公开(公告)号：EP3626734A1

公开(公告)日：2020-03-25

申请号：EP17901101.0

申请日：2017-03-16

Applicant: Shenzhen Institutes of Advanced Technology

Inventor： REN, Peigen ,  ZHANG, Jian ,  TENG, Bin ,  LI, Jian ,  YAO, Zhenyu

IPC: C07K14/47 ,  C12N15/12 ,  A61K38/17 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P1/16 ,  A61P9/10

Abstract: The present disclosure relates to a peptide that regulates fat metabolism and uses thereof in the preparation of a medicament for the treatment of diseases associated with abnormalities in energy metabolism, particularly fat metabolism. The peptide of the present disclosure can reduce fat absorption, reduce fat accumulation in the liver and regulate fat metabolism, and has an advantage of being orally administered as compared with other general peptide products, and thus can also be used as an active ingredient of a health care product for regulating fat metabolism.

公开(公告)号：EP3521815A1

公开(公告)日：2019-08-07

申请号：EP17910501.0

申请日：2017-12-29

Applicant: Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS)

Inventor： WU, Yin ,  ZEN, Hairong ,  LIU, Xin

IPC: G01N24/08

Abstract: Provided is a method for measuring pH. Using amide protons as an endogenous contrast agent, a chemical exchange saturation transfer effect ratio R of amide protons corresponding to a pH-known amide proton solution under different saturation powers is measured by the method, then a function relation between pH and R is established according to different pH-known amide proton solutions and the corresponding measured R thereto, and finally the desired pH is calculated according to experimentally measured R i and the function relation. The method can eliminate the impact of concentration and does not require any estimation or measurement of the parameters such as the concentration of exchangeable protons, the longitudinal relaxation time of water, etc., and therefore can measure pH more accurately, conveniently and non-invasively. In addition, amide groups have a relatively low chemical exchange rate, and can be imaged stably under a clinical magnetic field strength, promising for clinical practices.

公开(公告)号：EP3511706A1

公开(公告)日：2019-07-17

申请号：EP17814509.0

申请日：2017-05-09

Applicant: Shenzhen Institutes of Advanced Technology

Inventor： XIA, Kai ,  WU, Tianzhun ,  SUN, Bin ,  ZENG, Qi

IPC: G01N27/30

Abstract: Provided are microelectrode array and method for preparing the same. The microelectrode array may have a modification layer disposed on a surface of an electrode thereof, and the modification layer comprises a platinum nanopillar modification layer, a platinum nanowire modification layer or a dendritic platinum modification layer. The modification layer can be adhered well to a substrate of the microelectrode and is less likely to fall off and cause electrode failure. The modified microelectrode has an increased surface area, reduced electrochemical impedance and increased charge injection capacity and charge storage capability of the electrode, this facilitating reducing the power consumption of an implantable system and improving the effect of electric stimulation.

公开(公告)号：EP3730976A1

公开(公告)日：2020-10-28

申请号：EP17935100.2

申请日：2017-12-29

Applicant: Shenzhen Institutes of Advanced Technology

Inventor： ZHENG, Hairong ,  XIA, Xiangxiang ,  CAI, Feiyan ,  KE, Manzhu ,  ZHOU, Hui ,  LI, Fei ,  XU, Di ,  LI, Yongchuan

IPC: G02B3/00

Abstract: A planar lens (100) and a manufacturing method for a planar lens (100) relate to the technical field of lenses, the planar lens (100) being a focusing lens and comprising an acoustic soft material tangible structure (110) and a cover layer (120), the acoustic soft material tangible structure (110) comprises a plurality of combination lenses (130) located in the same plane, each combination lens (130) comprises a circular part (131) and a plurality of concentric annular parts (132) which are continuously arranged around the circular part (131), the thicknesses of each two adjacent annular parts (132) in each combination lens (130) are different, and the thickness of each annular part (132) is related to the focal length of the respective combination lens (130); and the cover layer (120) covers the outer surface of the acoustic soft material tangible structure (110) to form the planar lens (100).

公开(公告)号：EP3716134A1

公开(公告)日：2020-09-30

申请号：EP17933117.8

申请日：2017-11-28

Applicant: Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences

Inventor： LI, Ye ,  FAN, Xiaomao ,  CAI, Yunpeng ,  YAO, Qihang ,  YANG, Yujie

IPC: G06K9/00 ,  A61B5/0402

Abstract: Present disclosure provides an ECG signal parallel analysis apparatus, method and a mobile terminal. The apparatus includes: an integrated memory, a CPU and a GPU. The integrated memory includes a first memory for being used by the CPU and a second memory for being used by the GPU, and the CPU may access the second memory. The CPU performs primary noise reduction on a received ECG original signal to obtain a primary ECG signal, and performs abnormal heartbeat classification preliminary screening on characteristic data extracted from the GPU to obtain suspected abnormal heartbeat data. The GPU performs characteristic extraction on the primary ECG signal to obtain characteristic data, performs secondary noise reduction on the primary ECG signal to obtain a secondary ECG signal, and processes the suspected abnormal heartbeat data and the secondary ECG signal by applying a template matching classification mode to obtain final abnormal heartbeat data. Present disclosure may increase efficiency of ECG signal analysis, and thus improves the timeliness of ECG signal analysis and feedback.

公开(公告)号：EP3607991A1

公开(公告)日：2020-02-12

申请号：EP17903960.7

申请日：2017-04-19

Applicant: Shenzhen Institutes of Advanced Technology

Inventor： CAI, Feiyan ,  LI, fei ,  WANG, Chen ,  QIU, Weibao ,  MENG, Long ,  WANG, Congzhi ,  XIAO, Yang ,  ZHENG, Hairong

IPC: A61M31/00 ,  A61M37/00

Abstract: The present disclosure relates to the acoustic manipulation technology and, in particular, to a system and method for manipulating particles based on a time reversal technique. An objective of the present disclosure is to manipulate the particles in any path in a non-uniform medium. To achieve the objective, the present disclosure provides the system for manipulating the particles based on a time reversal technique including array transducers, a signal reception and transmission control device and a host. The array transducers are communicatively connected to the signal reception and transmission control device. The signal reception and transmission control device is communicatively connected to the host. Therefore, the present disclosure can be applied to fields such as in vivo site-specific medicament administration and reproductive medicine, and has high practical values. The present disclosure further provides the method for manipulating the particles based on a time reversal technique.

公开(公告)号：EP4066749B1

公开(公告)日：2024-08-14

申请号：EP21710176.5

申请日：2021-02-05

IPC: A61B17/02 ,  A61H35/02 ,  A61B34/32 ,  A61B34/30

CPC classification number: A61B17/0231 ,  A61B34/30 ,  A61B34/32 ,  A61B2090/37120160201 ,  A61B2034/206520160201 ,  A61B2090/06420160201 ,  A61F2009/005220130101

公开(公告)号：EP4375366A1

公开(公告)日：2024-05-29

申请号：EP22845457.5

申请日：2022-07-22

Applicant: Shenzhen Institutes of Advanced Technology

Inventor： YU, Tao ,  WU, Lianghuan ,  TANG, Hongting ,  GUO, Shuyuan

IPC: C12N1/21 ,  C12N15/52 ,  C12N15/31 ,  C12P19/02

CPC classification number: Y02E50/10 ,  C12N1/16 ,  C12N15/81 ,  C07K14/195 ,  C12P19/02 ,  C12N15/52 ,  C12N15/74

Abstract: A method for producing glucose and derivatives thereof by means of biotransformation with a recombinant yeast, which belongs to the technical field of synthetic biology. A construction method comprises any one of the following steps: i, knocking out metabolic pathway-related enzymes of glucose and derivatives thereof in a yeast strain; ii, enhancing or using an activity of synthetic pathway-related enzymes of glucose and derivatives thereof in the yeast strain; and iii, enhancing or using a capability of glucose and derivatives thereof in the yeast strain to enter and exit the yeast. Further provided are a recombinant yeast strain capable of producing glucose or derivatives thereof at a high yield and the use thereof in the conversion of a non-grain low-carbon carbon source. The low-carbon non-grain carbon source synthesized by means of using photoelectrocatalysis or traditional chemical industry is used as a substrate, and rapid preparation of food product raw materials glucose and derivatives thereof from the non-grain carbon source is realized by means of recombinant yeast cells.

公开(公告)号：EP3716134B1

公开(公告)日：2023-01-04

申请号：EP17933117.8

申请日：2017-11-28

Inventor： LI, Ye ,  FAN, Xiaomao ,  CAI, Yunpeng ,  YAO, Qihang ,  YANG, Yujie

IPC: A61B5/308 ,  A61B5/332 ,  A61B5/00 ,  G06K9/00 ,  G16H50/20 ,  G16H50/70

公开(公告)号：EP3730046A1

公开(公告)日：2020-10-28

申请号：EP17935744.7

申请日：2017-12-28

Applicant: Shenzhen Institutes of Advanced Technology

Inventor： ZHENG, Hairong ,  LIU, Xin ,  ZOU, Chao ,  CHENG, Chuanli ,  QIAO, Yangzi ,  TIE, Changjun

IPC: A61B5/01

Abstract: The present invention provides a magnetic resonance temperature imaging method and apparatus, and relates to the field of magnetic resonance. According to the magnetic resonance temperature imaging method and apparatus, accuracy and precision of a water-fat tissue temperature image at a current moment are improved by using a two-step iterative temperature estimation algorithm, a magnetic resonance signal model includes multiple fat peaks, and a fourth strength amplitude value of a water signal, a fourth strength amplitude value of a fat signal, a fourth field drift caused by a non-uniform main magnetic field, and the water-fat tissue temperature image at the current moment that minimize a difference between signal strength and signal strength before fitting are estimated.