Abstract:
A cuvette adapted to contain spherical particles having a specific binding agent on the surface thereof and which have a detectably different light scattering characteristic in the presence of a material having a specific binding partner therefor, and which includes a window through which light can be projected for the purpose of determining any change in light scattering properties of the contents of the cuvette, and an optical element occupying at least part of a wall of the cuvette which, when light passes theretrough, causes at least some of the light to be deflected off axis towards a particular point. By using such a cuvette in combination with a light level detector located as the said particular point, a cuvette can be identified before an assay is performed by checking the light level at the said particular point. The optical element may be a hologram or a diffraction grating or a lens or any combination thereof. A method of checking whether a cuvette inserted into a testing apparatus, includes such an optical element is described as well as a method of performing an assay which includes a cuvette validating step.
Abstract:
A portable device for detecting an analyte associated with a target organic molecule in a liquid and/or solid substance. The device includes a test chamber, a probe, and a sensor. The test chamber contains a liquid volume of test solution including an analytical reagent selected to react with the analyte. The test chamber is sealed by a pierceable membrane wall. The probe is removably positionable to pierce the membrane wall to deposit a sample in the test chamber to form a test mixture with the test solution. The sensor is positioned to detect one or more characteristics of the test mixture in the test chamber indicative of a reaction between the analyte and the analytical reagent.
Abstract:
A method and apparatus for performing rapid gold analyses, e.g., in soil or rock samples. The method comprises contacting the gold-containing solution with an oxidizing agent, and at least one crown ether; then separating the gold-crown ether complex from the remaining components of the solution; then recovering the gold ions from the gold-crown ether complex; then contacting the resulting gold-containing solution with a label means such as a chromophobe, and thereafter measuring the amount of bound label means in the solution. The apparatus (10, 11) includes an optical source (14) that irradiates a sample complex (12) with incident radiation of a first wavelength, a detector (20) that detects fluoresced light of a second wavelength, a detector (21) that detects transmitted light of the first wavelength, and a detector (15) for detecting the intensity of the source radiation. A processor (46) corrects the detected fluoresced and transmitted light for variations in the intensity of the incident radiation, and separately determines the gold concentration based on the respective corrected fluoresced and transmitted light, and selects which of the two measurements represents the most accurate measure of the gold concentration.
Abstract:
A system for conducting an assay comprises a power source (16), a controller (13) for controlling the assay and a plurality of assay units (14) operatively connected to one another such that the controller can communicate with the assay units and the system is capable of conducting the assay. An assay device comprises a substantially circular body (24) having a plurality of chambers in fluid connection such that fluid can pass between said chambers and a central hub (200) having a sample inlet (202) disposed therein for receiving a sample.
Abstract:
Measuring device (1; 15) for determining the composition of the liquid phase of a liquid-gas mixture, comprising a duct (2) defining a flow direction (X) of the mixture parallel to the longitudinal development axis (Y) of the duct (2) and a measuring element (4) arranged in the duct (2) and suited to determine the composition of a liquid layer that flows in contact with the internal surface (3) of the duct (2). The internal surface (3) of the duct (2) comprises an intercepting surface (5, 5') suited to convey part of the liquid layer towards the measuring element (4), arranged so that it is incident on the flow direction (X) and developed according to a conveyance trajectory that has a helical section and whose tangent to the outlet end (7, 7') intersects the measuring element (4).
Abstract:
The present disclosure relates to a diagnostic cartridge for immunodiagnosis, and a reader and a diagnostic system using the same. A diagnostic cartridge, including the diagnostic pad and the color reaction pad, is provided to detect a color reaction and a fluorescence reaction through the single diagnostic cartridge.
Abstract:
Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.
Abstract:
Disclosed are an analysis device and a method of determining a mounted state of a cartridge mounted in the analysis device. The analysis device includes: a mounting unit configured to mount a cartridge on which at least one well for containing a specimen is formed; a measuring unit configured to measure at least one signal corresponding to the at least one well formed on the cartridge; and an operation processor configured to process the at least one measured signal with respect to the at least one well measured by the measuring unit, wherein the operation processor determines a mounted state of the cartridge based on the at least one measured signal with respect to the at least one well formed on the cartridge.
Abstract:
Disclosed are an analysis device and a method of determining a mounted state of a cartridge mounted in the analysis device. The analysis device includes: a mounting unit configured to mount a cartridge on which at least one well for containing a specimen is formed; a measuring unit configured to measure at least one signal corresponding to the at least one well formed on the cartridge; and an operation processor configured to process the at least one measured signal with respect to the at least one well measured by the measuring unit, wherein the operation processor determines a mounted state of the cartridge based on the at least one measured signal with respect to the at least one well formed on the cartridge.
Abstract:
A configuration of detecting light from the front face of a light source is the best for confirming the variation of a light quantity, but when a plurality of light sources are present, as many detectors for checking a light quantity as the light sources are necessary and the apparatus configuration becomes complex. In the present invention, a detector for checking a light source light quantity is installed in a reaction container transfer mechanism used commonly for a plurality of detection sections, and the light quantities of light sources are checked with the detector.