公开(公告)号：AU2007345315A1

公开(公告)日：2008-07-31

申请号：AU2007345315

申请日：2007-06-28

Applicant: UNIV NORTHWESTERN

Inventor： MIRKIN CHAD ,  SALAITA KHALID

IPC: G03F7/00

Abstract: Lithographic and nanolithographic methods that involve patterning a first compound on a substrate surface, exposing non-patterned areas of the substrate surface to a second compound and removing the first compound while leaving the second compound intact. The resulting hole patterns can be used as templates for either chemical etching of the patterned area of the substrate or metal deposition on the patterned area of the substrate.

公开(公告)号：WO2008020851A3

公开(公告)日：2008-04-24

申请号：PCT/US2006032316

申请日：2006-08-18

Applicant: UNIV NORTHWESTERN ,  MIRKIN CHAD A ,  VEGA RAFAEL A ,  MASPOCH DANIEL ,  SALAITA KHALID

Inventor： MIRKIN CHAD A ,  VEGA RAFAEL A ,  MASPOCH DANIEL ,  SALAITA KHALID

IPC: G01N33/543 ,  G01N33/553 ,  G01N33/569

CPC classification number: A61K31/70 ,  B82Y5/00 ,  B82Y30/00 ,  C12N7/00 ,  C12N2770/00011 ,  G01N33/56983 ,  Y10S977/802

Abstract: A novel coordination chemistry or metal ion binding approach to controlling the site- isolation and orientation of virus particles, such as TMV, on a nanoarray template generated by lithography including Dip Pen Nanolithography. By using the surface chemistry that is inherent in many viruses, metal-ion based or inorganic coordination chemistry was used to immobilize individual virus particles without the need for their genetic modification. Single particle control will enable a wide variety of studies involving viruses that are not possible with microarrays because of the size mismatch between the architecture of the virus and the features that make up such arrays. These include: single particle, single cell infectivity studies, the exploration of such structures as templates in materials synthesis and molecular electronics, and studies aimed at understanding how surface presentation can influence their bioactivity. This is a pioneering example of such control at the single-particle level, and therefore, commercial use of nanoarrays in biological systems.

Abstract translation: 一种新颖的配位化学或金属离子结合方法，用于控制病毒颗粒（如TMV）的位置分离和取向，通过平版印刷产生的纳米阵列模板，包括Dip Pen Nanoithography。 通过使用许多病毒固有的表面化学，使用金属离子或无机配位化学来固定个体病毒颗粒，而不需要进行遗传修饰。 由于病毒架构与组成这些阵列的特征之间的大小不匹配，单粒子控制将能够进行涉及病毒的各种研究，这些病毒是微不足道的。 这些包括：单粒子，单细胞感染性研究，材料合成和分子电子学模板等结构的探索，以及旨在了解表面呈现如何影响其生物活性的研究。 这是在单粒子水平上的这种控制的开创性例子，因此在生物系统中商业使用纳米阵列。

公开(公告)号：WO2008091279A3

公开(公告)日：2008-11-13

申请号：PCT/US2007015009

申请日：2007-06-28

Applicant: UNIV NORTHWESTERN ,  MIRKIN CHAD ,  SALAITA KHALID

Inventor： MIRKIN CHAD ,  SALAITA KHALID

IPC: G03F7/00

CPC classification number: G03F7/0002 ,  Y10S977/849 ,  Y10S977/855 ,  Y10S977/856 ,  Y10S977/857 ,  Y10S977/888 ,  Y10T428/24479 ,  Y10T428/24802

Abstract: Lithographic and nanolithographic methods that involve patterning a first compound on a substrate surface, exposing non-patterned areas of the substrate surface to a second compound and removing the first compound while leaving the second compound intact. The resulting hole patterns can be used as templates for either chemical etching of the patterned area of the substrate or metal deposition on the patterned area of the substrate.

Abstract translation: 包括在基底表面上图案化第一化合物的平版印刷和纳米光刻方法，将基底表面的未图案化区域暴露于第二化合物并除去第一化合物同时保留第二化合物。 所得到的孔图案可以用作用于对衬底的图案化区域进行化学蚀刻或在衬底的图案化区域上的金属沉积的模板。

公开(公告)号：WO2004005582A2

公开(公告)日：2004-01-15

申请号：PCT/US0321220

申请日：2003-07-07

Applicant: UNIV NORTHWESTERN ,  MIRKIN CHAD ,  ZHANG YI ,  SALAITA KHALID

Inventor： MIRKIN CHAD ,  ZHANG YI ,  SALAITA KHALID

IPC: B01L3/00 ,  C40B60/14 ,  C25B

CPC classification number: C40B60/14 ,  B01J2219/00387 ,  B01J2219/00436 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01L3/5027 ,  B81C1/00111 ,  B81C1/00714 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  C25F1/00 ,  C40B40/04 ,  G03F7/0002 ,  H01L51/0006 ,  H01L51/0017

Abstract: The invention provides a simple and convenient strategy for reducing the dimensions of organic micro- and nanostructures on metal surfaces. By varying electrochemical desorption conditions, organic structures patterned by Dip-Pen Nanolithography or any of the micro-contact printing procedures can be gradually desorbed in a controlled fashion. The electrochemical desorption is initiated at the exterior of the feature and moves inward as a function of time. The desorption process and adsorbate desorption are modified and controlled as a function of substrate morphology, adsorbate head and tail groups, and electrolyte solvent and salt. Different nanostructures made of different adsorbates can be miniaturized based upon judicious selection of adsorbate and supporting electrolyte.

Abstract translation: 本发明提供了用于减小金属表面上的有机微米结构和纳米结构的尺寸的简单方便的策略。 通过改变电化学解吸条件，通过蘸笔纳米平版印刷或任何微接触印刷程序图案化的有机结构可以以受控方式逐渐解吸。 电化学解吸在特征外部开始并随时间向内移动。 解吸过程和吸附物解吸作用随着底物形态，吸附头和尾基团以及电解质溶剂和盐而变化和控制。 基于明智选择吸附物和支持电解质，可以使由不同吸附物制成的不同纳米结构小型化。

公开(公告)号：ES2362797T3

公开(公告)日：2011-07-13

申请号：ES06851430

申请日：2006-08-18

Applicant: UNIV NORTHWESTERN

Inventor： MIRKIN CHAD ,  VEGA RAFAEL ,  MASPOCH DANIEL ,  SALAITA KHALID

IPC: G01N33/50

Abstract: Un arreglo que comprende: una superficie de sustrato, en donde la superficie del sustrato incluye sitios de enlazamiento para una partícula biológica y también sitios que no enlazan la partícula biológica, caracterizado porque dichos sitios de enlazamiento incluyen sitios de enlazamiento de iones metálicos, o sitios de enlazamiento para el metal catiónico divalente, en donde los sitios de enlazamiento sobre la superficie de sustrato tienen cada uno una forma y un tamaño; y una partícula biológica dispuesta sobre cada uno de los sitios de enlazamiento, caracterizada porque la partícula biológica es una proteína, un anticuerpo, o una célula.

公开(公告)号：CA2654973A1

公开(公告)日：2008-07-31

申请号：CA2654973

申请日：2007-06-28

Applicant: UNIV NORTHWESTERN

Inventor： SALAITA KHALID ,  MIRKIN CHAD

IPC: G03F7/00

Abstract: Lithographic and nanolithographic methods that involve patterning a first compound on a substrate surface, exposing non-patterned areas of the substr ate surface to a second compound and removing the first compound while leavi ng the second compound intact. The resulting hole patterns can be used as te mplates for either chemical etching of the patterned area of the substrate o r metal deposition on the patterned area of the substrate.

公开(公告)号：DE602006020747D1

公开(公告)日：2011-04-28

申请号：DE602006020747

申请日：2006-08-18

Applicant: UNIV NORTHWESTERN

Inventor： MIRKIN CHAD A ,  VEGA RAFAEL A ,  MASPOCH DANIEL ,  SALAITA KHALID

IPC: G01N33/50

公开(公告)号：AT502299T

公开(公告)日：2011-04-15

申请号：AT06851430

申请日：2006-08-18

Applicant: UNIV NORTHWESTERN

Inventor： MIRKIN CHAD ,  VEGA RAFAEL ,  MASPOCH DANIEL ,  SALAITA KHALID

IPC: G01N33/50

Abstract: A nanoarray template utilizing coordination chemistry or metal ion binding to control the site-isolation and orientation of virus particles is provided. The nanoarray template is generated by lithography including Dip Pen Nanolithography. The surface chemistry that is inherent in many viruses, metal-ion based or inorganic coordination chemistry is used to immobilize individual virus particles without the need for their genetic modification. Single particle control enables a wide variety of studies involving viruses that are not possible with microarrays, including single particle, single cell infectivity studies, exploration of such structures as templates in materials synthesis and molecular electronics, and studies aimed at understanding how surface presentation influences their bioactivity. This is an example of such control at the single-particle level, and therefore, commercial use of nanoarrays in biological systems.

公开(公告)号：AU2003247904A8

公开(公告)日：2004-01-23

申请号：AU2003247904

申请日：2003-07-07

Applicant: UNIV NORTHWESTERN

Inventor： SALAITA KHALID ,  MIRKIN CHAD ,  ZHANG YI

IPC: B01L3/00 ,  C40B60/14 ,  C25F1/00 ,  C23C22/82

Abstract: The invention provides a simple and convenient strategy for reducing the dimensions of organic micro- and nanostructures on metal surfaces. By varying electrochemical desorption conditions, organic structures patterned by Dip-Pen Nanolithography or any of the micro-contact printing procedures can be gradually desorbed in a controlled fashion. The electrochemical desorption is initiated at the exterior of the feature and moves inward as a function of time. The desorption process and adsorbate desorption are modified and controlled as a function of substrate morphology, adsorbate head and tail groups, and electrolyte solvent and salt. Different nanostructures made of different adsorbates can be miniaturized based upon judicious selection of adsorbate and supporting electrolyte.

公开(公告)号：AU2003247904A1

公开(公告)日：2004-01-23

申请号：AU2003247904

申请日：2003-07-07

Applicant: UNIV NORTHWESTERN

Inventor： SALAITA KHALID ,  MIRKIN CHAD ,  ZHANG YI

IPC: B01L3/00 ,  C40B60/14

Abstract: The invention provides a simple and convenient strategy for reducing the dimensions of organic micro- and nanostructures on metal surfaces. By varying electrochemical desorption conditions, organic structures patterned by Dip-Pen Nanolithography or any of the micro-contact printing procedures can be gradually desorbed in a controlled fashion. The electrochemical desorption is initiated at the exterior of the feature and moves inward as a function of time. The desorption process and adsorbate desorption are modified and controlled as a function of substrate morphology, adsorbate head and tail groups, and electrolyte solvent and salt. Different nanostructures made of different adsorbates can be miniaturized based upon judicious selection of adsorbate and supporting electrolyte.