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公开(公告)号：CA3150736A1
公开(公告)日：2021-02-18
申请号：CA3150736
申请日：2020-08-13
Applicant: VERTEX PHARMA
Inventor： ANGELL PAUL , COCHRAN JOHN E , LITTLER BENJAMIN J , SIESEL DAVID ANDREW , URBINA ARMANDO , ANDERSON COREY DON , CLEMENS JEREMY J , CLEVELAND THOMAS , COON TIMOTHY RICHARD , FRIEMAN BRYAN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE , SWIFT SARA E , ZHOU JINGLAN
IPC: C07D207/08 , C07D207/09 , C07D213/61 , C07D213/62 , C07D213/70 , C07D213/74 , C07D231/20 , C07D401/04 , C07D401/14 , C07D513/22
Abstract: The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.
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公开(公告)号：ES2751741T3
公开(公告)日：2020-04-01
申请号：ES15151822
申请日：2012-09-28
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , STUDLEY JOHN , PIERARD FRANCOISE YVONNE THEODORA MARIE , DURRANT STEVEN JOHN , LITTLER BENJAMIN JOSEPH , HUGHES ROBERT MICHAEL , SIESEL DAVID ANDREW , ANGELL PAUL , URBINA ARMANDO , SHI YI
IPC: C07D413/04 , A61K31/497 , A61P35/00
Abstract: Un proceso para preparar un compuesto de fórmula I-2:**Fórmula** o una sal del mismo, que comprende la etapa de hacer reaccionar un compuesto de fórmula 4-iv:**Fórmula** con un compuesto de la siguiente estructura:**Fórmula** en condiciones de acoplamiento adecuadas para formar un compuesto de fórmula 5-i:**Fórmula** y desproteger el compuesto de fórmula 5-i en condiciones de desprotección de Boc adecuadas, en el que las condiciones de acoplamiento cruzado adecuadas comprenden combinar un catalizador de paladio adecuado con una base adecuada en un disolvente adecuado, y en el que el catalizador de paladio adecuado se selecciona entre Pd[P(tBu)3]2, Pd(dtbpf)Cl2, Pd(PPh3)2Cl2, Pd(PCy3)2Cl2, Pd(dppf)Cl2 y Pd(dppe)Cl2; el disolvente adecuado se selecciona entre uno o más de los siguientes: tolueno, MeCN, agua, EtOH, IPA, 2-Me-THF o IPAc; y la base adecuada se selecciona entre K2CO3, Na2CO3 o K3PO4.
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公开(公告)号：HUE046429T2
公开(公告)日：2020-03-30
申请号：HUE15151822
申请日：2012-09-28
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , STUDLEY JOHN , PIERARD FRANCOISE YVONNE THEODORA MARIE , DURRANT STEVEN JOHN , LITTLER BENJAMIN JOSEPH , HUGHES ROBERT MICHAEL , SIESEL DAVID ANDREW , ANGELL PAUL , URBINA ARMANDO , SHI YI
IPC: A61P35/00
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公开(公告)号：RS59337B1
公开(公告)日：2019-10-31
申请号：RSP20191197
申请日：2012-09-28
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , STUDLEY JOHN , PIERARD FRANCOISE YVONNE THEODORA MARIE , DURRANT STEVEN JOHN , LITTLER BENJAMIN JOSEPH , HUGHES ROBERT MICHAEL , SIESEL DAVID ANDREW , ANGELL PAUL , URBINA ARMANDO , SHI YI
IPC: C07D413/04 , A61K31/497 , A61P35/00
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公开(公告)号：AU2017206213B2
公开(公告)日：2019-05-23
申请号：AU2017206213
申请日：2017-07-20
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , STUDLEY JOHN , PIERARD FRANCOISE YVONNE THEODORA MARIE , DURRANT STEVEN JOHN , LITTLER BENJAMIN JOSEPH , HUGHES ROBERT MICHAEL , SIESEL DAVID ANDREW , ANGELL PAUL , URBINA ARMANDO , SHI YI
IPC: C07D413/04 , A61K31/497 , A61P35/00
Abstract: Abstract [002821 The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. [002831 The compounds of this invention have formula I or II: NH 0 -N NH2 04 H -R4 R N- Rla RC R4 R lb wherein the variables are as defined herein.
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Patent Agency Ranking
公开(公告)号：IN929KON2014A
公开(公告)日：2015-08-21
申请号：IN929KON2014
申请日：2014-04-28
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , STUDLEY JOHN , PIERARD FRANCOISE YVONNE THEODORA MARIE , DURRANT STEVEN JOHN , LITTLER BENJAMIN JOSEPH , HUGHES ROBERT MICHAEL , SIESEL DAVID ANDREW , ANGELL PAUL , URBINA ARMANDO , SHI YI
IPC: C07D413/04
Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula (I) or (II) wherein the variables are as defined herein.
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公开(公告)号：AU2012315611A8
公开(公告)日：2014-05-08
申请号：AU2012315611
申请日：2012-09-28
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , STORCK PIERRE-HENRI , STUDLEY JOHN , PIERARD FRANCOISE YVONNE THEODORA MARIE , DURRANT STEVEN JOHN , LITTLER BENJAMIN JOSEPH , ANGELL PAUL , HUGHES ROBERT MICHAEL , SIESEL DAVID ANDREW , URBINA ARMANDO , ZWICKER CARL , LOCONTE NICHOLAS , BARDER TIMOTHY
IPC: C07D413/14 , A61K31/497 , A61P35/00
Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; solid forms of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I-l : wherein the variables are as defined herein. Additionally, the compounds of this invention have formula II: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.
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公开(公告)号：CA3124539A1
公开(公告)日：2013-04-04
申请号：CA3124539
申请日：2012-09-28
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , STUDLEY JOHN , PIERARD FRANCOISE YVONNE THEODORA MARIE , DURRANT STEVEN JOHN , LITTLER BENJAMIN JOSEPH , HUGHES ROBERT MICHAEL , SIESEL DAVID ANDREW , ANGELL PAUL , URBINA ARMANDO , SHI YI
IPC: C07C269/06 , C07D413/04
Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I or II:wherein the variables are as defined herein.
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公开(公告)号：AU2020330570B2
公开(公告)日：2025-03-27
申请号：AU2020330570
申请日：2020-08-13
Applicant: VERTEX PHARMA
Inventor： ANGELL PAUL , COCHRAN JOHN E , LITTLER BENJAMIN J , SIESEL DAVID ANDREW , URBINA ARMANDO , ANDERSON COREY DON , CLEMENS JEREMY J , CLEVELAND THOMAS , COON TIMOTHY RICHARD , FRIEMAN BRYAN , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE , SWIFT SARA E , ZHOU JINGLAN
IPC: C07D207/08 , C07D207/09 , C07D213/61 , C07D213/62 , C07D213/70 , C07D213/74 , C07D231/20 , C07D401/04 , C07D401/14 , C07D513/22
Abstract: The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.
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公开(公告)号：HRP20240606T1
公开(公告)日：2024-07-19
申请号：HRP20240606
申请日：2020-08-13
Applicant: VERTEX PHARMA
Inventor： ANGELL PAUL , COCHRAN JOHN E , LITTLER BENJAMIN J , SIESEL DAVID ANDREW , URBINA ARMANDO , ANDERSON COREY DON , CLEMENS JEREMY J , CLEVELAND THOMAS , COON TIMOTHY RICHARD , FRIEMAN BRYAN , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE , SWIFT SARA E , ZHOU JINGLAN
IPC: C07D207/08 , C07D207/09 , C07D213/61 , C07D213/62 , C07D213/70 , C07D213/74 , C07D231/20 , C07D401/04 , C07D401/14 , C07D513/22
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