公开(公告)号：JP2010133733A

公开(公告)日：2010-06-17

申请号：JP2008307656

申请日：2008-12-02

Applicant: Tosoh Corp ,  東ソー株式会社

Inventor： NAKAMURA KOJI ,  FUJII SATOSHI

IPC: G01N30/88 ,  B01D15/08 ,  B01J39/08 ,  B01J39/18 ,  B01J39/26 ,  B01J47/12 ,  C08F8/34 ,  G01N30/02

Abstract: PROBLEM TO BE SOLVED: To provide a cation exchanger capable of efficiently introducing a carboxylic acid group or sulfonic acid group into the surface of a carrier for chromatography under a condition more moderate than before using a small amount of a reagent. SOLUTION: The cation exchanger is manufactured by the first step (1) for introducing an epoxy group into the carrier for chromatography and the second step (2) for reacting a compound having a thiol group or carboxylic acid group in its molecule or a compound having the thiol group or sulfonic acid group in its molecule with the epoxy group. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种能够在比使用少量试剂之前更适中的条件下，有效地将羧酸基或磺酸基引入载体表面的色谱法的阳离子交换剂。 解决方案：阳离子交换器由第一步（1）制备，用于将环氧基引入载体进行色谱分离，第二步（2）使分子中具有硫醇基或羧酸基的化合物反应，或 在其分子中具有环氧基的硫醇基或磺酸基的化合物。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JPH03141232A

公开(公告)日：1991-06-17

申请号：JP27729289

申请日：1989-10-26

Applicant: TOSOH CORP

Inventor： HIRAKAWA KAZUNARI ,  FUJII SATOSHI ,  HOSOSE YASUNOBU ,  SEKIZAWA KAZUHIKO

IPC: C07B61/00 ,  C07C17/25 ,  C07C21/04 ,  C07C21/06

Abstract: PURPOSE:To suppress the concentration of a produced olefin below a specific ratio when the dehydrochlorination reaction of a chlorinated saturated hydrocarbon is performed in the presence of an offretite-erionite zeolite catalyst containing an alkali metal cation as an exchangeable cation. CONSTITUTION:When the dehydrochlorination reaction of a 2-4C chlorinated saturated hydrocarbon is performed in the presence of an OE zeolite catalyst containing an alkali metal cation as an exchangeable cation, the concentration of the produced olefin in the reaction mixture is controlled below 25vol.% and the reaction is performed at 200-350 deg.C and at a gas space rate of 50-7000/hr. Since the catalyst has high dehydrochlorination activity to give a high conversion to the raw material, the reaction product is readily separated from the raw material, and since the lowering of the catalytic activity of the catalyst caused by the deposition of carbonaceous substances on the catalyst is extremely little to elongate the life of the catalyst, the continuous operation of the reaction is possible. The catalyst may be an OE zeolite mixed with an alkali metal salt.

公开(公告)号：JP2012141212A

公开(公告)日：2012-07-26

申请号：JP2010294125

申请日：2010-12-28

Applicant: Tosoh Corp ,  東ソー株式会社

Inventor： FUJII SATOSHI ,  NAKAMURA KOJI

IPC: G01N30/88 ,  G01N30/26 ,  G01N30/32 ,  G01N30/60 ,  G01N30/86

Abstract: PROBLEM TO BE SOLVED: To provide a porous carrier which has a high absorption amount of pharmaceutical materials by its own antibody, tends not to degrade by washing under an alkali condition, is manufactured with low cost, is less likely to consolidate when a refining operation is performed with a large scale column under high linear velocity, and has a high porosity and sufficient mechanical strength.SOLUTION: The porous carrier has (1) the porosity of 80% or more and (2) the column pressure loss of 0.03 MPa or more and less than 0.3 MPa.

Abstract translation: 待解决的问题：为了提供通过其自身抗体具有高吸收量的药物的多孔载体，在碱性条件下通过洗涤倾向不降解，以低成本制造，不太可能固化时 在高线速度下用大规模柱进行精炼操作，具有高孔隙率和足够的机械强度。 解决方案：多孔载体具有（1）孔隙率为80％以上，（2）柱压力损失为0.03MPa以上且小于0.3MPa。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JPH02169528A

公开(公告)日：1990-06-29

申请号：JP32193588

申请日：1988-12-22

Applicant: TOSOH CORP

Inventor： TAKAHASHI MITSURU ,  NAGASAKI YOSHITAKA ,  FUJII SATOSHI

IPC: C07C29/147 ,  C07C31/38 ,  C07C31/40

Abstract: PURPOSE:To provide the subject compound by reacting a fluorine-containing carboxylic acid ester with a metal boron hydride in a specific alcohol solvent and/or an ether solvent and subsequently in the solvent containing metal or ethanol. CONSTITUTION:When a compound of formula I (n is 1 or 2; R is fluorine- containing group having a 1-20C straight chain or branched chain) is reacted with a metal boron hydride (preferably sodium boron hydride), the compound of formula I is added to a solvent consisting of an alcohol of formula R OH (R is aliphatic group having a 3-5C straight chain or branched chain) and/or ether for the reaction an subsequently methanol or ethanol is added to the solvent is an amount of 1-30wt.% of the solvent to finish the reaction. The temperature of the reaction is preferably 20-80 deg.C. The method prevents a sudden exothermic reaction or the generation of dangerous hydrogen to provide the objective compound safely, simply and in a high yield.