公开(公告)号：CZ20022119A3

公开(公告)日：2003-02-12

申请号：CZ20022119

申请日：2002-06-17

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  FOURQUEZ JEAN-MARIE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE ,  NOSJEAN OLIVIER ,  BOULANGER MICHELLE

IPC: C07D295/18 ,  A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185

Abstract: A compound of formula (I):wherein:represents an optionally substituted saturated carbon ring having from 4 to 8 ring members,R1 and R4, which may be identical or different, each represents hydrogen or acyl,R2 and R3, which may be identical or different, each represents hydrogen or alkyl,R5 and R6, which may be identical or different, each represents hydrogen or alkyl, or R5 and R6 together, with the nitrogen atom carrying them, form an optionally substituted nitrogen-containing heterocycle,stereoisomers thereof, and also addition salts thereof with a pharmaceutically acceptable acid.Medicinal products containing the same which are useful for treatment of glucose intolerance or of disorders associated with hyperglycaemia.

公开(公告)号：ZA200203867B

公开(公告)日：2003-01-02

申请号：ZA200203867

申请日：2002-05-15

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE ,  BOULANGER MICHELLE

IPC: A61K31/40 ,  A61K31/426 ,  C07D295/10 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  C07D207/16 ,  C07D277/04 ,  C07D277/06 ,  C07D295/185 ,  C07K5/02 ,  C07D ,  A61K

Abstract: Alpha amino acid derivatives (I), their optical isomers and addition salts, are new. Alpha amino acid derivatives of formula (I), their optical isomers and addition salts, are new: A = five-membered heterocycle, optionally substituted by a cyano group; Ak = 1-6C alkylene; X = single bond or phenylene; R1, R2, R4 = H or 1-6C alkyl; Y = NR4 or CH-NO2; R3 = NO2 or CN; and provided that: (i) when Y is CH-NO2, then R3 may further be 1-6C alkyl; and (ii) when A is unsubstituted, then Ak is propylene, X is a bond, Y is NH and R3 is NO2, are excluded.

公开(公告)号：FR2826003A1

公开(公告)日：2002-12-20

申请号：FR0107934

申请日：2001-06-18

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  FOURQUEZ JEAN MARIE ,  LEVENS NIGEL ,  HUSSON ROBERT BERNADETTE ,  NOSJEAN OLIVIER ,  BOULANGER MICHELLE

IPC: C07D295/18 ,  A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185 ,  C07D207/12

Abstract: Cyclic alpha- amino gamma-hydroxy amides (I), their stereoisomers, and acid addition salts are new. Cyclic alpha- amino gamma-hydroxy amides (I), their stereoisomers, and acid addition salts are new. ring A = 4-8 membered saturated C ring that may be substituted by one or more 1-6C alkyl groups; R1 and R4 = H or 1-6C acyl; R2 and R3 = H or 1-6C alkyl; R5 and R6 = H, 1-6C alkyl, or together with the N atom form a saturated mono- or bicyclic nitrogen heterocycle having 1-3 heteroatoms (additional heteroatoms being O, N, or S) optionally substituted by one or more groups CN, COOR7, COR7, NO2, CONR8aR8b, S(O)nR9, or PO3R10aR10b; R7 = H or 1-6C alkyl; R8a and R8b = H, 1-6C alkyl or together form a N heterocycle as defined; R9 = H, 1-6C alkyl, or phenyl, biphenyl, naphthyl, or tetrahydronaphthyl all these aryl groups being optionally substituted by halogen, 1-6C alkyl or alkoxy, OH, 1-6C polyhalolalkyl, NO2, or 1 or 2 C alkylene dioxy; R10a and R10b = H or 1-6C alkyl; n = 1, 2, or 3.

公开(公告)号：AU4065402A

公开(公告)日：2002-11-21

申请号：AU4065402

申请日：2002-05-15

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  BOULANGER MICHELLE ,  HUSSON-ROBERT BERNADETTE ,  NOSJEAN OLIVIER ,  LEVENS NIGEL ,  BENOIST ALAIN ,  PORTEVIN BERNARD

IPC: C07D295/10 ,  A61K31/40 ,  A61K31/426 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  C07D207/16 ,  C07D277/04 ,  C07D277/06 ,  C07D295/185 ,  C07K5/02 ,  C07D295/192 ,  C07D277/22 ,  C07D277/30 ,  A61K31/401

Abstract: Alpha amino acid derivatives (I), their optical isomers and addition salts, are new. Alpha amino acid derivatives of formula (I), their optical isomers and addition salts, are new: A = five-membered heterocycle, optionally substituted by a cyano group; Ak = 1-6C alkylene; X = single bond or phenylene; R1, R2, R4 = H or 1-6C alkyl; Y = NR4 or CH-NO2; R3 = NO2 or CN; and provided that: (i) when Y is CH-NO2, then R3 may further be 1-6C alkyl; and (ii) when A is unsubstituted, then Ak is propylene, X is a bond, Y is NH and R3 is NO2, are excluded.

公开(公告)号：NO20022285L

公开(公告)日：2002-11-18

申请号：NO20022285

申请日：2002-05-14

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE ,  BOULANGER MICHELLE

IPC: A61K31/40 ,  C07D295/10 ,  A61K31/426 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  C07D207/16 ,  C07D277/04 ,  C07D277/06 ,  C07D295/185 ,  C07K5/02

Abstract: Alpha amino acid derivatives (I), their optical isomers and addition salts, are new. Alpha amino acid derivatives of formula (I), their optical isomers and addition salts, are new: A = five-membered heterocycle, optionally substituted by a cyano group; Ak = 1-6C alkylene; X = single bond or phenylene; R1, R2, R4 = H or 1-6C alkyl; Y = NR4 or CH-NO2; R3 = NO2 or CN; and provided that: (i) when Y is CH-NO2, then R3 may further be 1-6C alkyl; and (ii) when A is unsubstituted, then Ak is propylene, X is a bond, Y is NH and R3 is NO2, are excluded.

公开(公告)号：NO20022285D0

公开(公告)日：2002-05-14

申请号：NO20022285

申请日：2002-05-14

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE ,  BOULANGER MICHELLE

IPC: A61K31/40 ,  C07D295/10 ,  A61K31/426 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  C07D207/16 ,  C07D277/04 ,  C07D277/06 ,  C07D295/185 ,  C07K5/02 ,  C07D

Abstract: Alpha amino acid derivatives (I), their optical isomers and addition salts, are new. Alpha amino acid derivatives of formula (I), their optical isomers and addition salts, are new: A = five-membered heterocycle, optionally substituted by a cyano group; Ak = 1-6C alkylene; X = single bond or phenylene; R1, R2, R4 = H or 1-6C alkyl; Y = NR4 or CH-NO2; R3 = NO2 or CN; and provided that: (i) when Y is CH-NO2, then R3 may further be 1-6C alkyl; and (ii) when A is unsubstituted, then Ak is propylene, X is a bond, Y is NH and R3 is NO2, are excluded.

公开(公告)号：SK285989B6

公开(公告)日：2008-01-07

申请号：SK8772002

申请日：2002-06-18

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  FOURQUEZ JEAN-MARIE ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  BOULANGER MICHELLE ,  HUSSON-ROBERT BERNADETTE

IPC: C07D295/00 ,  A61K31/00 ,  C07D295/18 ,  A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185

Abstract: Described are compounds of the formula (I), in which the substituents have meaning described in claims, method for their preparation and pharmaceutical compositions containing thereof in the treatment of glucose intolerance and of disorders associated with hyperglycaemia, such as type II diabetes or obesity.

公开(公告)号：ES2266422T3

公开(公告)日：2007-03-01

申请号：ES02291192

申请日：2002-05-14

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE

IPC: C07D207/16 ,  C07D295/10 ,  A61K31/40 ,  A61K31/426 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  C07D277/04 ,  C07D277/06 ,  C07D295/18 ,  C07D295/185 ,  C07K5/02

Abstract: Compuesto de fórmula (I): (Ver fórmula) donde ~ (Ver fórmula) representa un heterociclo nitrogenado de 5 eslabones eventualmente sustituido con un grupo ciano, ~ Ak representa una cadena alquileno(C1-C6) lineal o ramificada, ~ X representa un enlace sencillo o un grupo fenileno, ~ R1 y R2, idénticos o diferentes, representan cada uno un átomo de hidrógeno o un grupo alquilo(C1-C6) lineal o ramificado, ~ Y representa NR4 o CH-NO2, ¿ R4 representa un átomo de hidrógeno o un grupo alquilo(C1-C6) lineal o ramificado, ~ R3 representa: - o bien un grupo seleccionado de entre alquilo(C1-C6) lineal o ramificado, nitro y ciano, en el caso en que Y representa CH-NO2, - o bien un grupo seleccionado de entre nitro y ciano cuando Y representa NR4, sus tautómeros si existen, sus isómeros ópticos y sus sales de adición de un ácido farmacéuticamente aceptable, excluyendo los compuestos en los cuales simultáneamente (Ver fórmula) representa un heterociclo nitrogenado de 5 eslabones no sustituido, Ak representa el grupo -(CH2)3-, X representa un enlace simple, Y representa NH y R3 representa el grupo nitro, entendiéndose que por heterociclo nitrogenado de 5 eslabones se entiende un grupo monocíclico saturado de 5 eslabones que contiene uno, dos o tres heteroátomos, siendo uno de estos heteroátomos un átomo de nitrógeno, y eligiéndose el o los heteroátomos suplementarios eventualmente presentes entre átomos de oxígeno, de nitrógeno o de azufre.

公开(公告)号：SI1258476T1

公开(公告)日：2006-10-31

申请号：SI200230350

申请日：2002-05-14

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE ,  BOULANGER MICHELLE

IPC: C07D207/00 ,  A61K31/00 ,  C07D295/10 ,  A61K31/40 ,  A61K31/426 ,  A61P3/00 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  C07D207/16 ,  C07D277/00 ,  C07D277/04 ,  C07D277/06 ,  C07D295/00 ,  C07D295/185 ,  C07K5/02

公开(公告)号：NO322155B1

公开(公告)日：2006-08-21

申请号：NO20022891

申请日：2002-06-17

Applicant: SERVIER LAB

Inventor： BOULANGER MICHELLE ,  WIERZBICKI MICHEL ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE ,  FOURQUEZ JEAN-MARIE

IPC: C07D295/18 ,  A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D237/14 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185

Abstract: A compound of formula (I):wherein:represents an optionally substituted saturated carbon ring having from 4 to 8 ring members,R1 and R4, which may be identical or different, each represents hydrogen or acyl,R2 and R3, which may be identical or different, each represents hydrogen or alkyl,R5 and R6, which may be identical or different, each represents hydrogen or alkyl, or R5 and R6 together, with the nitrogen atom carrying them, form an optionally substituted nitrogen-containing heterocycle,stereoisomers thereof, and also addition salts thereof with a pharmaceutically acceptable acid.Medicinal products containing the same which are useful for treatment of glucose intolerance or of disorders associated with hyperglycaemia.