provided.
-
公开(公告)号：WO2020180899A1
公开(公告)日：2020-09-10
申请号：PCT/US2020/020847
申请日：2020-03-03
Applicant: QUANTUM-SI INCORPORATED
Inventor： BELLOS, Michael , AHMAD, Faisal R. , BEACH, James , COUMANS, Michael , HOSALI, Sharath , KABIRI, Ali , PRESTON, Kyle , SCHMID, Gerard , SHEN, Bing , ROTHBERG, Jonathan M.
Abstract: Apparatus and methods relating to attenuating excitation radiation incident on a sensor (1-122) in an integrated device that is used for sample analysis are described. At least one semiconductor film (1-336) of a selected material and crystal morphology is located between a waveguide (1-115) and a sensor (1-122) in an integrated device that is formed on a substrate (1-105). Rejection ratios greater than 100 or more can be obtained for excitation and emission wavelengths that are 40 nm apart for a single layer of semiconductor material (1-135).
-
Patent Agency Ranking
公开(公告)号：WO2019023174A1
公开(公告)日：2019-01-31
申请号：PCT/US2018/043390
申请日：2018-07-24
Applicant: QUANTUM-SI INCORPORATED
Inventor： ROTHBERG, Jonathan M. , CIPRIANY, Benjamin , REARICK, Todd , GLENN, Paul E. , AHMAD, Faisal R. , ROSWECH, Todd , LATHROP, Brittany , CONNOLLY, Thomas
Abstract: A hand-held bioanalytic instrument is described that can perform massively parallel sample analysis including single-molecule gene sequencing. The instrument includes a pulsed optical source that produces ultrashort excitation pulses and a compact beam-steering assembly. The beam-steering assembly provides automated alignment of excitation pulses to an interchangeable bio-optoelectronic chip that contains tens of thousands of reaction chambers or more. The optical source, beam-steering assembly, bio-optoelectronic chip, and coupling optics register to an alignment structure in the instrument that can form at least one wall of an enclosure and dissipate heat.
-
公开(公告)号：EP4424846A2
公开(公告)日：2024-09-04
申请号：EP24173538.0
申请日：2015-08-07
Applicant: Quantum-Si Incorporated
Inventor： ROTHBERG, Jonathan M. , KABIRI, Ali , SICKLER, Jason W. , GYARFAS, Brett J. , LACKEY, Jeremy , SCHMID, Gerard , GLENN, Paul E. , WEST, Lawrence C. , CIPRIANY, Benjamin , FIFE, Keith G.
IPC: C12Q1/6874
CPC classification number: C12Q1/6874 , G01N21/6452 , G01N21/648 , G01N2021/641920130101 , G01N2021/642120130101 , G01N21/6408 , G01N21/6428
Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
-
公开(公告)号：EP4113104A3
公开(公告)日：2023-02-22
申请号：EP22190053.3
申请日：2017-06-01
Applicant: Quantum-Si Incorporated
Inventor： ROTHBERG, Jonathan M. , KABIRI, Ali , SCHMID, Gerard , FIFE, Keith G. , BEACH, James , SICKLER, Jason W. , WEST, Lawrence C. , GLENN, Paul E. , PRESTON, Kyle , GHASEMI, Farshid , CIPRIANY, Benjamin , LACKEY, Jeremy
IPC: G01N21/64 , C12Q1/68 , C12Q1/6874
Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device may include multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes a surface having a trench region recessed from a portion of the surface and an array of sample wells, disposed in the trench region. The integrated device also includes a waveguide configured to couple excitation energy to at least one sample well in the array and positioned at a first distance from a surface of the trench region and at a second distance from the surface in a region separate from the trench region. The first distance is smaller than the second distance. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.
-
公开(公告)号：EP4113104A2
公开(公告)日：2023-01-04
申请号：EP22190053.3
申请日：2017-06-01
Applicant: Quantum-Si Incorporated
Inventor： ROTHBERG, Jonathan M. , KABIRI, Ali , SCHMID, Gerard , FIFE, Keith G. , BEACH, James , SICKLER, Jason W. , WEST, Lawrence C. , GLENN, Paul E. , PRESTON, Kyle , GHASEMI, Farshid , CIPRIANY, Benjamin , LACKEY, Jeremy
IPC: G01N21/64 , C12Q1/68 , C12Q1/6874
Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device may include multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes a surface having a trench region recessed from a portion of the surface and an array of sample wells, disposed in the trench region. The integrated device also includes a waveguide configured to couple excitation energy to at least one sample well in the array and positioned at a first distance from a surface of the trench region and at a second distance from the surface in a region separate from the trench region. The first distance is smaller than the second distance. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.
-
公开(公告)号：EP4045679A1
公开(公告)日：2022-08-24
申请号：EP20811821.6
申请日：2020-10-28
Applicant: Quantum-Si Incorporated
Inventor： ROTHBERG, Jonathan M. , LEAMON, John H. , SCHULTZ, Jonathan C. , MILLHAM, Michele , LV, Caixia , MA, Xiaoxiao
-
-
-
-
-
-
-
-
-
Search Results
35
records
(took 0.066 seconds)
