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    Method and apparatus for sample injection in liquid chromatography
    22.
    发明授权
    Method and apparatus for sample injection in liquid chromatography 有权
    液相色谱中样品注入的方法和装置

    公开(公告)号：US08047060B2

    公开(公告)日：2011-11-01

    申请号：US11814574

    申请日：2006-01-31

    Applicant: Theodore A. Dourdeville ,  Russell L. Keene ,  Theodore D. Ciolkosz ,  James E. Usowicz

    Inventor： Theodore A. Dourdeville ,  Russell L. Keene ,  Theodore D. Ciolkosz ,  James E. Usowicz

    IPC: G01N1/00 ,  G01N30/00

    CPC classification number: G01N30/20 ,  G01N30/22 ,  G01N2030/202 ,  Y10T137/0396 ,  Y10T137/4636 ,  Y10T137/86863

    Abstract: The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves. The present invention further provides a method to reduce the pressure and flow rate transients associated with pressurization of the sample loop contents when the sample loop is introduced to chromatography system delivery pressure.

    Abstract translation: 本发明提供了一种基本上消除压力或流速的破坏性瞬变的方法和装置，其可能降低色谱柱的效率和使用寿命。 通过消除与致动样品注射阀相关联的流动阻塞间隔，本发明能够通过色谱系统保持流动相液体的基本上恒定的流动。 本发明还提供了一种方法，当将样品环引入色谱系统输送压力时，减少与样品环含量的加压相关的压力和流速瞬变。

    Peltier based freeze-thaw valves and method of use
    24.
    发明授权
    Peltier based freeze-thaw valves and method of use 有权
    基于珀尔帖的冻融阀及其使用方法

    公开(公告)号：US07128081B2

    公开(公告)日：2006-10-31

    申请号：US11148615

    申请日：2005-06-09

    Applicant: Theodore A. Dourdeville

    Inventor： Theodore A. Dourdeville

    IPC: F17D1/18 ,  F15C1/04

    CPC classification number: B01L3/502738 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0677 ,  F16K13/10 ,  F16K99/0001 ,  F16K99/0003 ,  F16K99/0021 ,  F16K99/0044 ,  F16K2099/0084 ,  F25B21/02 ,  G01N30/20 ,  G01N35/1097 ,  G05D23/1919 ,  H01L35/325 ,  Y10T137/0391 ,  Y10T137/2196 ,  Y10T137/2251 ,  Y10T137/6606 ,  G01N2030/303 ,  G01N2030/204

    Abstract: A freeze-thaw valve is provided using a Peltier heat pump where the thermal short-circuit path between a cooled thermal mass and a heated thermal mass is reduced or absent and the valve state transition time is minimized. The freeze-thaw valve comprises a Peltier heat pump mounted to a heat exchange surface that comprises a cross-drilled copper water jacket or manifold. The Peltier heat pump is operated to maintain a cooled thermal mass at a substantially constant low temperature. A resistance heating element is used to produce a heated thermal mass. The freeze-thaw segment of a fluid conduit is commutated to contact either the heated or the cooled thermal mass to thaw and therefore open the valve or cool and thus close the valve. The operation of the Peltier heat pump at a constant temperature avoids problems inherent in the use of a Peltier heat pump to both heat and cool a freeze thaw segment.

    Abstract translation: 使用珀尔帖热泵提供冷冻解冻阀，其中冷却的热质量和加热的热质量之间的热短路径减少或不存在，并且阀状态转变时间最小化。 冻融阀包括安装到热交换表面的珀尔帖热泵，该热交换表面包括交叉钻孔的铜水套或歧管。 Peltier热泵运行，以保持冷却的热质量在基本上恒定的低温。 电阻加热元件用于产生加热的热质。 流体导管的冻融段被换向以接触加热或冷却的热物质以解冻，因此打开阀或冷却并因此关闭阀。 帕尔帖热泵在恒定温度下的运行避免了使用帕尔帖热泵对冷冻解冻段进行加热和冷却的固有问题。

    Coupler for placing two or more fluid streams in communication
    25.
    发明授权
    Coupler for placing two or more fluid streams in communication 有权
    用于将两个或多个流体流放置在通信中的耦合器

    公开(公告)号：US06367847B1

    公开(公告)日：2002-04-09

    申请号：US09263453

    申请日：1999-03-05

    Applicant: Theodore A. Dourdeville ,  Dennis DellaRovere ,  Joseph D. Antocci

    Inventor： Theodore A. Dourdeville ,  Dennis DellaRovere ,  Joseph D. Antocci

    IPC: F16L3900

    CPC classification number: F16L19/02 ,  F16L19/025 ,  F16L19/07 ,  F16L49/06 ,  G01N30/10 ,  G01N30/20 ,  G01N2030/205 ,  G01N30/6095

    Abstract: One embodiment of the present coupler comprises two or more conduits for transporting fluid. Each of the two or more conduits has at least one end defining an opening in said conduit, and each of the conduits has an axis running parallel to the flow of fluid through said conduit. The coupler further comprises a housing body having a first housing planar surface. The housing body holds the two or more conduits in alignment wherein the axis of each conduit is substantially parallel, and at least one end of each conduit is aligned about said first housing planar surface. And, the coupler has a cap element having a cap planar surface. The cap planar surface is fixed to the first housing planar surface in sealed engagement. At least one of the first housing planar surface and the cap planar surface has a channel in fluid communication with the opening in the conduits. The channel allows two or more fluid streams, each fluid stream defined by one of said conduits, to be placed in communication.

    Abstract translation: 本耦合器的一个实施例包括两个或更多个用于输送流体的导管。 两个或更多个导管中的每一个具有限定所述导管中的开口的至少一个端部，并且每个导管具有平行于通过所述导管的流体流动的轴线。 联接器还包括具有第一壳体平面的壳体。 壳体保持两个或更多个导管对准，其中每个导管的轴线基本上平行，并且每个导管的至少一个端部围绕所述第一壳体平面表面对准。 并且，耦合器具有具有盖平面的盖元件。 盖平表面以密封接合方式固定到第一壳体平面表面。 第一壳体平面表面和盖平面表面中的至少一个具有与管道中的开口流体连通的通道。 通道允许两个或多个流体流，由所述管道之一限定的每个流体流被放置成连通。

    Flow cell, analyte measurement apparatus and methods related thereto
    26.
    发明授权
    Flow cell, analyte measurement apparatus and methods related thereto 有权
    流动池，分析物测量装置及其相关方法

    公开(公告)号：US06188813B1

    公开(公告)日：2001-02-13

    申请号：US09247699

    申请日：1999-02-10

    Applicant: Theodore A. Dourdeville ,  Anthony C. Gilby ,  Dennis DellaRovere

    Inventor： Theodore A. Dourdeville ,  Anthony C. Gilby ,  Dennis DellaRovere

    IPC: G02B600

    CPC classification number: G01N30/74 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2030/746 ,  G02B6/381

    Abstract: A modular flow cell having a high optical throughput, a long optical path length and a small cross-section. The modular flow cell configuration includes remote ports or connections for liquid and light input, and liquid and light output. The flow cell includes a flow cell body having two ends, each with a respective end interface secured thereto. The flow cell is configured to form a part of a modular flow cell assembly. The flow cell body includes a channel having a through-aperture with an inner surface. A light guiding material, e.g. a transparent fluoropolymer material having a refractive index less than the refractive index of common chromatography solvents, is disposed proximate to the channel to form a light guiding through-aperture in the flow cell body. The channel is formed of materials that can provide the necessary mechanical strength and a fluid seal, and more particularly, includes materials such as polyetheretherketone (PEEK), which can develop a fluid seal at the interface between the flow cell body end and each end interface.

    Abstract translation: 具有高光学吞吐量，长光程长度和小横截面的模块化流通池。 模块化流通池配置包括用于液体和光输入的远程端口或连接以及液体和光输出。 流动池包括具有两个端部的流动池体，每个端部具有固定到其上的相应的端部界面。 流动池被配置成形成模块化流通池组件的一部分。 流通池主体包括具有内表面的通孔的通道。 导光材料，例如 折射率小于普通色谱溶剂的折射率的透明含氟聚合物材料设置在通道附近，以在流动池主体中形成导光通孔。 该通道由能够提供必要的机械强度和流体密封的材料形成，更具体地，包括诸如聚醚醚酮（PEEK）的材料，其可以在流动池主体端部和每个端部界面之间的界面处形成流体密封 。

    Active pump phasing to enhance chromatographic reproducibility
    27.
    发明授权
    Active pump phasing to enhance chromatographic reproducibility 失效
    主动泵定相提高色谱重现性

    公开(公告)号：US5897781A

    公开(公告)日：1999-04-27

    申请号：US870661

    申请日：1997-06-06

    Applicant: Theodore A. Dourdeville

    Inventor： Theodore A. Dourdeville

    IPC: B01D15/08 ,  B01J4/02 ,  F04B13/00 ,  F04B23/06 ,  F04B49/06 ,  G01N30/32

    CPC classification number: G01N30/32 ,  F04B13/00 ,  F04B23/06 ,  F04B49/065 ,  F04B2201/0201 ,  G01N2030/326

    Abstract: A fluid delivery method and apparatus implementing active phasing to actively restore the substantially exact mechanical positions of driven components in a delivery system in order to precisely reproduce the mechanical signature and hydraulic characteristics of the system from run to run without perturbing output flow. The delivery system is configured to intelligently drive pump pistons to a known position and to deliver fluid(s) at a known pressure, and includes a plurality of pump modules each including motor driven syringes having respective pistons configured to reciprocate under control of a control mechanism. Pump phasing is accomplished through a mechanism of compensation delivery of the syringes. An independent, motor-driven syringe of any given pump in a plurality of pumps in a system has the ability to act as a delivering syringe to maintain a prescribed output flow while one other syringe of each of the plurality of pumps is repositioned under load. With the delivering syringe maintaining output flow, the syringe which is repositioning, i.e. being phased, can substantially simultaneously arrive at a destination position and at a destination pressure.

    Abstract translation: 实现有源定相的流体输送方法和装置主动地恢复输送系统中驱动部件的基本精确的机械位置，以便精确地再现系统的运行到运行的机械特征和液压特性而不扰乱输出流。 输送系统构造成将泵活塞智能地驱动到已知位置并且以已知压力输送流体，并且包括多个泵模块，每个泵模块包括具有相应活塞的马达驱动注射器，该活塞构造成在控制机构的控制下往复运动 。 泵的定相是通过注射器的补偿输送机制完成的。 在系统中的多个泵中的任何给定的泵的独立的电机驱动的注射器具有作为输送注射器保持规定的输出流量的能力，同时多个泵中的每一个的另一个注射器被重新定位在负载下。 在输送注射器保持输出流量的情况下，重新定位的注射器（即定相）可以基本上同时到达目的地位置和目的地压力。

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