公开(公告)号：WO1992006180A1

公开(公告)日：1992-04-16

申请号：PCT/US1991007103

申请日：1991-09-27

Applicant: UNIVERSITY OF CONNECTICUT

Inventor： UNIVERSITY OF CONNECTICUT ,  WU, George, Y. ,  WU, Catherine, H.

IPC: C12N07/00

CPC classification number: C12N15/86 ,  A61K48/00 ,  C12N7/00 ,  C12N15/87 ,  C12N2730/10122 ,  C12N2740/13043 ,  C12N2740/13045 ,  C12N2810/10 ,  C12N2810/80 ,  C12N2810/859

Abstract: Viruses or cells are targeted for selective internalization into a target in vivo. A molecule specific for a receptor on the surface of the target cell is introduced onto the surface of the virus or cell. The modified virus or cell binds the receptor in vivo and is internalized by the target cell. The method provides vectors for selective delivery of nucleic acids to specific cell types in vivo and a means to alter the tropism of an infectious agent.

Abstract translation: 病毒或细胞被靶向用于体内靶向选择性内化。 将靶细胞表面上的受体特异的分子引入病毒或细胞的表面。 修饰的病毒或细胞在体内结合受体并被靶细胞内化。 该方法提供用于在体内选择性递送核酸到特定细胞类型的载体，以及改变感染因子的向性的方法。