公开(公告)号：US20140014585A1

公开(公告)日：2014-01-16

申请号：US13939731

申请日：2013-07-11

Applicant: Theodore A. Dourdeville ,  Charles Phoebe ,  Rolf Grigat

Inventor： Theodore A. Dourdeville ,  Charles Phoebe ,  Rolf Grigat

IPC: G01N30/04

CPC classification number: G01N30/04 ,  G01N24/08 ,  G01N24/084 ,  G01N24/085 ,  G01N30/78 ,  G01N30/82 ,  G01N2030/8411 ,  G01R33/302 ,  G01R33/307 ,  G01R33/44 ,  G01R33/46

Abstract: An apparatus for chromatographic interfacing includes an interfacing unit, a sample acquisition unit, and a sample trapping unit. The interfacing unit includes (i) a chromatographic inflow valve adapted to receive a chromatographic sample separation flow, (ii) a chromatographic outflow valve adapted to allow discharge of the sample separation flow, (iii) a loop expulsion inflow valve adapted to receive an expulsion fluid flow, and (iv) a loop expulsion outflow valve in fluid communication with the loop expulsion inflow valve and adapted to allow discharge of a fluid. The sample acquisition unit includes (i) an inflow selector in selectable fluid communication with the chromatographic inflow valve or the loop expulsion inlet valve, (ii) an outflow selector in fluid communication with the loop expulsion outflow valve, and (iii) one or more collection loops, each loop being independently selectable to establish fluid communication between the inflow selector valve and the outflow selector valve. The sample trapping unit includes (i) a trap in selectable fluid communication with the loop expulsion outflow valve and defining a flow path from a first port to a second port and through a stationary phase disposed therebetween, the stationary phase adapted to trap an analyte of interest from a fraction of the chromatographic sample separation flow, and (ii) a scavenging gas source in selectable fluid communication with the flow path and a vacuum source in selectable fluid communication with the flow path, the scavenging gas source and vacuum source adapted to substantially dry the stationary phase.

Abstract translation: 用于色谱界面的装置包括接口单元，样品采集单元和样品捕获单元。 接口单元包括（i）适于接收色谱样品分离流的色谱流入阀，（ii）适于允许样品分离流排出的色谱流出阀，（iii）适于接收排出的环排出流入阀 流体流动，以及（iv）与环排出流入阀流体连通并适于允许流体排出的环排出流出阀。 样品采集单元包括（i）与色谱流入阀或环排出口阀可选择性流体连通的流入选择器，（ii）与环排出流出阀流体连通的流出选择器，以及（iii）一个或多个 收集回路，每个回路可独立选择，以建立流入选择阀和流出选择阀之间的流体连通。 样品捕集单元包括（i）与环排出流出阀可选择性地流体连通并且限定从第一端口到第二端口的流动通道并且通过其间设置的固定相的捕集器，所述固定相适于捕获分析物的分析物 来自一部分色谱样品分离流的兴趣，和（ii）与流路可选择地流体连通的清除气体源和与流动路径可选择地流体连通的真空源，清除气体源和真空源适于基本上 干燥固定相。

公开(公告)号：US6099724A

公开(公告)日：2000-08-08

申请号：US233555

申请日：1999-01-20

Applicant: Theodore A. Dourdeville

Inventor： Theodore A. Dourdeville

IPC: B01D15/08 ,  B01J4/02 ,  F04B13/00 ,  F04B23/06 ,  F04B49/06 ,  G01N30/32 ,  B10D15/08

CPC classification number: G01N30/32 ,  F04B13/00 ,  F04B23/06 ,  F04B49/065 ,  F04B2201/0201 ,  G01N2030/326

Abstract: A fluid delivery method and apparatus implementing active phasing to actively restore the substantially exact mechanical positions of driven components in a delivery system in order to precisely reproduce the mechanical signature and hydraulic characteristics of the system from run to run without perturbing output flow. The delivery system is configured to intelligently drive pump pistons to a known position and to delivery fluid(s) at a known pressure, and includes a plurality of pump modules each including motor driven syringes having respective pistons configured to reciprocate under control of a control mechanism. Pump phasing is accomplished through a mechanism of compensation delivery of the syringes. An independent, motor-driven syringe of any given pump in a plurality of pumps in a system has the ability to act as a delivering syringe to maintain a prescribed output flow while one other syringe of each of the plurality of pumps is repositioned under load. With the delivering syringe maintaining output flow, the syringe which is repositioning, i.e. being phased, can substantially simultaneously arrive at a destination position and at a destination pressure.

Abstract translation: 实现有源定相的流体输送方法和装置主动地恢复输送系统中驱动部件的基本精确的机械位置，以便精确地再现系统的运行到运行的机械特征和液压特性而不扰乱输出流。 输送系统被配置为智能地将泵活塞驱动到已知位置并以已知压力输送流体，并且包括多个泵模块，每个泵模块包括电动机驱动的注射器，其具有被配置为在控制机构的控制下往复运动 。 泵的定相是通过注射器的补偿输送机制完成的。 在系统中的多个泵中的任何给定的泵的独立的电机驱动的注射器具有作为输送注射器保持规定的输出流量的能力，同时多个泵中的每一个的另一个注射器被重新定位在负载下。 在输送注射器保持输出流量的情况下，重新定位的注射器（即定相）可以基本上同时到达目的地位置和目的地压力。

公开(公告)号：US10031113B2

公开(公告)日：2018-07-24

申请号：US12528704

申请日：2008-02-28

Applicant: Theodore A. Dourdeville

Inventor： Theodore A. Dourdeville

IPC: F16K11/074 ,  G01N30/60 ,  B23K20/02 ,  B23K20/233 ,  B23K20/24 ,  B23K101/14 ,  B23K103/14

Abstract: An HPLC apparatus includes a heat exchanger formed from diffusion-bonded first and second titanium substrates. At least two conduits for counterflow are defined between the first and second substrates.

公开(公告)号：US09024635B2

公开(公告)日：2015-05-05

申请号：US13252684

申请日：2011-10-04

Applicant: Theodore A. Dourdeville ,  Charles H. Phoebe, Jr.

Inventor： Theodore A. Dourdeville ,  Charles H. Phoebe, Jr.

IPC: G01V3/00 ,  G01N30/82 ,  G01N24/08 ,  G01R33/30 ,  G01R33/44 ,  G01N30/78 ,  G01N30/84

CPC classification number: G01N30/82 ,  G01N24/08 ,  G01N24/084 ,  G01N24/085 ,  G01N30/78 ,  G01N2030/8411 ,  G01R33/307 ,  G01R33/44

Abstract: A device for performing chromatographic separations and nuclear magnetic resonance analysis has trapping means for holding a separated sample and to form a held separated sample and placing said held separated sample in said nuclear magnetic resonance assembly. One preferred trapping means forms a held separated sample and a passed separated sample. The passed separated sample is discharged from the device. Preferred trapping means comprise a trapping column or a separated sample loop.

Abstract translation: 用于进行色谱分离和核磁共振分析的装置具有用于保持分离的样品并形成保持的分离的样品并将所述保持的分离的样品放置在所述核磁共振组件中的捕集装置。 一个优选的捕获装置形成保持的分离的样品和通过的分离的样品。 通过的分离样品从装置中排出。 优选的捕集装置包括捕集塔或分离的样品环。

公开(公告)号：US08881582B2

公开(公告)日：2014-11-11

申请号：US13227078

申请日：2011-09-07

Applicant: Theodore A. Dourdeville ,  Russell L. Keene ,  Theodore D. Ciolkosz ,  James E. Usowicz

Inventor： Theodore A. Dourdeville ,  Russell L. Keene ,  Theodore D. Ciolkosz ,  James E. Usowicz

IPC: G01N30/38 ,  G01N30/20

CPC classification number: F16K11/0853 ,  G01N30/20 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207 ,  Y10T137/0396 ,  Y10T137/86871

Abstract: The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves. The present invention further provides a method to reduce the pressure and flow rate transients associated with pressurization of the sample loop contents when the sample loop is introduced to chromatography system delivery pressure.

Abstract translation: 本发明提供了用于基本上消除压力或流速的破坏性瞬变的方法和装置，其可能降低色谱柱的效率和使用寿命。 通过消除与致动样品注射阀相关联的流动阻塞间隔，本发明能够通过色谱系统保持流动相液体的基本上恒定的流动。 本发明还提供了一种方法，当将样品环引入色谱系统输送压力时，减少与样品环含量的加压相关的压力和流速瞬变。

公开(公告)号：US06610201B2

公开(公告)日：2003-08-26

申请号：US09952934

申请日：2001-09-14

Applicant: Theodore A. Dourdeville

Inventor： Theodore A. Dourdeville

IPC: B01D1508

CPC classification number: G01N30/24 ,  B01D15/166 ,  G01N30/36 ,  G01N2030/326

Abstract: High pressure capillary liquid chromatography solvent delivery is effected at substantially low volume and atmospheric pressure. The low volume solvent composition is subsequently pressurized and expelled at high pressure into a receiving device such as a column. The solvent composition is expelled from a fluid metering system configured to deliver liquids at low pressures to a storage matrix via an isolation valve. The solvent composition is delivered to the storage matrix in reverse order such that the first volume of liquid delivered into the storage matrix is the last volume of liquid expelled out. Liquid pre-existing within the storage matrix is transferred into a fluid accumulator in fluid communication with the storage matrix. The fluid accumulator is enveloped in a pressure caisson which can be pressurized or depressurized in response to sensor signals obtained from a fluid volume displacement transducer and a pressure sensor, in accordance with solvent composition cycle formation. As the caisson is pressurized, the pressure acting on the fluid accumulator causes the solvent composition within the storage matrix to be expelled out past the isolation valve into a chromatographic column.

Abstract translation: 高压毛细管液相色谱溶剂输送在基本上低体积和大气压下进行。 随后将低体积溶剂组合物加压并在高压下排出到诸如柱的接收装置中。 溶剂组合物从被配置成经由隔离阀将低压液体输送到储存基质的流体计量系统排出。 溶剂组合物以相反的顺序输送到储存基质，使得输送到储存基质中的第一体积的液体是排出的最后一液体体积。 在存储矩阵内预先存在的液体被转移到与存储矩阵流体连通的流体蓄积器中。 流体蓄能器被包围在压力沉箱中，其可以响应于根据溶剂组成循环形成从流体容积位移传感器和压力传感器获得的传感器信号而被加压或减压。 当沉箱被加压时，作用在流体蓄液器上的压力导致储存基质中的溶剂组合物被排出通过隔离阀进入色谱柱。

公开(公告)号：US06404193B1

公开(公告)日：2002-06-11

申请号：US09829064

申请日：2001-04-09

Applicant: Theodore A. Dourdeville

Inventor： Theodore A. Dourdeville

IPC: G01V300

CPC classification number: G01N30/84 ,  G01N2030/8441 ,  G01R33/30 ,  G01R33/56536

Abstract: A method and apparatus in which the limitation upon analysis caused by variation of the magnetic susceptibility of the solvent conveying a sample to an NMR spectrometer can be addressed. The solvent composition which is used to bring about elution of analyte from devices such as chromatography columns can be varied without causing a corresponding variation of the solvent composition used to transport the analyte to the NMR spectrometer. The decoupling is achieved by the summing into the chromatographic stream, post column, a solvent composition which is complementary to the instantaneous composition emerging from the column, such that the magnetic susceptibility of the summed streams remains constant.

Abstract translation: 可以解决由将样品输送到NMR光谱仪的溶剂的磁化率变化引起的分析限制的方法和装置。 用于使分析物从诸如色谱柱的装置洗脱的溶剂组合物可以变化，而不会导致用于将分析物输送到NMR光谱仪的溶剂组成的相应变化。 通过将色谱流，柱后和与柱的瞬时成分互补的溶剂组成相加，使得相加的流的磁化率保持恒定，可实现去耦。

公开(公告)号：US5637208A

公开(公告)日：1997-06-10

申请号：US267087

申请日：1994-06-24

Applicant: Theodore A. Dourdeville

Inventor： Theodore A. Dourdeville

IPC: F04B49/00 ,  F04B7/00 ,  F04B49/02 ,  F04B49/06 ,  F04B49/22 ,  G01N30/32 ,  G01N30/34 ,  G01N30/36 ,  B01D15/08 ,  B01D17/12

CPC classification number: G01N30/36 ,  F04B49/022 ,  F04B49/065 ,  F04B49/22 ,  F04B7/0007 ,  F04B2201/0201 ,  F04B2205/03 ,  F04B2205/06 ,  G01N2030/326 ,  G01N2030/328 ,  Y10T137/86002 ,  Y10T137/86163

Abstract: A pumping system for continuously delivering fluid at a selected flow rate to a receiving system. The system includes at least a first and a second pumping unit, each of the individual units comprises a syringe and a valve. The syringe comprises a piston and a piston actuator, cylinder, and pressure sensor. The valve comprises a positively-actuated zero switching volume valve and valve actuator. The first and second pumping units are in fluid communication with one another and are capable of independent actuation. The individual valves are arranged to isolate either the first syringe or the second syringe, respectively, from the receiving system while at least one of the syringes remains in fluid communication with the receiving system whereby system pressure can be continuously monitored and the selected system flow rate maintained. A controller receives inputs from the first and second pressure sensors and activates in response to the inputs the first and second syringes individually, and also activates the first and second valves individually such that when fluid communication is established between the isolated syringe and the receiving system substantially no system flow error is produced. The pressure sensor is positioned within each pumping unit, permitting a pumping unit which has been refilled offline to perform compression of its cylinder contents without perturbation of the on-line process, and which further permits discrimination of the point in the compression cycle where compression has been completed and fluid delivery to the system will commence.

Abstract translation: 一种用于将选定流量的流体连续输送到接收系统的泵送系统。 该系统包括至少第一和第二抽吸单元，每个单独的单元包括注射器和阀。 注射器包括活塞和活塞致动器，气缸和压力传感器。 该阀包括一个积极致动的零开关量阀和阀致动器。 第一和第二泵送单元彼此流体连通并且能够独立地致动。 各个阀被布置成分别将第一注射器或第二注射器与接收系统隔离，同时至少一个注射器保持与接收系统流体连通，从而可以连续监测系统压力，并且选择的系统流量 保持。 控制器接收来自第一和第二压力传感器的输入并响应于第一和第二注射器的输入单独地启动，并且还分别启动第一和第二阀，使得当在隔离的注射器和接收系统之间建立基本上 不产生系统流量误差。 压力传感器位于每个泵送单元内，允许已经离线重新填充的泵送单元在不影响在线过程的情况下对其气缸内容进行压缩，并且还允许在压缩循环中区分点 已经完成，流体输送到系统将开始。

公开(公告)号：US4534659A

公开(公告)日：1985-08-13

申请号：US574541

申请日：1984-01-27

Applicant: Theodore A. Dourdeville ,  Anthony Lymneos

Inventor： Theodore A. Dourdeville ,  Anthony Lymneos

IPC: B01F3/08 ,  B01F5/00 ,  B01F5/06 ,  B01F13/00

CPC classification number: B01F3/088 ,  B01F13/0059 ,  B01F5/0603

Abstract: A passive fluid mixing system having one or more mixers each comprising a mixing chamber (12), a fluid entrance passageway (18) and a fluid exit passageway (20), the passageways being located at opposite ends of the chamber and displaced substantially 180.degree. from each other and lying at least in part in common plane including the axis (13) of the chamber.

Abstract translation: 一种具有一个或多个混合器的被动流体混合系统，每个混合器包括混合室（12），流体入口通道（18）和流体出口通道（20），所述通道位于室的相对端并基本上位移180° 彼此并且至少部分地位于包括腔室的轴线（13）的公共平面中。

公开(公告)号：US20130056084A1

公开(公告)日：2013-03-07

申请号：US13227078

申请日：2011-09-07

Applicant: Theodore A. Dourdeville ,  Russell L. Keene ,  Theodore D. Ciolkosz ,  James E. Usowicz

Inventor： Theodore A. Dourdeville ,  Russell L. Keene ,  Theodore D. Ciolkosz ,  James E. Usowicz

IPC: F15D1/00

CPC classification number: F16K11/0853 ,  G01N30/20 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207 ,  Y10T137/0396 ,  Y10T137/86871

Abstract: The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves. The present invention further provides a method to reduce the pressure and flow rate transients associated with pressurization of the sample loop contents when the sample loop is introduced to chromatography system delivery pressure.

Abstract translation: 本发明提供了一种基本上消除压力或流速的破坏性瞬变的方法和装置，其可能降低色谱柱的效率和使用寿命。 通过消除与致动样品注射阀相关联的流动阻塞间隔，本发明能够通过色谱系统保持流动相液体的基本上恒定的流动。 本发明还提供了一种方法，当将样品环引入色谱系统输送压力时，减少与样品环含量的加压相关的压力和流速瞬变。