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公开(公告)号：DE69906000T2
公开(公告)日：2004-01-08
申请号：DE69906000
申请日：1999-10-12
Applicant: SERVIER LAB
Inventor： LANGLOIS MICHEL , MATHE-ALLAINMAT MONIQUE , LEFAS-LE GALL MARIE , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: A61K31/16 , A61K31/165 , A61K31/17 , A61K31/335 , A61K31/343 , A61K31/352 , A61K31/353 , A61K31/38 , A61K31/381 , A61K31/395 , C07D339/00 , A61K31/4355 , A61K31/437 , A61P1/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/18 , C07C233/23 , C07C233/74 , C07C235/34 , C07C235/40 , C07C275/26 , C07D307/79 , C07D307/80 , C07D307/81 , C07D311/92 , C07D333/58 , C07D333/60 , C07D471/04 , C07D491/04 , C07D491/048 , C07D493/04
Abstract: Cycloalkene substituted cyclic derivatives (I) are new. Cycloalkene substituted cyclic derivatives of formula (I), their enantiomers, diastereoisomers and their acid or base addition salts are new. A = a group of formula (i) or (ii) (optionally substituted by Ra, ORa, OH, CORa, formyl, COORa, COOH or OCORa; Ra = 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 1-6C polyhaloalkyl, 3-8C cycloalkyl, 3-8C cycloalkyl-(1-6C) alkyl, 3-8C cycloalkenyl, 3-8C cycloalkenyl-(1-6C) alkyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, amino or halo), aryl, aryl-(1-6C) alkyl, heteroaryl or heteroaryl-(1-6C) alkyl; X, Y' = O, S or CH2; D' = benzene or naphthalene; a-d = single or double bond; Z = O, S, CH2 or NR ; R = H, 1-6C alkyl, aryl or aryl-(1-6C) alkyl; D'' = benzene or pyridine; R = H, halo, OH, SH, Ra, ORa, S(O)nRa or a (un)saturated 5- to 7-membered ring of formula (iii) (optionally substituted with at least one 1-6C alkyl, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl, OH or =O); n = 0-2; E = O or -S(O)n-; G1, G2 = single bond, -(CH2)t- (optionally substituted with at least one OH, COOH, formyl, Ra, ORa, COORa, CORa or halo; p, q = 0-4; p + q = 1-4; B' = -NR aC(Q)R a, -NR aC(Q)NR aR a or -C(Q)NR aR a; R a-R a = H or Ra; Q = O or S; aryl = phenyl, naphthyl, biphenyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); heteroaryl = 5- to 10-membered mono- or polycyclic aromatic ring containing 1-3 N, O or S (optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); and provided that q = 0 and p = 4, or q = 4 and p = 0 do not apply, when A is naphthyl (optionally substituted with methoxy or methyl), G1 and G2 are single bonds and B' is a group of formula (iv) or NHCOCH3; that A is other than halo substituted naphthyl, when G1 is a single bond and p + q is 1; B' is other than urea, when A is indolyl substituted on position 2 with a group of formula (v); and that B' is other than CONH-aryl, when A is indolyl substituted on position 2 with carboxyl or alkoxycarbonyl, p is 1, q is 0 (p is 0 and q is 1) and G1 is single bond. A Independent claim is also included for the preparation of (I).
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公开(公告)号：NZ505323A
公开(公告)日：2002-10-25
申请号：NZ50532398
申请日：1998-12-11
Applicant: SERVIER LAB
Inventor： LANGLOIS MICHEL , MATHEALLAINMAT MONIQUE , JELLIMANN CAROLE , ANDRIEUX JEAN , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: C07D333/74 , A61K31/165 , A61K31/343 , A61K31/381 , A61K31/403 , A61P9/06 , A61P25/20 , A61P25/22 , A61P43/00 , C07C233/05 , C07C233/18 , C07C233/60 , C07C235/34 , C07C275/24 , C07C275/26 , C07D209/60 , C07D209/90 , C07D307/77 , C07D307/92 , C07D307/93 , C07D333/78 , C07D307/91 , C07D311/80 , C07D311/82 , C07D333/76 , C07D335/08 , C07D335/10 , C07D209/58 , C07D209/80 , A61K31/335 , A61K31/38 , A61K31/395 , C07D219/02 , C07D219/04 , C07D335/12
Abstract: A compound of formula (I) or the enantiomers and diastereoisomers and addition salts thereof wherein: A forms with the group to which it is bonded a tricyclic system selected from A1, A2, A3 and A4; R1 is hydrogen, halogen, alkyl, alkoxy, hydroxy or oxo; R2 and R3 are independently halogen, Ra, ORa, CORa, OCORa or COORa with the symbols (R2)m and (R3)m' denote that the ring in question may be substituted by from 1 to 3 groups (which may be the same or different) belonging to the definitions for R2 and R3; Ra is hydrogen, trihaloalkyl or optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl or aryl; X, when A is a tricyclic A1, A2, A3 and A4, is sulphur, (CH2)q -CH=CH-, or NR4 or X is oxygen when A is the tricyclic system A1 and n is an integer such that 0[n[3 or p is an integer such that 1[p[3 when n is 1, 2 or 3 and the chain of formula B' is in the b position and A is either A2, A3 or A4 and X is -CH=CH- or A is the group A1, and such that 0[p[3; in all other cases, it is possible for the chain of formula B' chain to be optionally substituted; R4 is hydrogen or optionally substituted alkyl; q is 1 or 2; B is NRa-C(=Z)-R5 Z is oxygen or sulphur; R5 is Ra or NR6R7 or -(C=Z)-NR6R7; R6 and R7 are independently Ra or with the proviso that: when the tricyclic group of formula A1 is a 6-methoxy-tetrahydro-benzo[cd]indole, B cannot represent NHCOMe and the compound of formula (I) is not: N-(4-methyl-2,3-dihydro-1H-1-phenalenyl)-1-cyclopropanecarboxamide; N-(4-methyl-2,3-dihydro-1H-1-phenalenyl)-2-chloroacetamide; 2-methyl-1,3,4,5-tetrahydrobenzo[cd]indole-3-carboxamide; N-(5-hydroxy-1,2,2a,3,4,5-hexahydro-4-acenaphthylenyl)acetamide; N-(5-hydroxy-1,2,2a,3,4,5-hexahydro-4-acenaphthylenyl)benzamide or N-(1,2,2a,3,4,5-hexahydro-4-acenaphthylenyl)acetamide. The compounds of formula (I) are useful for treating conditions of the central nervous system.
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公开(公告)号：NZ507692A
公开(公告)日：2002-06-28
申请号：NZ50769299
申请日：1999-05-10
Applicant: SERVIER LAB
Inventor： DELAGRANGE PHILIPPE , LESIEUR DANIEL , KLUPSCH FREDERIQUE , GUILLAUMET GERALD , VIAUD MARIE-CLAUDE , LANGLOIS MICHEL , BENNEJEAN CAROLINE , RENARD PIERRE
IPC: C07D295/12 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/19 , A61K31/27 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/382 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4402 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/4453 , A61K31/453 , A61K31/454 , A61K31/473 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P1/00 , A61P3/06 , A61P3/10 , A61P5/02 , A61P9/00 , A61P15/08 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/36 , C07C233/40 , C07C233/43 , C07C233/62 , C07C233/65 , C07C237/48 , C07C271/20 , C07C271/30 , C07C275/24 , C07C275/40 , C07C311/46 , C07C317/32 , C07C323/40 , C07C323/41 , C07C323/44 , C07C323/62 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/20 , C07D209/60 , C07D209/90 , C07D213/70 , C07D221/08 , C07D221/10 , C07D233/42 , C07D233/84 , C07D235/06 , C07D235/14 , C07D261/20 , C07D295/18 , C07D307/68 , C07D307/77 , C07D307/81 , C07D307/92 , C07D311/58 , C07D311/60 , C07D311/92 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/40 , C07D333/50 , C07D333/56 , C07D333/58 , C07D333/74 , C07D335/06 , C07D335/08 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/06 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/048 , C07D491/052 , C07D493/04 , C07D495/04 , C07D495/14 , C07D521/00 , C07C311/37 , C07D307/85
Abstract: A compound of the general formula R-A-R' for use in the treatment of seasonal affective disorder, sleep disorder, cardiovascular pathologies, insomnia and fatigue resulting from jet-lag, appetite disorders and obesity. Wherein; A represents a ring system of Formula (II), (III) or (IV); R represents a group of formula (V), (VI), (VII) or (VIII); and R' represents a group of Formula (IX), wherein R5 represents a group of Formula X.
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24.发明专利
公开(公告)号：HK1033455A1
公开(公告)日：2001-08-31
申请号：HK01104169
申请日：2001-06-18
Applicant: SERVIER LAB
Inventor： LANGLOIS MICHEL , MATHE-ALLAINMAT MONIQUE , JELLIMANN CAROLE , ANDRIEUX JEAN , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: C07D333/74 , A61K31/165 , A61K31/343 , A61K31/381 , A61K31/403 , A61P9/06 , A61P25/20 , A61P25/22 , A61P43/00 , C07C233/05 , C07C233/18 , C07C233/60 , C07C235/34 , C07C275/24 , C07C275/26 , C07D209/60 , C07D209/90 , C07D307/77 , C07D307/92 , C07D307/93 , C07D333/78 , C07C , C07D , A61K
Abstract: The invention concerns compounds of formula (I) in which: A forms a tricyclic system of formula A1, A2, A3 or A4; R1 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or oxo group; (R2)m and (R3)m' are such as defined in the description; n represents an integer such that 0
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公开(公告)号：AU5362199A
公开(公告)日：2000-04-13
申请号：AU5362199
申请日：1999-10-12
Applicant: SERVIER LAB
Inventor： LANGLOIS MICHEL , MATHE-ALLAINMAT MONIQUE , GALL MARIE LEFAS-LE , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: C07D339/00 , A61K31/16 , A61K31/165 , A61K31/17 , A61K31/335 , A61K31/343 , A61K31/352 , A61K31/353 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/4355 , A61K31/437 , A61P1/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/18 , C07C233/23 , C07C233/74 , C07C235/34 , C07C235/40 , C07C275/26 , C07D307/79 , C07D307/80 , C07D307/81 , C07D311/92 , C07D333/58 , C07D333/60 , C07D471/04 , C07D491/04 , C07D491/048 , C07D493/04 , C07C233/58 , C07C233/17 , C07C233/22 , C07D307/83 , C07D311/74
Abstract: Cycloalkene substituted cyclic derivatives (I) are new. Cycloalkene substituted cyclic derivatives of formula (I), their enantiomers, diastereoisomers and their acid or base addition salts are new. A = a group of formula (i) or (ii) (optionally substituted by Ra, ORa, OH, CORa, formyl, COORa, COOH or OCORa; Ra = 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 1-6C polyhaloalkyl, 3-8C cycloalkyl, 3-8C cycloalkyl-(1-6C) alkyl, 3-8C cycloalkenyl, 3-8C cycloalkenyl-(1-6C) alkyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, amino or halo), aryl, aryl-(1-6C) alkyl, heteroaryl or heteroaryl-(1-6C) alkyl; X, Y' = O, S or CH2; D' = benzene or naphthalene; a-d = single or double bond; Z = O, S, CH2 or NR ; R = H, 1-6C alkyl, aryl or aryl-(1-6C) alkyl; D'' = benzene or pyridine; R = H, halo, OH, SH, Ra, ORa, S(O)nRa or a (un)saturated 5- to 7-membered ring of formula (iii) (optionally substituted with at least one 1-6C alkyl, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl, OH or =O); n = 0-2; E = O or -S(O)n-; G1, G2 = single bond, -(CH2)t- (optionally substituted with at least one OH, COOH, formyl, Ra, ORa, COORa, CORa or halo; p, q = 0-4; p + q = 1-4; B' = -NR aC(Q)R a, -NR aC(Q)NR aR a or -C(Q)NR aR a; R a-R a = H or Ra; Q = O or S; aryl = phenyl, naphthyl, biphenyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); heteroaryl = 5- to 10-membered mono- or polycyclic aromatic ring containing 1-3 N, O or S (optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); and provided that q = 0 and p = 4, or q = 4 and p = 0 do not apply, when A is naphthyl (optionally substituted with methoxy or methyl), G1 and G2 are single bonds and B' is a group of formula (iv) or NHCOCH3; that A is other than halo substituted naphthyl, when G1 is a single bond and p + q is 1; B' is other than urea, when A is indolyl substituted on position 2 with a group of formula (v); and that B' is other than CONH-aryl, when A is indolyl substituted on position 2 with carboxyl or alkoxycarbonyl, p is 1, q is 0 (p is 0 and q is 1) and G1 is single bond. A Independent claim is also included for the preparation of (I).
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Patent Agency Ranking26.发明专利
公开(公告)号：AU3610499A
公开(公告)日：1999-11-29
申请号：AU3610499
申请日：1999-05-10
Applicant: SERVIER LAB
Inventor： LESIEUR DANIEL , KLUPSCH FREDERIQUE , GUILLAUMET GERALD , VIAUD MARIE-CLAUDE , LANGLOIS MICHEL , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: C07D295/12 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/19 , A61K31/27 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/382 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4402 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/4453 , A61K31/453 , A61K31/454 , A61K31/473 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P1/00 , A61P3/06 , A61P3/10 , A61P5/02 , A61P9/00 , A61P15/08 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/36 , C07C233/40 , C07C233/43 , C07C233/62 , C07C233/65 , C07C237/48 , C07C271/20 , C07C271/30 , C07C275/24 , C07C275/40 , C07C311/46 , C07C317/32 , C07C323/40 , C07C323/41 , C07C323/44 , C07C323/62 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/20 , C07D209/60 , C07D209/90 , C07D213/70 , C07D221/08 , C07D221/10 , C07D233/42 , C07D233/84 , C07D235/06 , C07D235/14 , C07D261/20 , C07D295/18 , C07D307/68 , C07D307/77 , C07D307/81 , C07D307/92 , C07D311/58 , C07D311/60 , C07D311/92 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/40 , C07D333/50 , C07D333/56 , C07D333/58 , C07D333/74 , C07D335/06 , C07D335/08 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/06 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/048 , C07D491/052 , C07D493/04 , C07D495/04 , C07D495/14 , C07D521/00 , C07C311/37 , C07D307/85
Abstract: The invention concerns compounds of formula (I): R-A-R' wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R 1 , R 2 , R 3 , v and R 4 are as defined in the description; R' represents a -(CH 2 )t-R 5 group wherein t and R 5 are as defined in the description.
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公开(公告)号：AU3445195A
公开(公告)日：1996-05-09
申请号：AU3445195
申请日：1995-10-25
Applicant: SERVIER LAB
Inventor： ANDRIEUX JEAN , LANGLOIS MICHEL , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: A61K31/16 , A61K31/17 , A61K31/22 , A61K31/34 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61P25/20 , A61P25/24 , A61P25/26 , C07C259/06 , C07C259/08 , C07C275/64 , C07C327/56 , C07C335/40 , C07D209/12 , C07D307/80 , C07D333/56 , A61K31/165
Abstract: O-Aryl methyl N-acyl or N-thioacyl hydroxylamine derivs. of formula ArCH2ON(R1)C(=X)R2 (I), their enantiomers and diastereoisomers are new. X = O or S; R1 = H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, or arylalkyl; R2 = R21 or R22; R21 = H or alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkylalkyl all of which may be substd.; R22 = alkylamino, cycloalkylamino, or cycloalkylalkylamino which may be substd. on the (cyclo)alkyl gps.; Ar = naphthyl, indolyl, benzofuranyl, or benzothiophenyl, all of which may be partially or fully hydrogenated. alkyl, alkoxy = 1-6C, alkenyl, alkynyl = 2-6C, cycloalkyl = 3-8C, and opt. substits. on these may be halo, alkyl or alkoxy. Opt. substits. on Ar gps. are one or more gps. R; R = halo, OH, Ra, -CH2Ra, -O-Ra, -CO-Ra or -O-CO-Ra; Ra = opt. substd. alkyl, alkenyl, alkynyl, opt. substd. cycloalkyl, opt. substd. cycloalkylalkyl, opt. substd. aryl or opt. substd. aralkyl; the substits. on aryl and aralkyl gps. may be halo, alkyl, alkoxy, OH and/or haloalkyl.
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公开(公告)号：PL195667B1
公开(公告)日：2007-10-31
申请号：PL33595499
申请日：1999-10-12
Applicant: SERVIER LAB
Inventor： LANGLOIS MICHEL , MATHE-ALLAINMAT MONIQUE , LAFAS-LE GALL MARIE , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: C07C233/23 , A61K31/16 , C07D339/00 , A61K31/165 , A61K31/17 , A61K31/335 , A61K31/343 , A61K31/352 , A61K31/353 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/4355 , A61K31/437 , A61P1/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/18 , C07C233/19 , C07C233/74 , C07C235/34 , C07C235/40 , C07C275/26 , C07D307/79 , C07D307/80 , C07D307/81 , C07D311/92 , C07D333/58 , C07D333/60 , C07D471/04 , C07D491/04 , C07D491/048 , C07D493/04
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公开(公告)号：DE69933147T2
公开(公告)日：2006-12-21
申请号：DE69933147
申请日：1999-05-10
Applicant: SERVIER LAB
Inventor： LESIEUR DANIEL , KLUPSCH FREDERIQUE , GUILLAUMET GERALD , VIAUD MARIE-CLAUDE , LANGLOIS MICHEL , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: C07C233/43 , C07D295/12 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/19 , A61K31/27 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/382 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4402 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/4453 , A61K31/453 , A61K31/454 , A61K31/473 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P1/00 , A61P3/06 , A61P3/10 , A61P5/02 , A61P9/00 , A61P15/08 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/36 , C07C233/40 , C07C233/62 , C07C233/65 , C07C237/48 , C07C271/20 , C07C271/30 , C07C275/24 , C07C275/40 , C07C311/37 , C07C311/46 , C07C317/32 , C07C323/40 , C07C323/41 , C07C323/44 , C07C323/62 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/20 , C07D209/60 , C07D209/90 , C07D213/70 , C07D221/08 , C07D221/10 , C07D233/42 , C07D233/84 , C07D235/06 , C07D235/14 , C07D261/20 , C07D295/18 , C07D307/68 , C07D307/77 , C07D307/81 , C07D307/85 , C07D307/92 , C07D311/58 , C07D311/60 , C07D311/92 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/40 , C07D333/50 , C07D333/56 , C07D333/58 , C07D333/74 , C07D335/06 , C07D335/08 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/06 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/048 , C07D491/052 , C07D493/04 , C07D495/04 , C07D495/14 , C07D521/00
Abstract: The invention concerns compounds of formula (I): R-A-R' wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R 1 , R 2 , R 3 , v and R 4 are as defined in the description; R' represents a -(CH 2 )t-R 5 group wherein t and R 5 are as defined in the description.
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公开(公告)号：ES2255261T3
公开(公告)日：2006-06-16
申请号：ES99918037
申请日：1999-05-10
Applicant: SERVIER LAB
Inventor： LESIEUR DANIEL , KLUPSCH FREDERIQUE , GUILLAUMET GERALD , VIAUD MARIE-CLAUDE , LANGLOIS MICHEL , BENNEJEAN CAROLINE
IPC: C07D295/12 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/19 , A61K31/27 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/382 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4402 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/4453 , A61K31/453 , A61K31/454 , A61K31/473 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P1/00 , A61P3/06 , A61P3/10 , A61P5/02 , A61P9/00 , A61P15/08 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/36 , C07C233/40 , C07C233/43 , C07C233/62 , C07C233/65 , C07C237/48 , C07C271/20 , C07C271/30 , C07C275/24 , C07C275/40 , C07C311/46 , C07C317/32 , C07C323/40 , C07C323/41 , C07C323/44 , C07C323/62 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/20 , C07D209/60 , C07D209/90 , C07D213/70 , C07D221/08 , C07D221/10 , C07D233/42 , C07D233/84 , C07D235/06 , C07D235/14 , C07D261/20 , C07D295/18 , C07D307/68 , C07D307/77 , C07D307/81 , C07D307/92 , C07D311/58 , C07D311/60 , C07D311/92 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/40 , C07D333/50 , C07D333/56 , C07D333/58 , C07D333/74 , C07D335/06 , C07D335/08 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/06 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/048 , C07D491/052 , C07D493/04 , C07D495/04 , C07D495/14 , C07D521/00 , C07C311/37 , C07D307/85
Abstract: Compuestos de **fórmula** donde: A representa: - un sistema cíclico de fórmula (II): en el cual u X representa un átomo de oxígeno o de azufre, o un grupo NR0 (donde R0 representa un átomo de hidrógeno, un grupo alquilo(C1-C6) lineal o ramificado, arilo, arilalquilo(C1-C6) lineal o ramificado o SO2Ph), u la representación ¿. significa que el enlace puede ser simple o doble entendiendo que se respeta la valencia de los átomos, u R¿¿ representa un grupo Ra, ORa, CORa, COORa, OCORa, OSO2CF3 o átomos de halógeno, representando Ra un átomo de hidrógeno, un grupo alquilo(C1-C6) lineal o ramificado, sustituido o no, alquenilo(C2-C6) lineal o ramificado sustituido o no, alquinilo(C2-C6) lineal o ramificado sustituido o no, polihaloalquilo(C1- C6) lineal o ramificado, cicloalquilo(C3-C8) sustituido o no, cicloalquil(C3-C8)alquilo(C1-C6) lineal o ramificado sustituido o no, cicloalquenilo(C3-C8) sustituido o no, cicloalquenil(C3-C8)alquilo(C1-C6) lineal o ramificado sustituido o no, arilo, arilalquilo(C1- C6) lineal o ramificado.
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