公开(公告)号：JP2002322150A

公开(公告)日：2002-11-08

申请号：JP2002073851

申请日：2002-03-18

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN-ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D491/056 ,  A61K31/40 ,  A61K31/403 ,  A61K31/407 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D209/80 ,  C07D209/94

Abstract: PROBLEM TO BE SOLVED: To provide a compound which exerts a useful pharmacological characteristic toward melatoninergic receptors. SOLUTION: The compound represented by formula (I), not including indeno[1,2-b]indol-10(5H)-one, is provided [wherein, R is H or an arbitrarily substituted alkenyl or an alkyl group; R1 , R2 , R3 , R4 , R5 , R6 , R7 and R8 are each H, an alkyl, an alkenyl, a hydroxy, an alkoxy, an alkenyloxy, an arylalkyl, an arylalkoxy, a carboxy, an acyloxy or an arylcarbonyloxy group, or one of R1 to R8 groups forms an alkylenedioxy group with a group adjacent to the one of R1 to R8 ]. In the compound, when R is not H, at least one of R1 to R8 groups is a hydroxy or an acyloxy group.

公开(公告)号：JP2002265469A

公开(公告)日：2002-09-18

申请号：JP2002065233

申请日：2002-03-11

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN-ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D487/06 ,  A61K31/407 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D487/04

Abstract: PROBLEM TO BE SOLVED: To provide a medicine which contains a compound having high affinity with a melatonin receptor and is useful for treating diseases related to the melatonin operation system. SOLUTION: The compound represented by the formula (R1 , R2 , R3 , R4 , R5 , R6 , and R8 are each H or the like, R7 is H or the like, or one of R1 to R8 forms a 1 to 2C alkylenedioxy together with another adjacent one of R1 to R8 ), its optically isomer (when the optical isomer exists), and its pharmacologically acceptable acid or base adduct; a process for preparing the same; and a pharmaceutical composition containing the same.

公开(公告)号：AU2009201068B2

公开(公告)日：2012-11-22

申请号：AU2009201068

申请日：2009-03-17

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/30 ,  A61K31/352 ,  A61P7/02 ,  A61P9/10 ,  C07D407/02 ,  C07D407/12 ,  C07D407/14

Abstract: NEW DIOSMETIN COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Abstract The invention relates to compounds of formula (1): HC OR3 0 CH 2 wherein R1, R2 and R3, which may be the same or different, each represent a hydrogen atom or the group of formula (A): 0 (A) The invention also relates to pharmaceutical compositions comprising a compound of 10 formula (1) and methods of treatment comprising administering compounds of formula (1) or a pharmaceutical composition thereof.

公开(公告)号：ME00680B

公开(公告)日：2011-12-20

申请号：MEP10909

申请日：2009-03-31

Applicant: SERVIER LAB

Inventor： RUPIN ALAIN ,  WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANÇOISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  PAYSANT JÉRÔME ,  LEFOULON FRANÇOIS

IPC: C07D311/30 ,  A61K31/35 ,  C07D407/12 ,  C07D407/14 ,  C07H15/26

Abstract: Jedinjenja formule (I): Gde R 1 R 2 i R 3 , koji mogu biti isti ili različiti, pojedinačno predstavljaju atom vodonika ili grupu formule (A): Lekovi.

公开(公告)号：PL2107055T3

公开(公告)日：2011-06-30

申请号：PL09290237

申请日：2009-03-31

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANÇOISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JÉRÔME ,  LEFOULON FRANÇOIS

IPC: A61K31/352 ,  C07D311/30 ,  A61K31/7012 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C07D407/12 ,  C07H15/26

公开(公告)号：NZ560749A

公开(公告)日：2010-11-26

申请号：NZ56074906

申请日：2006-02-28

Applicant: SERVIER LAB

Inventor： VERBEUREN TONY ,  RUPIN ALAIN ,  SANSILVESTRI-MOREL PATRICIA ,  VALLEZ MARIE-ODILE ,  BOUSSARD MARIE-FRANCOISE ,  WIERZBICKI MICHEL

IPC: A61K31/352 ,  A61P7/02

Abstract: Disclosed is the use of diosmetin compounds of formula (I) wherein the substituents are disclosed within the specification in the manufacture of a medicament for the prevention and/or treatment of thrombotic pathologies.

公开(公告)号：FR2929276B1

公开(公告)日：2010-04-23

申请号：FR0801779

申请日：2008-04-01

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  VERBEUREN TONY ,  SANSILVESTRI MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/30 ,  A61K31/352 ,  A61K31/7012 ,  A61K31/7048 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C07H15/26

公开(公告)号：ECSP099216A

公开(公告)日：2010-03-31

申请号：ECSP099216

申请日：2009-03-30

Applicant: SERVIER LAB

Inventor： LEFOULON FRANCOIS ,  VERBEUREN TONY ,  RUPIN ALAIN ,  SANSILVESTRI-MOREL PATRICIA ,  WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  PAYSANT JEROME

IPC: A61K31/44 ,  C07D213/74

Abstract: Compuestos de fórmula (I) : en la que R1, R2 y R3, idénticos o diferentes, representan cada uno un átomo de hidrógeno o el grupo de fórmula (A) :

公开(公告)号：BRPI0900983A2

公开(公告)日：2009-11-17

申请号：BRPI0900983

申请日：2009-03-31

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/00 ,  A61K31/352 ,  A61P7/02 ,  A61P9/12 ,  A61P9/14

Abstract: Diosmetin derivatives (I), are new. Diosmetin derivatives of formula (I), are new. R1-R3 : H or (2S,3S,4R,5S)-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid moiety. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Anticoagulant; Antiinflammatory; Vasotropic; Antidiabetic; Hypotensive; Antiarteriosclerotic; Analgesic; Antianginal; Anorectic; Cerebroprotective. MECHANISM OF ACTION : None given.

公开(公告)号：HU226674B1

公开(公告)日：2009-06-29

申请号：HU0201024

申请日：2002-03-19

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN-ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D209/94 ,  C07D491/056 ,  A61K31/40 ,  A61K31/403 ,  A61K31/407 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  A61P9/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D209/80

Abstract: Compound of formula (I):wherein:R represents hydrogen or a group selected from alkenyl and optionally substituted alkyl,each of R1 to R8, which may be identical or different, represents hydrogen or a group selected from alkyl, alkenyl, hydroxy, alkoxy, alkenyloxy, arylalkyl, arylalkoxy, carboxy, acyloxy and arylcarbonyloxy,or one of R1 to R8 forms with an adjacent one R1 to R8 an alkylenedioxy group,its optical isomers when they exist, and addition salts thereof with a pharmaceutically acceptable acid or base,with the proviso that:when R does not represent hydrogen, then at least one of R1 to R8 represents hydroxy or acyloxy,and the compounds of formula (I) are other than indeno[1,2-b]indol-10(5H)-one and medicinal products containing the same which are useful for treatment of disorders of the melatoninergic system.