公开(公告)号：JP2003212793A

公开(公告)日：2003-07-30

申请号：JP2002311846

申请日：2002-10-25

Applicant: VIVUS INC

Inventor： PLACE VIRGIL A ,  WILSON LELAND F ,  DOHERTY JR PAUL C ,  HANAMOTO MARK S ,  SPIVACK ALFRED P ,  GESUNDHEIT NEIL ,  BENNETT SEAN R

IPC: A61K45/00 ,  A61K9/00 ,  A61K9/02 ,  A61K31/00 ,  A61K31/15 ,  A61K31/21 ,  A61K31/295 ,  A61K31/48 ,  A61K31/5377 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  A61K31/56 ,  A61K45/06 ,  A61M31/00 ,  A61P9/12 ,  A61P15/00 ,  A61P15/02 ,  A61P21/02 ,  A61P31/00 ,  A61P43/00

Abstract: PROBLEM TO BE SOLVED: To provide a pharmaceutical formulation useful in conjunction with a method for preventing the occurrence of yeast infection, for improving vaginal muscle tone and tissue health, for enhancing vaginal lubrication, and for minimizing collagen misdeposition resulting from hypoxia, and to provide a drug delivery device for administering a pharmaceutical formulation directly to the clitoral area. SOLUTION: This drug delivery device for administering the pharmaceutical formulation directly to the clitoral area in a female individual has a slender patch having upper and lower regions. The pharmaceutical formulation for preventing the occurrence of the yeast infection in the female individual, a pharmaceutical formulation for improving the vaginal muscle tone and tissue health in the female individual, the pharmaceutical formulation for enhancing vaginal lubrication in the female individual, and a pharmaceutical formulation for minimizing collagen misdeposition in the female individual are also provided. COPYRIGHT: (C)2003,JPO

公开(公告)号：CA2503391A1

公开(公告)日：2004-05-06

申请号：CA2503391

申请日：2003-10-22

Applicant: VIVUS INC

Inventor： WILSON LELAND F ,  SPIVAK ALFRED P ,  HANAMOTO MARK S ,  GESUNDHEIT NEIL ,  BENNETT SEAN R ,  PLACE VIRGIL A

IPC: A61K9/00 ,  A61K9/02 ,  A61K9/127 ,  A61K31/00 ,  A61K31/15 ,  A61K31/21 ,  A61K31/295 ,  A61K31/4178 ,  A61K31/437 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4704 ,  A61K31/48 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/502 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  A61K31/56 ,  A61K45/06 ,  A61K45/08 ,  A61P15/12

Abstract: An immediate release topical pharmaceutical composition is provided which is administrable on an as-needed basis to enhance female sexual desire and responsiveness. The formulation contains a Type III, Type IV, Type V, or nonspecific phosphodiesterase inhibitor as an active agent.

公开(公告)号：AU2003284877A1

公开(公告)日：2004-05-13

申请号：AU2003284877

申请日：2003-10-22

Applicant: VIVUS INC

Inventor： PLACE VIRGIL A ,  WILSON LELAND F ,  DOHERTY PAUL C ,  HANAMOTO MARK S ,  SPIVAK ALFRED P ,  GESUNDHEIT NEIL ,  BENNETT SEAN R

IPC: A61K9/00 ,  A61K9/02 ,  A61K9/127 ,  A61K31/00 ,  A61K31/15 ,  A61K31/21 ,  A61K31/295 ,  A61K31/4178 ,  A61K31/437 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4704 ,  A61K31/48 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/502 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  A61K31/56 ,  A61K45/06 ,  A61K45/08 ,  A61P15/12

Abstract: A topical pharmaceutical composition is provided for the treatment of female sexual dysfunction, wherein the composition is formulated so as to contain a therapeutically effective amount of a phosphodiesterase inhibitor and a pharmaceutically acceptable carrier for topical administration. The phosphodiesterase inhibitor is generally selected from Type III, Type IV, Type V, and nonspecific phosphodiesterase inhibitors.

公开(公告)号：WO2004037262A2

公开(公告)日：2004-05-06

申请号：PCT/US0333642

申请日：2003-10-22

Applicant: VIVUS INC

Inventor： PLACE VIRGIL A ,  WILSON LELAND F ,  DOHERTY PAUL C DI ,  HANAMOTO MARK S ,  SPIVAK ALFRED P ,  GESUNDHEIT NEIL ,  BENNETT SEAN R

IPC: A61K9/00 ,  A61K9/02 ,  A61K9/127 ,  A61K31/00 ,  A61K31/15 ,  A61K31/21 ,  A61K31/295 ,  A61K31/4178 ,  A61K31/437 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4704 ,  A61K31/48 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/502 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  A61K31/56 ,  A61K45/06 ,  A61K45/08 ,  A61P15/12

CPC classification number: A61K31/00 ,  A61K9/0034 ,  A61K9/02 ,  A61K9/127 ,  A61K31/15 ,  A61K31/21 ,  A61K31/295 ,  A61K31/4178 ,  A61K31/437 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4704 ,  A61K31/48 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/502 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00

Abstract: An immediate release topical pharmaceutical composition is provided which is administrable on an as-needed basis to enhance female sexual desire and responsiveness. The formulation contains a Type III, Type IV, Type V, or nonspecific phosphodiesterase inhibitor as an active agent.

Abstract translation: 提供了立即释放的局部药物组合物，其可以根据需要施用以增强女性的性欲和反应性。 该制剂含有III型，IV型，V型或非特异性磷酸二酯酶抑制剂作为活性剂。

公开(公告)号：AU1125399A

公开(公告)日：1999-05-17

申请号：AU1125399

申请日：1998-10-28

Applicant: VIVUS INC

Inventor： PLACE VIRGIL A ,  WILSON LELAND F ,  DOHERTY PAUL C ,  HANAMOTO MARK S ,  SPIVACK ALFRED P ,  GESUNDHEIT NEIL ,  BENNETT SEAN R

IPC: A61K45/00 ,  A61K9/00 ,  A61K9/02 ,  A61K31/00 ,  A61K31/15 ,  A61K31/21 ,  A61K31/295 ,  A61K31/48 ,  A61K31/5377 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  A61K31/56 ,  A61K45/06 ,  A61M31/00 ,  A61P9/12 ,  A61P15/00 ,  A61P15/02 ,  A61P21/02 ,  A61P31/00 ,  A61P43/00

Abstract: Methods and formulations for treating female sexual dysfunction are provided. A pharmaceutical composition formulated so as to contain a selected vasoactive agent is administered to the vagina, vulvar area or urethra of the individual undergoing treatment. Suitable vasoactive agents are vasodilators, including naturally occurring prostaglandins, synthetic prostaglandin derivatives, endothelial-derived relaxation factors, vasoactive intestinal polypeptide agonists, smooth muscle relaxants, leukotriene inhibitors, and others. The formulations are also useful for preventing the occurrence of yeast infections, improving vaginal muscle tone and tissue health, enhancing vaginal lubrication, and minimizing excess collagen deposition. A clitoral drug delivery device is also provided.

公开(公告)号：EP1027057A4

公开(公告)日：2003-01-02

申请号：EP98954031

申请日：1998-10-28

Applicant: VIVUS INC

Inventor： PLACE VIRGIL A ,  WILSON LELAND F ,  DOHERTY PAUL C JR ,  HANAMOTO MARK S ,  SPIVACK ALFRED P ,  GESUNDHEIT NEIL ,  BENNETT SEAN R

IPC: A61K45/00 ,  A61K9/00 ,  A61K9/02 ,  A61K31/00 ,  A61K31/15 ,  A61K31/21 ,  A61K31/295 ,  A61K31/48 ,  A61K31/5377 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  A61K31/56 ,  A61K45/06 ,  A61M31/00 ,  A61P9/12 ,  A61P15/00 ,  A61P15/02 ,  A61P21/02 ,  A61P31/00 ,  A61P43/00

CPC classification number: B82Y5/00 ,  A61K9/0034 ,  A61K9/02 ,  A61K31/00 ,  A61K31/15 ,  A61K31/21 ,  A61K31/295 ,  A61K31/48 ,  A61K31/5377 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00