公开(公告)号：EP3566655A1

公开(公告)日：2019-11-13

申请号：EP17934679.6

申请日：2017-12-26

Applicant: Shenzhen Institutes of Advanced Technology

Inventor： XIAO, Yang ,  ZHENG, Hairong ,  WANG, Congzhi ,  NIU, Lili ,  DENG, Zhiting

IPC: A61B8/08

Abstract: A method and a device for acquiring biomechanical parameters based on an ultrasonic elastomyogram are provided, wherein the method includes: synchronously collecting a dynamic myodynamics image sequence and a dynamic elasticity image sequence of a single skeletal muscle under continuous stretching; acquiring a myodynamics parameter corresponding to each myodynamics image in the dynamic myodynamics image sequence and an elasticity modulus value corresponding to each elasticity image in the dynamic elasticity image sequence respectively; and generating an ultrasonic elastomyogram curve with the myodynamics parameter as the abscissa and the synchronized elasticity modulus value as the ordinate, and estimating a muscle biomechanical parameter based on the ultrasonic elastomyogram curve. Dynamically changing biomechanical parameters can be obtained, and the obtained muscle biomechanical parameters have relatively high accuracy.

公开(公告)号：EP3851514A1

公开(公告)日：2021-07-21

申请号：EP18928020.9

申请日：2018-07-26

Applicant: Shenzhen Institutes of Advanced Technology

Inventor： ZHENG, Hairong ,  LIU, Xiufang ,  MENG, Long ,  WANG, Yuchen ,  ZHOU, Wei ,  NIU, Lili ,  HUANG, Xiaowei ,  WANG, Congzhi

IPC: C12M1/42 ,  C12N15/09

Abstract: The present invention provides a gene transfection system and method. The gene transfection system includes an acoustothermal module (10) and a signal generating module (20); the acoustothermal module (10) includes a piezoelectric substrate (11), an acoustothermal chip (13) arranged on the piezoelectric substrate (11) and N sound-absorbing vessels (13) arranged on the acoustothermal chip (12) and used for cultivating recipient cells, and N is an integer greater than or equal to 1; the signal generating module (20) is used to output basic frequency signals; the acoustothermal chip (12) is used to convert the basic frequency signal to an acoustic wave signal, establish a temperature gradient field with the acoustic wave signal, and control the temperature of the recipient cell in the sound-absorbing vessels with the temperature gradient field, so that the pores are opened on the membranes of the recipient cell, and the nucleic acids or other substances can go into the cells through these pores. The present invention can solve the existing problems in the current non-viral transfection methods, such as being difficult to be excreted from the body, high energy, high toxicity, and low efficiency on certain types of cells, etc., and the present invention can reduce cost and thereby improve the practicability of the gene therapy compared with the traditional gene transfection methods.

公开(公告)号：EP3607991A1

公开(公告)日：2020-02-12

申请号：EP17903960.7

申请日：2017-04-19

Applicant: Shenzhen Institutes of Advanced Technology

Inventor： CAI, Feiyan ,  LI, fei ,  WANG, Chen ,  QIU, Weibao ,  MENG, Long ,  WANG, Congzhi ,  XIAO, Yang ,  ZHENG, Hairong

IPC: A61M31/00 ,  A61M37/00

Abstract: The present disclosure relates to the acoustic manipulation technology and, in particular, to a system and method for manipulating particles based on a time reversal technique. An objective of the present disclosure is to manipulate the particles in any path in a non-uniform medium. To achieve the objective, the present disclosure provides the system for manipulating the particles based on a time reversal technique including array transducers, a signal reception and transmission control device and a host. The array transducers are communicatively connected to the signal reception and transmission control device. The signal reception and transmission control device is communicatively connected to the host. Therefore, the present disclosure can be applied to fields such as in vivo site-specific medicament administration and reproductive medicine, and has high practical values. The present disclosure further provides the method for manipulating the particles based on a time reversal technique.