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    CATALYTIC DEAMINATION FOR CARPROLACTAM PRODUCTION
    22.
    发明申请
    CATALYTIC DEAMINATION FOR CARPROLACTAM PRODUCTION 审中-公开
    卡普拉康生产的催化清除

    公开(公告)号：WO2008103366A2

    公开(公告)日：2008-08-28

    申请号：PCT/US2008002202

    申请日：2008-02-20

    Applicant: UNIV MICHIGAN STATE ,  FROST JOHN W

    Inventor： FROST JOHN W

    IPC: C07D201/02 ,  C07D201/16

    CPC classification number: C07D201/00 ,  C07D201/02 ,  C07D201/08 ,  Y02P20/52

    Abstract: Catalytic processes for preparing caprolactam, pipecolinic acid, and their derivatives, from lysine or alpha-amino-epsilon-caprolactam starting materials, and products produced thereby. A process for preparing caprolactam or a derivative thereof, the process comprising contacting a reactant comprising lysine or alpha aminocaprolactam with a catalyst and a gas comprising hydrogen gas, in the presence of a solvent. The catalyst may be provided on a support material, such as a transition metal.

    Abstract translation: 由赖氨酸或α-氨基-ε-己内酰胺原料制备己内酰胺，哌可林酸及其衍生物的催化方法，以及由此制得的产物。 一种制备己内酰胺或其衍生物的方法，所述方法包括使包含赖氨酸或α-氨基己内酰胺的反应物与催化剂和包含氢气的气体在溶剂存在下接触。 催化剂可以提供在载体材料如过渡金属上。

    Copper catalyzed process for producing 4-substituted azetidinone derivatives
    28.
    发明授权
    Copper catalyzed process for producing 4-substituted azetidinone derivatives 失效
    用于生产4-取代的氮杂环丁酮衍生物的铜催化方法

    公开(公告)号：US5808055A

    公开(公告)日：1998-09-15

    申请号：US498499

    申请日：1995-07-05

    Applicant: Masashi Nakajima, deceased ,  Yasuharu Kimura ,  Kiyohito Imai

    Inventor： Masashi Nakajima, deceased ,  Yasuharu Kimura ,  Kiyohito Imai

    IPC: C07D201/02 ,  C07D205/09 ,  C07D403/12 ,  C07D405/12 ,  C07F7/18

    CPC classification number: C07D403/12 ,  C07D201/02 ,  C07D205/09 ,  C07D405/12

    Abstract: A process for producing a 4-substituted azetidinone derivative represented by the following general formula �III!: ##STR1## (wherein OR is a protected hydroxy group, Y is an alkyl group, an alkoxy group, a silyloxy group, a carbamoyloxy group, an amino group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group, and n is an integer of 0 or 1, provided that n does not represent 0 when Y is an alkoxy group, silyloxy group, carbamoyloxy group or amino group), characterized in that a 2-azetidinone derivative represented by the following general formula �I!: ##STR2## (wherein OR is as defined above, and X is an alkyl group or a substituted or unsubstituted aromatic group) is reacted with thiocarboxylic acid represented by the following general formula �II!: HSCO--(CH.sub.2).sub.n --Y �II! (wherein Y and n are respectively as defined above) in an organic solvent in the presence of copper compounds.

    Abstract translation: 用于制备由以下通式[III]表示的4-取代的氮杂环丁酮衍生物的方法：其中OR为被保护的羟基，Y为烷基，烷氧基，甲硅烷氧基， 氨基甲酰氧基，氨基，取代或未取代的芳基或取代或未取代的杂环基，并且n为0或1的整数，条件是当Y为烷氧基时，n不为0，甲硅烷氧基，氨基甲酰氧基 或氨基），其特征在于由以下通式[I]表示的2-氮杂环丁酮衍生物：其中OR如上所定义，X为烷基或取代或未取代的芳族基团 ）与铜化合物存在下的有机溶剂中由以下通式[II]表示的硫代羧酸反应：HSCO-（CH 2）n Y [II]（其中Y和n分别如上定义）。

    Process of synthesizing N-acyl auxiliaries
    29.
    发明授权
    Process of synthesizing N-acyl auxiliaries 失效
    合成N-酰基助剂的方法

    公开(公告)号：US5594134A

    公开(公告)日：1997-01-14

    申请号：US414541

    申请日：1995-03-31

    Applicant: Guo-Jie Ho ,  David J. Mathre

    Inventor： Guo-Jie Ho ,  David J. Mathre

    IPC: C07D201/02 ,  C07D205/04 ,  C07D207/12

    CPC classification number: C07D201/02

    Abstract: A process of synthesizing N-acyl auxiliary compounds is disclosed. A compound of the formula: ##STR1## is reacted with an anhydride in the presence of a lithium salt and an amine base to produce the N-acylated auxiliary.

    Abstract translation: 公开了合成N-酰基辅助化合物的方法。 在锂盐和胺碱的存在下，使下式的化合物与一种酸酐反应得到N-酰化的辅助物。

    Preparation of 5-membered ring heterocycles
    30.
    发明授权
    Preparation of 5-membered ring heterocycles 失效
    五元环杂环的制备

    公开(公告)号：US5453516A

    公开(公告)日：1995-09-26

    申请号：US165463

    申请日：1993-12-13

    Applicant: Rolf Fischer ,  Rolf Pinkos

    Inventor： Rolf Fischer ,  Rolf Pinkos

    IPC: C07D201/02 ,  C07D207/26 ,  C07D207/267 ,  C07D307/33 ,  C07D315/00 ,  C07D207/27 ,  C07D307/28

    CPC classification number: C07D201/02 ,  C07D207/267 ,  C07D307/33 ,  C07D315/00

    Abstract: A process for preparing 5-membered ring heterocycles of the general formula I ##STR1## where R.sup.1 is methyl or hydroxyethyl,R.sup.2,R.sup.3,R.sup.4,R.sup.5 and R.sup.6 are hydrogen, C.sub.1 - to C.sub.12 -alkyl, C.sub.2 - to C.sub.12 -alkenyl, aryl, C.sub.3 - to C.sub.8 -cycloalkyl, C.sub.1 - to C.sub.12 -alkoxy, halogen, C.sub.2 - to C.sub.20 -alkoxycarbonylalkyl, C.sub.2 - to C.sub.20 -alkylcarbonyloxy, formyl, C.sub.2 - to C.sub.20 -formylalkyl, benzoyl or --CH(OR.sup.3)(OR.sup.5), or R.sup.3 and R.sup.5 together are a C.sub.2 - to C.sub.7 -alkylene chain which is unsubstituted or monosubstituted to pentasubstituted by R.sup.4 or a .dbd.CH--CH.dbd.CH--CH.dbd. unit which is unsubstituted or monosubstituted to tetrasubstituted by R.sup.4,X is oxygen or N--R.sup.4by reacting 5-membered ring heterocycles of the general formula II ##STR2## where R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and X have the abovementioned meanings and Y is hydrogen, acetyl or C.sub.2 - to C.sub.20 -alkoxycarbonyl, with dimethyl or ethylene carbonate in the presence of a nitrogen-containing base at from 50.degree. to 300.degree. C. and from 0.01 to 50 bar is described.

    Abstract translation: 其中R 1是甲基或羟乙基，R 2，R 3，R 4，R 5和R 6是氢，C 1 -C 12 - 烷基，C 2 -C 12的通式I（I）的五元环杂环的制备方法 - 烯基，芳基，C 3 -C 8 - 环烷基，C 1 -C 12 - 烷氧基，卤素，C 2 -C 20 - 烷氧基羰基烷基，C 2 -C 20 - 烷基羰氧基，甲酰基，C 2 -C 20甲酰烷基，苯甲酰基或-CH ）（OR 5）或R 3和R 5一起是未被取代或单取代以被R4或a = CH-CH = CH-CH =未被R4单取代或单取代的单元的C2至C7-亚烷基链， X是通过使通式II的5-元环杂环（II）其中R 2，R 3，R 4，R 5，R 6和X具有上述含义并且Y是氢，乙酰基或C 2 - 在含有50〜300℃的含氮碱和0.01〜50巴的存在下，与二甲基或碳酸亚乙酯进行反应。

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