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公开(公告)号：CA2719356C
公开(公告)日：2020-04-07
申请号：CA2719356
申请日：2009-03-30
Applicant: TORAY INDUSTRIES
Inventor： UENO YOSHIYUKI , FUJITA MASAKI , SUGAYA HIROYUKI
Abstract: Provided is a separation membrane module suffering from little sticking of organic matters, proteins, platelets and so on. A separation membrane which is a membrane comprising a polymer, characterized in that a functional layer is formed on the surface in one side of the membrane, the peak area percentage of carbon derived from ester group measured by the electron spectroscopy for chemical analysis (ESCA) on the surface of the preceding functional layer is 0.1% (by atomic number) or more but not more than 10 (% by atomic number), and the peak area percentage of carbon derived from ester group measured by the electron spectroscopy for chemical analysis (ESCA) on the surface opposite to the functional layer is not more than 10 (% by atomic number); and a separation membrane module provided with the same as a built-in membrane.
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公开(公告)号：CA3105469A1
公开(公告)日：2020-03-05
申请号：CA3105469
申请日：2019-08-30
Applicant: TORAY INDUSTRIES
Inventor： KOGAWA TAISUKE , FUJITA MASAKI , TANAHASHI KAZUHIRO , YAMADA SATOSHI , TANAKA NOBUAKI , TSUCHIKURA HIROSHI
IPC: A61F2/06 , A61F2/07 , A61L27/18 , A61L27/34 , A61L27/40 , A61L27/50 , A61L27/58 , A61L31/06 , A61L31/10 , A61L31/12 , A61L31/14 , A61L33/00
Abstract: A goal of the present invention is to provide a cylindrical member for implantation that is capable of maintaining high patency through the achievement of antithrombotic properties, low swelling, and a low Young's modulus. The present invention provides a cylindrical member, for implantation, comprising a cylindrical base that has an elongation of 5100%, inclusive, in the major axis direction under a 20 N tensile load, and a block copolymer comprising a polyalkylene glycol block and a polyhydroxyalkanoic acid block. The mass percentage of the polyalkylene glycol with respect to the total mass of the block copolymer is 525%, inclusive, and a film comprising the block copolymer has a Young's modulus of 200 MPa or less.
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公开(公告)号：CA3092567A1
公开(公告)日：2019-10-03
申请号：CA3092567
申请日：2019-01-25
Applicant: TORAY INDUSTRIES
Inventor： KOGAWA TAISUKE , FUJITA MASAKI , KOYAMATSU YUICHI , TANAHASHI KAZUHIRO , KIDOBA KAZUYUKI
Abstract: The purpose of the present invention is to provide a biodegradable block copolymer which combines high conformability with excellent degradability. The present invention provides a block copolymer which comprises a poly(alkylene glycol) block and a poly(hydroxyalkanoic acid) block, wherein the proportion by mass of the poly(alkylene glycol) block to the whole mass is 10-60%, the block copolymer having a carbon-nucleus relaxation time T1? regarding the carbonyl carbon atom of 20 ms or less and satisfying expression 1. ?=?1×?2=20 (expression 1) ?1 is the degree of crystallization of the poly(alkylene glycol) block. ?2 is the degree of crystallization of a poly-A block, where A is a repeating unit, among the repeating units contained in the poly(hydroxyalkanoic acid) block, that is the highest in the degree of crystallization of the homopolymer made up of the same repeating units alone.
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公开(公告)号：CA2935808C
公开(公告)日：2018-08-21
申请号：CA2935808
申请日：2015-02-12
Applicant: TORAY INDUSTRIES
Inventor： FUJITA MASAKI , KADOWAKI KOJI , SAKAGUCHI YUKA , TANAHASHI KAZUHIRO , TSUCHIKURA HIROSHI , YAMADA SATOSHI
Abstract: The present invention aims to provide an artificial blood vessel composed of a cylindrical multiple-woven fabric structure, which allows only a small amount of blood leakage and can achieve both antithrombogenicity and cellular affinity. The present invention provides an artificial blood vessel comprising a cylindrical fabric structure in which a cylindrical fabric whose inside contacts blood is arranged, wherein the cylindrical fabric is a fabric prepared by interlacing a plurality of warp yarns and a plurality of weft yarns with each other into a cylindrical shape; the warp yarns and the weft yarns constituting the cylindrical fabric comprise a multifilament yarn having a single yarn fineness of not more than 0.50 dtex, and are bound to an antithrombogenic material; the antithrombogenic material forms an antithrombogenic material layer having a thickness of 1 to 600 nm inside the cylindrical fabric; and the water permeability under conditions where a pressure of 16 kPa is applied to the inner surface is less than 300 mL/cm2/min.
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25.发明专利
公开(公告)号：CA2819838C
公开(公告)日：2018-08-21
申请号：CA2819838
申请日：2011-12-09
Applicant: TORAY INDUSTRIES
Inventor： TANAHASHI KAZUHIRO , NAKANISHI MEGUMI , YAMAMURA YASUFUMI , FUJITA MASAKI
Abstract: The present invention aims to provide spherical biodegradable particles which have improved flexibility, cause less aggregation among particles, and have improved particle shape-recovering ability after passing through a catheter or the like, and a method for producing the particles. The present invention provides biodegradable particles comprising a synthetic polymer chemically cross-linked to a polyvalent carboxylic acid, which biodegradable particles have a water content of 20 to 90% in the water-saturated state.
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Patent Agency Ranking
公开(公告)号：AU2014355413B2
公开(公告)日：2017-06-22
申请号：AU2014355413
申请日：2014-11-27
Applicant: TORAY INDUSTRIES
Inventor： FUJITA MASAKI , KADOWAKI KOJI , SAKAGUCHI YUKA , TANAHASHI KAZUHIRO
IPC: A61L33/00
Abstract: The purpose of the present invention is to provide an anti-thrombotic material in which heparin or an anti-thrombotic compound other than a heparin derivative is fixed to a base material, elution of the compound exhibiting anti-thrombotic properties from the base material is avoided, and high anti-thrombotic properties are maintained over a long period. The present invention provides an anti-thrombotic material that includes: a covering material containing a polymer skeleton structure, a 4-(aminomethyl)benzene carboxy-imidamide or a benzene-amidine skeleton structure, and a methoxy benezene sulfonic acid amide skeleton structure; and a base material containing a surface that is covered by the covering material. The covering material is covalently bonded with the base material, and a peak abundance ratio of carbonyl-group-derived components on the surface, with respect to all the components of a C1s peak measured using X-ray electron spectroscopy, is equal to or greater than 1.0 atom number %.
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公开(公告)号：CA2987236A1
公开(公告)日：2016-12-01
申请号：CA2987236
申请日：2016-05-27
Applicant: TORAY INDUSTRIES
Inventor： KADOWAKI KOJI , SAITO AKIHIRO , NAKANISHI MEGUMI , FUJITA MASAKI , TANAHASHI KAZUHIRO
IPC: A61L33/00
Abstract: The purpose of the present invention is to provide an antithrombotic material which exhibits high antithrombotic activity that is sustained over a long period, while reducing the thickness of the coating material. The present invention is an antithrombotic material comprising a coating material containing a compound having anionic anti-clotting activity and including sulfur atoms together with a cationic polymer containing, as a constituent monomer, a compound selected from the group consisting of alkylene imine, vinyl amine, allyl amine, lysine, protamine and diallyl dimethyl ammonium chloride, and a substrate having the surface thereof coated by said coating material, wherein the cationic polymer is covalently bonded to the substrate, and the compound having anionic anticoagulant activity and including sulfur atoms is immobilized on the substrate surface by ionic bonding with the cationic polymer, and the average thickness of the coating material is 15-400nm.
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公开(公告)号：CA2947823A1
公开(公告)日：2015-11-12
申请号：CA2947823
申请日：2015-05-08
Applicant: TORAY INDUSTRIES , INOUE KANJI
Inventor： INOUE KANJI , YAGI TAKAHIRO , FUJITA MASAKI , KADOWAKI KOJI , TANAHASHI KAZUHIRO
IPC: A61F2/01
Abstract: In the present invention, disclosed is an endovascular treatment aid with which it can be confirmed that the endovascular treatment aid is in close contact with a blood vessel, and leakage of a captured substance is prevented. The endovascular treatment aid is provided with: a flexible shaft; a filter that is fixed to the shaft so as to form an opening on a proximal end side, that when opened assumes a conical shape the bottom surface of which is a ring which has elastic restoring force and which is fixed to the opening, and that can be opened or closed in the shape of an umbrella; and linear support members that are each fixed so as to connect the ring and a part of the shaft, and that make it possible to close the filter with the application of an external force to the proximal end side. A coil composed of a radiopaque material is wound about the ring. When the filter is closed, the ring assumes a shape in which a plurality of mountains oriented toward the distal end side and a plurality of valleys oriented toward the proximal end side are alternately generated, and the mountains and valleys are made to be close to one another. The coil is disposed on the ring so as to include a position fixed by the support members which are on the ring, and so as not to include the positions of the vertices of the mountains and the vertices of the valleys.
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公开(公告)号：CA2928629A1
公开(公告)日：2015-06-04
申请号：CA2928629
申请日：2014-11-27
Applicant: TORAY INDUSTRIES
Inventor： KADOWAKI KOJI , FUJITA MASAKI , SAKAGUCHI YUKA , TANAHASHI KAZUHIRO
IPC: A61L33/10
Abstract: The purpose of the present invention is to provide an antithrombotic material capable of enhancing safety in terms of low hemolytic toxicity and actualizing a high antithrombotic property persistently over an extended period of time. The prtesent invention provides an antithrombotic material furnished with a covering material, including a polymer containing a compound selected from the group consisting of alkylene imine, vinyl amine, allyl amine, lysine, protamine, and diallyl dimethyl ammonium chloride as a structural monomer and a sulfur atom-containing anionic compound having anticoagulant activity, and a base material, the surface of which is covered by this covering material, wherein the polymer bonds covalently with the base material and the abundance ratio of nitrogen atoms to the abundance of all atoms measured by X-ray electron spectroscopy on the surface is 6.0-12.0 atom%.
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公开(公告)号：CA2927423A1
公开(公告)日：2015-06-04
申请号：CA2927423
申请日：2014-11-27
Applicant: TORAY INDUSTRIES
Inventor： FUJITA MASAKI , KADOWAKI KOJI , SAKAGUCHI YUKA , TANAHASHI KAZUHIRO
IPC: A61L33/00
Abstract: The purpose of the present invention is to provide an anti-thrombotic material in which heparin or an anti-thrombotic compound other than a heparin derivative is fixed to a base material, elution of the compound exhibiting anti-thrombotic properties from the base material is avoided, and high anti-thrombotic properties are maintained over a long period. The present invention provides an anti-thrombotic material that includes: a covering material containing a polymer skeleton structure, a 4-(aminomethyl)benzene carboxy-imidamide or a benzene-amidine skeleton structure, and a methoxy benezene sulfonic acid amide skeleton structure; and a base material containing a surface that is covered by the covering material. The covering material is covalently bonded with the base material, and a peak abundance ratio of carbonyl-group-derived components on the surface, with respect to all the components of a C1s peak measured using X-ray electron spectroscopy, is equal to or greater than 1.0 atom number %.
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