公开(公告)号：AU2003284877A1

公开(公告)日：2004-05-13

申请号：AU2003284877

申请日：2003-10-22

Applicant: VIVUS INC

Inventor： PLACE VIRGIL A ,  WILSON LELAND F ,  DOHERTY PAUL C ,  HANAMOTO MARK S ,  SPIVAK ALFRED P ,  GESUNDHEIT NEIL ,  BENNETT SEAN R

IPC: A61K9/00 ,  A61K9/02 ,  A61K9/127 ,  A61K31/00 ,  A61K31/15 ,  A61K31/21 ,  A61K31/295 ,  A61K31/4178 ,  A61K31/437 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4704 ,  A61K31/48 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/502 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  A61K31/56 ,  A61K45/06 ,  A61K45/08 ,  A61P15/12

Abstract: A topical pharmaceutical composition is provided for the treatment of female sexual dysfunction, wherein the composition is formulated so as to contain a therapeutically effective amount of a phosphodiesterase inhibitor and a pharmaceutically acceptable carrier for topical administration. The phosphodiesterase inhibitor is generally selected from Type III, Type IV, Type V, and nonspecific phosphodiesterase inhibitors.

公开(公告)号：AU2256601A

公开(公告)日：2001-06-18

申请号：AU2256601

申请日：2000-12-08

Applicant: VIVUS INC

Inventor： DOHERTY PAUL C ,  PLACE VIRGIL A ,  SMITH WILLIAM L

IPC: A61K9/02 ,  A61K9/00 ,  A61K31/00 ,  A61K31/343 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/426 ,  A61K31/437 ,  A61K31/4412 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/47 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/485 ,  A61K31/496 ,  A61K31/50 ,  A61K31/501 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/505 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/549 ,  A61K31/5513 ,  A61K31/5517 ,  A61K45/00 ,  A61K45/06 ,  A61P9/00 ,  A61P15/10 ,  A61P25/02 ,  A61P43/00 ,  A61K45/08

Abstract: A pharmaceutical formulation is provided for treating erectile dysfunction in a mammalian male individual. The pharmaceutical formulation includes a phosphodiesterase inhibitor or a pharmaceutically acceptable salt, ester, amide or derivative thereof, that is administered transmucosally within the context of an effective dosing regimen. Preferred modes of administration include transbuccal, sublingual and transrectal routes. A kit for the administration of the pharmaceutical formulation is also provided.

公开(公告)号：IE81089B1

公开(公告)日：2000-03-08

申请号：IE133091

申请日：1991-04-22

Applicant: VIVUS INC

Inventor： PLACE VIRGIL A ,  GALE ROBERT M ,  BERGGREN RANDALL G

IPC: A61F5/41 ,  A61K9/00 ,  A61K31/417 ,  A61K31/517 ,  A61K31/5575 ,  A61K9/02 ,  A61M31/00 ,  A61P15/12 ,  A61K9/08 ,  A61K9/10 ,  A61K47/10

Abstract: Erectile dysfunction, particularly impotence, priapism and Peyronie's disease is treated by the transurethral administration of a therapeutically effective agent. For impotence, the agents include vasodilators, for priapism, the agents include vasoconstrictors and for Peyronie's disease, the agents include anti-inflammatory agents. The agents are preferably administered to the urethra by means of a penile insert (1) having a rapidly releasing coating (4) of the agent on its exterior surface or by means of an inserter (27) carrying a load of agent (31) which can be displaced into the urethra.

公开(公告)号：AU1125499A

公开(公告)日：1999-05-17

申请号：AU1125499

申请日：1998-10-28

Applicant: VIVUS INC

Inventor： DOHERTY PAUL C ,  PLACE VIRGIL A ,  SMITH WILLIAM L

IPC: A61K9/02 ,  A61K31/00 ,  A61K31/343 ,  A61K31/381 ,  A61K31/4015 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/426 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/47 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/485 ,  A61K31/496 ,  A61K31/50 ,  A61K31/501 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/549 ,  A61K31/5513 ,  A61K45/00 ,  A61K45/06 ,  A61P15/10 ,  A61K31/505

公开(公告)号：NZ305560A

公开(公告)日：1998-11-25

申请号：NZ30556096

申请日：1996-03-07

Applicant: VIVUS INC

Inventor： PLACE VIRGIL A

IPC: A61K38/00 ,  A61F5/41 ,  A61K9/00 ,  A61K31/445 ,  A61K31/48 ,  A61K31/505 ,  A61K31/54 ,  A61K31/557 ,  A61K33/00 ,  A61K45/00 ,  A61P9/00 ,  A61P13/02 ,  A61P15/00 ,  A61M31/00

Abstract: A method is provided for preventing erectile dysfunction, particularly vasculogenic impotence, in a male individual. The method involves periodic administration of a vasoactive agent throughout a 24-hour period. The agent and dosage regimen are selected such that regularly increased blood flow to the penis is achieved, in turn preventing arterial occlusion and vascular deterioration of the muscular fibers of the vessels and collagen fibers of the cavernosal tissue.

公开(公告)号：CZ320497A3

公开(公告)日：1998-05-13

申请号：CZ320497

申请日：1996-04-10

Applicant: US HEALTH ,  VIVUS INC

Inventor： KEEFER LARRY K ,  SAAVEDRA JOSEPH E ,  DOHERTY PAUL C ,  HANAMOTO MARK S ,  PLACE VIRGIL A

IPC: A61M3/00 ,  A61K31/13 ,  A61K31/44 ,  A61K31/655 ,  A61K31/785 ,  A61K47/48 ,  A61P13/02 ,  A61P15/00 ,  A61P15/10 ,  C08F8/30 ,  A61K38/00 ,  A61L27/00 ,  A61L31/00

Abstract: A method of treatment for impotency is provided. The method involves the administration of nitric oxide by a nitric oxide-releasing agent capable of providing a penile erection-inducing amount of nitric oxide to the corpus cavernosum of the penis of an impotent male animal. Also provided is a nitric oxide delivery means for use in the method.

公开(公告)号：NO974062D0

公开(公告)日：1997-09-04

申请号：NO974062

申请日：1997-09-04

Applicant: VIVUS INC

Inventor： PLACE VIRGIL A

IPC: A61K38/00 ,  A61F5/41 ,  A61K9/00 ,  A61K31/445 ,  A61K31/48 ,  A61K31/505 ,  A61K31/54 ,  A61K31/557 ,  A61K33/00 ,  A61K45/00 ,  A61P9/00 ,  A61P13/02 ,  A61P15/00 ,  A61K

Abstract: A method is provided for preventing erectile dysfunction, particularly vasculogenic impotence, in a male individual. The method involves periodic administration of a vasoactive agent throughout a 24-hour period. The agent and dosage regimen are selected such that regularly increased blood flow to the penis is achieved, in turn preventing arterial occlusion and vascular deterioration of the muscular fibers of the vessels and collagen fibers of the cavernosal tissue.

公开(公告)号：MX9604330A

公开(公告)日：1997-06-28

申请号：MX9604330

申请日：1995-03-20

Applicant: VIVUS INC

Inventor： PLACE VIRGIL A

IPC: A61B5/00 ,  A61B5/055 ,  A61B5/103 ,  A61B5/11 ,  A61B5/20 ,  A61B8/06 ,  A61F5/41 ,  A61K9/00 ,  A61K49/00 ,  A61M31/00 ,  A61B05/00 ,  A61B05/055 ,  A61B08/00 ,  A61B19/00

Abstract: Se provee un método para diagnosticar la disfuncion eréctil vasculogénica la impotencia vasculogénica y el síndrome de Peyronie. El método comprende la administracion transuretral de un agente vasodilatador para inducir una ereccion, seguida por la evaluacion hemodinámica utilizando ultrasonografía duplex, RMN, angiografía o similares. Se provee también estuches para llevar a cabo el método de diagnostico, así como métodos de tratamiento basados en la conclusion del diagnostico. Los estuches para diagnosticar la disfuncion eréctil comprende un agente vasodilatador (4) efectivo para inducir la ereccion del pene, un medio de suministro de fármaco (1, 11 o 49) para administrar transuretralmente el agente vasodilatador; un recipiente (15 o 55) para alojar el agente y el medio de suministro de fármaco e instrucciones escritas para usar el agente y el medio de suministro de fármaco.

公开(公告)号：FI963798A0

公开(公告)日：1996-09-24

申请号：FI963798

申请日：1996-09-24

Applicant: VIVUS INC

Inventor： PLACE VIRGIL A

IPC: A61B5/00 ,  A61B5/055 ,  A61B5/103 ,  A61B5/11 ,  A61B5/20 ,  A61B8/06 ,  A61F5/41 ,  A61K9/00 ,  A61K49/00 ,  A61M31/00 ,  A61B

Abstract: A method for diagnosing vasculogenic erectile dysfunction, including vasculogenic impotence and Peyronie's syndrome, is provided. The method involves transurethral administration of a vasodilating agent to induce an erection, followed by hemodynamic evaluation using duplex ultrasonography, NMR, angiography, or the like. Kits for conducting the diagnostic method are provided as well, as are methods of treatment based on the diagnostic conclusion.

公开(公告)号：AU2005248938A1

公开(公告)日：2006-02-02

申请号：AU2005248938

申请日：2005-12-23

Applicant: VIVUS INC

Inventor： PLACE VIRGIL A ,  SMTIH WILLIAM L ,  JNR PAUL C DOHERTY

IPC: A61K45/06 ,  A61K9/00 ,  A61K45/08