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公开(公告)号：US09671342B2
公开(公告)日：2017-06-06
申请号：US11804151
申请日：2007-05-17
Applicant: Michael R. Gambini , Edward J. Lakatos , Anthony L. Cerrone , Eugene F. Young , Susan Atwood Stone
Inventor： Michael R. Gambini , Edward J. Lakatos , Anthony L. Cerrone , Eugene F. Young , Susan Atwood Stone
CPC classification number: G01N21/6428 , B01L3/5085 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/1811 , C12Q1/686 , C12Q2545/101 , G01N21/0303 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/06113 , G01N2201/0628 , G01N2201/0635 , G01N2201/0636 , G01N2201/068 , C12Q2563/107
Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.
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公开(公告)号：US20160047743A1
公开(公告)日：2016-02-18
申请号：US14783170
申请日：2014-04-16
Applicant: SANOGI-AVENTIS DEUTSCHLAND GMBH
Inventor： Gertrud Blei , Mario Bock
CPC classification number: G01N21/4738 , A61M5/31 , A61M5/3155 , A61M5/31568 , A61M2005/3126 , A61M2205/3306 , A61M2205/3379 , A61M2205/3553 , A61M2205/3592 , A61M2205/502 , A61M2205/505 , A61M2205/52 , A61M2205/581 , A61M2205/6081 , A61M2205/8206 , A61M2209/04 , G01N2201/021 , G01N2201/0628 , G01N2201/0634 , G06F19/00 , G06F19/3468
Abstract: A sensor device configured to be attached to a drug delivery device and configured to illuminate the drug delivery device when attached, the sensor device having an OLED having a transparent first electrode, a transparent second electrode and a central layer disposed between the first and second electrodes, the central layer comprising at least one organic layer, the at least one organic layer configured to emit light through the transparent first electrode, and an optical sensor arranged to receive light reflected from a surface of the drug delivery device, wherein the central layer of the OLED has a region without the at least one organic layer and wherein the optical sensor is arranged, when the sensor device is attached to the drug delivery device, to view a predetermined area of the surface of the drug delivery device through the region without the at least one organic layer.
Abstract translation: 传感器装置，被配置为附接到药物递送装置并且被配置为在附着时照射药物递送装置，所述传感器装置具有OLED，其具有透明的第一电极，透明的第二电极和设置在第一和第二电极之间的中心层 ，所述中心层包括至少一个有机层，所述至少一个有机层被配置为通过所述透明第一电极发光;以及光学传感器，被配置为接收从所述药物递送装置的表面反射的光，其中所述中心层 所述OLED具有没有所述至少一个有机层的区域，并且其中当所述传感器装置附接到所述药物递送装置时，所述光学传感器被布置成通过所述区域观察所述药物递送装置的表面的预定区域， 至少一个有机层。
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公开(公告)号：US08557569B2
公开(公告)日：2013-10-15
申请号：US12217410
申请日：2008-07-03
Applicant: Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
Inventor： Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
CPC classification number: G01N21/6486 , B01L7/52 , C12Q2545/101 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
Abstract: An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.
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公开(公告)号：US20120142112A1
公开(公告)日：2012-06-07
申请号：US12961675
申请日：2010-12-07
Applicant: Vincent P. Schnee
Inventor： Vincent P. Schnee
CPC classification number: G01N21/66 , G01N21/77 , G01N33/22 , G01N2201/0628 , Y10T436/17 , Y10T436/170769 , Y10T436/173076
Abstract: A senor uses a transduction mechanism of attenuating electroluminescence. Luminescence from a light emitting diode is attenuated as a consequence of direct interaction of an analyte and a electroluminescent material, An electroluminescent diode sensor (EDS) is fabricated in a way that allows the electroluminescent material in the diode to be exposed to gaseous, liquid or solid sample(s) which may affect the luminescence intensity of the diode,
Abstract translation: 传声器使用衰减电致发光的转导机制。 来自发光二极管的发光作为分析物和电致发光材料的直接相互作用的结果被衰减。电致发光二极管传感器（EDS）以允许二极管中的电致发光材料暴露于气体，液体或 可能影响二极管的发光强度的固体样品，
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公开(公告)号：US07460222B2
公开(公告)日：2008-12-02
申请号：US10535647
申请日：2003-11-14
Applicant: Stefan Kalveram , Friedrich Ziegler , Hans-Peter Haar , Hans List , Jean-Michel Asfour
Inventor： Stefan Kalveram , Friedrich Ziegler , Hans-Peter Haar , Hans List , Jean-Michel Asfour
CPC classification number: G01N21/8483 , G01N2201/0628 , H01L27/288
Abstract: The invention concerns a measuring device for the optical analysis of a diagnostic test element (10) comprising a light source (16), a photodetector (24) and a device (12) for positioning the test element (10) between the light source (16) and photodetector (24) where the light source (16) has one or several organic light-emitting diodes (OLEDs) and the OLEDs (14) for a composite structure with an imaging optics (20) and/or a photodetector (24) by means of a support substrate.
Abstract translation: 本发明涉及一种用于诊断测试元件（10）的光学分析的测量装置，包括光源（16），光电检测器（24）和用于将测试元件（10）定位在光源（ 16）和光电检测器（24），其中光源（16）具有一个或几个有机发光二极管（OLED）和用于具有成像光学器件（20）和/或光电检测器（24）的复合结构的OLED ）通过支撑衬底。
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Patent Agency Ranking
公开(公告)号：US20070154939A1
公开(公告)日：2007-07-05
申请号：US11711416
申请日：2007-02-26
Applicant: Anthony Cerrone , Edward Lakatos , Michael Gambini , Eugene Young , John Atwood , Susan Stone , Judith Atwood
Inventor： Anthony Cerrone , Edward Lakatos , Michael Gambini , Eugene Young , John Atwood , Susan Stone , Judith Atwood
CPC classification number: G01N21/6428 , B01L3/5085 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/1811 , C12Q1/686 , C12Q2545/101 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/06113 , G01N2201/0628 , G01N2201/0635 , G01N2201/0636 , G01N2201/068 , C12Q2563/107
Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.
Abstract translation: 光学仪器监测具有温度循环阻滞的反应装置中DNA的PCR复制，所述反应装置具有小瓶的反应成分，包括在双链DNA存在下发荧光的染料。 分束器将激发光束传递到小瓶以使染料发荧光。 来自染料的发射光束通过分束器传递到CCD检测器，处理器从该CCD检测器计算DNA浓度。 具有多个参考发射器的参考条发射不同强度的参考光束，处理器从该参考光束选择用于补偿漂移的最佳发射器。 自动调整曝光时间以保持CCD和处理器的最佳动态范围。 分束器和相关的滤光器的模块与选定的染料相关联，并且可替代不同的染料。
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公开(公告)号：US20070148761A1
公开(公告)日：2007-06-28
申请号：US11705856
申请日：2007-02-13
Applicant: Anthony Cerrone , Edward Lakatos , Michael Gambini , Eugene Young , Judith Atwood , John Atwood , Susan Stone
Inventor： Anthony Cerrone , Edward Lakatos , Michael Gambini , Eugene Young , Judith Atwood , John Atwood , Susan Stone
IPC: C12M1/34
CPC classification number: G01N21/6428 , B01L3/5085 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/1811 , C12Q1/686 , C12Q2545/101 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/06113 , G01N2201/0628 , G01N2201/0635 , G01N2201/0636 , G01N2201/068 , C12Q2563/107
Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having vials of reaction ingredients. A beam splitter passes an excitation beam to the vials. An emission beam from the reaction ingredients can be passed by the beam splitter to a detector from which a processor can compute DNA concentration. A reference strip with a plurality of reference emitters can be provided which emits reference beams of different intensity, from which the processor can select an optimum emitter for compensating for drift. Exposure time can be automatically adjusted for keeping within optimum dynamic ranges of the detector and processor. A module of the beam splitter and associated optical filters can be associated with a selected dye, and can be replaceable for different dyes.
Abstract translation: 光学仪器在具有小瓶反应成分的反应设备中监测DNA的PCR复制。 分束器将激发光束传递到小瓶。 来自反应成分的发射光束可以通过分光器传递到检测器，处理器可以从该分光器计算DNA浓度。 可以提供具有多个参考发射器的参考条，其发射不同强度的参考光束，处理器可以从其中选择用于补偿漂移的最佳发射器。 曝光时间可以自动调整，以保持在检测器和处理器的最佳动态范围内。 分束器和相关联的滤光器的模块可以与所选择的染料相关联，并且可以替代不同的染料。
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公开(公告)号：US20070102654A1
公开(公告)日：2007-05-10
申请号：US10561079
申请日：2004-06-17
Applicant: Harmannus Franciscus Schoo
Inventor： Harmannus Franciscus Schoo
IPC: G01N21/85
CPC classification number: G01N21/7703 , G01N21/274 , G01N21/4133 , G01N21/43 , G01N21/645 , G01N2021/7786 , G01N2201/0628 , H01L27/288 , H01L51/5036
Abstract: The invention relates to an optical sensor comprising at least one detection module which comprises an organic light emitting diode (1) and an organic detection photodiode (2, 2a) for measuring emitted light which during the use of the sensor reaches the photodiode via the sample holder. Optionally, a sensor according to the invention further comprises a plastic waveguide.
Abstract translation: 本发明涉及一种光学传感器，其包括至少一个检测模块，该检测模块包括有机发光二极管（1）和用于测量发射光的有机检测光电二极管（2,2a），所述发射光在传感器的使用期间经由光电二极管经由 样品架 可选地，根据本发明的传感器还包括塑料波导。
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公开(公告)号：US20060128009A1
公开(公告)日：2006-06-15
申请号：US11333483
申请日：2006-01-17
Applicant: Anthony Cerrone , Edward Lakatos , Michael Gambini , Eugene Young , Susan Stone , Judith Atwood
Inventor： Anthony Cerrone , Edward Lakatos , Michael Gambini , Eugene Young , Susan Stone , Judith Atwood
IPC: C12M1/34
CPC classification number: G01N21/6428 , B01L3/5085 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/1811 , C12Q1/686 , C12Q2545/101 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/06113 , G01N2201/0628 , G01N2201/0635 , G01N2201/0636 , G01N2201/068 , C12Q2563/107
Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.
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公开(公告)号：US06995348B2
公开(公告)日：2006-02-07
申请号：US10432296
申请日：2001-10-10
Applicant: Donal Bradley , John De Mello , Andrew De Malio
Inventor： Donal Bradley , John De Mello , Andrew De Malio
IPC: H01L31/00
CPC classification number: G01N21/6454 , G01N21/05 , G01N21/253 , G01N21/31 , G01N2021/0346 , G01N2021/6482 , G01N2201/0628
Abstract: A microfabricated detection system, comprising: a substrate chip; a chamber defined by the substrate chip to which a fluid sample is in use delivered; and at least one detector comprising at least one light-emitting diode including an organic semi-conductor element for emitting light into the chamber and at least one photocell including an organic semiconductor element for receiving light from the chamber.
Abstract translation: 一种微加工检测系统，包括：基板芯片; 由流体样品在其中使用的衬底芯片限定的室; 以及至少一个检测器，包括至少一个发光二极管，所述发光二极管包括用于将光发射到所述腔室中的有机半导体元件和至少一个包含用于接收来自所述腔室的光的有机半导体元件的光电池。
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