公开(公告)号：CA2690823A1

公开(公告)日：2008-12-24

申请号：CA2690823

申请日：2008-06-17

Applicant: UNIV NORTHWESTERN

Inventor： MIRKIN CHAD ,  HUANG LING ,  HUO FENGWEI ,  HURST SARAH J ,  QIN LIDONG ,  JANG JAE-WON ,  KAKKASSERY JOSEPH J

IPC: B82B3/00 ,  B41F17/00 ,  B41J3/00 ,  B82B1/00 ,  C07K17/00 ,  C09D11/10 ,  C40B50/14

Abstract: Provided is a direct write patterning method utilizing a mixture comprising an ink of choice and an ink carrier matrix. The method involves disposing the mixture on a tip or stamp and transporting the mixture from the tip or stamp on a surface to form a pattern that contains the ink. The method does not require chemical or physical modification of either the tip or stamp or the surface prior to transporting the mixture to the surface. The method can be applied for patterning hard inks such as nanomaterials and crystallized polymers and soft inks such as biomaterials including peptides and proteins. Also provided are related biomaterial and hard ink arrays.

公开(公告)号：CA2483697A1

公开(公告)日：2003-11-20

申请号：CA2483697

申请日：2003-05-07

Applicant: UNIV NORTHWESTERN

Inventor： MIRKIN CHAD ,  CAO YUN-WEI ,  JIN RONGCHAO

IPC: G01N21/65 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/543 ,  G01N33/553 ,  G01N33/566 ,  G01N33/58

Abstract: The invention encompasses reagents comprising particles with at least one Raman dye and a specific binding members bound thereto and methods of using such reagents. The invention also encompasses reagents of a specific binding member and two or more different Raman dyes and methods for using such reagents. New types of particle probes having a specific binding member boun d thereto are described. These reagents are used in a novel detection strategy that utilizes the catalytic properties of the Au nanoparticles to generate a silver coating that can behave as a surface-enhanced Raman scattering (SERS) promoter for the dye-labeled particles that have been captured by target and an underlying chip in microarray format. The strategy provides the high sensitivity and high selectivity attributes of grey-scale scanometric detection but provides a route to multiplexing and ratioing capabilities sin ce a very large number of probes can be designed based upon the concept of usin g a Raman tag as a spectroscopic fingerprint in detection. These spectra are used as fingerprints to differentiate oligonucleotide or other targets in on e solution. This method has been used to distinguish six dissimilar DNA target s with six Raman labeled nanoparticle probes, and also two RNA targets with single nucleotide polymorphisms (SNPs).

公开(公告)号：AU2021254270A1

公开(公告)日：2022-11-24

申请号：AU2021254270

申请日：2021-04-09

Applicant: UNIV NORTHWESTERN

Inventor： MIRKIN CHAD ,  CALLMANN CASSANDRA

IPC: A61K8/14 ,  A61K9/127 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713

Abstract: The disclosure is generally related to nanoparticles have an oxidized tumor cell lysate encapsulated therein and oligonucleotides on the surface thereof. Methods of making and using the nanoparticles are also provided herein.

公开(公告)号：ES2856091T3

公开(公告)日：2021-09-27

申请号：ES12831067

申请日：2012-09-14

Applicant: UNIV NORTHWESTERN

Inventor： MIRKIN CHAD ,  KO CAROLINE ,  STEGH ALEXANDER ,  GILJOHANN DAVID ,  LUCIANO JANINA ,  JENSEN SAM

IPC: A61K49/18 ,  A61P25/00 ,  A61P35/00 ,  C12N15/113

Abstract: Una composición para su uso en el tratamiento de un paciente que padece una enfermedad neurodegenerativa y en necesidad de una composición que es capaz de atravesar la barrera hematoencefálica, comprendiendo dicha composición un nanoconjungado funcionalizado que comprende una nanopartícula, comprendiendo el nanoconjugado un polinucleótido unido a la superficie que tiene una secuencia que es 75 % complementaria o más a un polinucleótido diana con el que se hibrida e inhibe la expresión del polinucleótido diana, en donde el nanoconjugado comprende 10 o más polinucleótidos sobre su superficie y tiene una masa de al menos 1 kilodalton.

公开(公告)号：SG11202102531WA

公开(公告)日：2021-04-29

申请号：SG11202102531W

申请日：2019-09-13

Applicant: UNIV NORTHWESTERN

Inventor： MIRKIN CHAD ,  MCMILLAN JANET ,  HAYES OLIVER

IPC: A61K38/14 ,  C07H21/02 ,  C07H21/04 ,  C12N9/96 ,  C12N11/06 ,  C12N15/115 ,  C12Q1/68

Abstract: The present disclosure is generally directed to methods for making protein polymers. The methods comprise utilizing oligonucleotides for controlling the association pathway of oligonucleotide-functionalized proteins into oligomeric/polymeric materials.

公开(公告)号：AT488858T

公开(公告)日：2010-12-15

申请号：AT00911560

申请日：2000-01-07

Applicant: UNIV NORTHWESTERN

Inventor： MIRKIN CHAD ,  PINER RICHARD ,  HONG SEUNGHUM

IPC: H01J49/00 ,  B05D1/00 ,  B05D1/18 ,  B05D1/26 ,  B81C1/00 ,  B82B3/00 ,  G01B7/34 ,  G01Q70/06 ,  G01Q70/14 ,  G01Q70/16 ,  G01Q80/00 ,  G03F7/00 ,  G03F7/16

Abstract: The invention provides a nanolithographic method, comprising: (i) providing a substrate; (ii) providing a nanoscopic tip coated with a patterning compound; (iii) contacting the coated tip with the substrate so that the patterning compound is applied to the substrate to produce a desired pattern; and (iv) wherein the patterning compound is anchored to the substrate.

公开(公告)号：AU2007345315A1

公开(公告)日：2008-07-31

申请号：AU2007345315

申请日：2007-06-28

Applicant: UNIV NORTHWESTERN

Inventor： MIRKIN CHAD ,  SALAITA KHALID

IPC: G03F7/00

Abstract: Lithographic and nanolithographic methods that involve patterning a first compound on a substrate surface, exposing non-patterned areas of the substrate surface to a second compound and removing the first compound while leaving the second compound intact. The resulting hole patterns can be used as templates for either chemical etching of the patterned area of the substrate or metal deposition on the patterned area of the substrate.

公开(公告)号：AT386570T

公开(公告)日：2008-03-15

申请号：AT01939491

申请日：2001-05-25

Applicant: UNIV NORTHWESTERN

Inventor： MIRKIN CHAD ,  PINER RICHARD ,  HONG SEUNGHUN

IPC: A61N5/00 ,  B05D1/00 ,  B05D1/18 ,  B05D1/26 ,  B82B3/00 ,  G01Q10/00 ,  G01Q60/00 ,  G01Q70/06 ,  G01Q70/16 ,  G01Q80/00 ,  G03F1/00 ,  G03F7/00 ,  G03F7/16 ,  G03F7/20 ,  G21G5/00 ,  H01L21/027

Abstract: The invention provides a lithographic method referred to as “dip pen” nanolithography (DPN). DPN utilizes a scanning probe microscope (SPM) tip (e.g., an atomic force microscope (AFM) tip) as a “pen,” a solid-state substrate (e.g., gold) as “paper,” and molecules with a chemical affinity for the solid-state substrate as “ink.” Capillary transport of molecules from the SPM tip to the solid substrate is used in DPN to directly write patterns consisting of a relatively small collection of molecules in submicrometer dimensions, making DPN useful in the fabrication of a variety of microscale and nanoscale devices. The invention also provides substrates patterned by DPN, including submicrometer combinatorial arrays, and kits, devices and software for performing DPN. The invention further provides a method of performing AFM imaging in air. The method comprises coating an AFM tip with a hydrophobic compound, the hydrophobic compound being selected so that AFM imaging performed using the coated AFM tip is improved compared to AFM imaging performed using an uncoated AFM tip. Finally, the invention provides AFM tips coated with the hydrophobic compounds.