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公开(公告)号：US10544966B2
公开(公告)日：2020-01-28
申请号：US15217902
申请日：2016-07-22
Applicant: Cepheid
Inventor： David Fromm , Tien Phan , Matthew Piccini
Abstract: Thermal control devices adapted to provide improved control and efficiency in temperature cycling are provided herein. Such thermal control device can include a thermoelectric cooler controlled in coordination with another thermal manipulation device to control an opposing face of the thermoelectric cooler and/or a microenvironment. Some such thermal control devices include a first and second thermoelectric cooler separated by a thermal capacitor. The thermal control devices can be configured in a planar configuration with a means for thermally coupling with a planar reaction vessel of a sample analyzer for use in thermal cycling in a polymerase chain reaction of the fluid sample in the reaction vessel. Methods of thermal cycling using such a thermal control devices are also provided.
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公开(公告)号：US12196460B2
公开(公告)日：2025-01-14
申请号：US17338264
申请日：2021-06-03
Applicant: Cepheid
Inventor： David Fromm , Tien Phan , Matthew Piccini
Abstract: Thermal control devices adapted to provide improved control and efficiency in temperature cycling are provided herein. Such thermal control device can include a thermoelectric cooler controlled in coordination with another thermal manipulation device to control an opposing face of the thermoelectric cooler and/or a microenvironment. Some such thermal control devices include a first and second thermoelectric cooler separated by a thermal capacitor. The thermal control devices can be configured in a planar configuration with a means for thermally coupling with a planar reaction vessel of a sample analyzer for use in thermal cycling in a polymerase chain reaction of the fluid sample in the reaction vessel. Methods of thermal cycling using such a thermal control devices are also provided.
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公开(公告)号：US20210364196A1
公开(公告)日：2021-11-25
申请号：US17338264
申请日：2021-06-03
Applicant: Cepheid
Inventor： David Fromm , Tien Phan , Matthew Piccini
Abstract: Thermal control devices adapted to provide improved control and efficiency in temperature cycling are provided herein. Such thermal control device can include a thermoelectric cooler controlled in coordination with another thermal manipulation device to control an opposing face of the thermoelectric cooler and/or a microenvironment. Some such thermal control devices include a first and second thermoelectric cooler separated by a thermal capacitor. The thermal control devices can be configured in a planar configuration with a means for thermally coupling with a planar reaction vessel of a sample analyzer for use in thermal cycling in a polymerase chain reaction of the fluid sample in the reaction vessel. Methods of thermal cycling using such a thermal control devices are also provided.
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公开(公告)号：US12280379B2
公开(公告)日：2025-04-22
申请号：US18054729
申请日：2022-11-11
Applicant: Cepheid
Inventor： Douglas B Dority , Tien Phan , David Fromm , Richard J. Casler, Jr. , Dustin Dickens , Stuart Morita , Matthew Piccini
Abstract: Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.
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公开(公告)号：US10562030B2
公开(公告)日：2020-02-18
申请号：US15217920
申请日：2016-07-22
Applicant: Cepheid
Inventor： Doug Dority , Tien Phan , David Fromm , Rick Casler , Dustin Dickens , Stuart Morita , Matthew Piccini
Abstract: Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.
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Patent Agency Ranking
公开(公告)号：US20230166263A1
公开(公告)日：2023-06-01
申请号：US18054729
申请日：2022-11-11
Applicant: Cepheid
Inventor： Douglas B. Dority , Tien Phan , David Fromm , Richard J. Casler, JR. , Dustin Dickens , Stuart Morita , Matthew Piccini
CPC classification number: B01L7/52 , H02P27/06 , H02P6/182 , G01N35/1095 , G01N35/00871 , B01L3/50273 , G01N35/1016 , B01L2300/023 , B01L2300/027 , B01L2300/1822 , B01L2300/0663 , B01L2300/1894 , B01L2400/0436 , B01L2400/0496 , G01N2201/0256 , G01N2035/00019 , G01N2035/00356 , B01L2200/04 , G01N2035/00316 , G01N2201/0221 , G01N2800/00 , B01L2200/0647 , B01L2400/0439 , B01L2200/025 , B01L2200/143 , B01L2300/1827 , B01L2300/14 , G01N33/4875
Abstract: Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.
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公开(公告)号：US11073310B2
公开(公告)日：2021-07-27
申请号：US16712797
申请日：2019-12-12
Applicant: Cepheid
Inventor： David Fromm , Tien Phan , Matthew Piccini
Abstract: Thermal control devices adapted to provide improved control and efficiency in temperature cycling are provided herein. Such thermal control device can include a thermoelectric cooler controlled in coordination with another thermal manipulation device to control an opposing face of the thermoelectric cooler and/or a microenvironment. Some such thermal control devices include a first and second thermoelectric cooler separated by a thermal capacitor. The thermal control devices can be configured in a planar configuration with a means for thermally coupling with a planar reaction vessel of a sample analyzer for use in thermal cycling in a polymerase chain reaction of the fluid sample in the reaction vessel. Methods of thermal cycling using such a thermal control devices are also provided.
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8.发明申请公开(公告)号：US20250130248A1
公开(公告)日：2025-04-24
申请号：US18920388
申请日：2024-10-18
Applicant: Cepheid
Inventor： Gowtham Subramaniam , Douglas B. Dority , Matthew Piccini , Jing Zhang
Abstract: Thermal control devices utilizing a thermal switch to facilitate cooling of a biological sample, particularly a biological sample tested with a semiconductor diagnostic detection chip. Such thermal switches can include a mass of thermally conductive material, such as copper or aluminum, that selectively contacts the diagnostic chip or sample tube by use of an air cylinder or a servo-driven moveable support. Alternatively, the thermal switch can utilize a thermally conductive material that selectively contacts the diagnostic chip or sample tube by use of an inflatable bladder. Alternatively, the thermal switch can utilize a voice coil and a heat sink to selectively contact the diagnostic chip. The thermal control device can further include thermal overshoot feature, such as an air blower or placement of a heat sink in close proximity to the chip or tube. Associated methods of assembly and use of thermal control devices are also provided herein.
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公开(公告)号：US11524301B2
公开(公告)日：2022-12-13
申请号：US16738944
申请日：2020-01-09
Applicant: Cepheid
Inventor： Douglas B Dority , Tien Phan , David Fromm , Richard J. Casler, Jr. , Dustin Dickens , Stuart Morita , Matthew Piccini
Abstract: Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.
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公开(公告)号：US20220253079A1
公开(公告)日：2022-08-11
申请号：US17574951
申请日：2022-01-13
Applicant: Cepheid
Inventor： Marissa Lee , Jessica Koay , Charles Rohrs , Earl Solis , Matthew Piccini , Richard J. Casler, JR.
Abstract: Thermal control devices and methods to provide improved control, speed and efficiency in temperature cycling are provided herein. Such thermal control device and methods can include one or more active elements, such a thermoelectric cooler device, that is controlled by an algorithm that regulates a temperature distribution of an adjacent reaction-vessel according to a temperature distribution command trajectory and estimated reaction-vessel temperature distribution. Some embodiments include two active elements that are bilaterally applied to opposing sides of the reaction-vessel. In some embodiments, the estimated reaction-vessel temperature is determined based on a state of power electronics of the element and a temperature output of one or more sensors of a portion of the element and/or an ambient environment of the reaction-vessel. Methods of calibration of such systems utilizing a thermal calibrator as a proxy for the reaction-vessel are also provided herein.
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