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21.
公开(公告)号:US07449486B2
公开(公告)日:2008-11-11
申请号:US11252232
申请日:2005-10-17
Applicant: Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
Inventor: Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
IPC: A61K31/433 , C07D285/12
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂,特别是KSP,以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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22.Additives comprising (N, N-diorganothiocarbamyl) phosphorothioites and lubricant compositions containing the same 失效
Title translation: 包含(N,N-二有机硫代氨基甲酰基)硫代磷酸酯和含有它们的润滑剂组合物的添加剂公开(公告)号:US4104181A
公开(公告)日:1978-08-01
申请号:US834368
申请日:1977-09-19
Applicant: Phillip S. Landis , Abraham O. M. Okorodudu
Inventor: Phillip S. Landis , Abraham O. M. Okorodudu
CPC classification number: C07F9/201 , C10M137/105 , C10M2223/047 , C10N2240/02 , C10N2240/401 , C10N2250/10
Abstract: Novel (N, N-diorganothiocarbamyl) phosphorothioites having the following general structures: ##STR1## and mixtures thereof impart good antiwear and EP properties to lubricant compositions (e.g. gear oils and cutting oils) containing them.
Abstract translation: 具有以下通用结构的新型(N,N-二有机硫代氨基甲酰基)硫代磷酸酯:其中含有它们的润滑剂组合物(例如齿轮油和切削油)具有良好的抗磨损性和EP性能。
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公开(公告)号:US3756802A
公开(公告)日:1973-09-04
申请号:US3756802D
申请日:1970-12-30
Applicant: CIBA GEIGY AG
Inventor: BERIGER E
IPC: C07F9/16 , C07F9/165 , C07F9/201 , C07F9/206 , C07F9/24 , C07F9/28 , C07F9/40 , C07F9/572 , C07F9/6533 , C07F9/6578 , A01N9/36
CPC classification number: C07F9/40 , C07F9/16 , C07F9/1656 , C07F9/201 , C07F9/206 , C07F9/24 , C07F9/28 , C07F9/5721 , C07F9/6533 , C07F9/6578
Abstract: A METHOD OF DEFOLIATING PLANTS, ESPECIALLY COTTON PLANTS, IS DISCLOSED, WHICH COMPRISES APPLYING TO SAID PLANTS A COMPOUND OF THE FORMULA
R1-S-P(-Y)-S-R2
WHEREIN R1 AND R2 EACH REPRESENTS AN ALKYL GROUP CONTAINING UP TO 6 CARBON ATOMS AND Y STANDS FOR HALOGEN.-
公开(公告)号:US3286000A
公开(公告)日:1966-11-15
申请号:US33059563
申请日:1963-12-16
Applicant: BAYER AG
Inventor: IVAR UGI , UWE FETZER , GUNTER UNTERSTENHOFER , WOLFGANG BEHRENZ
IPC: C07F9/09 , C07F9/12 , C07F9/141 , C07F9/165 , C07F9/18 , C07F9/201 , C07F9/24 , C07F9/30 , C07F9/32 , C07F9/40 , C07F9/44 , C07F9/6571 , C07F9/6574
CPC classification number: C07F9/6574 , C07F9/091 , C07F9/12 , C07F9/141 , C07F9/1651 , C07F9/18 , C07F9/201 , C07F9/24 , C07F9/2408 , C07F9/242 , C07F9/30 , C07F9/3264 , C07F9/3282 , C07F9/4075 , C07F9/44 , C07F9/657118
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公开(公告)号:US2866806A
公开(公告)日:1958-12-30
申请号:US39250453
申请日:1953-11-16
Applicant: ETHYL CORP
Inventor: MARKLEY FRANCIS X , LARSON MELVIN L
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公开(公告)号:US2841525A
公开(公告)日:1958-07-01
申请号:US57886156
申请日:1956-04-18
Applicant: MONSANTO CHEMICALS
Inventor: BIRUM GAIL H , WEESNER WILLIAM E
CPC classification number: C07F9/201 , C07F9/141 , C07F9/4006
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公开(公告)号:US2500195A
公开(公告)日:1950-03-14
申请号:US69528146
申请日:1946-09-06
Applicant: STANDARD OIL DEV CO
Inventor: MCDERMOTT JOHN P
IPC: C07C329/00 , C07F9/165 , C07F9/201
CPC classification number: C10M1/08 , C07F9/165 , C07F9/201 , C10M2201/041 , C10M2201/042 , C10M2201/062 , C10M2203/10 , C10M2205/00 , C10M2205/18 , C10M2205/20 , C10M2207/021 , C10M2207/027 , C10M2207/08 , C10M2207/125 , C10M2207/129 , C10M2207/144 , C10M2207/146 , C10M2207/16 , C10M2207/28 , C10M2207/40 , C10M2207/404 , C10M2209/082 , C10M2211/00 , C10M2211/044 , C10M2211/06 , C10M2215/202 , C10M2219/024 , C10M2219/044 , C10M2219/062 , C10M2219/066 , C10M2219/087 , C10M2219/088 , C10M2219/089 , C10M2223/04 , C10M2223/042 , C10M2223/045 , C10M2223/121 , C10N2210/00 , C10N2210/02 , C10N2210/03 , C10N2240/08 , C10N2250/10
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公开(公告)号:US20180334441A1
公开(公告)日:2018-11-22
申请号:US16009030
申请日:2018-06-14
Applicant: Array Biopharma Inc.
Inventor: Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen Laird , John Robinson , Shelley Allen
IPC: C07D285/12 , C07F9/6539 , C07F9/201 , C07D417/12 , C07D417/06 , C07D271/107 , C07D413/12 , C07D413/06 , C07D413/04 , C07D401/12 , C07D417/04
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors.
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公开(公告)号:US4251469A
公开(公告)日:1981-02-17
申请号:US74846
申请日:1979-09-13
Applicant: Horst Zinke , Joachim Lorenz
Inventor: Horst Zinke , Joachim Lorenz
CPC classification number: C10M137/105 , C07F9/1651 , C07F9/201 , C10M2203/06 , C10M2203/10 , C10M2205/00 , C10M2205/026 , C10M2207/024 , C10M2207/025 , C10M2207/026 , C10M2207/028 , C10M2207/123 , C10M2207/129 , C10M2207/16 , C10M2207/22 , C10M2207/284 , C10M2207/285 , C10M2207/289 , C10M2209/084 , C10M2211/08 , C10M2215/04 , C10M2215/044 , C10M2215/064 , C10M2215/065 , C10M2215/066 , C10M2215/08 , C10M2215/082 , C10M2215/14 , C10M2215/182 , C10M2215/22 , C10M2215/221 , C10M2215/224 , C10M2215/225 , C10M2215/226 , C10M2215/26 , C10M2215/28 , C10M2215/30 , C10M2217/028 , C10M2217/046 , C10M2217/06 , C10M2219/024 , C10M2219/044 , C10M2219/046 , C10M2219/082 , C10M2219/086 , C10M2219/087 , C10M2219/089 , C10M2219/09 , C10M2219/10 , C10M2219/102 , C10M2219/104 , C10M2219/106 , C10M2219/108 , C10M2223/04 , C10M2223/041 , C10M2223/042 , C10M2223/043 , C10M2223/045 , C10M2223/047 , C10M2223/06 , C10M2223/061 , C10N2210/02 , C10N2210/04 , C10N2210/05
Abstract: Trithio- and tetrathiophosphates with mercaptocarboxylic acid derivatives are preeminently suitable as extreme pressure additives for lubricants. They reduce signs of wear and have no or only an insignificant corrosive action on the parts to be protected.
Abstract translation: 具有巯基羧酸衍生物的三硫代磷酸酯和四硫代磷酸酯非常适合用作润滑剂的极压添加剂。 它们减少了磨损的迹象,对被保护部件没有或只有微不足道的腐蚀作用。
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30.Lubricant compositions containing sulfur-containing esters of phosphoric acid 失效
Title translation: 含有磷酸的含硫酯的润滑剂组合物公开(公告)号:US4197209A
公开(公告)日:1980-04-08
申请号:US881211
申请日:1978-02-27
Applicant: Horst Zinke , Joachim Lorenz
Inventor: Horst Zinke , Joachim Lorenz
CPC classification number: C10M137/105 , C07F9/1651 , C07F9/201 , C10M2203/06 , C10M2203/10 , C10M2205/00 , C10M2205/026 , C10M2207/024 , C10M2207/025 , C10M2207/026 , C10M2207/028 , C10M2207/123 , C10M2207/129 , C10M2207/16 , C10M2207/22 , C10M2207/284 , C10M2207/285 , C10M2207/289 , C10M2209/084 , C10M2211/08 , C10M2215/04 , C10M2215/044 , C10M2215/064 , C10M2215/065 , C10M2215/066 , C10M2215/08 , C10M2215/082 , C10M2215/14 , C10M2215/182 , C10M2215/22 , C10M2215/221 , C10M2215/224 , C10M2215/225 , C10M2215/226 , C10M2215/26 , C10M2215/28 , C10M2215/30 , C10M2217/028 , C10M2217/046 , C10M2217/06 , C10M2219/024 , C10M2219/044 , C10M2219/046 , C10M2219/082 , C10M2219/086 , C10M2219/087 , C10M2219/089 , C10M2219/09 , C10M2219/10 , C10M2219/102 , C10M2219/104 , C10M2219/106 , C10M2219/108 , C10M2223/04 , C10M2223/041 , C10M2223/042 , C10M2223/043 , C10M2223/045 , C10M2223/047 , C10M2223/06 , C10M2223/061 , C10N2210/02 , C10N2210/04 , C10N2210/05
Abstract: Trithio- and tetrathiophosphates with mercaptocarboxylic acid derivatives are preeminently suitable as extreme pressure additives for lubricants. They reduce signs of wear and have no or only an insignificant corrosive action on the parts to be protected.
Abstract translation: 具有巯基羧酸衍生物的三硫代磷酸酯和四硫代磷酸酯非常适合用作润滑剂的极压添加剂。 它们减少了磨损的迹象,对被保护部件没有或只有微不足道的腐蚀作用。
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