公开(公告)号：JP2003089639A

公开(公告)日：2003-03-28

申请号：JP2002196850

申请日：2002-07-05

Applicant: SERVIER LAB

Inventor： LANGLOIS MICHEL ,  MATHE-ALLAINMAT MONIQUE ,  LEFAS-LE GALL MARIE ,  BENNEJEAN CAROLINE ,  RENARD PIERRE ,  DELAGRANGE PHILIPPE

IPC: C07D339/00 ,  A61K31/16 ,  A61K31/165 ,  A61K31/17 ,  A61K31/335 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/4355 ,  A61K31/437 ,  A61P1/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07C233/18 ,  C07C233/23 ,  C07C233/74 ,  C07C235/34 ,  C07C235/40 ,  C07C275/26 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D311/92 ,  C07D333/58 ,  C07D333/60 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D493/04

Abstract: PROBLEM TO BE SOLVED: To obtain a new cyclic compound having pharmacological action on the receptor for a compound having melatonin-like activity. SOLUTION: This new cyclic compound is expressed by formula (I) [R is ORa , SRa , Ra or a cyclic group; A is a cyclic structure group; G1 and G2 are each an alkylene chain or a single bond; B is NR a C(Q)R a , NR a C(Q)NR a R a or C(Q)NR a R a ; and (p) and (q) are numbers satisfying the formula 1

公开(公告)号：NO327076B1

公开(公告)日：2009-04-20

申请号：NO994947

申请日：1999-10-11

Applicant: SERVIER LAB

Inventor： DELAGRANGE PHILIPPE ,  LANGLOIS MICHEL ,  MATHE-ALLAINMAT MONIQUE ,  BENNEJEAN CAROLINE ,  RENARD PIERRE ,  GALL MARIE LEFAS-LE

IPC: C07C233/23 ,  A61K31/16 ,  C07D339/00 ,  A61K31/165 ,  A61K31/17 ,  A61K31/335 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/4355 ,  A61K31/437 ,  A61P1/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07C233/18 ,  C07C233/74 ,  C07C235/34 ,  C07C235/40 ,  C07C275/26 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D311/92 ,  C07D333/58 ,  C07D333/60 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D493/04

Abstract: Cycloalkene substituted cyclic derivatives (I) are new. Cycloalkene substituted cyclic derivatives of formula (I), their enantiomers, diastereoisomers and their acid or base addition salts are new. A = a group of formula (i) or (ii) (optionally substituted by Ra, ORa, OH, CORa, formyl, COORa, COOH or OCORa; Ra = 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 1-6C polyhaloalkyl, 3-8C cycloalkyl, 3-8C cycloalkyl-(1-6C) alkyl, 3-8C cycloalkenyl, 3-8C cycloalkenyl-(1-6C) alkyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, amino or halo), aryl, aryl-(1-6C) alkyl, heteroaryl or heteroaryl-(1-6C) alkyl; X, Y' = O, S or CH2; D' = benzene or naphthalene; a-d = single or double bond; Z = O, S, CH2 or NR ; R = H, 1-6C alkyl, aryl or aryl-(1-6C) alkyl; D'' = benzene or pyridine; R = H, halo, OH, SH, Ra, ORa, S(O)nRa or a (un)saturated 5- to 7-membered ring of formula (iii) (optionally substituted with at least one 1-6C alkyl, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl, OH or =O); n = 0-2; E = O or -S(O)n-; G1, G2 = single bond, -(CH2)t- (optionally substituted with at least one OH, COOH, formyl, Ra, ORa, COORa, CORa or halo; p, q = 0-4; p + q = 1-4; B' = -NR aC(Q)R a, -NR aC(Q)NR aR a or -C(Q)NR aR a; R a-R a = H or Ra; Q = O or S; aryl = phenyl, naphthyl, biphenyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); heteroaryl = 5- to 10-membered mono- or polycyclic aromatic ring containing 1-3 N, O or S (optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); and provided that q = 0 and p = 4, or q = 4 and p = 0 do not apply, when A is naphthyl (optionally substituted with methoxy or methyl), G1 and G2 are single bonds and B' is a group of formula (iv) or NHCOCH3; that A is other than halo substituted naphthyl, when G1 is a single bond and p + q is 1; B' is other than urea, when A is indolyl substituted on position 2 with a group of formula (v); and that B' is other than CONH-aryl, when A is indolyl substituted on position 2 with carboxyl or alkoxycarbonyl, p is 1, q is 0 (p is 0 and q is 1) and G1 is single bond. A Independent claim is also included for the preparation of (I).

公开(公告)号：AT267163T

公开(公告)日：2004-06-15

申请号：AT98959957

申请日：1998-12-11

Applicant: SERVIER LAB

Inventor： LANGLOIS MICHEL ,  MATHE-ALLAINMAT MONIQUE ,  JELLIMANN CAROLE ,  ANDRIEUX JEAN ,  BENNEJEAN CAROLINE ,  RENARD PIERRE ,  DELAGRANGE PHILIPPE

IPC: C07D333/74 ,  A61K31/165 ,  A61K31/343 ,  A61K31/381 ,  A61K31/403 ,  A61P9/06 ,  A61P25/20 ,  A61P25/22 ,  A61P43/00 ,  C07C233/05 ,  C07C233/18 ,  C07C233/60 ,  C07C235/34 ,  C07C275/24 ,  C07C275/26 ,  C07D209/60 ,  C07D209/90 ,  C07D307/77 ,  C07D307/92 ,  C07D307/93 ,  C07D333/78

Abstract: The invention concerns compounds of formula (I) in which: A forms a tricyclic system of formula A1, A2, A3 or A4; R1 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or oxo group; (R2)m and (R3)m' are such as defined in the description; n represents an integer such that 0

公开(公告)号：EA002818B1

公开(公告)日：2002-10-31

申请号：EA199900819

申请日：1999-10-11

Applicant: SERVIER LAB

Inventor： LANGLOIS MICHRL ,  MATHE-ALLAINMAT MONIQUE ,  LEFAS-LEGALL MARIE ,  BENNEJEAN CAROLINE ,  RENARD PIERRE ,  DELAGRANGE PHILIPPE

IPC: A61K31/16 ,  A61K31/165 ,  A61K31/17 ,  A61K31/335 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/4355 ,  A61K31/437 ,  A61P1/00 ,  A61P3/04 ,  C07D339/00 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07C233/18 ,  C07C233/23 ,  C07C233/74 ,  C07C235/34 ,  C07C235/40 ,  C07C275/26 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D311/92 ,  C07D333/58 ,  C07D333/60 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D493/04 ,  C07C233/06 ,  C07D333/54 ,  A61K31/35

Abstract: Изобретениеотноситсяк соединениямформулы (I)где R представляет OR, SRили Rгруппуилициклическуюгруппу?Аимеетциклическоестроение,Gи Gпредставляюталкиленовуюцепьилипростуюсвязь,Впредставляет -NRC(Q)R, -NRC(Q)NRRили C(Q)NRR,ри q такие, чтобы 1≤р+q≤4.

公开(公告)号：EA199900819A2

公开(公告)日：2000-04-24

申请号：EA199900819

申请日：1999-10-11

Applicant: SERVIER LAB

Inventor： LANGLOIS MICHRL ,  MATHE-ALLAINMAT MONIQUE ,  LEFAS-LEGALL MARIE ,  BENNEJEAN CAROLINE ,  RENARD PIERRE ,  DELAGRANGE PHILIPPE

IPC: C07D339/00 ,  A61K31/16 ,  A61K31/165 ,  A61K31/17 ,  A61K31/335 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/4355 ,  A61K31/437 ,  A61P1/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07C233/18 ,  C07C233/23 ,  C07C233/74 ,  C07C235/34 ,  C07C235/40 ,  C07C275/26 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D311/92 ,  C07D333/58 ,  C07D333/60 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D493/04

Abstract: Изобретениеотноситсяк соединениямформулы (I):где R представляет OR, SRили Rгруппуилициклическуюгруппу,A имеетциклическоестроение,Gи Gпредставляюталкиленовуюцепьилипростуюсвязь,B представляет -NRC(Q)R, -NRC(Q)NRRили -C(Q)NRR,p и q такие, чтобы 1 ≤ p + q ≤ 4

公开(公告)号：AR044975A1

公开(公告)日：2005-10-12

申请号：ARP040102314

申请日：2004-07-01

Applicant: SERVIER LAB

Inventor： LANGLOIS MICHEL ,  MATHE-ALLAINMAT MONIQUE ,  CHAHED MONCEF AMINE ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  BENNEJEAN CAROLINE ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE

IPC: A61P25/00 ,  A61P35/00 ,  C07C233/05 ,  C07C233/06 ,  A61K31/16

Abstract: Compuestos ligandos de receptores de melatonina útiles en el tratamiento de desórdenes del S.N.C.. Reivindicación 1: Compuestos de fórmula (1) caracterizados porque: R1, representa un grupo alquilo C1-6 lineal o ramificado; R2 representa un grupo alquilo C1-6 lineal o ramificado, un grupo alquenilo C2-6 lineal o ramificado, un grupo cicloalquilo C3-8, un grupo cicloalquilo(C3-8)-alquilo(C1-6) donde la parte alquilo puede ser lineal o ramificada, un grupo arilo, un grupo arilo-alquilo(C1-6) donde la parte alquilo puede ser lineal o ramificada, un grupo heteroarilo, un grupo heteroarilo-alquilo(C1-6) donde la parte alquilo puede ser lineal o ramificada, o un grupo alquilo C1-6 lineal o ramificado sustituido por uno o más átomos de halógeno, n es 1 o 2, entendiéndose que: "arilo" indica un grupo fenilo, naftilo o bifenilo; "heteroarilo" indica cualquier grupo aromático mono- bi-cíclico que contiene entre 1 y 3 heteroátomos seleccionados entre O, S y N, donde los grupos arilo y heteroarilo así definidos pueden ser sustituidos por 1 a 3 grupos seleccionados entre alquilo C1-6 lineal o ramificado, alcoxi C1-6 lineal o ramificado, hidroxi, carboxi, formilo, nitro, ciano, polihaloalquilo c1-6 lineal o ramificado, alcoxicarbonilo y átomos de halógeno, sus enantiómeros y diastereoisómeros, y sus sales de adición con un ácido o base farmacéuticamente aceptable.

公开(公告)号：SI0994102T1

公开(公告)日：2003-06-30

申请号：SI9930237

申请日：1999-10-12

Applicant: SERVIER LAB

Inventor： LANGLOIS MICHEL ,  MATHE-ALLAINMAT MONIQUE ,  LEFAS-LE GALL MARIE ,  BENNEJEAN CAROLINE ,  RENARD PIERRE ,  DELAGRANGE PHILIPPE

IPC: A61K31/16 ,  A61K31/165 ,  A61K31/17 ,  A61K31/335 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  C07D339/00 ,  A61K31/4355 ,  A61K31/437 ,  A61P1/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07C233/18 ,  C07C233/23 ,  C07C233/74 ,  C07C235/34 ,  C07C235/40 ,  C07C275/26 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D311/92 ,  C07D333/58 ,  C07D333/60 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D493/04

Abstract: Cycloalkene substituted cyclic derivatives (I) are new. Cycloalkene substituted cyclic derivatives of formula (I), their enantiomers, diastereoisomers and their acid or base addition salts are new. A = a group of formula (i) or (ii) (optionally substituted by Ra, ORa, OH, CORa, formyl, COORa, COOH or OCORa; Ra = 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 1-6C polyhaloalkyl, 3-8C cycloalkyl, 3-8C cycloalkyl-(1-6C) alkyl, 3-8C cycloalkenyl, 3-8C cycloalkenyl-(1-6C) alkyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, amino or halo), aryl, aryl-(1-6C) alkyl, heteroaryl or heteroaryl-(1-6C) alkyl; X, Y' = O, S or CH2; D' = benzene or naphthalene; a-d = single or double bond; Z = O, S, CH2 or NR ; R = H, 1-6C alkyl, aryl or aryl-(1-6C) alkyl; D'' = benzene or pyridine; R = H, halo, OH, SH, Ra, ORa, S(O)nRa or a (un)saturated 5- to 7-membered ring of formula (iii) (optionally substituted with at least one 1-6C alkyl, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl, OH or =O); n = 0-2; E = O or -S(O)n-; G1, G2 = single bond, -(CH2)t- (optionally substituted with at least one OH, COOH, formyl, Ra, ORa, COORa, CORa or halo; p, q = 0-4; p + q = 1-4; B' = -NR aC(Q)R a, -NR aC(Q)NR aR a or -C(Q)NR aR a; R a-R a = H or Ra; Q = O or S; aryl = phenyl, naphthyl, biphenyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); heteroaryl = 5- to 10-membered mono- or polycyclic aromatic ring containing 1-3 N, O or S (optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); and provided that q = 0 and p = 4, or q = 4 and p = 0 do not apply, when A is naphthyl (optionally substituted with methoxy or methyl), G1 and G2 are single bonds and B' is a group of formula (iv) or NHCOCH3; that A is other than halo substituted naphthyl, when G1 is a single bond and p + q is 1; B' is other than urea, when A is indolyl substituted on position 2 with a group of formula (v); and that B' is other than CONH-aryl, when A is indolyl substituted on position 2 with carboxyl or alkoxycarbonyl, p is 1, q is 0 (p is 0 and q is 1) and G1 is single bond. A Independent claim is also included for the preparation of (I).

公开(公告)号：AU755115B2

公开(公告)日：2002-12-05

申请号：AU5362199

申请日：1999-10-12

Applicant: SERVIER LAB

Inventor： LANGLOIS MICHEL ,  MATHE-ALLAINMAT MONIQUE ,  GALL MARIE LEFAS-LE ,  BENNEJEAN CAROLINE ,  RENARD PIERRE ,  DELAGRANGE PHILIPPE

IPC: C07D339/00 ,  A61K31/16 ,  A61K31/165 ,  A61K31/17 ,  A61K31/335 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/4355 ,  A61K31/437 ,  A61P1/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07C233/18 ,  C07C233/23 ,  C07C233/74 ,  C07C235/34 ,  C07C235/40 ,  C07C275/26 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D311/92 ,  C07D333/58 ,  C07D333/60 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D493/04 ,  C07C233/58 ,  C07C233/17 ,  C07C233/22 ,  C07D307/83 ,  C07D311/74

Abstract: Cycloalkene substituted cyclic derivatives (I) are new. Cycloalkene substituted cyclic derivatives of formula (I), their enantiomers, diastereoisomers and their acid or base addition salts are new. A = a group of formula (i) or (ii) (optionally substituted by Ra, ORa, OH, CORa, formyl, COORa, COOH or OCORa; Ra = 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 1-6C polyhaloalkyl, 3-8C cycloalkyl, 3-8C cycloalkyl-(1-6C) alkyl, 3-8C cycloalkenyl, 3-8C cycloalkenyl-(1-6C) alkyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, amino or halo), aryl, aryl-(1-6C) alkyl, heteroaryl or heteroaryl-(1-6C) alkyl; X, Y' = O, S or CH2; D' = benzene or naphthalene; a-d = single or double bond; Z = O, S, CH2 or NR ; R = H, 1-6C alkyl, aryl or aryl-(1-6C) alkyl; D'' = benzene or pyridine; R = H, halo, OH, SH, Ra, ORa, S(O)nRa or a (un)saturated 5- to 7-membered ring of formula (iii) (optionally substituted with at least one 1-6C alkyl, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl, OH or =O); n = 0-2; E = O or -S(O)n-; G1, G2 = single bond, -(CH2)t- (optionally substituted with at least one OH, COOH, formyl, Ra, ORa, COORa, CORa or halo; p, q = 0-4; p + q = 1-4; B' = -NR aC(Q)R a, -NR aC(Q)NR aR a or -C(Q)NR aR a; R a-R a = H or Ra; Q = O or S; aryl = phenyl, naphthyl, biphenyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); heteroaryl = 5- to 10-membered mono- or polycyclic aromatic ring containing 1-3 N, O or S (optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); and provided that q = 0 and p = 4, or q = 4 and p = 0 do not apply, when A is naphthyl (optionally substituted with methoxy or methyl), G1 and G2 are single bonds and B' is a group of formula (iv) or NHCOCH3; that A is other than halo substituted naphthyl, when G1 is a single bond and p + q is 1; B' is other than urea, when A is indolyl substituted on position 2 with a group of formula (v); and that B' is other than CONH-aryl, when A is indolyl substituted on position 2 with carboxyl or alkoxycarbonyl, p is 1, q is 0 (p is 0 and q is 1) and G1 is single bond. A Independent claim is also included for the preparation of (I).

公开(公告)号：PL195667B1

公开(公告)日：2007-10-31

申请号：PL33595499

申请日：1999-10-12

Applicant: SERVIER LAB

Inventor： LANGLOIS MICHEL ,  MATHE-ALLAINMAT MONIQUE ,  LAFAS-LE GALL MARIE ,  BENNEJEAN CAROLINE ,  RENARD PIERRE ,  DELAGRANGE PHILIPPE

IPC: C07C233/23 ,  A61K31/16 ,  C07D339/00 ,  A61K31/165 ,  A61K31/17 ,  A61K31/335 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/4355 ,  A61K31/437 ,  A61P1/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07C233/18 ,  C07C233/19 ,  C07C233/74 ,  C07C235/34 ,  C07C235/40 ,  C07C275/26 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D311/92 ,  C07D333/58 ,  C07D333/60 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D493/04

公开(公告)号：AT234808T

公开(公告)日：2003-04-15

申请号：AT99402495

申请日：1999-10-12

Applicant: SERVIER LAB

Inventor： LANGLOIS MICHEL ,  MATHE-ALLAINMAT MONIQUE ,  LEFAS-LE GALL MARIE ,  BENNEJEAN CAROLINE ,  RENARD PIERRE ,  DELAGRANGE PHILIPPE

IPC: C07D339/00 ,  A61K31/16 ,  A61K31/165 ,  A61K31/17 ,  A61K31/335 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/4355 ,  A61K31/437 ,  A61P1/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07C233/18 ,  C07C233/23 ,  C07C233/74 ,  C07C235/34 ,  C07C235/40 ,  C07C275/26 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D311/92 ,  C07D333/58 ,  C07D333/60 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D493/04

Abstract: Cycloalkene substituted cyclic derivatives (I) are new. Cycloalkene substituted cyclic derivatives of formula (I), their enantiomers, diastereoisomers and their acid or base addition salts are new. A = a group of formula (i) or (ii) (optionally substituted by Ra, ORa, OH, CORa, formyl, COORa, COOH or OCORa; Ra = 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 1-6C polyhaloalkyl, 3-8C cycloalkyl, 3-8C cycloalkyl-(1-6C) alkyl, 3-8C cycloalkenyl, 3-8C cycloalkenyl-(1-6C) alkyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, amino or halo), aryl, aryl-(1-6C) alkyl, heteroaryl or heteroaryl-(1-6C) alkyl; X, Y' = O, S or CH2; D' = benzene or naphthalene; a-d = single or double bond; Z = O, S, CH2 or NR ; R = H, 1-6C alkyl, aryl or aryl-(1-6C) alkyl; D'' = benzene or pyridine; R = H, halo, OH, SH, Ra, ORa, S(O)nRa or a (un)saturated 5- to 7-membered ring of formula (iii) (optionally substituted with at least one 1-6C alkyl, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl, OH or =O); n = 0-2; E = O or -S(O)n-; G1, G2 = single bond, -(CH2)t- (optionally substituted with at least one OH, COOH, formyl, Ra, ORa, COORa, CORa or halo; p, q = 0-4; p + q = 1-4; B' = -NR aC(Q)R a, -NR aC(Q)NR aR a or -C(Q)NR aR a; R a-R a = H or Ra; Q = O or S; aryl = phenyl, naphthyl, biphenyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); heteroaryl = 5- to 10-membered mono- or polycyclic aromatic ring containing 1-3 N, O or S (optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); and provided that q = 0 and p = 4, or q = 4 and p = 0 do not apply, when A is naphthyl (optionally substituted with methoxy or methyl), G1 and G2 are single bonds and B' is a group of formula (iv) or NHCOCH3; that A is other than halo substituted naphthyl, when G1 is a single bond and p + q is 1; B' is other than urea, when A is indolyl substituted on position 2 with a group of formula (v); and that B' is other than CONH-aryl, when A is indolyl substituted on position 2 with carboxyl or alkoxycarbonyl, p is 1, q is 0 (p is 0 and q is 1) and G1 is single bond. A Independent claim is also included for the preparation of (I).