公开(公告)号：US20190107439A1

公开(公告)日：2019-04-11

申请号：US16081806

申请日：2017-03-10

Applicant: Regents of the University of Minnesota

Inventor： Robert Vince ,  Swati Sudhakar More ,  James Melvin Beach

IPC: G01J3/28 ,  G01J3/02

Abstract: In general, an imaging system to synchronously record a spatial image and a spectral image of a portion of the spatial image is described. In some examples, a beam splitter of the imaging system splits an optical beam, obtained from a viewing device, into a first split beam directed by the imaging system to a spatial camera and a second split beam directed by the imaging system to the entrance slit of an imaging spectrograph that is coupled to a spectral camera. An electronic apparatus synchronously triggers the spatial camera and the spectral camera to synchronously record a spatial image and a spectral image, respectively.

公开(公告)号：US20170172410A1

公开(公告)日：2017-06-22

申请号：US15449585

申请日：2017-03-03

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Robert Vince ,  Swati Sudhakar More

IPC: A61B3/12 ,  A61B5/00 ,  A61B3/14

CPC classification number: A61B3/12 ,  A61B3/14 ,  A61B5/4848 ,  A61K38/063 ,  G01N21/31 ,  G01N33/5038

Abstract: Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Parkinson's disease (PD). Also described herein is the use of a VNIR hyperspectral imaging system in high throughput screening of potential therapeutics against PD.

公开(公告)号：US20150231051A1

公开(公告)日：2015-08-20

申请号：US14434722

申请日：2013-10-11

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Robert Vince ,  Abbas Raza ,  Christine Dreis

IPC: A61K8/49 ,  C07D487/16 ,  A61Q17/04 ,  C07D239/54

CPC classification number: A61K8/4953 ,  A61Q17/04 ,  A61Q19/08 ,  C07D239/54 ,  C07D487/04 ,  C07D487/16

Abstract: The invention provides compounds of formula I; or a salt thereof as described herein. The invention also provides dermatological compositions comprising a compound of formula I or mixtures of one or more compounds of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for protecting skin or DNA from photodamage or repairing photodamaged skin or DNA.

Abstract translation: 本发明提供式I化合物; 或其盐。 本发明还提供包含式I化合物或一种或多种式I化合物的混合物的皮肤病学组合物，制备式I化合物的方法，可用于制备式I化合物的中间体和用于保护皮肤或DNA免受光损伤的治疗方法或 修复光损伤的皮肤或DNA。

公开(公告)号：US12055436B2

公开(公告)日：2024-08-06

申请号：US17455031

申请日：2021-11-16

Applicant: Regents of the University of Minnesota

Inventor： Robert Vince ,  Swati Sudhakar More ,  James Melvin Beach

IPC: G01J3/28 ,  G01J3/02

CPC classification number: G01J3/2803 ,  G01J3/0248 ,  G01J3/027

Abstract: In general, an imaging system to synchronously record a spatial image and a spectral image of a portion of the spatial image is described. In some examples, a beam splitter of the imaging system splits an optical beam, obtained from a viewing device, into a first split beam directed by the imaging system to a spatial camera and a second split beam directed by the imaging system to the entrance slit of an imaging spectrograph that is coupled to a spectral camera. An electronic apparatus synchronously triggers the spatial camera and the spectral camera to synchronously record a spatial image and a spectral image, respectively.

公开(公告)号：US12006294B2

公开(公告)日：2024-06-11

申请号：US16429507

申请日：2019-06-03

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Swati S. More ,  Robert Vince

IPC: C07D233/64 ,  A61K31/167 ,  A61P5/48 ,  A61P25/16 ,  A61P35/00 ,  C07C279/06 ,  C07C279/08 ,  C07C279/18 ,  C07C279/22 ,  C07C281/14 ,  C07C281/16 ,  C07C281/18 ,  C07C335/04 ,  C07C335/12 ,  C07C335/40 ,  C07D213/61 ,  C07D231/38 ,  C07D233/44 ,  C07D233/50 ,  C07D233/52 ,  C07D239/06 ,  C07D239/18 ,  C07D239/22 ,  C07D239/47

CPC classification number: C07D233/44 ,  A61P5/48 ,  A61P25/16 ,  A61P35/00 ,  C07C279/06 ,  C07C279/08 ,  C07C279/18 ,  C07C279/22 ,  C07C281/14 ,  C07C281/16 ,  C07C281/18 ,  C07C335/04 ,  C07C335/12 ,  C07C335/40 ,  C07D213/61 ,  C07D231/38 ,  C07D233/50 ,  C07D233/52 ,  C07D233/64 ,  C07D239/06 ,  C07D239/18 ,  C07D239/22 ,  C07D239/47 ,  A61K31/167

Abstract: The invention provides methods for producing analgesia in an animal comprising administering to the animal a compound of the formula Ia′, Ib′, Ic′, and Id′:




and pharmaceutically acceptable salts thereof, wherein the variables A, R6, R7, R8, R9, Rx, L, X, Y, and Z have the meaning as described herein.

公开(公告)号：US11819276B2

公开(公告)日：2023-11-21

申请号：US17939566

申请日：2022-09-07

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Robert Vince ,  Swati Sudhakar More

IPC: G01J3/28 ,  A61B3/12 ,  G01N21/31 ,  G01J3/00 ,  G01J3/40 ,  G01N21/25 ,  A61B3/14 ,  A61K38/06 ,  G01N33/50 ,  A61B5/00

CPC classification number: A61B3/12 ,  A61B3/14 ,  A61B5/4848 ,  A61K38/063 ,  G01J3/00 ,  G01J3/28 ,  G01J3/40 ,  G01N21/25 ,  G01N21/31 ,  G01N33/5038

Abstract: Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Alzheimer's disease (AD). Also described herein is the use of a VNIR hyperspectral imaging system in high throughput screening of potential therapeutics against AD.

公开(公告)号：US11503999B2

公开(公告)日：2022-11-22

申请号：US16160208

申请日：2018-10-15

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Robert Vince ,  Swati Sudhakar More

IPC: G01J3/28 ,  A61B3/12 ,  G01N21/31 ,  G01J3/00 ,  G01J3/40 ,  G01N21/25 ,  A61B3/14 ,  A61K38/06 ,  G01N33/50 ,  A61B5/00

Abstract: Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Alzheimer's disease (AD). Also described herein is the use of a VNIR hyperspectral imaging system in high throughput screening of potential therapeutics against AD.

公开(公告)号：US20220023267A1

公开(公告)日：2022-01-27

申请号：US17381308

申请日：2021-07-21

Applicant: Regents of the University of Minnesota

Inventor： Robert Vince ,  Swati Sudhakar More

IPC: A61K31/426 ,  A61P25/28 ,  A61K31/22 ,  A61K31/385 ,  A61K31/265 ,  A61K31/554 ,  A61K31/198

Abstract: The invention provides compositions and methods for treating conditions associated with decreased activity of hydrogen sulfide.

公开(公告)号：US20190282531A1

公开(公告)日：2019-09-19

申请号：US16353974

申请日：2019-03-14

Applicant: Regents of the University of Minnesota

Inventor： Robert Vince ,  Rohit Singh ,  Swati Sudhakar More

IPC: A61K31/216 ,  A61K45/06 ,  A61P29/00

Abstract: The invention provides methods and compositions for producing analgesia in an animal.

公开(公告)号：US10098540B2

公开(公告)日：2018-10-16

申请号：US15449585

申请日：2017-03-03

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Robert Vince ,  Swati Sudhakar More

IPC: A61B3/12 ,  A61B5/04 ,  G01J3/30 ,  G01J3/40 ,  G01J3/443 ,  G01J9/00 ,  G01N21/31 ,  A61B3/14 ,  A61B5/00

Abstract: Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Parkinson's disease (PD). Also described herein is the use of a VNIR hyperspectral imaging system in high throughput screening of potential therapeutics against PD.