公开(公告)号：US20160339145A1

公开(公告)日：2016-11-24

申请号：US15106468

申请日：2014-12-19

Applicant: KENT STATE UNIVERSITY

Inventor： Elda Hegmann ,  Torsten Hegmann ,  Yunxiang Gao

IPC: A61L27/18 ,  A61L27/56 ,  C08J9/26 ,  C08G63/682 ,  C09K19/38 ,  C12N5/00 ,  A61L27/58

CPC classification number: A61L27/18 ,  A61L27/3834 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/63 ,  A61L2400/00 ,  A61L2400/08 ,  C08G63/6822 ,  C08J9/26 ,  C08J2201/0442 ,  C08J2207/10 ,  C08J2367/04 ,  C09K19/3833 ,  C09K19/3838 ,  C09K2219/00 ,  C12N5/0062 ,  C12N2533/30 ,  C12N2537/10 ,  C08L67/04 ,  C08L101/12

Abstract: A polymeric scaffold contains pendant liquid crystal side chains and has fully interconnected pores. Such a polymeric scaffold will preferably be 3D in nature and elastomeric, biocompatible and biodegradable. Such 3D liquid crystal elastomer (LCE) scaffolds can be used for various biomedical applications, including cell culture applications. A method for the production of such a polymeric scaffold containing liquid crystals and having interconnected pores is also disclosed that uses a metal foam sacrificial template as a scaffold to produce the polymeric smart response scaffold of the present invention. Consistent and controlled pore sizes result from etching the sacrificial metal foam template away from the polymeric scaffold, permitting the incorporation of growth factors, when needed, for enhancing cell viability and proliferation.

Abstract translation: 聚合物支架包含侧链液晶侧链并且具有完全互连的孔。 这种聚合物支架本质上优选为3D，弹性体，生物相容性和生物降解性。 这种3D液晶弹性体（LCE）支架可用于各种生物医学应用，包括细胞培养应用。 还公开了一种用于生产含有液晶并具有互连孔的聚合物支架的方法，其使用金属泡沫牺牲模板作为支架来生产本发明的聚合智能反应支架。 通过将牺牲金属泡沫模板蚀刻离开聚合物支架，导致一致和受控的孔径，允许在需要时引入生长因子以增强细胞活力和增殖。

公开(公告)号：US09006303B2

公开(公告)日：2015-04-14

申请号：US12530450

申请日：2007-03-08

Applicant: Yugen Zhang ,  Jackie Y. Ying ,  Pranab K. Singapore

Inventor： Yugen Zhang ,  Jackie Y. Ying ,  Pranab K. Singapore

IPC: C08F14/00 ,  B01J31/16 ,  B01J20/26 ,  B01J20/28 ,  B01J20/285 ,  B01J31/02 ,  B01J31/06 ,  B01J37/00 ,  C08F212/08 ,  C08J9/26 ,  B01J21/08

CPC classification number: B01J31/1625 ,  B01J20/265 ,  B01J20/267 ,  B01J20/28057 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28083 ,  B01J20/28092 ,  B01J20/285 ,  B01J21/08 ,  B01J31/0234 ,  B01J31/0237 ,  B01J31/0244 ,  B01J31/063 ,  B01J31/067 ,  B01J31/1658 ,  B01J37/0018 ,  B01J2231/32 ,  C08F212/08 ,  C08J9/26 ,  C08J2201/024 ,  C08J2201/0442 ,  C08J2205/048 ,  C08J2325/04 ,  Y02P20/588 ,  C08F212/36

Abstract: The invention provides a particulate material comprising porous polymeric microparticles having a mesoporous structure. A process for making the particles is also presented. The process comprises impregnating a porous microparticulate template material with a liquid comprising one or more monomers. The one or more monomers are then polymerized in and/or on the template material to form a polymer, and the template material is then removed to produce the particulate material.

Abstract translation: 本发明提供包含具有中孔结构的多孔聚合物微粒的颗粒材料。 还提出了制备颗粒的方法。 该方法包括用包含一种或多种单体的液体浸渍多孔微粒模板材料。 然后将一种或多种单体在模板材料中和/或模板材料上聚合以形成聚合物，然后除去模板材料以产生颗粒材料。

公开(公告)号：US08372322B2

公开(公告)日：2013-02-12

申请号：US12578001

申请日：2009-10-13

Applicant: Arnaud Morin ,  Pascal Gentile ,  Nicolas Pauc

Inventor： Arnaud Morin ,  Pascal Gentile ,  Nicolas Pauc

IPC: B29C67/20 ,  C08J9/26 ,  C08J7/14 ,  C08J5/22 ,  H01M8/00

CPC classification number: H01M4/8867 ,  B01D67/003 ,  B01D2325/021 ,  C08J9/26 ,  C08J2201/0442 ,  C08J2327/18 ,  H01M4/8626 ,  H01M2008/1095 ,  Y10T428/249978

Abstract: The invention relates to a process for the formation of pores of controlled shape, dimensions and distribution in a polymer matrix comprising a step of embedding silicon nanowires and/or nanotrees in a nonpolymerized polymer matrix or a nonpolymerized polymer matrix in suspension or in solution in at least one solvent, a step of curing the polymer matrix, and a step of removing the silicon nanowires and/or nanotrees by chemical treatment. The process of the invention can be used for the manufacture of a proton exchange membrane fuel cell active layer. The invention has applications in the field of manufacture of proton exchange membrane fuel cells, in particular.

Abstract translation: 本发明涉及在聚合物基质中形成受控形状，尺寸和分布的孔的方法，包括将硅纳米线和/或纳米线嵌入非聚合的聚合物基质或非聚合的聚合物基质中的悬浮液或溶液中的溶液 至少一种溶剂，固化聚合物基质的步骤，以及通过化学处理除去硅纳米线和/或纳米线的步骤。 本发明的方法可用于制造质子交换膜燃料电池活性层。 本发明特别是在质子交换膜燃料电池的制造领域中的应用。

公开(公告)号：US08022110B2

公开(公告)日：2011-09-20

申请号：US12562908

申请日：2009-09-18

Applicant: Yasuharu Yamada ,  Tomoyuki Suzuki ,  Jun Sakai ,  Norihiro Tomokiyo

Inventor： Yasuharu Yamada ,  Tomoyuki Suzuki ,  Jun Sakai ,  Norihiro Tomokiyo

IPC: C08J9/26 ,  C08L9/08

CPC classification number: C08J9/26 ,  C08G2101/00 ,  C08J2201/0442 ,  C08J2379/08 ,  C08L79/08

Abstract: A porous polyimide obtained by removing a silica phase from an organic-inorganic polymer hybrid having a molecule structure in which a polyimide phase and the silica phase are held together by covalent bond.

Abstract translation: 从具有分子结构的有机 - 无机聚合物杂化物中除去二氧化硅得到的多孔聚酰亚胺，其中聚酰亚胺相和二氧化硅相通过共价键保持在一起。

公开(公告)号：US20100048745A1

公开(公告)日：2010-02-25

申请号：US12562908

申请日：2009-09-18

Applicant: Yasuharu YAMADA ,  Tomoyuki Suzuki ,  Jun Sakai ,  Norihiro Tomokiyo

Inventor： Yasuharu YAMADA ,  Tomoyuki Suzuki ,  Jun Sakai ,  Norihiro Tomokiyo

IPC: C08J9/26

CPC classification number: C08J9/26 ,  C08G2101/00 ,  C08J2201/0442 ,  C08J2379/08 ,  C08L79/08

Abstract: A porous polyimide obtained by removing a silica phase from an organic-inorganic polymer hybrid having a molecule structure in which a polyimide phase and the silica phase are held together by covalent bond.

Abstract translation: 从具有分子结构的有机 - 无机聚合物杂化物中除去二氧化硅得到的多孔聚酰亚胺，其中聚酰亚胺相和二氧化硅相通过共价键保持在一起。

公开(公告)号：US06929764B2

公开(公告)日：2005-08-16

申请号：US09992084

申请日：2001-11-19

Applicant: Peng Jiang ,  Vicki L. Colvin

Inventor： Peng Jiang ,  Vicki L. Colvin

IPC: C08J9/26 ,  C08J9/40 ,  B29C71/02 ,  B29D11/00 ,  C09K3/00 ,  C23F4/04

CPC classification number: C08J9/40 ,  B01J13/0021 ,  B01J13/0043 ,  B01J13/0047 ,  C08J9/26 ,  C08J2201/0442 ,  C08J2201/046

Abstract: Ordered, monodisperse macroporous polymers, their corresponding ordered, monodisperse colloids, and methods of preparing them are disclosed. The methods use an ordered, monodisperse colloidal template to define the polymer pore morphology, which in turn acts as a mold for the growth of a new ordered, monodisperse colloid. The macroporous polymer may be prepared with either spherical or ellipsoidal pores from a wide variety of polymeric systems. The new ordered, monodisperse colloid may be grown from a wide variety of materials including ceramics, semiconductors, metals and polymers. These materials are potentially useful in optical, micro-filtering and drug delivery applications.

Abstract translation: 公开了有序的单分散大孔聚合物，它们相应的有序单分散胶体及其制备方法。 该方法使用有序的单分散胶体模板来定义聚合物孔隙形态，其反过来作为新的有序单分散胶体生长的模具。 大孔聚合物可以用来自各种各样的聚合物体系的球形或椭圆形孔制备。 新的有序单分散胶体可以从各种材料生长，包括陶瓷，半导体，金属和聚合物。 这些材料在光学，微量过滤和药物递送应用中是潜在的。

公开(公告)号：WO2016177872A1

公开(公告)日：2016-11-10

申请号：PCT/EP2016/060160

申请日：2016-05-06

Applicant: CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIEL

Inventor： SELHUBER-UNKEL, Christine ,  HÖLKEN, Iris ,  GUTEKUNST, Sören Björn ,  ADELUNG, Rainer

IPC: B29C67/20 ,  C08J9/26 ,  B01J20/30 ,  B01J20/28 ,  A61L12/14 ,  A01N25/04 ,  A01N25/10 ,  A01N25/16

CPC classification number: B01J20/28095 ,  A01N25/34 ,  A61L12/14 ,  B01J20/261 ,  B01J20/28047 ,  B01J20/28085 ,  B01J20/3057 ,  B29C67/202 ,  B29K2033/26 ,  B29K2105/0061 ,  B29K2909/02 ,  C02F1/285 ,  C02F2303/04 ,  C08J9/0038 ,  C08J9/26 ,  C08J2201/026 ,  C08J2201/0442 ,  C08J2205/022 ,  C08J2205/044 ,  C08J2205/05 ,  C08J2205/052 ,  C08J2207/10 ,  C08J2207/12 ,  C08J2333/02 ,  C08J2333/10 ,  C08J2333/26 ,  C08J2371/02 ,  A01N25/10

Abstract: The invention relates to a porous hydrogel matrix having substantially interconnected tunnel-shaped micropores with a three-dimensional configuration of an interconnected hollow tetrapod network. Such matrices may be used to entrap motile cells that migrate into the micropores of said matrix. The matrices of the invention are formed by a method comprising the steps of providing a solution of a hydrogel-forming material,providing a template material with a three-dimensional configuration corresponding to the negative configuration of the desired interconnected porous structure of the hydrogel material, said template material comprising interconnected zinc oxide tetrapod (t-ZnO)networks, casting the solution of hydrogel-forming material onto the template and removing the template material from the hydrogel material by acid hydrolysis of the template material.

Abstract translation: 本发明涉及具有互连的中空四足动物网络的三维构造的基本相互连接的隧道状微孔的多孔水凝胶基体。 这样的基质可用于捕获迁移到所述基质微孔中的运动细胞。 本发明的基质通过包括以下步骤的方法形成：提供水凝胶形成材料的溶液，提供模板材料，其具有对应于所述水凝胶材料的所需互连多孔结构的负构型的三维构型， 所述模板材料包括相互连接的氧化锌四足（t-ZnO）网络，将水凝胶形成材料的溶液浇铸到模板上，并通过模板材料的酸水解从水凝胶材料中除去模板材料。

公开(公告)号：WO0024437A8

公开(公告)日：2000-06-29

申请号：PCT/GB9903558

申请日：1999-10-28

Applicant: ASHBY SCIENT LTD ,  FULLER JESS PAUL ,  PEGG DAVID ,  BIRD ROBERT MCLEAN ,  CLIFFORD TIMOTHY BURGESS ,  CLAYSON TONY

Inventor： FULLER JESS PAUL ,  PEGG DAVID ,  BIRD ROBERT MCLEAN ,  CLIFFORD TIMOTHY BURGESS ,  CLAYSON TONY

IPC: C12M1/00 ,  A61F2/06 ,  A61F2/08 ,  A61F2/10 ,  A61F2/24 ,  A61F2/28 ,  A61F13/00 ,  A61K35/39 ,  A61K45/00 ,  A61K47/04 ,  A61K47/30 ,  A61L15/26 ,  A61L15/44 ,  A61L27/00 ,  A61L27/18 ,  A61L29/06 ,  A61P3/10 ,  A61P5/00 ,  A61P31/00 ,  A61P43/00 ,  C08J9/26 ,  C12M3/00 ,  C12M3/06 ,  C12N5/06

CPC classification number: C08J9/26 ,  A61L15/26 ,  A61L27/18 ,  A61L29/06 ,  C08J2201/0442 ,  C08J2383/04 ,  C12M21/08 ,  C12M23/24 ,  C12M25/02 ,  C08L83/04

Abstract: A method of making a silicone rubber having a structure adapted for growth of cells or living tissue, which comprises contacting a silicone rubber precursor with a biologically-acceptable sacrificial filler, curing the resultant mixture and removing the sacrificial filler to form a structured silicone rubber.

公开(公告)号：EP2300516B1

公开(公告)日：2012-10-03

申请号：EP09785329.5

申请日：2009-07-14

Applicant: Invibio Limited

Inventor： JARMAN-SMITH, Marcus ,  WHITEHEAD, Tony ,  ELLERAY, Andrew ,  DEVINE, John

IPC: C08J3/20 ,  C08J9/26

CPC classification number: C08J9/26 ,  C08J3/203 ,  C08J2201/044 ,  C08J2201/0442 ,  C08J2201/0444 ,  C08J2371/10 ,  Y10T428/2982

公开(公告)号：EP1776949A8

公开(公告)日：2010-06-30

申请号：EP07102048.1

申请日：2000-10-26

Applicant: MIP Technologies AB

Inventor： SELLERGREN, Börje ,  BÜCHEL, Gunter

IPC: A61K9/16 ,  C08J9/26

CPC classification number: C08J9/26 ,  B01J20/268 ,  B01J20/28019 ,  B01J20/3057 ,  B01J2220/52 ,  C07K17/14 ,  C08J2201/0442

Abstract: A porous, molecularly imprinted polymer and a process for its preparation are described. The porous, molecularly imprinted polymer is characterised in that it is obtainable by providing a porous silica; attaching a molecular template to the surface of the porous silica; filling the pores of the porous silica with a polymer; removing the silica and the molecular template, thereby leaving a porous, molecularly imprinted polymer. The process is characterised by the above defined process steps. Also described are a porous polymer vesicle and its preparation with the same features as defined for the porous, molecularly imprinted polymer and its preparation, except for the lack of the molecular template and thus the lack of the molecular imprint in the porous polymer.